Advanced search
Publication Cover
Pharmacogenomics Volume 15, 2014 - Issue 2
Submit an article Journal homepage
948
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Personalizing the Management of Heart Failure in Congenital Heart Disease: Challenges and Opportunities

Simon de Denusa Faculty of Pharmacy, Université de Montréal, Montreal, Canada and Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada. [email protected]View further author information
,
Gregor Andelfingerb Faculty of Medicine, Université de Montréal, Montreal, Canada and Sainte-Justine Hospital, Montreal, QC, CanadaView further author information
&
Paul Khairyc Montreal Heart Institute, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada and Faculty of Medicine, Université de Montréal, Montreal, CanadaView further author information
Pages 123-127 | Published online: 21 Jan 2014

References

  • van der Linde D , KoningsEE, SlagerMAet al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J. Am. Coll. Cardiol. 58(21) , 2241–2247 (2011).
  • Khairy P , Ionescu-IttuR, MackieAS, AbrahamowiczM, PiloteL, MarelliAJ. Changing mortality in congenital heart disease. J. Am. Coll. Cardiol.56(14) , 1149–1157 (2010).
  • Zomer AC , VaartjesI, UiterwaalCSet al. Circumstances of death in adult congenital heart disease. Int. J. Cardiol. 154(2) , 168–172 (2012).
  • Kantor PF , AndelfingerG, DanceaA, KhairyP. Heart failure in congenital heart disease. Can. J. Cardiol.29(7) , 753–754 (2013).
  • Eindhoven JA , van den Bosch AE, Jansen PR, Boersma E, Roos-Hesselink JW. The usefulness of brain natriuretic peptide in complex congenital heart disease: a systematic review. J. Am. Coll. Cardiol.60(21) , 2140–2149 (2012).
  • Dore A , HoudeC, ChanKLet al. Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial. Circulation 112(16) , 2411–2416 (2005).
  • Manickaraj AK , MitalS. Personalized medicine in pediatric cardiology: do little changes make a big difference? Curr. Opin. Pediatr.24(5) , 584–591 (2012).
  • Khairy P . Defibrillators and cardiac resynchronization therapy in congenital heart disease: evolving indications. Expert Rev. Med. Devices5(3) , 267–271 (2008).
  • Kirk R , DipchandAI, EdwardsLBet al. The Registry of the International Society for Heart and Lung Transplantation: fifteenth pediatric heart transplantation report – 2012. J. Heart Lung Transplant. 31(10) , 1065–1072 (2012).
  • Christie JD , EdwardsLB, KucheryavayaAYet al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report – 2010. J. Heart Lung Transplant. 29(10) , 1104–1118 (2010).
  • Greutmann M , PretreR, FurrerLet al. Heart transplantation in adolescent and adult patients with congenital heart disease: a case–control study. Transplant. Proc. 41(9) , 3821–3826 (2009).
  • Mitchell MB , CampbellDN, IvyDet al. Evidence of pulmonary vascular disease after heart transplantation for fontan circulation failure. J. Thorac. Cardiovasc. Surg. 128(5) , 693–702 (2004).
  • Preuss C , AndelfingerG. Genetics of heart failure in congenital heart disease. Can. J. Cardiol.29(7) , 803–810 (2013).
  • Costa MW , GuoG, WolsteinOet al. Functional characterization of a novel mutation in nkx2–5 associated with congenital heart disease and adult-onset cardiomyopathy. Circ. Cardiovasc. Genet. 6(3) , 238–247 (2013).
  • Carey AS , LiangL, EdwardsJet al. The impact of cnvs on outcomes for infants with single ventricle heart defects. Circ. Cardiovasc. Genet. 6(5) , 444–451 (2013).
  • Soemedi R , WilsonIJ, BenthamJet al. Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. Am. J. Hum. Genet. 91(3) , 489–501 (2012).
  • Greenway SC , PereiraAC, LinJCet al. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of fallot. Nat. Genet.41(8) , 931–935 (2009).
  • Hitz MP , Lemieux-PerreaultLP, MarshallCet al. Rare copy number variants contribute to congenital left-sided heart disease. PLoS Genet. 8(9) , e1002903 (2012).
  • Zaidi S , ChoiM, WakimotoHet al. De novo mutations in histone-modifying genes in congenital heart disease. Nature498(7453) , 220–223 (2013).
  • Webber SA , BoyleGJ, GribarSet al. Polymorphisms in cytokine genes do not predict progression to end-stage heart failure in children. Cardiol. Young 12(5) , 461–464 (2002).
  • Yuan S , ZaidiS, BruecknerM. Congenital heart disease: emerging themes linking genetics and development. Curr. Opin. Genet. Dev.23(3) , 352–359 (2013).
  • Fahed AC , GelbBD, SeidmanJG, SeidmanCE. Genetics of congenital heart disease: the glass half empty. Circ. Res.112(4) , 707–720 (2013).
  • Mital S , ChungWK, ColanSDet al. Renin–angiotensin–aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation 123(21) , 2353-2362 (2011).
  • Hsu DT , ZakV, MahonyLet al. Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation 122(4) , 333–340 (2010).
  • Girnita DM , OhmannEL, BrooksMMet al. Gene polymorphisms impact the risk of rejection with hemodynamic compromise: a multicenter study. Transplantation 91(12) , 1326–1332 (2011).
  • Auerbach SR , ManlhiotC, ReddySet al. Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation. J. Am. Coll. Cardiol. 53(20) , 1909–1917 (2009).
  • Feingold B , BrooksMM, ZeeviAet al. Renal function and genetic polymorphisms in pediatric heart transplant recipients. J. Heart Lung Transplant. 31(9) , 1003–1008 (2012).
  • Filippo SD , ZeeviA, McDadeKKet al. Impact of tgfβ1 gene polymorphisms on late renal function in pediatric heart transplantation. Hum. Immunol. 66(2) , 133–139 (2005).
  • Gijsen V , MitalS, van Schaik RH et al. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J. Heart Lung Transplant.30(12) , 1352–1359 (2011).
  • Zheng H , WebberS, ZeeviAet al. Tacrolimus dosing in pediatric heart transplant patients is related to CYP3A5 and mdr1 gene polymorphisms. Am. J. Transplant. 3(4) , 477–483 (2003).
  • Gijsen V , MitalS, van Schaik RH et al. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J. Heart Lung Transplant.30(12) , 1352–1359 (2011).
  • Zhao W , FakhouryM, BaudouinVet al. Population pharmacokinetics and pharmacogenetics of once daily prolonged-release formulation of tacrolimus in pediatric and adolescent kidney transplant recipients. Eur. J. Clin. Pharmacol. 69(2) , 189–195 (2013).
  • Thervet E , LoriotMA, BarbierSet al. Optimization of initial tacrolimus dose using pharmacogenetic testing. Clin. Pharmacol. Ther. 87(6) , 721–726 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.