2,243
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Genome-Wide miRNA Expression Profiling of Human Lymphoblastoid Cell Lines Identifies Tentative SSRI Antidepressant Response Biomarkers

, , , , , , & show all
Pages 1129-1139 | Published online: 21 Aug 2012

References

  • Souery D , OswaldP, MassatI et al. Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study. J. Clin. Psychiatry 68(7) , 1062–1070 (2007).
  • Kirchheiner J , NickchenK, BauerM et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry 9(5) , 442–473 (2004).
  • Gelenberg AJ . A review of the current guidelines for depression treatment. J. Clin. Psychiatry71(7) , e15 (2010).
  • Ising M , LucaeS, BinderEB et al. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch. Gen. Psychiatry 66(9) , 966–975 (2009).
  • Garriock HA , KraftJB, ShynSI et al. A genomewide association study of citalopram response in major depressive disorder. Biol. Psychiatry 67(2) , 133–138 (2010).
  • Uher R , PerroudN, NgMY et al. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am. J. Psychiatry 167(5) , 555–564 (2010).
  • Clark SL , AdkinsDE, AbergK et al. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. Psychol. Med. 42(6) , 1151–1162] (2012).
  • Goldstein DB . Common genetic variation and human traits. N. Engl. J. Med.360(17) , 1696–1698 (2009).
  • Morag A , Pasmanik-ChorM, Oron-KarniV, RehaviM, StinglJC, GurwitzD. Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. Pharmacogenomics12(2) , 171–184 (2011).
  • Berezikov E . Evolution of microRNA diversity and regulation in animals. Nat. Rev. Genet.12(12) , 846–860 (2011).
  • Long JM , LahiriDK. Advances in MicroRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders. Exp. Neurol.235(2) , 402–418 (2012).
  • Yoo AS , SunAX, LiL et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476(7359) , 228–231 (2011).
  • Shomron N . MicroRNAs and Pharmacogenomics. Pharmacogenomics11(5) , 629–632 (2010).
  • Mouillet-Richard S , BaudryA, LaunayJM, KellermannO. MicroRNAs and depression. Neurobiol. Dis.46(2) , 272–278 (2012).
  • O‘Connor RM , DinanTG, CryanJF. Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression. Mol. Psychiatry17(4) , 359–376 (2012).
  • Baudry A , Mouillet-RichardS, SchneiderB, LaunayJM, KellermannO. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science329(5998) , 1537–1541 (2010).
  • Morag A , KirchheinerJ, RehaviM, GurwitzD. Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways. Pharmacogenomics11(3) , 327–340 (2010).
  • Wong CK , LauKM, ChanIH et al. MicroRNA-21* regulates the prosurvival effect of GM-CSF on human eosinophils. Immunobiology doi:10.1016/j.imbio.2012.05.019 (2012) (Epub ahead of print).
  • Galiveti CR , RozhdestvenskyTS, BrosiusJ, LehrachH, KonthurZ. Application of housekeeping npcRNAs for quantitative expression analysis of human transcriptome by real-time PCR. RNA16(2) , 450–461 (2010).
  • Mestdagh P , Van Vlierberghe P, De Weer A et al. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol.10 , R64 (2009).
  • Zhang W , DolanME. Use of cell lines in the investigation of pharmacogenetic loci. Curr. Pharm. Des.15(32) , 3782–3795 (2009).
  • Coulombe-Huntington J , LamKC, DiasC, MajewskiJ. Fine-scale variation and genetic determinants of alternative splicing across individuals. PLoS Genet.5(12) , e1000766 (2009).
  • Bleibel WK , DuanS, HuangRS et al. Identification of genomic regions contributing to etoposide-induced cytotoxicity. Hum. Genet. 125(2) , 173–180 (2009).
  • Dolan ME , NewboldKG, NagasubramanianR et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 64(12) , 4353–4356 (2004).
  • Hartford CM , DuanS, DelaneySM et al. Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. Blood 113(10) , 2145–2153 (2009).
  • Huang RS , DuanS, BleibelWK et al. A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc. Natl Acad. Sci. USA 104(23) , 9758–9763 (2007).
  • Pinto N , LudemanSM, DolanME. Drug focus: pharmacogenetic studies related to cyclophosphamide-based therapy. Pharmacogenomics10(12) , 1897–1903 (2009).
  • Li L , FridleyB, KalariK et al. Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res. 68(17) , 7050–7058 (2008).
  • Fry RC , SvenssonJP, ValiathanC et al. Genomic predictors of interindividual differences in response to DNA damaging agents. Genes Dev. 22(19) , 2621–2626 (2008).
  • Wheeler HE , DolanME. Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics13(1) , 55–70 (2012).
  • Jepson JE , ReenanRA. RNA editing in regulating gene expression in the brain. Biochim. Biophys. Acta1779 , 459–470 (2008).
  • Wheeler G , Ntounia-FousaraS, GrandaB, RathjenT, DalmayT. Identification of new central nervous system specific mouse microRNAs. FEBS Lett.580 , 2195–2200 (2006).
  • Gardiner E , BeveridgeNJ, WuJQ et al. Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells. Mol. Psychiatry doi:10.1038/mp.2011.78 (2011) (Epub ahead of print).
  • Guidi M , Muiños-GimenoM, KagerbauerB et al. Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol. Biol. 11 , 95 (2010).
  • Zhao C , SunG, LiS et al. MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Proc. Natl Acad. Sci. USA 107(5) , 1876–1881 (2010).
  • Wulczyn FG , SmirnovaL, RybakA et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 21(2) , 415–426 (2007).
  • Zhou R , YuanP, WangY et al. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology 34(6) , 1395–1405 (2009).
  • Rinaldi A , VincentiS, De Vito F et al. Stress induces region specific alterations in microRNAs expression in mice. Behav. Brain Res.208 , 265–269 (2010).
  • Luikart BW , PerederiyJV, WestbrookGL. Dentate gyrus neurogenesis, integration and microRNAs. Behav. Brain Res.227(2) , 348–355 (2012).
  • Magill ST , CambronneXA, LuikartBW et al. microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc. Natl Acad. Sci. USA 107(47) , 20382–20387 (2010).
  • Luikart BW , BensenAL, WashburnEK et al. miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS ONE 6(5) , e19077 (2011).
  • Numakawa T , YamamotoN, ChibaS et al. Growth factors stimulate expression of neuronal and glial miR-132. Neurosci. Lett. 505(3) , 242–247 (2011).
  • Liu NK , WangXF, LuQB, XuXM. Altered microRNA expression following traumatic spinal cord injury. Exp. Neurol.219(2) , 424–429 (2009).
  • Wanet A , TachenyA, ArnouldT, RenardP. miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Res.40(11) , 4742–4753 (2012).
  • Maness PF , SchachnerM. Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat. Neurosci.1 , 19–26 (2007).
  • Montag-Sallaz M , SchachnerM, MontagD. Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol. Cell Biol.22(22) , 7967–7981 (2002).
  • Montag-Sallaz M , BaarkeA, MontagD. Aberrant neuronal connectivity in CHL1-deficient mice is associated with altered information processing-related immediate early gene expression. J. Neurobiol.57(1) , 67–80 (2003).
  • Morellini F , LepsveridzeE, KählerB, DityatevA, SchachnerM. Reduced reactivity to novelty, impaired social behavior, and enhanced basal synaptic excitatory activity in perforant path projections to the dentate gyrus in young adult mice deficient in the neural cell adhesion molecule CHL1. Mol. Cell. Neurosci.34(2) , 121–136 (2007).
  • Demyanenko GP , SiesserPF, WrightAG et al. L1 and CHL1 cooperate in thalamocortical axon targeting. Cereb. Cortex 21(2) , 401–412 (2011).
  • Chen QY , ChenQ, FengGY et al. Case–control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population. Schizophr. Res. 73(2–3) , 269–274 (2005).
  • Frints SG , MarynenP, HartmannD et al. CALL interrupted in a patient with non-specific mental retardation: gene dosage dependent alteration of murine brain development and behavior. Hum. Mol. Genet. 12(13) , 1463–1474 (2003).
  • Desarnaud F , JakovcevskiM, MorelliniF, SchachnerM. Stress downregulates hippocampal expression of the adhesion molecules NCAM and CHL1 in mice by mechanisms independent of DNA methylation of their promoters. Cell Adh. Migr.2(1) , 38–44 (2008).
  • Castrén E , VõikarV, RantamäkiT. Role of neurotrophic factors in depression. Curr. Opin. Pharmacol.7(1) , 18–21 (2007).
  • Benusková L . Antidepressants and synaptic plasticity: a hypothesis. Med. Hypotheses35(1) , 17–22 (1991).
  • Gorman JM , DochertyJP. A hypothesized role for dendritic remodeling in the etiology of mood and anxiety disorders. J. Neuropsychiatry Clin. Neurosci.22(3) , 256–264 (2010).
  • Bjartmar L , AlkhoriL, RuudJ et al. Long-term treatment with antidepressants, but not environmental stimulation, induces expression of NP2 mRNA in hippocampus and medial habenula. Brain Res. 1328 , 25–33 (2010).
  • Chen F , MadsenTM, WegenerG, NyengaardJR. Imipramine treatment increases the number of hippocampal synapses and neurons in a genetic animal model of depression. Hippocampus20(12) , 1376–1384 (2010).
  • Im HI , KennyPJ. MicroRNAs in neuronal function and dysfunction. Trends Neurosci.35(5) , 325–334 (2012).

▪ Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.