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Research Article

Effects of SLCO1B1 Polymorphisms on Plasma Estrogen Concentrations in Women with Breast Cancer Receiving Aromatase Inhibitors Exemestane and Letrozole

, , , , , , , , , , & ORCID Icon show all
Pages 571-580 | Received 12 Feb 2019, Accepted 15 Mar 2019, Published online: 13 Jun 2019

References

  • Howlader N , AltekruseSF , LiCIet al. US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. JNCI J. Natl Cancer Inst.106(5), pii:dju055 (2014).
  • Geisler J , HaynesB , AnkerG , DowsettM , LønningPE. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J. Clin. Oncol.20(3), 751–757 (2002).
  • Geisler J , KingN , AnkerGet al. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients . Clin. Cancer Res.4(9), 2089–2093 (1998).
  • Cuzick J , SestakI , BaumMet al. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol.11(12), 1135–1141 (2010).
  • Regan MM , NevenP , Giobbie-HurderAet al. Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up. Lancet Oncol.12(12), 1101–1108 (2011).
  • Smith I , YardleyD , BurrisHet al. Comparative efficacy and safety of adjuvant letrozole versus anastrozole in postmenopausal patients with hormone receptor-positive, node-positive early breast cancer: final results of the randomized Phase III femara versus anastrozole clinical evaluation (FACE) trial. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol.35(10), 1041–1048 (2017).
  • Goss PE , IngleJN , PritchardKIet al. Exemestane versus anastrozole in postmenopausal women with early breast cancer: NCIC CTG MA.27 – a randomized controlled Phase III trial. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol.31(11), 1398–1404 (2013).
  • Early Breast Cancer Trialists’ Collaborative Group . Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet386(10001), 1341–1352 (2015).
  • Miller WR , LarionovAA. Understanding the mechanisms of aromatase inhibitor resistance. Breast Cancer Res.14(1), 201 (2012).
  • Ingle JN , BuzdarAU , SchaidDJet al. Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer. Cancer Res.70(8), 3278–3286 (2010).
  • Hertz DL , HenryNL , RaeJM. Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients. Pharmacogenomics18(5), 481–499 (2017).
  • Kalliokoski A , NiemiM. Impact of OATP transporters on pharmacokinetics. Br. J. Pharmacol.158(3), 693–705 (2009).
  • Gregory BJ , ChenSM , MurphyMA , AtchleyDH , KamdemLK. Impact of the OATP1B1 c.521T>C single nucleotide polymorphism on the pharmacokinetics of exemestane in healthy postmenopausal female volunteers. J. Clin. Pharm. Ther.42(5), 547–553 (2017).
  • Dudenkov TM , IngleJN , BuzdarAUet al. SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway . Breast Cancer Res. Treat.164(1), 189–199 (2017).
  • Henry NL , GilesJT , AngDet al. Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Breast Cancer Res. Treat.111(2), 365–372 (2008).
  • Desta Z , KreutzY , NguyenATet al. Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age. Clin. Pharmacol. Ther.90(5), 693–700 (2011).
  • Robarge JD , DestaZ , NguyenATet al. Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer. Breast Cancer Res. Treat.161(3), 453–461 (2017).
  • Hertz DL , SpethKA , KidwellKM et al. Variable aromatase inhibitor plasma concentrations do not correlate with circulating estrogen concentrations in postmenopausal breast cancer patients. Breast Cancer Res. Treat.165(3), 659–668 (2017).
  • Henry NL , AzzouzF , DestaZet al. Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J. Clin. Oncol.30(9), 936–942 (2012).
  • Pasqualini JR , ChetriteG , BlackerCet al. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients. J. Clin. Endocrinol. Metab.81(4), 1460–1464 (1996).
  • Ramsey LB , MoncrieffeH , SmithCNet al. Association of SLCO1B1*14 allele with poor response to methotrexate in juvenile idiopathic arthritis patients. ACR Open Rheumatol.1, 58–62 (2019).
  • Wang L , EllsworthKA , MoonIet al. Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors. Cancer Res.70(1), 319–328 (2010).
  • Ghimenti C , Mello-GrandM , GrossoEet al. Regulation of aromatase expression in breast cancer treated with anastrozole neoadjuvant therapy. Exp. Ther. Med.5(3), 902–906 (2013).
  • Fuhrman BJ , SchairerC , GailMHet al. Estrogen metabolism and risk of breast cancer in postmenopausal women. JNCI J. Natl Cancer Inst.104(4), 326–339 (2012).
  • Key T , ApplebyP , BarnesI , ReevesG. Endogenous Hormones and Breast Cancer Collaborative Group.Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J. Natl Cancer Inst.94(8), 606–616 (2002).
  • Brown SB , HankinsonSE. Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids99, 8–10 (2015).
  • Smiley DA , KhalilRA. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr. Med. Chem.16(15), 1863–1887 (2009).
  • Wang X , PankratzVS , FredericksenZet al. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Hum. Mol. Genet.19(14), 2886–2897 (2010).
  • Lønning PE . The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum. Ann. Oncol.22(3), 503–514 (2011).
  • Borrie AE , RoseRV , ChoiY-Het al. Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer. Breast Cancer Res. Treat.172(2), 371–379 (2018).
  • Kadakia KC , KidwellKM , SeewaldNJet al. Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors. Breast Cancer Res. Treat.164(2), 411–419 (2017).
  • Shitara Y . Clinical importance of OATP1B1 and OATP1B3 in drug–drug interactions. Drug Metab. Pharmacokinet.26(3), 220–227 (2011).

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