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Pharmacogenomics Volume 15, 2014 - Issue 4
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Research Article

MTHFR Functional Genetic Variation and Methotrexate Treatment Response in Rheumatoid Arthritis: A Meta-Analysis

Michael D Morgan1 Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James‘s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UKView further author information
,
Nashwa Al-Shaarawy2 Rheumatology & Rehabilitation Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptView further author information
,
Steve Martin1 Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James‘s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UKView further author information
,
James I Robinson1 Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James‘s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UKView further author information
,
Sarah Twigg3 NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UKView further author information
,
YEAR Consortium3 NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UKView further author information
,
Awadalla A Magdy4 Rheumatology & Rehabilitation, Faculty of Medicine, Suez Canal University, Cairo, EgyptView further author information
,
Aziza Sayed Omar2 Rheumatology & Rehabilitation Department, Faculty of Medicine, Suez Canal University, Ismailia, EgyptView further author information
,
Maivel H Ghattas5 Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, EgyptView further author information
,
Paul Emery1 Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James‘s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UK;3 NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UKView further author information
,
Jennifer H Barrett3 NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK;6 Section of Epidemiology & Biostatistics, Leeds Institute of Cancer Studies & Pathology, Leeds Cancer Research UK Centre, St James‘s University Hospital, Leeds, UKView further author information
&
Ann W Morgan3 NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK;1 Leeds Institute of Rheumatic & Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James‘s University Hospital, Beckett Street, Leeds, West Yorkshire, LS9 7TF, UKCorrespondence[email protected]
View further author information
 show all
Pages 467-475 | Published online: 13 Mar 2014

References

  • Weinblatt ME , CoblynJS, FoxDA et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N. Engl. J. Med. 312(13) , 818–822 (1985).
  • Cronstein BN . Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol. Rev.57(2) , 163–172 (2005).
  • Aggarwal P , NaikS, MishraKP, AggarwalA, MisraR. Correlation between methotrexate efficacy and toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation. Indian J. Med. Res.124(5) , 521–526 (2006).
  • Dervieux T , WesselsJAM, van der Straaten T et al. Gene–gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis. Pharmacogenet. Genomics19(12) , 935–944 (2009).
  • Frosst P , BlomHJ, MilosR et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10(1) , 111–113 (1995).
  • Ghodke Y , ChopraA, JoshiK, PatwardhanB. Are thymidylate synthase and methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients? Clin. Rheumatol.27(6) , 787–789 (2008).
  • Stamp LK , ChapmanPT, O‘DonnellJL et al. Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenet. Genomics 20(6) , 367–376 (2010).
  • Taniguchi A , UranoW, TanakaE et al. Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice. Pharmacogenet. Genomics 17(6) , 383–390 (2007).
  • van der Put NM , GabreelsF, StevensEM et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am. J. Hum. Genet. 62(5) , 1044–1051 (1998).
  • Wessels JAM , de Vries-Bouwstra JK, Heijmans BT et al. Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. Arthritis Rheum.54(4) , 1087–1095 (2006).
  • Lee YH , SongGG. Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. Clin. Drug Investig.30(2) , 101–108 (2010).
  • Owen SA , LuntM, BowesJ et al. MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms. Pharmacogenomics J.13(2) , 137–147 (2011).
  • Spyridopoulou KP , DimouNL, HamodrakasSJ, BagosPG. Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis. Pharmacogenet. Genomics22(2) , 117–133 (2012).
  • Fisher MC , CronsteinBN. Meta-analysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity. J. Rheumatol.36(3) , 539–545 (2009).
  • Berkun Y , LevartovskyD, RubinowA et al. Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene. Ann. Rheum. Dis. 63(10) , 1227–1231 (2004).
  • Pinals RS , MasiAT, LarsenRA. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum.24(10) , 1308–1315 (1981).
  • van der Heijde DM , van ‘t Hof MA, van Riel PL et al. Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. Ann. Rheum. Dis.49(11) , 916–920 (1990).
  • Dersimonian R , LairdN. Meta-analysis in clinical trials. Control. Clin. Trials7(3) , 177–188 (1986).
  • Higgins JPT , ThompsonSG. Quantifying heterogeneity in a meta-analysis. Statist. Med.21(11) , 1539–1558 (2002).
  • Lee YC , CuiJ, CostenbaderKH, ShadickNA, WeinblattME, KarlsonEW. Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology48(6) , 613–617 (2009).

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