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Research Highlights: Highlights from the Latest Articles in Pharmacogenomics of Warfarin Dosing

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Pages 861-864 | Published online: 07 Jun 2012

References

  • The International Warfarin Pharmacogenetics Consortium. Estimation of the warfarin dose with clinical and pharmacogenetic data. N. Engl. J. Med.360(8) , 753–764 (2009).
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References

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  • Rieder MJ , ReinerAP, GageBF et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N. Engl. J. Med. 352 , 2285–2293 (2005).
  • International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N. Engl. J. Med.360 , 753–764 (2009).
  • Dwell MD , AwadT, JohnsonJA et al. CYP4F2 genetic variant alters required warfarin dose. Blood111 , 4106–4112 (2008).
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  • Cooper GM , JohnsonJA, LangaeeTY et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 112 , 1022–1027 (2008).
  • Borgiani P , CiccacciC, ForteV et al. CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. Pharmacogenomics10 , 261–266 (2009).
  • Pautas E , MoreauC, Gouin-ThibaultI et al. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. Clin. Pharmacol. Ther. 87 , 57–64 (2010).
  • Zhang JE , JorgensenAL, AlfirevicA et al. Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. Pharmacogenet. Genomics 19 , 781–789 (2009).
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  • Perini JA , StruchinerCJ, Silva-AssunçãoE, Suarez-KurtzG. Impact of CYP4F2 rs2108622 on the stable warfarin dose in an admixed patient cohort. Clin. Pharmacol. Ther.87 , 417–420 (2010).
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