172
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Validation of Warfarin Pharmacogenetic Algorithms In 586 Han Chinese Patients

, , , , , , & show all
Pages 1465-1474 | Published online: 10 Aug 2015

References

  • Yin T , MiyataT . Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1-rationale and perspectives . Thromb. Res.120 ( 1 ), 1 – 10 ( 2007 ).
  • Wysowski DK , NourjahP , SwartzL . Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action . Arch. Intern. Med.167 ( 13 ), 1414 – 1419 ( 2007 ).
  • Loebstein R , YonathH , PelegDet al. Interindividual variability in sensitivity to warfarin – nature or nurture? Clin. Pharmacol. Ther. 70 ( 2 ), 159 – 164 ( 2001 ).
  • Gage B , EbyC , JohnsonJet al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin . Clin. Pharmacol. Ther.84 ( 3 ), 326 – 331 ( 2008 ).
  • Sconce EA , KhanTI , WynneHAet al. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen . Blood106 ( 7 ), 2329 – 2333 ( 2005 ).
  • Anderson JL , HorneBD , StevensSMet al. Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation . Circulation116 ( 22 ), 2563 – 2570 ( 2007 ).
  • Miao L , YangJ , HuangC , ShenZ . Contribution of age, body weight, and CYP2C9 and VKORC1 genotype to the anticoagulant response to warfarin: proposal for a new dosing regimen in Chinese patients . Eur. J. Clin. Pharmacol.63 ( 12 ), 1135 – 1141 ( 2007 ).
  • Zhu Y , ShennanM , ReynoldsKKet al. Estimation of warfarin maintenance dose based on VKORC1 (-1639G>A) and CYP2C9 genotypes . Clin. Chem.53 ( 7 ), 1199 – 1205 ( 2007 ).
  • Wang T-L , LiH-L , TjongW-Yet al. Genetic factors contribute to patient-specific warfarin dose for Han Chinese . Clin. Chim. Acta396 ( 1 ), 76 – 79 ( 2008 ).
  • Wen M , LeeM , ChenJet al. Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes . Clin. Pharmacol. Ther.84 ( 1 ), 83 – 89 ( 2008 ).
  • Consortium IWP . Estimation of the warfarin dose with clinical and pharmacogenetic data . N. Eng. J. Med.360 ( 8 ), 753 ( 2009 ).
  • Huang S-W , ChenH-S , WangX-Qet al. Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose: a prospective study in Chinese patients . Pharmacogenet. Genomics19 ( 3 ), 226 – 234 ( 2009 ).
  • Ohno M , YamamotoA , OnoAet al. Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients . Eur. J. Clin. Pharmacol.65 ( 11 ), 1097 – 1103 ( 2009 ).
  • Sandanaraj E , LalS , CheungYBet al. VKORC1 diplotype-derived dosing model to explain variability in warfarin dose requirements in Asian patients . Drug Metabol. Pharmacokinet.24 ( 4 ), 365 ( 2009 ).
  • Wadelius M , ChenLY , LindhJDet al. The largest prospective warfarin-treated cohort supports genetic forecasting . Blood113 ( 4 ), 784 – 792 ( 2009 ).
  • Gu Q , KongY , SchneedeJet al. VKORC1–1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in Southwest China . Eur. J. Clin. Pharmacol.66 ( 12 ), 1217 – 1227 ( 2010 ).
  • Cho H-J , OnY-K , BangOYet al. Development and comparison of a warfarin-dosing algorithm for Korean patients with atrial fibrillation . Clin. Ther.33 ( 10 ), 1371 – 1380 ( 2011 ).
  • Yang J , HuangC , ShenZ , MiaoL . Contribution of 1173C>T polymorphism in the VKORC1 gene to warfarin dose requirements in Han Chinese patients receiving anticoagulation . Int. J. Clin. Pharmacol. Ther.49 ( 1 ), 23 – 29 ( 2011 ).
  • You JH , WongRS , WayeMMet al. Warfarin dosing algorithm using clinical, demographic and pharmacogenetic data from Chinese patients . J. Thromb. Thrombolysis31 ( 1 ), 113 – 118 ( 2011 ).
  • Tan SL , LiZ , SongGBet al. Development and comparison of a new personalized warfarin stable dose prediction algorithm in Chinese patients undergoing heart valve replacement . Die Pharmazie67 ( 11 ), 930 – 937 ( 2012 ).
  • Wei M , YeF , XieDet al. A new algorithm to predict warfarin dose from polymorphisms of CYP4F2, CYP2C9 and VKORC1 and clinical variables: derivation in Han Chinese patients with non valvular atrial fibrillation . Thromb. Haemost.107 ( 6 ), 1083 ( 2012 ).
  • Zhong S-L , YuX-Y , LiuYet al. Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients . Pharmacogenet. Genomics22 ( 3 ), 176 – 182 ( 2012 ).
  • Wu AH , WangP , SmithAet al. Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations . Pharmacogenomics9 ( 2 ), 169 – 178 ( 2008 ).
  • Lubitz SA , ScottSA , RothlaufEBet al. Comparative performance of gene-based warfarin dosing algorithms in a multiethnic population . J. Thromb. Haemost.8 ( 5 ), 1018 – 1026 ( 2010 ).
  • Finkelman BS , GageBF , JohnsonJA , BrensingerCM , KimmelSE . Genetic warfarin dosing: tables versus algorithms . J. Am. Coll. Cardiol.57 ( 5 ), 612 – 618 ( 2011 ).
  • Liu Y , YangJ , XuQet al. Comparative performance of warfarin pharmacogenetic algorithms in Chinese patients . Thromb. Res.130 ( 3 ), 435 – 440 ( 2012 ).
  • Marin-Leblanc M , PerreaultS , BahrounIet al. Validation of warfarin pharmacogenetic algorithms in clinical practice . Pharmacogenomics13 ( 1 ), 21 – 29 ( 2012 ).
  • Li X , LiuR , LuoZYet al. Comparison of the predictive abilities of pharmacogenetics-based warfarin dosing algorithms using seven mathematical models in Chinese patients . Pharmacogenomics16 ( 6 ), 583 – 590 ( 2015 ).
  • Rahman M , BinesmaelTM , PayneN , ButchartEG . Increased sensitivity to warfarin after heart valve replacement . Ann. Pharmacother.40 ( 3 ), 397 – 401 ( 2006 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.