Polymorphic Thymidylate Synthase Gene Impacts on Overall Survival of Patients with Epithelial Ovarian Cancer After Platinum-Based Chemotherapy

• Cannistra SA . Cancer of the ovary. N. Engl. J. Med.351(24) , 2519–2529 (2004).
   PubMed Web of Science ®Google Scholar
• Piver MS . Ovarian carcinoma. A decade of progress. Cancer54(Suppl. 11) , S2706–S2715 (1984).
   PubMedGoogle Scholar
• Johnston PG , LenzHJ, LeichmanCG et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5fluorouracil in human colorectal and gastric tumors. Cancer Res. 55(7) , 1407–1412 (1995).
   PubMed Web of Science ®Google Scholar
• Leichman CG . Predictive and prognostic markers in gastrointestinal cancers. Curr. Opin Oncol.13(4) , 291–299 (2001).
   PubMed Web of Science ®Google Scholar
• Mizutani Y , WadaH, YoshidaO et al. Significance of thymidylate synthase activity in renal cell carcinoma. Clin. Cancer Res. 9(4) , 1453–1460 (2003).
   PubMed Web of Science ®Google Scholar
• Nomura T , NakagawaM, FujitaY, HanadaT, MimataH, NomuraY. Clinical significance of thymidylate synthase expression in bladder cancer. Int. J. Urol.9(7) , 368–376 (2002).
   PubMed Web of Science ®Google Scholar
• Pestalozzi BC , PetersonHF, GelberRD et al. Prognostic importance of thymidylate synthase expression in early breast cancer. J. Clin. Oncol. 15(5) , 1923–1931 (1997).
   PubMed Web of Science ®Google Scholar
• Shintani Y , OhtaM, HirabayashiH et al. New prognostic indicator for non-small-cell lung cancer, quantitation of thymidylate synthase by real-time reverse transcription polymerase chain reaction. Int. J. Cancer 104(6) , 790–795 (2003).
   PubMed Web of Science ®Google Scholar
• Suzuki M , TsukagoshiS, SagaY, OhwadaM, SatoI. Enhanced expression of thymidylate synthase may be of prognostic importance in advanced cervical cancer. Oncology57(1) , 50–54 (1999).
   PubMed Web of Science ®Google Scholar
• Edler D , HallstromM, JohnstonPG, MagnussonI, RagnhammarP, BlomgrenH. Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer. Clin. Cancer Res.6(4) , 1378–1384 (2000).
   PubMed Web of Science ®Google Scholar
• Takizawa M , KawakamiK, ObataT et al. In vitro sensitivity to platinum-derived drugs is associated with expression of thymidylate synthase and dihydropyrimidine dehydrogenase in human lung cancer. Oncol. Rep.15(6) , 1533–1539 (2006).
   PubMed Web of Science ®Google Scholar
• Scanlon KJ , Kashani-SabetM. Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells. Proc. Natl Acad. Sci. USA85(3) , 650–653 (1988).
   PubMed Web of Science ®Google Scholar
• Lai GM , OzolsRF, SmythJF, YoungRC, HamiltonTC. Enhanced DNA repair and resistance to cisplatin in human ovarian cancer. Biochem. Pharmacol.37(24) , 4597–4600 (1988).
   PubMed Web of Science ®Google Scholar
• Masuda H , OzolsRF, LaiGM, FojoA, RothenbergM, HamiltonTC. Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines. Cancer Res.48(20) , 5713–5716 (1988).
   PubMed Web of Science ®Google Scholar
• Wang C , WengY, WangH, ShiY, MaD. Relationship between the expression of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase and survival in epithelial ovarian cancer. J. Huazhong. Univ. Sci. Technolog. Med. Sci.30(4) , 494–499 (2010).
   PubMedGoogle Scholar
• Skibola CF , ForrestMS, CoppedeF et al. Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood 104(7) , 2155–2162 (2004).
   PubMed Web of Science ®Google Scholar
• Mandola MV , StoehlmacherJ, ZhangW et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 14(5) , 319–327 (2004).
   PubMedGoogle Scholar
• Pullmann R Jr, Abdelmohsen K, Lal A, Martindale JL, Ladner RD, Gorospe M. Differential stability of thymidylate synthase 3´-untranslated region polymorphic variants regulated by AUF1. J. Biol. Chem.281(33) , 23456–23463 (2006).
   PubMed Web of Science ®Google Scholar
• Pullarkat ST , StoehlmacherJ, GhaderiV et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 1(1) , 65–70 (2001).
   PubMedGoogle Scholar
• Horie N , AibaH, OguroK, HojoH, TakeishiK. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5´-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct. Funct.20(3) , 191–197 (1995).
   PubMed Web of Science ®Google Scholar
• Kawakami K , OmuraK, KanehiraE, WatanabeY. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res.19(4B) , 3249–3252 (1999).
   PubMed Web of Science ®Google Scholar
• Kawakami K , SalongaD, ParkJM et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin. Cancer Res. 7(12) , 4096–4101 (2001).
   PubMed Web of Science ®Google Scholar
• Mandola MV , StoehlmacherJ, Muller-WeeksS et al. A novel single nucleotide polymorphism within the 5´ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF1 binding and alters transcriptional activity. Cancer Res. 63(11) , 2898–2904 (2003).
   PubMed Web of Science ®Google Scholar
• Kawakami K , WatanabeG. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res.63(18) , 6004–6007 (2003).
   PubMed Web of Science ®Google Scholar
• Lurje G , ZhangW, YangD et al. Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. Pharmacogenet. Genomics 18(2) , 161–168 (2008).
   PubMed Web of Science ®Google Scholar
• Hitre E , BudaiB, AdleffV et al. Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. Pharmacogenet. Genomics 15(10) , 723–730 (2005).
   PubMed Web of Science ®Google Scholar
• Ulrich CM , BiglerJ, BostickR, FosdickL, PotterJD. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res.62(12) , 3361–3364 (2002).
   PubMed Web of Science ®Google Scholar
• Gusella M , FrigoAC, BolzonellaC et al. Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer. Br. J. Cancer 100(10) , 1549–1557 (2009).
   PubMed Web of Science ®Google Scholar
• Jennings BA , KwokCS, WillisG, MatthewsV, WawruchP, LokeYK. Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis. Pharmacogenet. Genomics22(4) , 290–304 (2012).
   PubMed Web of Science ®Google Scholar
• Lenz HJ , LeichmanCG, DanenbergKD et al. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J. Clin. Oncol. 14(1) , 176–182 (1996).
   PubMed Web of Science ®Google Scholar
• Chu E , AllegraCJ. The role of thymidylate synthase in cellular regulation. Adv. Enzyme Regul.36 , 143–163 (1996).
   PubMedGoogle Scholar
• Rahman L , VoellerD, RahmanM et al. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 5(4) , 341–351 (2004).
   PubMed Web of Science ®Google Scholar
• Ruzzo A , GrazianoF, LoupakisF et al. Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy. Pharmacogenomics J. 8(4) , 278–288 (2008).
   PubMed Web of Science ®Google Scholar
• Fernandez-Contreras ME , Sanchez-HernandezJJ, GonzalezE et al. Combination of polymorphisms within 5´ and 3´ untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients. Int. J. Oncol. 34(1) , 219–229 (2009).
   PubMed Web of Science ®Google Scholar
• Gosens MJ , MoerlandE, LemmensVP, RuttenHT, Tan-GoI, van den Brule AJ. Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer. Int. J. Cancer123(8) , 1941–1949 (2008).
   PubMed Web of Science ®Google Scholar
• Etienne-Grimaldi MC , FormentoJL, FrancoualM et al. K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. Clin. Cancer Res.14(15) , 4830–4835 (2008).
   PubMed Web of Science ®Google Scholar
• Kealey C , BrownKS, WoodsideJV et al. A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations. Hum. Genet. 116(5) , 347–353 (2005).
   PubMed Web of Science ®Google Scholar
• Bast RC Jr. Molecular approaches to personalizing management of ovarian cancer. Ann. Oncol.22(Suppl. 8) , viii5–viii15 (2011).
   PubMedGoogle Scholar
• Hall M , RustinG. Recurrent ovarian cancer: when and how to treat. Curr. Oncol. Rep.13(6) , 459–471 (2011).
   PubMed Web of Science ®Google Scholar
• Geurts SM , de Vegt F, van Altena AM et al. Considering early detection of relapsed ovarian cancer: a review of the literature. Int. J. Gynecol. Cancer21(5) , 837–845 (2011).
   PubMed Web of Science ®Google Scholar

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• Innate Immunity in Heart, Lung and Blood Disease: Programs for Genomic Applications. www.pharmgat.org/IIPGA2/Bioinformatics
   Google Scholar