Identification of Clinical and Pharmacogenetic Factors Influencing Metformin Response in Type 2 Diabetes Mellitus

References

• Goyal R , JialalI. Diabetes mellitus Type 2. In: StatPearls.StatPearls Publishing, FL, USA (2023).
   Google Scholar
• Zheng Y , LeySH , HuFB. Global aetiology and epidemiology of Type 2 diabetes mellitus and its complications. Nat. Rev. Endocrinol.14, 88–98 (2018).
   PubMed Web of Science ®Google Scholar
• Chen L , MaglianoDJ , ZimmetPZ. The worldwide epidemiology of Type 2 diabetes mellitus – present and future perspectives. Nat. Rev. Endocrinol.8, 228–236 (2011).
   PubMed Web of Science ®Google Scholar
• US FDA . Highlights of Prescribing Information.Silver Spring, MD, USA (2023). LABEL (fda.gov)
   Google Scholar
• Nathan DM . Finding new treatments for diabetes – how many, how fast … how good?N. Engl. J. Med.356, 437–440 (2007).
   PubMed Web of Science ®Google Scholar
• Diabetes Prevention Program Research Group . Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study. Diabetes Care35, 731–737 (2012).
   PubMed Web of Science ®Google Scholar
• Pernicova I , KorbonitsM. Metformin – mode of action and clinical implications for diabetes and cancer. Nat. Rev. Endocrinol.10, 143–156 (2014).
   PubMed Web of Science ®Google Scholar
• Takane H , ShikataE , OtsuboK , HiguchiS , IeiriI. Polymorphism in human organic cation transporters and metformin action. Pharmacogenomics9, 415–422 (2008).
   PubMed Web of Science ®Google Scholar
• Nies AT , KoepsellH , DammeK , SchwabM. Organic cation transporters (OCTs, MATEs), In Vitro and In Vivo evidence for the importance in drug therapy. Handb. Exp. Pharmacol.2011(201), 105–167 (2011).
   Google Scholar
• Emami Riedmaier A , FiselP , NiesAT , SchaeffelerE , SchwabM. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol. Sci.34, 126–135 (2013).
   PubMed Web of Science ®Google Scholar
• Chen L , PawlikowskiB , SchlessingerAet al. Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet. Genomics20, 687–699 (2010).
   PubMed Web of Science ®Google Scholar
• Nakamichi N , ShimaH , AsanoSet al. Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. J. Pharm. Sci.102, 3407–3417 (2013).
   PubMed Web of Science ®Google Scholar
• Zhou M , XiaL , WangJ. Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine. Drug Metab. Dispos. Biol. Fate Chem.35, 1956–1962 (2007).
   PubMed Web of Science ®Google Scholar
• Shu Y , BrownC , CastroRAet al. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin. Pharmacol. Ther.83, 273–280 (2008).
   PubMed Web of Science ®Google Scholar
• Shu Y , SheardownSA , BrownCet al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J. Clin. Invest.117, 1422–1431 (2007).
   PubMed Web of Science ®Google Scholar
• Becker ML , VisserLE , van SchaikRHN , HofmanA , UitterlindenAG , StrickerBHC. Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study. Diabetes58, 745–749 (2009).
   PubMed Web of Science ®Google Scholar
• Toyama K , YonezawaA , TsudaMet al. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. Pharmacogenet. Genomics20, 135–138 (2010).
   PubMed Web of Science ®Google Scholar
• Hemauer SJ , PatrikeevaSL , NanovskayaTN , HankinsGDV , AhmedMS. Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. Am. J. Obstet. Gynecol.202, 383; e1–e7 (2010).
   PubMed Web of Science ®Google Scholar
• Saiz-Rodríguez M , OchoaD , ZubiaurPet al. Identification of transporter polymorphisms influencing metformin pharmacokinetics in healthy volunteers. J. Pers. Med.13, 489 (2023).
   PubMed Web of Science ®Google Scholar
• World Medical Association . World Medical Association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA310(20), 2191–2194 (2013).
   PubMed Web of Science ®Google Scholar
• Vijayananthan A , NawawiO. The importance of good clinical practice guidelines and its role in clinical trials. Biomed. Imaging Interv. J.4(1), e5 doi: 10.2349/biij.4.1.e5 (2008).
   PubMedGoogle Scholar
• Rothman KJ . No adjustments are needed for multiple comparisons. Epidemiol. Camb. Mass1, 43–46 (1990).
   PubMedGoogle Scholar
• Savitz DA , OlshanAF. Describing data requires no adjustment for multiple comparisons: a reply from Savitz and Olshan. Am. J. Epidemiol.147, 813–814 (1998).
   PubMed Web of Science ®Google Scholar
• Thompson JR . Invited commentary: re: multiple comparisons and related issues in the interpretation of epidemiologic data. Am. J. Epidemiol.147, 801–806 (1998).
   PubMed Web of Science ®Google Scholar
• Inzucchi SE , BergenstalRM , BuseJBet al. Management of hyperglycemia in Type 2 diabetes: a patient-centered approach. Diabetes Care35, 1364–1379 (2012).
   PubMed Web of Science ®Google Scholar
• Stratton IM . Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes (UKPDS 35): prospective observational study. BMJ321, 405–412 (2000).
   PubMed Web of Science ®Google Scholar
• Holman RR , PaulSK , BethelMA , MatthewsDR , NeilHAW. 10-Year follow-up of intensive glucose control in Type 2 diabetes. N. Engl. J. Med.359, 1577–1589 (2008).
   PubMed Web of Science ®Google Scholar
• ADVANCE Collaborative Group; Patel A , MacMahonS , ChalmersJ , NealB , BillotLet al. Intensive blood glucose control and vascular outcomes in patients with Type 2 diabetes. N. Engl. J. Med.358, 2560–2572 (2008).
   PubMed Web of Science ®Google Scholar
• UK Prospective Diabetes Study (UKPDS) Group . Effect of intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34). Lancet Lond. Engl.352, 854–865 (1998).
   PubMed Web of Science ®Google Scholar
• Davies MJ , ArodaVR , CollinsBSet al. Management of hyperglycemia in Type 2 diabetes, 2022. A Consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care45, 2753–2786 (2022).
   PubMed Web of Science ®Google Scholar
• Meyer Zu Schwabedissen HE , VerstuyftC , KroemerHK , BecquemontL , KimRB. Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am. J. Physiol.-Ren. Physiol.298, F997–F1005 (2010).
   PubMed Web of Science ®Google Scholar
• Cho SK , ChungJ-Y. The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment. Int. J. Clin. Pharmacol. Ther.54, 253–262 (2016).
   PubMed Web of Science ®Google Scholar
• Chen P , CaoY , ChenS , LiuZ , ChenS , GuoY. Association of SLC22A1, SLC22A2, SLC47A1, and SLC47A2 polymorphisms with metformin efficacy in Type 2 diabetic patients. Biomedicines10, 2546 (2022).
   PubMed Web of Science ®Google Scholar
• Toyama K , YonezawaA , MasudaSet al. Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. Br. J. Pharmacol.166, 1183–1191 (2012).
   PubMed Web of Science ®Google Scholar
• Vohra M , SharmaAR , MallyaSet al. Implications of genetic variations, differential gene expression, and allele-specific expression on metformin response in drug-naïve Type 2 diabetes. J. Endocrinol. Invest.46, 1205–1218 (2022).
   PubMed Web of Science ®Google Scholar
• Wang J . The plasma membrane monoamine transporter (PMAT): structure, function, and role in organic cation disposition. Clin. Pharmacol. Ther.100, 489–499 (2016).
   PubMed Web of Science ®Google Scholar
• Dawed AY , ZhouK , Van LeeuwenNet al. Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in Type 2 diabetes: an IMI DIRECT study. Diabetes Care42, 1027–1033 (2019).
   PubMed Web of Science ®Google Scholar
• Saiz-Rodríguez M , BelmonteC , RománMet al. Effect of ABCB1 C3435T polymorphism on pharmacokinetics of antipsychotics and antidepressants. Basic Clin. Pharmacol. Toxicol.123, 474–485 (2018).
   PubMed Web of Science ®Google Scholar
• Taegtmeyer AB , BreenJB , SmithJet al. Effect of ABCB1 genotype on pre- and post-cardiac transplantation plasma lipid concentrations. J. Cardiovasc. Transl. Res.4, 304–312 (2011).
   PubMed Web of Science ®Google Scholar
• Li Q , HongJ , WuJet al. The role of common variants of ABCB1 and CYP7A1 genes in serum lipid levels and lipid-lowering efficacy of statin treatment: a meta-analysis. J. Clin. Lipidol.8, 618–629 (2014).
   PubMed Web of Science ®Google Scholar
• Tous M , RibasV , FerréNet al. Turpentine-induced inflammation reduces the hepatic expression of the multiple drug resistance gene, the plasma cholesterol concentration and the development of atherosclerosis in apolipoprotein E deficient mice. Biochim. Biophys Acta BBA Mol. Cell Biol. Lipids1733, 192–198 (2005).
   PubMed Web of Science ®Google Scholar
• Wu J , WangX , ChenHet al. Type 2 diabetes risk and lipid metabolism related to the pleiotropic effects of an ABCB1 variant: a Chinese family-based cohort study. Metabolites12, 875 (2022).
   PubMed Web of Science ®Google Scholar
• Hegedüs C , TelbiszÁ , HegedűsT , SarkadiB , Özvegy-LaczkaC. Lipid regulation of the ABCB1 and ABCG2 multidrug transporters. Adv Cancer Res.125, 97–137 (2015).
   PubMed Web of Science ®Google Scholar
• Feise RJ . Do multiple outcome measures require p-value adjustment?BMC Med. Res. Methodol.2, 8 (2002).
   PubMedGoogle Scholar
• Perneger TV . What’s wrong with Bonferroni adjustments. BMJ316, 1236–1238 (1998).
   PubMed Web of Science ®Google Scholar