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Research Article

Pharmacogenetic Testing in Primary Care Practice: Opinions of Physicians, Pharmacists and Patients

, , , , & ORCID Icon
Pages 589-598 | Received 08 Jan 2019, Accepted 05 Apr 2019, Published online: 13 Jun 2019

References

  • Green JS , O’BrienTJ , ChiappinelliVA , HarralsonAF. Pharmacogenomics instruction in US and Canadian medical schools: implications for personalized medicine. Pharmacogenomics11(9), 1331–1340 (2010).
  • Dion-Labrie M , FortinMC , HébertMJ , DoucetH. Réflexion éthique sur la médecine personnalisée: l’alliance de la science et de la médecine enfin réalisée?Rev. Colomb. Bioét.3(2), 33–56 (2008).
  • Commission De L’éthique En Science Et En Technologie (CEST) . Soins de santé personnalisés: document de consultation. QC, Canada (2012). www.ethique.gouv.qc.ca/fr/assets/documents/SSP/SSP_document_de_consultation_Web.pdf
  • Spear BB , Heath-ChiozziM , HuffJ. Clinical application of pharmacogenetics. Trends Mol. Med.7(5), 201–204 (2001).
  • Lee JW , AminkengF , BhavsarAPet al. The emerging era of pharmacogenomics: current successes, future potential, and challenges. Clin. Genet.86(1), 21–28 (2014).
  • Zed PJ , Abu-LabanRB , BalenRMet al. Incidence, severity and preventability of medication-related visits to the emergency department: a prospective study. CMAJ178(12), 1563–1569 (2008).
  • PharmGKB . Drug label annotations (2018). www.pharmgkb.org/labelAnnotations
  • Singh A . Pharmacogenomics: the potential of genetically guided prescribing. Austr. Fam. Phys.36(10), 820–824 (2008).
  • Letarte N , LavoieA , SheehanNet al. La pharmacothérapie personnalisée et la pharmacogénétique. Pharmactuel46(4), 258–268 (2013).
  • Ndegwa S . La pharmacogénomique et la warfarine [Notes sur les technologies de la santé en émergence]. Agence Canadienne des Médicaments et des technologies de la santé104, 1–8 (2007).
  • Poncin J . Les Américains sont-ils favorables à la pharmacogénomique?L’Observatoire de la génétique (2003). www.omics-ethics.org/observatoire/zoom/zoom_03/z_no10_03/z_no10_03_2.html
  • Gossard F , HametP. Pour distinguer génétique, génomique, pharmacogénétique et pharmacogénomique dans les problèmes éthiques. Les pratiques de recherche biomdicales visitées par la bioéthique (2003).
  • Hall SS . Personalized medicine’s bitter pill. MIT Technology Review ( 2003). www.technologyreview.com/s/401777/personalized-medicines-bitter-pill/
  • Rothstein MA . Pharmcogenomics Social, Ethical and Clinical Dimension. Éditions John Wiley & Sons (2003).
  • Mallal S , PhillipsE , CarosiGet al. HLA-B*5701 screening for hypersensitivity to abacavir . N. Engl. J. Med.358(6), 568–579 (2008).
  • Pirmohamed M , BurnsideG , ErikssonNet al. A randomized trial of genotype-guided dosing of warfarin. N. Engl. J. Med.369(24), 2294–2303 (2013).
  • Olson MC , MacielA , GariepyJFet al. Clinical impact of pharmacogenetic-guided treatment for patients exhibiting neuropsychiatric disorders: a randomized controlled trial. Prim Care Companion CNS Disord19(2), doi: 10.4088/PCC.16m02036. (2017).
  • Bradley P , ShiekhM , MehraVet al. Improved efficacy with targeted pharmacogenetic-guided treatment of patients with depression and anxiety: a randomized clinical trial demonstrating clinical utility. J Psychiatr Res96, 100–107 (2018).
  • Perez V , SalavertA , EspadalerJet al. Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder: results of a randomized, double-blind clinical trial. BMC Psychiatry17(1), 250 (2017).
  • Ielmini M , PoloniN , CaselliIet al. The utility of pharmacogenetic testing to support the treatment of bipolar disorder. Pharmgenomics Pers Med11, 35–42 (2018).
  • Wiltshire T , DongOM. Clinical pharmacogenetics: how do we ensure a favorable future for patients?Pharmacogenomics19(6), 553–562 (2018).
  • Drozda K , PacanowskiMA. Clinical trial designs to support clinical utility of pharmacogenomic testing. Pharmacotherapy37(9), 1000–1004 (2017).
  • Owusu Obeng A , FeiK , LevyKD et al. Physician-reported benefits and barriers to clinical implementation of genomic medicine: a multi-site IGNITE-network survey. J. Pers. Med.8(3), pii:E24 (2018).
  • Selkirk CG , WeissmanSM , AndersonA , HulickPJ. Physicians’ preparedness for integration of genomic and pharmacogenetic testing into practice within a major healthcare system. Genet. Test. Mol. Biomarkers17(3), 219–225 (2013).
  • Hull LE , LehmannLS , LynchJA. Gene-based prescribing is here – are providers ready?Am. J. Med.pii: S0002-9343(19)30231-1 (2019). ( Epub ahead of print).
  • Birch L , PétryF. L’utilisation des groupes de discussion dans l’élaboration des politiques en santé. Recherches qualitatives29(3), 103–132 (2011).
  • Rabiee F . Focus-group interview and data analysis. Proc. Nutr. Soc.63(4), 655–660 (2004).
  • Baribeau C , GermainM. L’entretien de groupe: considérations théoriques et méthodologiques. Recherches Qualitatives29(1), 28–49 (2010).
  • Tong A , SainsburyP , CraigJ. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care19(6), 349–357 (2007).
  • Blackburn MÈ , GaudreaultM , TremblayJ-F , VeilletteS. Portrait des 16–24 ans sans diplôme résidant sur le territoire de la Commission scolaire de Charlevoix. 93 (2005).
  • Blackburn M-È , JoyalI , BrooksS , TardifS , ArbourN. Étude sur l’abandon et la persévérance à la Mesure de formation de la main-d’œuvre d’Emploi-Québec. 98 (2013).
  • Blackburn M-È , TardifS. Étude sur l’abandon et la persévérance de trois mesures d’aide à l’emploi d’Emploi-Québec. 61 (2016).
  • Guest G , NameyE , McKennaK. How many focus groups are enough? Building an evidence base for nonprobability sample sizes. Field Methods29(1), 3–22 (2017).
  • Blackburn M-È . Les représentations sociales de la pharmacogénomique au Québec: éléments de prospective. Thèse de doctorat en sciences humaines appliquées415 (2012).
  • Paillé P , MucchielliA. L’analyse qualitative en sciences humaines et sociales. (4th). ColinA (Ed.). Paris, France (2016).
  • Miles MB , HubermanAM. Qualitative data analysis: An expanded sourcebook, 2nd ed.Sage Publications, Inc, CA, USA (1994).
  • Denzin NK . Interpretive Interactionism. 2,Sage Publications, Inc, CA, USA (2001).
  • Chan CY , ChuaBY , SubramaniamM , SuenEL , LeeJ. Clinicians’ perceptions of pharmacogenomics use in psychiatry. Pharmacogenomics18(6), 531–538 (2017).
  • De Denus S , LetarteN , HurlimannTet al. An evaluation of pharmacists’ expectations towards pharmacogenomics. Pharmacogenomics14(2), 165–175 (2013).
  • Mccullough KB , FormeaCM , BergKDet al. Assessment of the pharmacogenomics educational needs of pharmacists. Am. J. Pharm. Educ.75(3), 51 (2011).
  • Fargher EA , EddyC , NewmanWet al. Patients’ and healthcare professionals’ views on pharmacogenetic testing and its future delivery in the NHS. Pharmacogenomics8(11), 1511–1519 (2007).
  • Haga SB , BurkeW , GinsburgGS , MillsR , AgansR. Primary care physicians’ knowledge of and experience with pharmacogenetic testing. Clin. Genet.82(4), 388–394 (2012).
  • Stanek EJ , SandersCL , TaberKAet al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin. Pharmacol. Ther.91(3), 450–458 (2012).
  • Cohn I , CohnRD , ItoS. Professional opportunity for pharmacists to integrate pharmacogenomics in medication therapy. Can. Pharm. J. (Ott)151(3), 167–169 (2018).
  • Scheuner MT , SieverdingP , ShekellePG. Delivery of genomic medicine for common chronic adult diseases: a systematic review. JAMA299(11), 1320–1334 (2008).
  • Peterson JF , FieldJR , ShiYet al. Attitudes of clinicians following large-scale pharmacogenomics implementation. Pharmacogenomics J.16(4), 393–398 (2016).
  • Haga SB , MillsR , MoaddebJ , LapointeNA , ChoA , GinsburgGS. Primary care providers’ use of pharmacist support for delivery of pharmacogenetic testing. Pharmacogenomics18(4), 359–367 (2017).
  • Payne K , FargherEA , RobertsSAet al. Valuing pharmacogenetic testing services: a comparison of patients’ and health care professionals’ preferences. Value Health14(1), 121–134 (2011).
  • Rogausch A , PrauseD , SchallenbergA , BrockmollerJ , HimmelW. Patients’ and physicians’ perspectives on pharmacogenetic testing. Pharmacogenomics7(1), 49–59 (2006).
  • Lemke AA , HuttenSelkirk CG , GlaserNSet al. Primary care physician experiences with integrated pharmacogenomic testing in a community health system. Per. Med.14(5), 389–400 (2017).
  • Albassam A , AlshammariS , OudaG , KoshyS , AwadA. Knowledge, perceptions and confidence of physicians and pharmacists towards pharmacogenetics practice in Kuwait. PLoS One13(9), (2018).
  • Relling MV , KleinTE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin. Pharmacol. Ther.89(3), 464–467 (2011).
  • Mcmahon T , TucciJ. The perceptions of pharmacists in Victoria, Australia on pharmacogenetics and its implications. Pharm. Pract. (Granada)9(3), 141–147 (2011).
  • Tuteja S , HaynesK , ZayacC , SpragueJE , BernhardtB , PyeritzR. Community pharmacists’ attitudes towards clinical utility and ethical implications of pharmacogenetic testing. Per Med10(8), 793–800 (2013).
  • Prince AE , RocheMI. Genetic information, non-discrimination, and privacy protections in genetic counseling practice. J. Genet. Couns.23(6), 891–902 (2014).
  • Genetic Non-Discrimination Act Canadian Minister of Justice (2018).
  • Yau A , HaqueM. Pharmacogenomics: knowledge, attitude and practice among future doctors and pharmacists – a pilot study. J. Appl. Pharm. Sci.6(2), 141–145 (2016).
  • Lesko LJ , JohnsonJA. Academia at the crossroads: education and training in pharmacogenomics. Per. Med.9(5), 497–506 (2012).
  • Génome Québec, Inc . Introduction à la génomique, QC, Canada (2018). www.genomequebec-education-formations.com/formations.
  • Mukerjee G , HustonA , KabakchievB , Piquette-MillerM , Van SchaikR , DorfmanR. User considerations in assessing pharmacogenomic tests and their clinical support tools. NPJ Genom. Med.3(26), (2018).
  • Devine EB , LeeCJ , OverbyCLet al. Usability evaluation of pharmacogenomics clinical decision support aids and clinical knowledge resources in a computerized provider order entry system: a mixed methods approach. Int. J. Med. Inform.83(7), 473–483 (2014).
  • Blagec K , KoopmannR , Crommentuijn-VanRhenen Met al. Implementing pharmacogenomics decision support across seven European countries: the ubiquitous pharmacogenomics (U-PGx) project. J. Am. Med. Inform. Assoc.25(7), 893–898 (2018).