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Research Article

NF1 Regulates Apoptosis in Ovarian Cancer Cells by Targeting MCL1 via miR-142–5p

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Pages 155-165 | Published online: 13 Dec 2018

References

  • Siegel RL , MillerKD , JemalA . Cancer statistics, 2018 . CA Cancer J. Clin.68 ( 1 ), 7 – 30 ( 2018 ).
  • Davis A , TinkerAV , FriedlanderM . “Platinum resistant” ovarian cancer: what is it, who to treat and how to measure benefit?Gynecol. Oncol.133 ( 3 ), 624 – 631 ( 2014 ).
  • Vaughan S , CowardJI , BastRCJret al. Rethinking ovarian cancer: recommendations for improving outcomes . Nat. Rev. Cancer11 ( 10 ), 719 ( 2011 ).
  • Patch A-M , ChristieEL , EtemadmoghadamDet al. Whole-genome characterization of chemoresistant ovarian cancer . Nature521 ( 7553 ), 489 ( 2015 ).
  • The Cancer Genome Atlas Research Network . Integrated genomic analyses of ovarian carcinoma . Nature474 ( 7353 ), 609 ( 2011 ).
  • Xu G , O’connellP , ViskochilDet al. The neurofibromatosis type 1 gene encodes a protein related to GAP . Cell62 ( 3 ), 599 – 608 ( 1990 ).
  • Brems H , BeertE , De RavelT , LegiusE . Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1 . Lancet Oncol.10 ( 5 ), 508 – 515 ( 2009 ).
  • Flotho C , SteinemannD , MullighanCet al. Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11 . Oncogene26 ( 39 ), 5816 ( 2007 ).
  • Seminog OO , GoldacreMJ . Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study . Br. J. Cancer108 ( 1 ), 193 ( 2013 ).
  • Patil S , ChamberlainRS . Neoplasms associated with germline and somatic NF1 gene mutations . Oncologist17 ( 1 ), 101 – 116 ( 2012 ).
  • Johannessen CM , ReczekEE , JamesMF , BremsH , LegiusE , CichowskiK . The NF1 tumor suppressor critically regulates TSC2 and mTOR . Proc. Natl Acad. Sci. USA102 ( 24 ), 8573 – 8578 ( 2005 ).
  • Dasgupta B , YiY , ChenDY , WeberJD , GutmannDH . Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors . Cancer Res.65 ( 7 ), 2755 – 2760 ( 2005 ).
  • Cox AD , DerCJ . Ras history: the saga continues . Small GTPases1 ( 1 ), 2 – 27 ( 2010 ).
  • Bollag G , ClappDW , ShihSet al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells . Nat. Genet.12 ( 2 ), 144 ( 1996 ).
  • Hölzel M , HuangS , KosterJet al. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome . Cell142 ( 2 ), 218 – 229 ( 2010 ).
  • Arima Y , HayashiH , KamataKet al. Decreased expression of neurofibromin contributes to epithelial–mesenchymal transition in neurofibromatosis type 1 . Exp. Dermatol.19 ( 8 ), e136 – e141 ( 2010 ).
  • Shapira S , BarkanB , FridmanE , KloogY , SteinR . The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways . Cell Death Differ.14 ( 5 ), 895 ( 2007 ).
  • Maertens O , JohnsonB , HollsteinPet al. Elucidating distinct roles for NF1 in melanomagenesis . Cancer Discov. CD-12-0313 ( 2012 ).
  • De Bruin EC , CowellCF , WarnePHet al. Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer . Cancer Discov. CD-13-0741 ( 2014 ).
  • Wertz IE , KusamS , LamCet al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 . Nature471 ( 7336 ), 110 ( 2011 ).
  • Ertel F , NguyenM , RoulstonA , ShoreGC . Programming cancer cells for high expression levels of MCL1 . EMBO Rep.14 ( 4 ), 328 – 336 ( 2013 ).
  • Bartel DP . MicroRNAs: genomics, biogenesis, mechanism, and function . Cell116 ( 2 ), 281 – 297 ( 2004 ).
  • Desjobert C , RenalierM-H , BergaletJet al. MiR-29a downregulation in ALK-positive anaplastic large-cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression . Blood117 ( 24 ), 6627 – 6637 ( 2011 ).
  • Gong J , ZhangJ , LiBet al. MicroRNA-125b promotes apoptosis by regulating the expression of MCL-1, BCL-w and IL-6R . Oncogene32 ( 25 ), 3071 ( 2013 ).
  • Chen W , DuJ , LiXet al. miR-509-3p promotes cisplatin-induced apoptosis in ovarian cancer cells through the regulation of anti-apoptotic genes . Pharmacogenomics18 ( 18 ), 1671 – 1682 ( 2017 ).
  • Li X , ChenW , ZengW , WanC , DuanS , JiangS . microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP . Br. J. Cancer116 ( 1 ), 66 ( 2017 ).
  • Zhou P , XuW , PengXet al. Large-scale screens of miRNA-mRNA interactions unveiled that the 3´UTR of a gene is targeted by multiple miRNAs . PLoS ONE8 ( 7 ), e68204 ( 2013 ).
  • Shi D , ZhaiB , ZhengY , RenR , HanM , WangX . Transcatheter arterial infusion chemotherapy increases expression level of miR-142-5p in stage III colorectal cancer . Indian J. Cancer52 ( 6 ), 47 ( 2015 ).
  • Ran FA , HsuPD , LinC-Yet al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity . Cell154 ( 6 ), 1380 – 1389 ( 2013 ).
  • Tsang FH-C , AuSL-K , WeiLet al. MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility . Front. Med.9 ( 3 ), 331 – 343 ( 2015 ).
  • Wang Z , LiuZ , FangX , YangH . MiR-142-5p suppresses tumorigenesis by targeting PIK3CA in non-small cell lung cancer . Cell. Physiol. Biochem.43 ( 6 ), 2505 – 2515 ( 2017 ).
  • Yan J , YangB , LinS , XingR , LuY . Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer . Gastric Cancer1 – 12 ( 2018 ).
  • Jia L , XiQ , WangHet al. miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity . Biochem. Biophys. Res. Comm.488 ( 2 ), 425 – 431 ( 2017 ).
  • Dahiya N , Sherman-BaustCA , WangT-Let al. MicroRNA expression and identification of putative miRNA targets in ovarian cancer . PLoS ONE3 ( 6 ), e2436 ( 2008 ).

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