Common Mutations and Polymorphisms Predicting Adverse Cardiovascular Events: Current View

• Manolio TA . Genomewide association studies and assessment of the risk of disease. N. Engl. J. Med.363(2) , 166–176 (2010).
   PubMed Web of Science ®Google Scholar
• Andreassi MG , AdlersteinD, CarpeggianiC et al. Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease. Atherosclerosis 223(2) , 409–415 (2012).
   PubMed Web of Science ®Google Scholar
• Helgadottir A , ThorleifssonG, ManolescuA et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316(5830) , 1491–1493 (2007).
   PubMed Web of Science ®Google Scholar
• Kathiresan S , VoightBF, PurcellS et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 41(3) , 334–341 (2009).
   PubMed Web of Science ®Google Scholar
• Schunkert H , KonigIR, KathiresanS et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43(4) , 333–338 (2011).
   PubMed Web of Science ®Google Scholar
• Takeuchi F , YokotaM, YamamotoK et al. Genome-wide association study of coronary artery disease in the Japanese. Eur. J. Hum. Genet. 20(3) , 333–340 (2011).
   PubMed Web of Science ®Google Scholar
• Samani NJ , ErdmannJ, Hall As et al. Genomewide association analysis of coronary artery disease. N. Engl. J. Med.357(5) , 443–453 (2007).
   PubMed Web of Science ®Google Scholar
• Tregouet DA , KonigIR, ErdmannJ et al. Genome-wide haplotype association study identifies the SLC22A3–LPAL2–LPA gene cluster as a risk locus for coronary artery disease. Nat. Genet. 41(3) , 283–285 (2009).
   PubMed Web of Science ®Google Scholar
• Wild PS , ZellerT, SchillertA et al. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ. Cardiovasc. Genet. 4(4) , 403–412 (2011).
   PubMedGoogle Scholar
• Peden JF , HopewellJC, SaleheenD et al. Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. 43(4) , 339–344 (2011).
   PubMed Web of Science ®Google Scholar
• Mehta NN . A genome-wide association study in Europeans and South Asians identifies 5 new loci for coronary artery disease. Circ. Cardiovasc. Genet.4(4) , 465–466 (2011).
   PubMedGoogle Scholar
• Erdmann J , GrosshennigA, BraundPS et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat. Genet. 41(3) , 280–282 (2009).
   PubMed Web of Science ®Google Scholar
• Erdmann J , WillenborgC, NahrstaedtJ et al. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10.11.23. Eur. Heart J. 32(2) , 158–168 (2010).
   PubMed Web of Science ®Google Scholar
• Davies RW , WellsGA, StewartAF et al. A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ. Cardiovasc. Genet. 5(2) , 217–225 (2012).
   PubMedGoogle Scholar
• Jeemon P , PettigrewK, SainsburyC, PrabhakaranD, PadmanabhanS. Implications of discoveries from genome-wide association studies in current cardiovascular practice. World J. Cardiol.3(7) , 230–247 (2011).
   PubMedGoogle Scholar
• Ndiaye NC , Azimi Nehzad M, El Shamieh S, Stathopoulou MG, Visvikis-Siest S. Cardiovascular diseases and genome-wide association studies. Clin. Chim. Acta412(19–20) , 1697–1701 (2011).
   PubMed Web of Science ®Google Scholar
• Henrichsen CN , VinckenboschN, ZollnerS et al. Segmental copy number variation shapes tissue transcriptomes. Nat. Genet. 41(4) , 424–429 (2009).
   PubMed Web of Science ®Google Scholar
• De Miguel-Yanes JM , ShraderP, PencinaMJ et al. Genetic risk reclassification for Type 2 diabetes by age below or above 50 years using 40 Type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care 34(1) , 121–125 (2011).
   PubMed Web of Science ®Google Scholar
• Meigs JB , ShraderP, SullivanLM et al. Genotype score in addition to common risk factors for prediction of Type 2 diabetes. N. Engl. J. Med. 359(21) , 2208–2219 (2008).
   PubMed Web of Science ®Google Scholar
• Lyssenko V , JonssonA, AlmgrenP et al. Clinical risk factors, DNA variants, and the development of Type 2 diabetes. N. Engl. J. Med. 359(21) , 2220–2232 (2008).
   PubMed Web of Science ®Google Scholar
• Schork NJ , TopolEJ. Genotype-based risk and pharmacogenetic sampling in clinical trials. J. Biopharm. Stat.20(2) , 315–333 (2010).
   PubMed Web of Science ®Google Scholar
• Florez JC , JablonskiKA, BayleyN et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N. Engl. J. Med.355(3) , 241–250 (2006).
   PubMed Web of Science ®Google Scholar
• Hivert MF , JablonskiKA, PerreaultL et al. Updated genetic score based on 34 confirmed Type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes 60(4) , 1340–1348 (2011).
   PubMed Web of Science ®Google Scholar
• Smith PG , DayNE. The design of case–control studies: the influence of confounding and interaction effects. Int. J. Epidemiol.13(3) , 356–365 (1984).
   PubMed Web of Science ®Google Scholar
• Shuldiner AR , O‘ConnellJR, BlidenKP et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 302(8) , 849–857 (2009).
   PubMed Web of Science ®Google Scholar
• Bauer T , BoumanHJ, Van Werkum JW, Ford NF, Ten Berg JM, Taubert D. Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ343 , d4588 (2011).
   PubMed Web of Science ®Google Scholar
• El Shamieh S , NdiayeNC, StathopoulouMG et al. Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels. PloS One 7(7) , e40777 (2012).
   PubMed Web of Science ®Google Scholar

▪ Website

• WHO. Cardiovascular diseases. www.who.int/mediacentre/factsheets/fs317/en/index.html
   Google Scholar