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Review

Pharmacogenetic Relevance of Endothelial Nitric Oxide Synthase Polymorphisms and Gene Interactions

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Pages 1423-1435 | Received 13 Jun 2018, Accepted 15 Oct 2018, Published online: 06 Nov 2018

References

  • Benjamin EJ , BlahaMJ , ChiuveSEet al. Heart Disease and Stroke Statistics-2017 update: a report from the American Heart Association . Circulation135 ( 10 ), e146 – e603 ( 2017 ).
  • Roth GA , ForouzanfarMH , MoranAEet al. Demographic and epidemiologic drivers of global cardiovascular mortality . N. Engl. J. Med.372 ( 14 ), 1333 – 1341 ( 2015 ).
  • Farah C , MichelLYM , BalligandJL . Nitric oxide signalling in cardiovascular health and disease . Nat. Rev. Cardiol.15 ( 5 ), 292 – 316 ( 2018 ).
  • Moncada S , HiggsA . The L-arginine-nitric oxide pathway . N. Engl. J. Med.329 ( 27 ), 2002 – 2012 ( 1993 ).
  • Emdin CA , KheraAV , KlarinDet al. Phenotypic consequences of a genetic predisposition to enhanced nitric oxide signaling . Circulation137 ( 3 ), 222 – 232 ( 2018 ).
  • Vanhoutte PM , ShimokawaH , FeletouM , TangEH . Endothelial dysfunction and vascular disease – a 30th anniversary update . Acta Physiol. (Oxf.)219 ( 1 ), 22 – 96 ( 2017 ).
  • Kathiresan S , SrivastavaD . Genetics of human cardiovascular disease . Cell148 ( 6 ), 1242 – 1257 ( 2012 ).
  • Casas JP , CavalleriGL , BautistaLE , SmeethL , HumphriesSE , HingoraniAD . Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review . Am. J. Epidemiol.164 ( 10 ), 921 – 935 ( 2006 ).
  • Cooke GE , DoshiA , BinkleyPF . Endothelial nitric oxide synthase gene: prospects for treatment of heart disease . Pharmacogenomics8 ( 12 ), 1723 – 1734 ( 2007 ).
  • Oliveira-Paula GH , LacchiniR , Tanus-SantosJE . Endothelial nitric oxide synthase: from biochemistry and gene structure to clinical implications of NOS3 polymorphisms . Gene575 ( 2 Pt 3 ), 584 – 599 ( 2016 ).
  • Oliveira-Paula GH , LacchiniR , Tanus-SantosJE . Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases . Nitric Oxide63 , 39 – 51 ( 2017 ).
  • Johnson JA , CavallariLH . Pharmacogenetics and cardiovascular disease – implications for personalized medicine . Pharmacol. Rev.65 ( 3 ), 987 – 1009 ( 2013 ).
  • Forstermann U , MunzelT . Endothelial nitric oxide synthase in vascular disease: from marvel to menace . Circulation113 ( 13 ), 1708 – 1714 ( 2006 ).
  • Fulton DJ . Transcriptional and posttranslational regulation of eNOS in the endothelium . Adv. Pharmacol.77 , 29 – 64 ( 2016 ).
  • Marsden PA , HengHH , SchererSWet al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene . J. Biol. Chem.268 ( 23 ), 17478 – 17488 ( 1993 ).
  • Lacchini R , SilvaPS , Tanus-SantosJE . A pharmacogenetics-based approach to reduce cardiovascular mortality with the prophylactic use of statins . Basic Clin. Pharmacol. Toxicol.106 ( 5 ), 357 – 361 ( 2010 ).
  • Metzger IF , SertorioJT , Tanus-SantosJE . Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes . Free Radic. Biol. Med.43 ( 6 ), 987 – 992 ( 2007 ).
  • Metzger IF , Souza-CostaDC , MarroniASet al. Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men . Pharmacogenet. Genomics15 ( 8 ), 565 – 570 ( 2005 ).
  • Luizon MR , MetzgerIF , LacchiniR , Tanus-SantosJE . Endothelial nitric oxide synthase polymorphism rs3918226 associated with hypertension does not affect plasma nitrite levels in healthy subjects . Hypertension59 ( 6 ), e52 ; author reply e53 ( 2012 ).
  • Metzger IF , IshizawaMH , Rios-SantosF , CarvalhoWA , Tanus-SantosJE . Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects . Pharmacogenomics J.11 ( 6 ), 393 – 399 ( 2011 ).
  • De Miranda JA , LacchiniR , BeloVAet al. The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents . J. Hum. Hypertens.29 ( 2 ), 109 – 114 ( 2015 ).
  • Miyamoto Y , SaitoY , NakayamaMet al. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a −786T–>C mutation associated with coronary spastic angina . Hum. Mol. Genet.9 ( 18 ), 2629 – 2637 ( 2000 ).
  • Nakayama M , YasueH , YoshimuraMet al. T-786–>C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm . Circulation99 ( 22 ), 2864 – 2870 ( 1999 ).
  • Salvi E , KutalikZ , GloriosoNet al. Genomewide association study using a high-density single nucleotide polymorphism array and case–control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase . Hypertension59 ( 2 ), 248 – 255 ( 2012 ).
  • Karantzoulis-Fegaras F , AntoniouH , LaiSLet al. Characterization of the human endothelial nitric-oxide synthase promoter . J. Biol. Chem.274 ( 5 ), 3076 – 3093 ( 1999 ).
  • Salvi E , KuznetsovaT , ThijsLet al. Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene . Hypertension62 ( 5 ), 844 – 852 ( 2013 ).
  • Zhang MX , ZhangC , ShenYHet al. Effect of 27 nt small RNA on endothelial nitric-oxide synthase expression . Mol. Biol. Cell19 ( 9 ), 3997 – 4005 ( 2008 ).
  • Zhang MX , ZhangC , ShenYHet al. Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene . J. Biol. Chem.283 ( 21 ), 14685 – 14693 ( 2008 ).
  • Tanus-Santos JE , DesaiM , FlockhartDA . Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants . Pharmacogenetics11 ( 8 ), 719 – 725 ( 2001 ).
  • Joshi MS , MineoC , ShaulPW , BauerJA . Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear . FASEB J.21 ( 11 ), 2655 – 2663 ( 2007 ).
  • Metzger IF , LuizonMR , LacchiniR , IshizawaMH , Tanus-SantosJE . Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects . Nitric Oxide28 , 33 – 38 ( 2013 ).
  • Kathiresan S , LarsonMG , VasanRSet al. Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community . Circulation112 ( 10 ), 1419 – 1427 ( 2005 ).
  • Ingelsson E , SyvanenAC , LindL . Endothelium-dependent vasodilation in conduit and resistance vessels in relation to the endothelial nitric oxide synthase gene . J. Hum. Hypertens.22 ( 8 ), 569 – 578 ( 2008 ).
  • Kullo IJ , GreeneMT , BoerwinkleE , ChuJ , TurnerST , KardiaSL . Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults . Atherosclerosis196 ( 2 ), 905 – 912 ( 2008 ).
  • Ihara H , TsutsukiH , IdaT , KozakiS , TsuyamaS , MossJ . Alternative polyadenylation sites of human endothelial nitric oxide synthase mRNA . Biochem. Biophys. Res. Commun.363 ( 1 ), 146 – 152 ( 2007 ).
  • Lai PF , MohamedF , MongeJC , StewartDJ . Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3′UTR . Cardiovasc. Res.59 ( 1 ), 160 – 168 ( 2003 ).
  • Crawford DC , NickersonDA . Definition and clinical importance of haplotypes . Ann. Rev. Med.56 , 303 – 320 ( 2005 ).
  • Luizon MR , BeloVA , FernandesKS , AndradeVL , Tanus-SantosJE , SandrimVC . Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjects . Mol. Biol. Rep.43 ( 6 ), 463 – 471 ( 2016 ).
  • Sandrim VC , LuizonMR , Izidoro-ToledoTC , CoelhoEB , MorenoHJr , Tanus-SantosJE . Functional VEGF haplotypes affect the susceptibility to hypertension . J. Hum. Hypertens.27 ( 1 ), 31 – 37 ( 2013 ).
  • Clark AG . The role of haplotypes in candidate gene studies . Genet. Epidemiol.27 ( 4 ), 321 – 333 ( 2004 ).
  • Balding DJ . A tutorial on statistical methods for population association studies . Nat. Rev. Genet.7 ( 10 ), 781 – 791 ( 2006 ).
  • Cardillo C , KilcoyneCM , CannonRO3rd , PanzaJA . Racial differences in nitric oxide-mediated vasodilator response to mental stress in the forearm circulation . Hypertension31 ( 6 ), 1235 – 1239 ( 1998 ).
  • Jones DS , AndrawisNS , AbernethyDR . Impaired endothelial-dependent forearm vascular relaxation in black Americans . Clin. Pharmacol. Ther.65 ( 4 ), 408 – 412 ( 1999 ).
  • Luizon MR , Izidoro-ToledoTC , SimoesAL , Tanus-SantosJE . Endothelial nitric oxide synthase polymorphisms and haplotypes in Amerindians . DNA Cell Biol.28 ( 7 ), 329 – 334 ( 2009 ).
  • Marroni AS , MetzgerIF , Souza-CostaDCet al. Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms . Nitric Oxide12 ( 3 ), 177 – 182 ( 2005 ).
  • Barbosa F Jr , SandrimVC , UzuelliJA , GerlachRF , Tanus-SantosJE . eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations . Nitric Oxide14 ( 1 ), 58 – 64 ( 2006 ).
  • Nagassaki S , MetzgerIF , Souza-CostaDC , MarroniAS , UzuelliJA , Tanus-SantosJE . eNOS genotype is without effect on circulating nitrite/nitrate level in healthy male population . Thromb. Res.115 ( 5 ), 375 – 379 ( 2005 ).
  • Cooper-Dehoff RM , JohnsonJA . Hypertension pharmacogenomics: in search of personalized treatment approaches . Nat. Rev. Nephrol.12 ( 2 ), 110 – 122 ( 2016 ).
  • Fontana V , LuizonMR , SandrimVC . An update on the pharmacogenetics of treating hypertension . J. Hum. Hypertens.29 ( 5 ), 283 – 291 ( 2015 ).
  • Fontana V , De FariaAP , Oliveira-PaulaGHet al. Effects of angiotensin-converting enzyme inhibition on leptin and adiponectin levels in essential hypertension . Basic Clin. Pharmacol. Toxicol.114 ( 6 ), 472 – 475 ( 2014 ).
  • Ismail H , MitchellR , McFarlaneSI , MakaryusAN . Pleiotropic effects of inhibitors of the RAAS in the diabetic population: above and beyond blood pressure lowering . Curr. Diab. Rep.10 ( 1 ), 32 – 36 ( 2010 ).
  • Silva PS , FontanaV , LuizonMRet al. eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril . Eur. J. Clin. Pharmacol.69 ( 2 ), 167 – 177 ( 2013 ).
  • Mason RP , JacobRF , KubantRet al. Effects of angiotensin receptor blockers on endothelial nitric oxide release: the role of eNOS variants . Br. J. Clin. Pharmacol.74 ( 1 ), 141 – 146 ( 2012 ).
  • Oliveira-Paula GH , LacchiniR , LuizonMRet al. Endothelial nitric oxide synthase tagSNPs influence the effects of enalapril in essential hypertension . Nitric Oxide55-56 , 62 – 69 ( 2016 ).
  • Pacanowski MA , ZinehI , Cooper-DehoffRM , PepineCJ , JohnsonJA . Genetic and pharmacogenetic associations between NOS3 polymorphisms, blood pressure, and cardiovascular events in hypertension . Am. J. Hypertens.22 ( 7 ), 748 – 753 ( 2009 ).
  • Zhang X , LynchAI , DavisBRet al. Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study . PLoS ONE7 ( 3 ), e34217 ( 2012 ).
  • Wu P , HaththotuwaR , KwokCSet al. Preeclampsia and future cardiovascular health: a systematic review and meta-analysis . Circ. Cardiovasc. Qual. Outcomes.10 ( 2 ), pii: e003497 ( 2017 ).
  • Sandrim VC , PaleiAC , MetzgerIF , GomesVA , CavalliRC , Tanus-SantosJE . Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble FMS-like tyrosine kinase-1 and soluble endogline in preeclampsia . Hypertension52 ( 2 ), 402 – 407 ( 2008 ).
  • Muniz L , LuizonMR , PaleiACet al. eNOS tag SNP haplotypes in hypertensive disorders of pregnancy . DNA Cell Biol.31 ( 12 ), 1665 – 1670 ( 2012 ).
  • Sandrim VC , PaleiAC , CavalliRCet al. eNOS haplotypes associated with gestational hypertension or preeclampsia . Pharmacogenomics9 ( 10 ), 1467 – 1473 ( 2008 ).
  • Sandrim VC , PaleiAC , SertorioJT , CavalliRC , DuarteG , Tanus-SantosJE . Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia . Mol. Hum. Reprod.16 ( 7 ), 506 – 510 ( 2010 ).
  • Sandrim VC , PaleiAC , LuizonMR , Izidoro-ToledoTC , CavalliRC , Tanus-SantosJE . eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension . Pharmacogenomics J.10 ( 1 ), 40 – 45 ( 2010 ).
  • Ding Y , VaziriND . Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric-oxide synthase expression . J. Pharmacol. Exp. Ther.292 ( 2 ), 606 – 609 ( 2000 ).
  • Taddei S , VirdisA , GhiadoniLet al. Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension . Hypertension37 ( 3 ), 943 – 948 ( 2001 ).
  • Lopez-Jaramillo P , NarvaezM , CalleAet al. Cyclic guanosine 3′,5′ monophosphate concentrations in pre-eclampsia: effects of hydralazine . Br. J. Obstet. Gynaecol.103 ( 1 ), 33 – 38 ( 1996 ).
  • Liao JK , LaufsU . Pleiotropic effects of statins . Ann. Rev. Pharmacol. Toxicol.45 , 89 – 118 ( 2005 ).
  • Abe K , NakayamaM , YoshimuraMet al. Increase in the transcriptional activity of the endothelial nitric oxide synthase gene with fluvastatin: a relation with the −786T>C polymorphism . Pharmacogenet. Genomics15 ( 5 ), 329 – 336 ( 2005 ).
  • Nagassaki S , SertorioJT , MetzgerIF , BemAF , RochaJB , Tanus-SantosJE . eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite . Free Radic. Biol. Med.41 ( 7 ), 1044 – 1049 ( 2006 ).
  • Andrade VL , SertorioJT , EleuterioNM , Tanus-SantosJE , FernandesKS , SandrimVC . Simvastatin treatment increases nitrite levels in obese women: modulation by T(-786)C polymorphism of eNOS . Nitric Oxide33 , 83 – 87 ( 2013 ).
  • Muniz JJ , LacchiniR , RinaldiTOet al. Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction . Pharmacogenomics J.13 ( 2 ), 189 – 196 ( 2013 ).
  • Peskircioglu L , AtacFB , ErdemSR , DeveciS , VerdiH , OzkardesH . The association between intron 4 VNTR, E298A and IVF 23 + 10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction . Int. J. Impot. Res.19 ( 2 ), 149 – 153 ( 2007 ).
  • Muniz JJ , LacchiniR , SertorioJTet al. Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction . Naunyn. Schmiedebergs. Arch. Pharmacol.386 ( 9 ), 805 – 811 ( 2013 ).
  • Gragasin FS , DavidgeST . The effects of propofol on vascular function in mesenteric arteries of the aging rat . Am. J. Physiol. Heart Circ. Physiol.297 ( 1 ), H466 – H474 ( 2009 ).
  • Oliveira-Paula GH , LacchiniR , PinheiroLCet al. Endothelial nitric oxide synthase polymorphisms affect the changes in blood pressure and nitric oxide bioavailability induced by propofol . Nitric Oxide75 , 77 – 84 ( 2018 ).
  • Zhong Q , ChenX , ZhaoY , LiuR , YaoS . Association of polymorphisms in pharmacogenetic candidate genes with propofol susceptibility . Sci. Rep.7 ( 1 ), 3343 ( 2017 ).
  • Aslibekyan S , ClaasSA , ArnettDK . To replicate or not to replicate: the case of pharmacogenetic studies: establishing validity of pharmacogenomic findings: from replication to triangulation . Circ. Cardiovasc. Genet.6 ( 4 ), 409 – 412 ; discussion 412 ( 2013 ).
  • Motsinger AA , RitchieMD , ReifDM . Novel methods for detecting epistasis in pharmacogenomics studies . Pharmacogenomics8 ( 9 ), 1229 – 1241 ( 2007 ).
  • Pander J , WesselsJA , MathijssenRH , GelderblomH , GuchelaarHJ . Pharmacogenetics of tomorrow: the 1 + 1 = 3 principle . Pharmacogenomics11 ( 7 ), 1011 – 1017 ( 2010 ).
  • Luizon MR , PereiraDA , SandrimVC . Pharmacogenomics of hypertension and preeclampsia: focus on gene–gene interactions . Front. Pharmacol.9 , 168 ( 2018 ).
  • Oliveira-Paula GH , LuizonMR , LacchiniRet al. Gene–gene interactions among PRKCA, NOS3 and BDKRB2 polymorphisms affect the antihypertensive effects of enalapril . Basic Clin. Pharmacol. Toxicol.120 ( 3 ), 284 – 291 ( 2017 ).
  • Sasser JM , MurphySR , GrangerJP . Emerging drugs for preeclampsia – the endothelium as a target . Expert Opin. Emerg. Drugs20 ( 4 ), 527 – 530 ( 2015 ).
  • Peiro C , RomachoT , CarraroR , Sanchez-FerrerCF . Visfatin/PBEF/Nampt: a new cardiovascular target?Front. Pharmacol.1 , 135 ( 2010 ).
  • Lovren F , PanY , ShuklaPCet al. Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis . Am. J. Physiol. Endocrinol. Metab.296 ( 6 ), E1440 – 1449 ( 2009 ).
  • Vallejo S , RomachoT , AnguloJet al. Visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activity . PLoS ONE6 ( 11 ), e27299 ( 2011 ).
  • Luizon MR , PaleiAC , CavalliRC , SandrimVC . Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives . Pharmacogenomics18 ( 6 ), 571 – 583 ( 2017 ).
  • Luizon MR , PaleiAC , SandrimVCet al. Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy . Pharmacogenomics J.14 ( 6 ), 535 – 541 ( 2014 ).
  • Luizon MR , PaleiACT , BeloVAet al. Gene–gene interactions in the NAMPT pathway, plasma visfatin/NAMPT levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy . Pharmacogenomics J.17 ( 5 ), 427 – 434 ( 2017 ).
  • Luizon MR , SandrimVC , PaleiACet al. Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy . Hypertens. Res.35 ( 9 ), 917 – 921 ( 2012 ).
  • Munshi A . Genetic variation in MDR1, LPL and eNOS genes and the response to atorvastatin treatment in ischemic stroke . Hum. Genet.131 ( 11 ), 1775 – 1781 ( 2012 ).
  • Kurth T , WinterAC , EliassenAHet al. Migraine and risk of cardiovascular disease in women: prospective cohort study . BMJ353 , i2610 ( 2016 ).
  • Kurth T , RohmannJL , ShapiroRE . Migraine and risk of cardiovascular disease . BMJ360 , k275 ( 2018 ).
  • Sutherland HG , GriffithsLR . Genetics of migraine: insights into the molecular basis of migraine disorders . Headache57 ( 4 ), 537 – 569 ( 2017 ).
  • Olesen J . Nitric oxide-related drug targets in headache . Neurotherapeutics7 ( 2 ), 183 – 190 ( 2010 ).
  • Goncalves FM , LuizonMR , SpecialiJG , Martins-OliveiraA , DachF , Tanus-SantosJE . Interaction among nitric oxide (NO)-related genes in migraine susceptibility . Mol. Cell. Biochem.370 ( 1–2 ), 183 – 189 ( 2012 ).
  • Goncalves FM , LuizonMR , SpecialiJG . Haplotypes in candidate genes related to nitric oxide pathway and vascular permeability associated with migraine and aura . J. Headache Pain13 ( 4 ), 335 – 336 ; author reply 337–338 ( 2012 ).
  • Goncalves FM , Martins-OliveiraA , SpecialiJGet al. Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine . DNA Cell Biol.29 ( 7 ), 357 – 362 ( 2010 ).
  • Goncalves FM , Martins-OliveiraA , SpecialiJGet al. Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine . DNA Cell Biol.30 ( 6 ), 363 – 369 ( 2011 ).
  • Luizon MR , GoncalvesFM , DachF . Gene–gene interactions implicated in vascular endothelial function in migraine . Headache58 ( 4 ), 601 – 602 ( 2018 ).
  • Frazer KA , MurraySS , SchorkNJ , TopolEJ . Human genetic variation and its contribution to complex traits . Nat. Rev. Genet.10 ( 4 ), 241 – 251 ( 2009 ).

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