Pharmacogenetics of Taste: Turning Bitter Pills Sweet?

• Lipchock SV , ReedDR, MennellaJA. Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis. Clin. Ther.34(3) , 728–733 (2012).
   PubMed Web of Science ®Google Scholar
• Bufe B , BreslinPA, KuhnC et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 15(4) , 322–327 (2005).
   PubMed Web of Science ®Google Scholar
• Chandrashekar J , HoonMA, RybaNJ, ZukerCS. The receptors and cells for mammalian taste. Nature444(7117) , 288–294 (2006).
   PubMed Web of Science ®Google Scholar
• Fox A . Six in ten “taste blind” to bitter chemical. Sci. News Lett.9 , 249 (1931).
   Google Scholar
• Blakeslee AF . Genetics of sensory thresholds: taste for phenyl thio carbamide. Proc. Natl Acad. Sci. USA18(1) , 120–130 (1932).
   PubMedGoogle Scholar
• Salmon TN , BlakesleeAF. Genetics of sensory thresholds: variations within single individuals in taste sensitivity for PTC. Proc. Natl Acad. Sci. USA21(2) , 78–83 (1935).
   PubMedGoogle Scholar
• Anliker JA , BartoshukL, FerrisAM, HooksLD. Children‘s food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Am. J. Clin. Nutr.54(2) , 316–320 (1991).
   PubMed Web of Science ®Google Scholar
• Khataan NH , StewartL, BrennerDM, CornelisMC, El-SohemyA. TAS2R38 genotypes and phenylthiocarbamide bitter taste perception in a population of young adults. J. Nutrigenet. Nutrigenomics2(4–5) , 251–256 (2009).
   PubMedGoogle Scholar
• Feeney E , O‘BrienS, ScannellA, MarkeyA, GibneyER. Genetic variation in taste perception: does it have a role in healthy eating? Proc. Nutr. Soc.70(1) , 135–143 (2011).
   PubMed Web of Science ®Google Scholar
• Mennella JA , SpectorAC, ReedDR, ColdwellSE. The bad taste of medicines: overview of basic research on bitter taste. Clin. Ther.35(8) , 1225–1246 (2013).
   PubMed Web of Science ®Google Scholar
• Swen JJ , GuchelaarHJ. Just how feasible is pharmacogenetic testing in the primary healthcare setting? Pharmacogenomics13(5) , 507–509 (2012).
   PubMed Web of Science ®Google Scholar
• Swen JJ , HuizingaTW, GelderblomH et al. Translating pharmacogenomics: challenges on the road to the clinic. PLoS Med. 4(8) , e209(2007).
   PubMed Web of Science ®Google Scholar
• Baguley D , LimE, BevanA, PalletA, FaustSN. Prescribing for children-taste and palatability affect adherence to antibiotics: a review. Arch. Dis. Child.97(3) , 293–297 (2012).
   PubMed Web of Science ®Google Scholar
• Mennella JA , BeauchampGK. Optimizing oral medications for children. Clin. Ther.30(11) , 2120–2132 (2008).
   PubMed Web of Science ®Google Scholar
• Standing JF , KhakiZF, WongIC. Poor formulation information in published pediatric drug trials. Pediatrics116(4) , e559–e562 (2005).
   PubMed Web of Science ®Google Scholar
• Milne CP , BrussJB. The economics of pediatric formulation development for off-patent drugs. Clin. Ther.30(11) , 2133–2145 (2008).
   PubMed Web of Science ®Google Scholar
• Chaudhari N , RoperSD. The cell biology of taste. J. Cell Biol.190(3) , 285–296 (2010).
   PubMed Web of Science ®Google Scholar
• Mennella JA , LukasewyczLD, GriffithJW, BeauchampGK. Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan. Chem. Senses36(4) , 345–355 (2011).
   PubMed Web of Science ®Google Scholar
• Schmidt HJ , BeauchampGK. Adult-like odor preferences and aversions in three-year-old children. Child Dev.59(4) , 1136–1143 (1988).
   PubMed Web of Science ®Google Scholar
• Zhao L , KirkmeyerSV, TepperBJ. A paper screening test to assess genetic taste sensitivity to 6-n-propylthiouracil. Physiol. Behav.78(4–5) , 625–633 (2003).
   PubMed Web of Science ®Google Scholar
• Westra AE , WitJM, SukhaiRN, de Beaufort ID. Regulating “higher risk, no direct benefit” studies in minors. Am. J. Bioeth.11(6) , 29–31 (2011).
   PubMed Web of Science ®Google Scholar
• Mennella JA , PepinoMY, DukeFF, ReedDR. Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet.11 , 60(2010).
   PubMedGoogle Scholar
• Kim UK , JorgensonE, CoonH, LeppertM, RischN, DraynaD. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science299(5610) , 1221–1225 (2003).
   PubMed Web of Science ®Google Scholar
• Bartoshuk LM , FastK, KarrerTA et al. PROP super tasters and the perception of sweetness and bitterness. Chem. Senses 17 , 594(1992).
   Google Scholar
• Reed DR . Birth of a new breed of supertaster. Chem. Senses33(6) , 489–491 (2008).
   PubMed Web of Science ®Google Scholar
• Tepper BJ , ChristensenCM, CaoJ. Development of brief methods to classify individuals by PROP taster status. Physiol. Behav.73(4) , 571–577 (2001).
   PubMed Web of Science ®Google Scholar
• Smutzer G , DesaiH, ColdwellSE, GriffithJW. Validation of edible taste strips for assessing PROP taste perception. Chem. Senses38(6) , 529–539 (2013).
   PubMed Web of Science ®Google Scholar
• Hayes JE , BartoshukLM, KiddJR, DuffyVB. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem. Senses33(3) , 255–265 (2008).
   PubMed Web of Science ®Google Scholar
• Keller KL , ReidA, MacDougallMC et al. Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4–6 year-old children. Obesity (Silver Spring) 18(6) , 1194–1200 (2010).
   PubMed Web of Science ®Google Scholar
• Negri R , Di Feola M, Di Domenico S et al. Taste perception and food choices. J. Pediatr. Gastroenterol. Nutr.54(5) , 624–629 (2012).
   PubMed Web of Science ®Google Scholar
• Padiglia A , ZonzaA, AtzoriE et al. Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. Am. J. Clin. Nutr. 92(3) , 539–545 (2010).
   PubMed Web of Science ®Google Scholar
• Hayes JE , WallaceMR, KnopikVS, HerbstmanDM, BartoshukLM, DuffyVB. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem. Senses36(3) , 311–319 (2011).
   PubMed Web of Science ®Google Scholar
• Hayes JE , FeeneyEL, AllenAL. Do polymorphisms in chemosensory genes matter for human ingestive behavior? Food Qual. Prefer.30(2) , 202–216 (2013).
   PubMed Web of Science ®Google Scholar
• Allen AL , McGearyJE, KnopikVS, HayesJE. Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31. Chem. Senses38(5) , 379–389 (2013).
   PubMed Web of Science ®Google Scholar
• Kuhn C , BufeB, WinnigM et al. Bitter taste receptors for saccharin and acesulfame K. J. Neurosci. 24(45) , 10260–10265 (2004).
   PubMed Web of Science ®Google Scholar
• Mennella JA , FinkbeinerS, ReedDR. The proof is in the pudding: children prefer lower fat but higher sugar than do mothers. Int. J. Obes. (Lond.)36(10) , 1285–1291 (2012).
   PubMed Web of Science ®Google Scholar
• Mennella JA , PepinoMY, ReedDR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics115(2) , e216–e222 (2005).
   PubMed Web of Science ®Google Scholar
• Fushan AA , SimonsCT, SlackJP, ManichaikulA, DraynaD. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr. Biol.19(15) , 1288–1293 (2009).
   PubMed Web of Science ®Google Scholar
• Fushan AA , SimonsCT, SlackJP, DraynaD. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Chem. Senses35(7) , 579–592 (2010).
   PubMed Web of Science ®Google Scholar
• Bartoshuk LM , DuffyVB, MillerIJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol. Behav.56(6) , 11651165–1171 (1994).
   PubMed Web of Science ®Google Scholar
• Keller KL , TepperBJ. Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. Obes. Res.12(6) , 904–912 (2004).
   PubMedGoogle Scholar
• Goldstein GL , DaunH, TepperBJ. Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents. Physiol. Behav.90(5) , 809–817 (2007).
   PubMed Web of Science ®Google Scholar
• Hayes JE , WallaceMR, KnopikVS, HerbstmanDM, BartoshukLM, DuffyVB. Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults. Chem. Senses36(3) , 311–319 (2011).
   PubMed Web of Science ®Google Scholar
• Meyerhof W , BatramC, KuhnC et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35(2) , 157–170 (2010).
   PubMed Web of Science ®Google Scholar
• Behrens M , MeyerhofW. Bitter taste receptors and human bitter taste perception. Cell. Mol. Life Sci.63(13) , 1501–1509 (2006).
   PubMed Web of Science ®Google Scholar

▪ Websites

• Periodic survey #44: Patient compliance with prescription regimens. www.aap.org/en-us/professional-resources/Research/Pages/PS44_Executive_Summary_PatientCompliancewithPrescriptionRegimens.aspx
   Google Scholar
• CHMP. reflection paper: formulations of choice for the paediatric population. www.emea.europa.eu.proxy.library.uu.nl/pdfs/human/paediatrics/19481005en.pdf
   Google Scholar