The ANKS1B Gene and its Associated Phenotypes: Focus on CNS Drug Response

References

• Ghersi E , VitoP , LopezP , AbdallahM , D’AdamioL. The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. J. Alzheimers Dis.6(1), 67–78 (2004).
   PubMed Web of Science ®Google Scholar
• McClay JL , AdkinsDE , ÅbergKet al. Genomewide pharmacogenomic analysis of response to treatment with antipsychotics. Mol. Psychiatry16(1), 76–85 (2011).
   PubMed Web of Science ®Google Scholar
• McClay JL , AdkinsDE , ÅbergKet al. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. Neuropsychopharmacology36(3), 616–626 (2011).
   PubMed Web of Science ®Google Scholar
• Teng S , YangJY , WangL. Genome-wide prediction and analysis of human tissue-selective genes using microarray expression data. BMC Med. Genomics6(Suppl. 1), S10 (2013).
   PubMedGoogle Scholar
• Letunic I , DoerksT , BorkP. SMART: recent updates, new developments and status in 2015. Nucl. Acids Res.43(D1), D257–D260 (2015).
   PubMed Web of Science ®Google Scholar
• Cunha SR , MohlerPJ. Ankyrin protein networks in membrane formation and stabilization. J. Cell. Mol. Med.13(11–12), 4364–4376 (2009).
   PubMed Web of Science ®Google Scholar
• Jordan BA , FernholzBD , BoussacMet al. Identification and verification of novel rodent postsynaptic density proteins. Mol. Cell Proteomics3(9), 857–871 (2004).
   PubMed Web of Science ®Google Scholar
• Lowenthal MS , MarkeySP , DosemeciA. Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins. J. Proteome Res.14(6), 2528–2538 (2015).
   PubMed Web of Science ®Google Scholar
• Fernández E , CollinsMO , UrenRTet al. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol. Systems Biol.5(1), 269 (2009).
   PubMedGoogle Scholar
• Fu X , McGrathS , PasillasM , NakazawaS , KampsMP. EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. Oncogene18(35), 4920–4929 (1999).
   PubMed Web of Science ®Google Scholar
• Jordan BA , FernholzBD , KhatriL , ZiffEB. Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Nat. Neurosci.10(4), 427–435 (2007).
   PubMed Web of Science ®Google Scholar
• Kurabi A , BrenerS , MobliM , KwanJJ , DonaldsonLW. A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. J. Mol. Biol.392(5), 1168–1177 (2009).
   PubMed Web of Science ®Google Scholar
• Jacob AL , JordanBA , WeinbergRJ. The organization of amyloid-β protein precursor intracellular domain-associated protein-1 in the rat forebrain. J. Comp. Neurol.518(16), 3221–3236 (2010).
   PubMed Web of Science ®Google Scholar
• Dosemeci A , ToyD , ReeseTS , Tao-ChengJ-H. AIDA-1 moves out of the postsynaptic density core under excitatory conditions. PLOS ONE10(9), e0137216 (2015).
   PubMed Web of Science ®Google Scholar
• Dosemeci A , ToyD , BurchA , BayerKU , Tao-ChengJ-H. CaMKII–mediated displacement of AIDA-1 out of the postsynaptic density core. FEBS Lett.590(17), 2934–2939 (2016).
   PubMed Web of Science ®Google Scholar
• Dosemeci A , WeinbergRJ , ReeseTS , Tao-ChengJ-H. The postsynaptic density: there is more than meets the eye. Front. Synaptic Neurosci.8, 23 (2016).
   PubMedGoogle Scholar
• Smirnova E , ShanbhagR , KurabiA , MobliM , KwanJJ , DonaldsonLW. Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS ONE8(6), e65605 (2013).
   PubMed Web of Science ®Google Scholar
• Saha S , ChantD , WelhamJ , McGrathJ. A systematic review of the prevalence of Schizophrenia. PLoS Med.2(5), e141 (2005).
   PubMed Web of Science ®Google Scholar
• van Os J , KapurS. Schizophrenia. Lancet374(9690), 635–645 (2009).
   PubMed Web of Science ®Google Scholar
• Malhotra AK , MurphyGM , KennedyJL. Pharmacogenetics of psychotropic drug response. Am. J. Psychiatry161(5), 780–796 (2004).
   PubMed Web of Science ®Google Scholar
• Meltzer H , MasseyB. The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr. Opin. Pharmacol.11(1), 59–67 (2011).
   PubMed Web of Science ®Google Scholar
• Lieberman JA , StroupTS , McEvoyJPet al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N. Engl. J. Med.353(12), 1209–1223 (2005).
   PubMed Web of Science ®Google Scholar
• Zhang J-P , MalhotraAK. Pharmacogenetics of antipsychotics: recent progress and methodological issues. Expert Opin. Drug Metab. Toxicol.9(2), 183–191 (2013).
   PubMed Web of Science ®Google Scholar
• Li J , YoshikawaA , BrennanMD , RamseyTL , MeltzerHY. Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes. Schizophr. Res.192, 194–204 (2018).
   PubMed Web of Science ®Google Scholar
• Kang S-G , CheeI-S , LeeK , LeeJ. rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride. Hum. Psychopharmacol.32(2), e2562 (2017).
   Web of Science ®Google Scholar
• Li Q , WineingerNE , FuD-Jet al. Genome-wide association study of paliperidone efficacy. Pharmacogenet. Genomics27(1), 7–18 (2017).
   PubMed Web of Science ®Google Scholar
• Stevenson JM , ReillyJL , HarrisMSHet al. Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. Transl. Psychiatry6, e739 (2016).
   PubMed Web of Science ®Google Scholar
• Hawcutt DB , FrancisB , CarrDFet al. Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. Lancet Respir. Med.6(6), 442–450 (2018).
   PubMed Web of Science ®Google Scholar
• Mahmoudpour SH , VeluchamyA , SiddiquiMKet al. Meta-analysis of genome wide association studies (GWAS) on the intolerance of angiotensin converting enzyme inhibitors. Pharmacogenet. Genomics27(3), 112–119 (2017).
   PubMed Web of Science ®Google Scholar
• Tian C , HromatkaBS , KieferAKet al. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat. Commun.8(1), 599 (2017).
   PubMedGoogle Scholar
• Ahola-Olli AV , WürtzP , HavulinnaASet al. Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am. J. Hum. Genet.100(1), 40–50 (2017).
   PubMed Web of Science ®Google Scholar
• Goes FS , McGrathJ , AvramopoulosDet al. Genome-wide association study of schizophrenia in Ashkenazi Jews. Am. J. Med. Geneti. Part B168(8), 649–659 (2015).
   PubMed Web of Science ®Google Scholar
• Vaidyanathan U , IsenJD , MaloneSM , MillerMB , McGueM , IaconoWG. Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study. Psychophysiology51(12), 1259–1271 (2014).
   PubMed Web of Science ®Google Scholar
• Luykx JJ , BakkerSC , LentjesEet al. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Mol. Psychiatry19(2), 228–234 (2014).
   PubMed Web of Science ®Google Scholar
• Cross-Disorder Group of the Psychiatric Genomics Consortium . Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet381(9875), 1371–1379 (2013).
   PubMed Web of Science ®Google Scholar
• Ahmeti KB , Ajroud-DrissS , Al-ChalabiAet al. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol.Aging34(1), 357.e7–19 (2013).
   PubMed Web of Science ®Google Scholar
• Comuzzie AG , ColeSA , LastonSLet al. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS ONE7(12), e51954 (2012).
   PubMed Web of Science ®Google Scholar
• Croteau-Chonka DC , MarvelleAF , LangeEMet al. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Obesity (Silver Spring)19(5), 1019–1027 (2011).
   PubMed Web of Science ®Google Scholar
• Davies G , LamM , HarrisSEet al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat. Commun.9(1), 2098 (2018).
   PubMedGoogle Scholar
• Lee JJ , WedowR , OkbayAet al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat. Genet.50(8), 1112–1121 (2018).
   PubMed Web of Science ®Google Scholar
• Yengo L , SidorenkoJ , KemperKEet al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700,000 individuals of European ancestry. bioRxiv274654 (2018).
   Google Scholar
• Sun Y , ChangS , LiuZet al. Genome-wide association study identifies common genetic risk factors for alcohol, heroin and methamphetamine dependence. bioRxiv505917 (2018).
   Google Scholar
• Cobb J , CuleE , MoncrieffeHet al. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics J.14(4), 356–364 (2014).
   PubMed Web of Science ®Google Scholar
• Garriock HA , KraftJB , ShynSIet al. A genomewide association study of citalopram response in major depressive disorder. Biol. Psychiatry67(2), 133–138 (2010).
   PubMed Web of Science ®Google Scholar
• Umehara H , NumataS , TajimaAet al. Calcium signaling pathway is associated with the long-term clinical response to selective serotonin reuptake inhibitors (SSRI) and SSRI with antipsychotics in patients with obsessive-compulsive disorder. PLoS ONE11(6), e0157232 (2016).
   PubMed Web of Science ®Google Scholar
• Schizophrenia Working Group of the Psychiatric Genomics Consortium . Biological insights from 108 schizophrenia-associated genetic loci. Nature511(7510), 421–427 (2014).
   PubMed Web of Science ®Google Scholar
• Wray NR , RipkeS , MattheisenMet al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet.50(5), 668–681 (2018).
   PubMed Web of Science ®Google Scholar
• Hoffmann TJ , ChoquetH , YinJet al. A large multiethnic genome-wide association study of adult body mass index identifies novel loci. Genetics210(2), 499–515 (2018).
   PubMed Web of Science ®Google Scholar
• Parker CC , ChengR , SokoloffGet al. Fine-mapping alleles for body weight in LG/J × SM/J F2 and F(34) advanced intercross lines. Mamm. Genome22(9–10), 563–571 (2011).
   PubMed Web of Science ®Google Scholar
• Purcell SM , MoranJL , FromerMet al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature506(7487), 185–190 (2014).
   PubMed Web of Science ®Google Scholar
• Castellani CA , MelkaMG , GuiJL , GalloAJ , O’ReillyRL , SinghSM. Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia. Clin. Transl. Med.6(1), 43 (2017).
   PubMedGoogle Scholar
• Li J , ShiM , MaZet al. Integrated systems analysis reveals a molecular network underlying autism spectrum disorders. Mol. Syst. Biol.10, 774 (2014).
   PubMed Web of Science ®Google Scholar
• Grünblatt E , OnedaB , EkiciABet al. High resolution chromosomal microarray analysis in paediatric obsessive–compulsive disorder. BMC Med. Genomics10(1), 68 (2017).
   PubMedGoogle Scholar
• Han S , LinY , WangMet al. Integrating brain methylome with GWAS for psychiatric risk gene discovery. bioRxiv440206 (2018).
   Google Scholar
• Aberg KA , XieLY , McClayJLet al. Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions. Epigenomics5(4), 367–377 (2013).
   PubMed Web of Science ®Google Scholar
• Kurita M , HollowayT , García-BeaAet al. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat. Neurosci.15(9), 1245–1254 (2012).
   PubMed Web of Science ®Google Scholar
• Papale LA , MadridA , LiS , AlischRS. Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors. Epigenetics12(4), 264–276 (2017).
   PubMed Web of Science ®Google Scholar
• Papale LA , LiS , MadridAet al. Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress. Neurobiol. Dis.96, 54–66 (2016).
   PubMed Web of Science ®Google Scholar
• Watson CT , SzutoriszH , GargPet al. Genome-wide DNA methylation profiling reveals epigenetic changes in the rat nucleus accumbens associated with cross-generational effects of adolescent THC exposure. Neuropsychopharmacology40(13), 2993–3005 (2015).
   PubMed Web of Science ®Google Scholar
• Sewal AS , PatzkeH , PerezEJet al. Experience modulates the effects of histone deacetylase inhibitors on gene and protein expression in the hippocampus: impaired plasticity in aging. J. Neurosci.35(33), 11729–11742 (2015).
   PubMed Web of Science ®Google Scholar
• Enga RM , RiceAC , WellerPet al. Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b. Neurosci. Lett.641, 26–32 (2017).
   PubMed Web of Science ®Google Scholar
• Tindi JO , ChávezAE , CvejicS , Calvo-OchoaE , CastilloPE , JordanBA. ANKS1B gene product AIDA-1 controls hippocampal synaptic transmission by regulating GluN2B subunit localization. J. Neurosci.35(24), 8986–8996 (2015).
   PubMed Web of Science ®Google Scholar
• Braff D , StoneC , CallawayE , GeyerM , GlickI , BaliL. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology15(4), 339–343 (1978).
   PubMed Web of Science ®Google Scholar
• Braff DL , GrillonC , GeyerMA. Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry49(3), 206–215 (1992).
   PubMed Web of Science ®Google Scholar
• Geyer MA , Krebs-ThomsonK , BraffDL , SwerdlowNR. Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology156(2–3), 117–154 (2001).
   PubMed Web of Science ®Google Scholar
• Lüscher C , MalenkaRC. NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harb. Perspect. Biol.4(6), pii: a005710 (2012)
   PubMed Web of Science ®Google Scholar
• Hardy J . Amyloid, the presenilins and Alzheimer’s disease. Trends Neuroscie.20(4), 154–159 (1997).
   PubMed Web of Science ®Google Scholar
• Duyckaerts C , DelatourB , PotierM-C. Classification and basic pathology of Alzheimer disease. Acta Neuropathol.118(1), 5–36 (2009).
   PubMed Web of Science ®Google Scholar
• Scholz C-J , WeberH , JungwirthSet al. Explorative results from multistep screening for potential genetic risk loci of Alzheimer’s disease in the longitudinal VITA study cohort. J. Neural. Transm. (Vienna)125(1), 77–87 (2018).
   PubMed Web of Science ®Google Scholar
• Ianov L , RaniA , BeasBS , KumarA , FosterTC. Transcription profile of aging and cognition-related genes in the medial prefrontal cortex. Front. Aging Neurosci.8, 113 (2016)
   PubMed Web of Science ®Google Scholar
• Webb A , PappAC , CurtisAet al. RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. BMC Genomics16, 990 (2015).
   PubMed Web of Science ®Google Scholar
• Sheffler DJ , KroezeWK , GarciaBGet al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc. Natl Acad. Sci. USA103(12), 4717–4722 (2006).
   PubMed Web of Science ®Google Scholar
• de Bartolomeis A , BuonaguroEF , IasevoliF. Serotonin–glutamate and serotonin–dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins. Psychopharmacology225(1), 1–19 (2013).
   PubMed Web of Science ®Google Scholar
• Abbas AI , YadavPN , YaoW-Det al. PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J. Neurosci.29(22), 7124–7136 (2009).
   PubMed Web of Science ®Google Scholar
• Iasevoli F , Ambesi-ImpiombatoA , FioreG , PanarielloF , MuscettolaG , de BartolomeisA. Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes. J. Psychopharmacol. (Oxford)25(7), 875–887 (2011).
   PubMed Web of Science ®Google Scholar
• Balu DT , CoyleJT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci. Biobehav. Rev.35(3), 848–870 (2011).
   PubMed Web of Science ®Google Scholar
• Deng C , PanB , EngelM , HuangX-F. Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway. Psychopharmacology (Berl.).226(2), 201–215 (2013).
   PubMed Web of Science ®Google Scholar
• Locke AE , KahaliB , BerndtSIet al. Genetic studies of body mass index yield new insights for obesity biology. Nature518(7538), 197–206 (2015).
   PubMed Web of Science ®Google Scholar
• Chang X , LimaL , LiuYet al. Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia. Front. Genet.9, 434 (2018).
   PubMed Web of Science ®Google Scholar
• D’Uva G , LauriolaM. Towards the emerging crosstalk: ERBB family and steroid hormones. Semin. Cell Dev. Biol.50, 143–152 (2016).
   PubMed Web of Science ®Google Scholar
• Faralli JA , GagenD , FillaMS , CrottiTN , PetersDM. Dexamethasone increases αvβ3 integrin expression and affinity through a calcineurin/NFAT pathway. Biochim. Biophys. Acta1833(12), 3306–3313 (2013).
   PubMed Web of Science ®Google Scholar
• Volkow ND , MoralesM. The brain on drugs: from reward to addiction. Cell162(4), 712–725 (2015).
   PubMed Web of Science ®Google Scholar
• Mulholland PJ , JordanBA , ChandlerLJ. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol46(6), 569–576 (2012).
   PubMed Web of Science ®Google Scholar
• Malhotra AK , MurphyGM , KennedyJL. Pharmacogenetics of psychotropic drug response. AJP161(5), 780–796 (2004).
   Google Scholar
• Guard DB , SwartzTD , RitterRC , BurnsGA , CovasaM. NMDA NR2 receptors participate in CCK-induced reduction of food intake and hindbrain neuronal activation. Brain Res.1266, 37–44 (2009).
   PubMed Web of Science ®Google Scholar
• Ritter RC . A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals. Physiol. Behavior.105(1), 94–99 (2011).
   PubMed Web of Science ®Google Scholar
• Nonogaki K , StrackAM , DallmanMF , TecottLH. Leptin-independent hyperphagia and Type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med.4(10), 1152–1156 (1998).
   PubMed Web of Science ®Google Scholar
• Mao H , LockyerP , LiLet al. Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ. Nat. Commun.8, 14960 (2017).
   PubMed Web of Science ®Google Scholar
• Gil SY , YounB-S , ByunKet al. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nat. Commun.4, 1862 (2013).
   PubMed Web of Science ®Google Scholar
• Li QS , TianC , SeabrookGR , DrevetsWC , NarayanVA. Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response. Transl. Psychiatry6(9), e889 (2016)
   PubMedGoogle Scholar
• Jordan BA , KreutzMR. Nucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling. Trends Neurosci.32(7), 392–401 (2009).
   PubMed Web of Science ®Google Scholar