327
Views
0
CrossRef citations to date
0
Altmetric
News & Views

Research Highlights: Highlights from the Latest Pharmacogenomic Genome-Wide Association Studies

&
Pages 357-360 | Published online: 25 Feb 2013

References

  • Rajagopalan PT , ZhangZ, McCourtL et al. Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics. Proc. Natl Acad. Sci. USA 99(21) , 13481–13486 (2002).
  • Johnston A , GudjonssonJE, SigmundsdottirH et al. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin. Immunol. 114(2) , 154–163 (2005).
  • Evans WE , CromWR, StewartCF et al. Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia. Lancet 1(8373) , 359–362 (1984).
  • Trevino LR , ShimasakiN, YangW et al. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J. Clin. Oncol. 27 , 5972–5978 (2009).
  • Tirona RG , LeakeBF, MerinoG et al. Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European– and African–Americans. J. Biol. Chem. 276 , 35669–35675 (2001).
  • Ramsey LB , BruunGH, YangW et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 22(1) , 1–8 (2012).

References

  • Early Breast Cancer Trialists‘ Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet365 , 1687–1717 (2005).
  • Kiyotani K , MushirodaT, TsunodaT et al. A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese. Hum. Mol. Genet. 21(7) , 1665–1672 (2012).
  • Borgna JL , RochefortH. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J. Biol. Chem.256 , 859–868 (1981).
  • Schroth W , GoetzMP, HamannU et al. Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. J. Am. Med. Assoc. 302 , 1429–1436 (2009).
  • Wegman P , ElingaramiS, CarstensenJ et al. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res. 9(1) , R7 (2007).
  • Kiyotani K , MushirodaT, ImamuraCK, et al. Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J. Clin. Oncol.28 , 1287–1293 (2010).

References

  • Nathan DM , BuseJB, DavidsonMB et al. Medical management of hyperglycaemia in Type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52 , 17–30 (2009).
  • Owen MR , DoranE, HalestrapAP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J.348 , 607–614 (2000).
  • Hawley SA , RossFA, ChevtzoffC et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 11 , 554–565 (2010).
  • Donnelly LA , DoneyAS, HattersleyAT et al. The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes. Diabet. Med. 23 , 128–133 (2006).
  • Zhou K , BellenguezC, SpencerCC et al.; GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group; Wellcome Trust Case Control Consortium 2. Common variants near ATM are associated with glycemic response to metformin in Type 2 diabetes. Nat. Genet.43(2) , 117–120 (2011).
  • Schalch DS , McFarlinDE, BarlowMH. An unusual form of diabetes mellitus in ataxia telangiectasia. N. Engl. J. Med.282 , 1396–1402 (1970).
  • Bar RS , LevisWR, RechlerMM et al. Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors. N. Engl. J. Med. 298 , 1164–1171 (1978).
  • Sun Y , ConnorsKE, YangDQ. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol. Cell. Biochem.306 , 239–245 (2007).
  • Huang X , WullschlegerS, ShpiroN et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem. J. 412 , 211–21 (2008).

References

  • Suhre K , ShinSY, PetersenAK et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature477(7362) , 54–60 (2011).
  • Hindorff LA , SethupathyP, JunkinsHA et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106 , 9362–9367 (2009).
  • Newgard CB , AttieAD. Getting biological about the genetics of diabetes. Nat. Med.16 , 388–391 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.