Pharmacogenomics of Cisplatin-Induced Ototoxicity

• McKeage MJ . Comparative adverse effect profiles of platinum drugs. Drug Saf.13 , 228–244 (1995).
   PubMed Web of Science ®Google Scholar
• Chen WC , JacksonA, BudnickAS et al. Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer 106 , 820–829 (2006).
   PubMed Web of Science ®Google Scholar
• Li Y , WomerRB, SilberJH. Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose. Eur. J. Cancer40 , 2445–2451 (2004).
   PubMed Web of Science ®Google Scholar
• Coradini PP , CiganaL, SelistreSG, RositoLS, BrunettoAL. Ototoxicity from cisplatin therapy in childhood cancer. J. Pediatr. Hematol. Oncol.29 , 355–360 (2007).
   PubMed Web of Science ®Google Scholar
• Kushner BH , BudnickA, KramerK, ModakS, CheungNK. Ototoxicity from high-dose use of platinum compounds in patients with neuroblastoma. Cancer107 , 417–422 (2006).
   PubMed Web of Science ®Google Scholar
• Brock PR , BellmanSC, YeomansEC, PinkertonCR, PritchardJ. Cisplatin ototoxicity in children: a practical scoring system. Med. Pediatr. Oncol.19 , 295–300 (1991).
   PubMedGoogle Scholar
• Bührer C , WeinelP, SauterS, ReiterA, RiehmH, LaszigR. Acute onset deafness in a 4-year-old girl after a single infusion of cis-platinum. Pediatr. Hematol. Oncol.7(2) , 145–148 (1990).
   PubMed Web of Science ®Google Scholar
• Bertolini P , LassalleM, MercierG et al. Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss. J. Pediatr. Hematol. Oncol. 26 , 649–655 (2004).
   Web of Science ®Google Scholar
• Knight KR , KraemerDF, NeuweltEA. Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development. J. Clin. Oncol.23 , 8588–8596 (2005).
   PubMed Web of Science ®Google Scholar
• Kopelman J , BudnickAS, SessionsRB, KramerMB, WongGY. Ototoxicity of high-dose cisplatin by bolus administration in patients with advanced cancer and normal hearing. Laryngoscope98 , 858–864 (1988).
   PubMed Web of Science ®Google Scholar
• Reddel RR , KeffordRF, GrantJM, CoatesAS, FoxRM. Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration. Cancer Treat. Rep.66 , 19–23 (1982).
   PubMedGoogle Scholar
• Bokemeyer C , BergerCC, HartmannJT et al. Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br. J. Cancer 77 , 1355–1362 (1998).
   PubMed Web of Science ®Google Scholar
• Huang E , TehBS, StrotherDR et al. Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity. Int. J. Radiat. Oncol. Biol. Phys. 52 , 599–605 (2002).
   PubMed Web of Science ®Google Scholar
• Ross CJD , Katzov-EckertH, DubeMP et al. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin therapy. Nat. Genet. 41 , 1345–1349 (2009).
   PubMed Web of Science ®Google Scholar
• Rybak LP , MukherjeaD, JajooS, RamkumarV. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J. Exp. Med.219(3) , 177–186 (2009).
   PubMed Web of Science ®Google Scholar
• Mukherjea D , RybakLP, SheehanK et al. The design and screening of drugs to prevent acquired sensorineural hearing loss. Expert Opin. Drug Discov. 6(5) , 1–15 (2011).
   PubMed Web of Science ®Google Scholar
• May P , WoldtE, MatzRL, BoucherP. The LDL receptor related protein (LRP) family: an old family of proteins with new physiological functions. Ann. Med.39 , 219–228 (2007).
   PubMed Web of Science ®Google Scholar
• Tauris J , ChristensenEI, NykjaerA, JacobsenC, PetersenCM, OvesenT. Cubilin and megalin co-localize in the neonatal inner ear. Audiol. Neurootol.14(4) , 267–278 (2009).
   PubMed Web of Science ®Google Scholar
• Mizuta K , SaitoA, WatanabeT et al. Ultrastructural localization of megalin in the rat cochlear duct. Hear. Res. 129 , 83–91 (1999).
   PubMed Web of Science ®Google Scholar
• Koenig O , RuettigerL, MuellerM et al. Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss. FASEB J. 22 , 410–417 (2008).
   PubMed Web of Science ®Google Scholar
• Riedemann L , LanversC, DeusterD et al. Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 8(1) , 23–28 (2008).
   PubMed Web of Science ®Google Scholar
• Hoban PR , RobsonCN, DaviesSM, HallAG, CattanRA, HicksonID. Reduced topoisomerase II and elevated α class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C. Biochem. Pharmacol.43 , 685–693 (1992).
   PubMed Web of Science ®Google Scholar
• Hayes JD , PulfordDJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol.30(6) , 445–600 (1995).
   PubMed Web of Science ®Google Scholar
• Kasahara M , MatsumuraE, WebbG, BoardPG, FigueroaF, KleinJ. Mapping of class α glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Genomics8(1) , 90–96 (1990).
   PubMed Web of Science ®Google Scholar
• Meyer DJ , ColesB, PembleSE, GilmoreKS, FraserGM, KettererB. Theta: a new class of glutathione transferases purified from rat and man. Biochem. J.274 , 409–414 (1991).
   PubMed Web of Science ®Google Scholar
• Pemble S , SchroederKR, SpencerSR. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and characterization of a genetic polymorphism. Biochem J.300 , 271–276 (1994).
   PubMed Web of Science ®Google Scholar
• Ross VL , BoardPG. Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochem J.294(Pt 2) , 373–380 (1993).
   PubMed Web of Science ®Google Scholar
• Board PG , BakerRT, ChelvanayagamG, JermiinLS. Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochem. J.328 , 929–935 (1997).
   PubMed Web of Science ®Google Scholar
• Ali-Osman F , AkandeO, AntounG, MaoJX, BuolamwiniJ. Molecular cloning, Characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J. Biol. Chem.272(15) , 10004–10012 (1997).
   PubMed Web of Science ®Google Scholar
• Board PG , CogganM, ChelvanayagamG et al. Identification, characterization, and crystal structure of the Omega class glutathione transferases. J. Biol. Chem. 275(32) , 24798–24806 (2000).
   PubMed Web of Science ®Google Scholar
• Terrier P , TownsendAJ, CoindreJM, TricheTJ, CowanKH. An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue. Am. J. Pathol.137(4) , 845–853 (1990).
   PubMed Web of Science ®Google Scholar
• Chao CC , HuangYT, MaCM, ChouWY, Lin-ChaoS. Overexpression of glutathione S-transferase and elevation of thiol pools in multidrug-resistant human colon cancer cell line. Mol. Pharmacol.41 , 69–75 (1992).
   PubMed Web of Science ®Google Scholar
• Moscow JA , FairchildCR, MaddenMJ et al. Expression of anionic glutathione S-transferase and P-glycoprotein genes in human tissues and tumors. Cancer Res. 49 , 1422–1428 (1989).
   PubMed Web of Science ®Google Scholar
• Tsuchida S , SatoK. Glutathione transferases and cancer. Crit. Rev. Biochem. Mol. Biol.27 , 337–384 (1992).
   PubMed Web of Science ®Google Scholar
• London SJ , YuanJM, ChungFL, GaoYT, CoetzeeGA, RossRK. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet356 , 724–729 (2000).
   PubMed Web of Science ®Google Scholar
• Stoehlmacher J , ParkD, ZhangW et al. Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer. J. Natl Cancer Inst. 94(12) , 936–942 (2002).
   PubMedGoogle Scholar
• Watson MA , StewartRK, SmithGB, MasseyTE, BellDA. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis19 , 275–280 (1998).
   PubMed Web of Science ®Google Scholar
• Hengstler JG , ArandM, HerreroME, OeschF. Polymorphisms in N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res.154 , 47–85 (1998).
   PubMedGoogle Scholar
• Ban N , TakahashiY, TakayamaT et al. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide. Cancer Res. 56 , 3577–3582 (1996).
   PubMed Web of Science ®Google Scholar
• Goto S , IidaT, ChoS, OkaM, KohnoS, KondoT. Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells. Free Radic. Res.31 , 549–558 (1999).
   PubMed Web of Science ®Google Scholar
• Sadzuka Y , ShimizuY, TakinoY. Role of glutathione S-transferase isoenzymes in cisplatin-induced nephrotoxicity in the rat. Toxicol. Lett.70 , 211–222 (1994).
   PubMed Web of Science ®Google Scholar
• Board PG . Gene deletion and partial deficiency of the glutathione S-transferase (ligandin) system in man. FEBS Lett.135(1) , 12–14 (1981).
   PubMed Web of Science ®Google Scholar
• DeJong JL , ChangCM, Whang-PengJ, KnutsenT, TuCP. The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA. Nucleic Acids Res.16 , 8541–8554 (1988).
   PubMed Web of Science ®Google Scholar
• Seidegård J , PeroRW. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet.69 , 66–68 (1985).
   PubMed Web of Science ®Google Scholar
• Widersten M , PearsonWR, EngströmA, MannervikB. Heterologous expression of the allelic variant µ-class glutathione transferases µ and ψ. Biochem. J.276 , 519–524 (1991).
   PubMed Web of Science ®Google Scholar
• Seidegård J , VorachekWR, PeroRW, PearsonWR. Hereditary differences in the xpression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl Acad. Sci. USA85 , 7293–7297 (1988).
   PubMed Web of Science ®Google Scholar
• McLellan RA , OscarsonM, AlexandrieAK et al. Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity. Mol. Pharmacol. 52(6) , 958–965 (1997).
   PubMed Web of Science ®Google Scholar
• Board P , CogganM, JohnstonP, RossV, SuzukiT, WebbG. Genetic heterogeneity of the human glutathione transferases: a complex of gene families. Pharmacol. Ther.48 , 357–369 (1990).
   PubMed Web of Science ®Google Scholar
• Garte S , GaspariL, AlexandrieAK et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol. Biomarkers Prev. 10(12) , 1239–1248 (2001).
   PubMed Web of Science ®Google Scholar
• Arand M , MuhlbauerR, HengstlerJ et al. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal. Biochem. 236(1) , 184–186 (1996).
   PubMed Web of Science ®Google Scholar
• Barahmani N , CarpentieriS, LiXN et al. Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Neuro. Oncol. 11(3) , 292–300 (2009).
   PubMed Web of Science ®Google Scholar
• Zhao Y , MarottaM, EichlerEE, EngC, TanakaH. Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione S-transferase (GST) genes. PLoS Genet.5(5) , e1000472 (2009).
   PubMed Web of Science ®Google Scholar
• Oldenburg J , KraggerudSM, CvancarovaM, LotheRA, FossaSD. Cisplatin-induced long-term hearing impairment is associated with specific glutathione S-transferase genotypes in testicular cancer survivors. J. Clin. Oncol.25(6) , 708–714 (2007).
   PubMed Web of Science ®Google Scholar
• Nakagawa K , YokotaJ, WadaM et al. Levels of glutathione S-transferase pi mRNA in human lung cancer cell lines correlate with the resistance to cisplatin and carboplatin. Jpn J. Cancer Res. 79(3) , 301–304 (1988).
   PubMedGoogle Scholar
• Puchalski RB , FahlWE. Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents. Proc. Natl Acad. Sci. USA87(7) , 2443–2447 (1990).
   PubMed Web of Science ®Google Scholar
• Green JA , RobertsonLJ, ClarkAH. Glutathione S-transferase expression in benign and malignant ovarian tumours. Br. J. Cancer68(2) , 235–239 (1993).
   PubMed Web of Science ®Google Scholar
• el Barbary A , AltschulerRA, SchachtJ. Glutathione S-transferases in the organ of corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization. Hear Res.71 , 80–90 (1993).
   PubMed Web of Science ®Google Scholar
• Touliatos JS , NeitzelL, WhitworthC, RybakLP, MalafaM. Effect of cisplatin on the expression of glutathione-S-transferase in the cochlea of the rat. Eur. Arch. Otorhinolaryngol.257(1) , 6–9 (2000).
   PubMed Web of Science ®Google Scholar
• Fujimura T , SuzukiH, UdakaT et al. Immunoreactivities for glutathione S-transferases and glutathione peroxidase in the lateral wall of pigmented and albino guinea pig cochlea. Med. Mol. Morphol. 41(3) , 139–144 (2008).
   PubMed Web of Science ®Google Scholar
• Peters U , Preisler-AdamsS, HebeisenA et al. Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs 11(8) , 639–643 (2000).
   PubMed Web of Science ®Google Scholar
• Engdahl B , TambsK, BorchgrevinkHM, HoffmanHJ. Screened and unscreened hearing threshold levels for the adult population: results from the Nord-Tr⊘ndelag hearing loss study. Int. J. Audiol.44(4) , 213–230 (2005).
   PubMed Web of Science ®Google Scholar
• Adler V , YinZM, FuchsSY et al. Regulation of JNK signaling by GSTp. EMBO J. 18 , 1321–1334 (1999).
   PubMed Web of Science ®Google Scholar
• Oldenburg J , FossåSD, IkdahlT. Genetic variants associated with cisplatin-induced ototoxicity. Pharmacogenomics9(10) , 1521–1530 (2008).
   PubMed Web of Science ®Google Scholar
• Oldenburg J , KraggerudSM, Bryd⊘yM, CvancarovaM, LotheRA, FossaSD. Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-S-transferase-P1 and -M1, a retrospective cross sectional study. J. Transl. Med.5 , 70 (2007).
   PubMed Web of Science ®Google Scholar
• Pussegoda K . Genetic variants associated with cisplatin-induced hearing loss. Clin. Genet.78 , 33–35 (2010).
   PubMed Web of Science ®Google Scholar
• Ochoa B , BobadillaN, ArrelinG et al. S-adenosyl-L-mehtionine increases serum BUN and creatinine in cisplatin-treated mice. Arch. Med. Res.40 , 54–58 (2009).
   PubMed Web of Science ®Google Scholar
• Ahmed ZM , MasmoudiS, KalayE et al. Mutations of LRTOMT, a fusion gene with alternative reading frames, causes nonsyndromic deafness in humans. Nat. Genet. 40 , 1335–1340 (2008).
   PubMed Web of Science ®Google Scholar
• Du X , SchwanderM, MorescoEM et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc. Natl Acad. Sci. USA 105 , 14609–14614 (2008).
   PubMed Web of Science ®Google Scholar
• Duman D , SirmaciA, CengizFB, OzdagH, TekinM. Screening of 38 genes identifies mutations in 62% of families with nonsyndromic deafness in Turkey. Genet. Test Mol. Biomarkers15(1–2) , 29–33 (2011).
   PubMed Web of Science ®Google Scholar
• Peters U , Preisler-AdamsS, Lanvers-KaminskyC, JürgensH, Lamprecht-DinnesenA. Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Res.23(2B) , 1249–1255 (2003).
   PubMed Web of Science ®Google Scholar
• Knoll C , SmithRJ, ShoresC, BlattJ. Hearing genes and cisplatin deafness: a pilot study. Laryngoscope116(1) , 72–74 (2006).
   PubMed Web of Science ®Google Scholar
• Caronia D , Patiño-GarcíaA, MilneRL et al. Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. Pharmacogenomics J. 9(5) , 347–353 (2009).
   PubMed Web of Science ®Google Scholar
• Filipski KK , MathijssenRH, MikkelsenTS, SchinkelAH, SparreboomA. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin. Pharmacol. Ther.86 , 396–402 (2009).
   PubMed Web of Science ®Google Scholar
• Ciarimboli G , DeusterD, KniefA et al. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am. J. Pathol. 176(3) , 1169–1180 (2010).
   PubMed Web of Science ®Google Scholar
• Hartford CM , DolanME. Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity. Pharmacogenomics8(9) , 1159–1168 (2007).
   PubMed Web of Science ®Google Scholar
• Dolan ME , NewboldKG, NagasubramanianR et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 64(12) , 353–4356 (2004).
   Web of Science ®Google Scholar
• Huang RS , DuanS, ShuklaSJ et al. Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach. Am. J. Hum. Genet. 81(3) , 427–437 (2007).
   PubMed Web of Science ®Google Scholar
• Shukla SJ , DuanS, BadnerJA, WuX, DolanME. Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis. Pharmacogenet. Genomics18(3) , 253–262 (2008).
   PubMed Web of Science ®Google Scholar
• Subramanian A , KuehnH, GouldJ, TamayoP, MesirovJP. GSEA-P: a desktop application for gene set enrichment analysis. Bioinformatics23(23) , 3251–3253 (2007).
   PubMed Web of Science ®Google Scholar

▪ Websites

• Drug metabolism www.drugmetabolism.co.uk/gst.aspx
   Google Scholar
• The Pharmacogenomics Knowledge Base www.pharmgkb.org
   Google Scholar
• Protein knowledgebase www.uniprot.org
   Google Scholar
• The Signaling Gateway www.signaling-gateway.org
   Google Scholar
• International HapMap Consortium www.ncbi.nlm.nih.gov/pubmed/16255080
   Google Scholar