From Genomes to Genomic Medicine: Enabling Personalized and Precision Medicine in the Middle East

References

• Grissa A . Arab economic integration: current reality and future prospects . Presented at : Economic Research Forum, No. 9405 . Cairo, Eygpt , 1–24 May 1994 .
   Google Scholar
• Rahim HFA , SibaiA , KhaderYet al. Non-communicable diseases in the Arab world . Lancet383 ( 9914 ), 356 – 367 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Teebi AS , TeebiSA . Genetic diversity among the Arabs . Community Genet.8 ( 1 ), 21 – 26 ( 2005 ).
   PubMedGoogle Scholar
• Yang X , Al-BustanS , FengQet al. The influence of admixture and consanguinity on population genetic diversity in Middle East . J. Hum. Genet.59 ( 11 ), 615 – 622 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Haber M , GauguierD , YouhannaSet al. Genome-wide diversity in the levant reveals recent structuring by culture . PLoS Genet.9 ( 2 ), e1003316 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Hamamy H . Consanguineous marriages: preconception consultation in primary health care settings . J. Community Genet.3 ( 3 ), 185 – 192 ( 2012 ).
   PubMedGoogle Scholar
• Özçelik T , OnatOE . Genomic landscape of the Greater Middle East . Nat. Genet.48 ( 9 ), 978 – 979 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Tadmouri GO . CTGA: the database for genetic disorders in Arab populations . Nucleic Acids Res.34 ( 90001 ), D602 – D606 ( 2006 ).
   PubMedGoogle Scholar
• Bener A , MohammadRR . Global distribution of consanguinity and their impact on complex diseases: genetic disorders from an endogamous population . Egypt. J. Med. Hum. Genet. ( 2017 ).
   Google Scholar
• Manolio TA , CollinsFS , CoxNJet al. Finding the missing heritability of complex diseases . Nature461 ( 7265 ), 747 – 753 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• QGP Research Consortium Qatar Genome Programme . www.qatargenome.org.qa/node/46 .
   Google Scholar
• Hunter-Zinck H , MusharoffS , SalitJet al. Population genetic structure of the people of Qatar . Am. J. Hum. Genet.87 ( 1 ), 17 – 25 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Rodriguez-Flores JL , FakhroK , HackettNRet al. Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar . Hum. Mutat.35 ( 1 ), 105 – 116 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Fakhro KA , StaudtMR , RamstetterMDet al. The Qatar genome: a population-specific tool for precision medicine in the Middle East . Hum Genome Var.3 , doi:10.1038/hgv.2016.16 ( 2016 ).
   PubMedGoogle Scholar
• Saudi Mendeliome Group . Comprehensive gene panels provide advantages over clinical exome sequencing for Mendelian diseases . Genome Biol.16 ( 1 ), 134 ( 2015 ).
   PubMedGoogle Scholar
• Anazi S , MaddirevulaS , FaqeihEet al. Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield . Mol. Psychiatry.22 ( 4 ), 615 – 624 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Scott EM , HaleesA , ItanYet al. Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery . Nat. Genet.48 , 1071 – 1076 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Turkish Genome Project Launched – BBMRI-ERIC: Gateway for Health . www.bbmri-eric.eu/news-events/turkish-genome-project-launched/ .
   Google Scholar
• Alsmadi O , JohnSE , TharejaGet al. Genome at juncture of early human migration: a systematic analysis of two whole genomes and thirteen exomes from Kuwaiti population subgroup of inferred Saudi Arabian tribe ancestry . PLoS ONE9 ( 6 ), e99069 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Al-Mulla F . The locked genomes: a perspective from Arabia . Appl. Transl. Genomics.3 ( 4 ), 132 – 133 ( 2014 ).
   PubMedGoogle Scholar
• Auton A , AbecasisGR , AltshulerDMet al. A global reference for human genetic variation . Nature526 ( 7571 ), 68 – 74 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Halim-Fikri H , EtemadA , Abdul LatifAZet al. The first Malay database toward the ethnic-specific target molecular variation . BMC Res. Notes8 , 176 ( 2015 ).
   PubMedGoogle Scholar
• Koshy R , RanawatA , ScariaV . al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations . J. Hum. Genet. doi: 10.1038/jhg.2017.67 ( 2017 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• HBKU Colleges College of Science & Engineering . www.hbku.edu.qa/en/cse#programs .
   Google Scholar
• Bilani N , DagherM , ZgheibNK . Precision genetic and genomic medicine in the Middle East and North Africa Region: are we there yet?Public Health Genomics doi: 10.1159/000473890 ( 2017 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• Bu R , GutiérrezMI , Al-RasheedM , BelgaumiA , BhatiaK . Variable drug metabolism genes in Arab population . Pharmacogenomics J.4 ( 4 ), 260 – 266 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Pathare A , Al KhaboriM , AlkindiSet al. Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients . J. Hum. Genet.57 ( 10 ), 665 – 669 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Alzahrani AM , RagiaG , HaniehH , ManolopoulosVG . Genotyping of CYP2C9 and VKORC1 in the Arabic population of Al-Ahsa, Saudi Arabia . Biomed Res. Int.2013 , 315980 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Shahin MHA , KhalifaSI , GongYet al. Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients . Pharmacogenet. Genomics21 ( 3 ), 130 – 135 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Esmerian MO , MitriZ , HabbalM-Zet al. Influence of CYP2C9 and VKORC1 polymorphisms on warfarin and acenocoumarol in a sample of Lebanese people . J. Clin. Pharmacol.51 ( 10 ), 1418 – 1428 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Sivadas A , SharmaP , ScariaV . Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets . Pharmacogenomics17 ( 17 ), 1891 – 1901 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Koshy R , SivadasA , ScariaV . Genetic epidemiology of familial Mediterranean fever through integrative analysis of whole genome and exome sequences from Middle East and North Africa . Clin. Genet. doi: 10.1111/cge.13070 ( 2017 ) ( Epub ahead of print ).
   PubMed Web of Science ®Google Scholar
• Ghaly M , SadounE , AlkurayaFet al. Genomics in the Gulf Region and Islamic Ethics: a special report in collaboration with the Research Center for Islamic Legislation and Ethics . WISH 2016, Institute of Global Health Innovation , London, UK ( 2016 ).
   Google Scholar
• Memish ZA , SaeediMY . Six-year outcome of the national premarital screening and genetic counseling program for sickle cell disease and β-thalassemia in Saudi Arabia . Ann. Saudi Med.31 ( 3 ), 229 – 235 ( 2011 ).
   PubMed Web of Science ®Google Scholar