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Review

A Personalized Approach to Pancreatic Ductal Adenocarcinoma and its Application in Surgical Practice

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 613-627 | Received 03 Mar 2021, Accepted 13 Aug 2021, Published online: 22 Oct 2021

References

  • Tarver T . Cancer Facts & Figures 2012. American Cancer Society (ACS). J. Consum. Health Internet16(3), 366–367 (2012).
  • Rahib L , SmithBD , AizenbergR , RosenzweigAB , FleshmanJM , MatrisianLM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res.74(11), 2913–2921 (2014).
  • Imamura M , DoiR , ImaizumiTet al. A randomized multicenter trial comparing resection and radiochemotherapy for resectable locally invasive pancreatic cancer. Surgery136(5), 1003–1011 (2004).
  • Bilici A . Prognostic factors related with survival in patients with pancreatic adenocarcinoma. World J. Gastroenterol.20(31), 10802 (2014).
  • Bateni SB , GingrichAA , HochJS , CanterRJ , BoldRJ. Defining value for pancreatic surgery in early-stage pancreatic cancer. JAMA Surgery154(10), e193019 (2019).
  • Zeng S , PöttlerM , LanB , GrützmannR , PilarskyC , YangH. Chemoresistance in pancreatic cancer. Int. J. Mol. Sci.20(18), 4504 (2019).
  • Sivakumar S , DeSantiago I , ChlonL , MarkowetzF. Master regulators of oncogenic KRAS response in pancreatic cancer: an integrative network biology analysis. PLoS Med.14(1), e1002223 (2017).
  • Griffin JF , PorukKE , WolfgangCL. Pancreatic cancer surgery: past, present, and future. Chin. J. Cancer Res.27(4), 332–348 (2015).
  • NCCN Guidelines . Pancreatic Adenocarcinoma (Version 3.2019) (2019). http://www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdf
  • Xue Y , WilcoxWR. Changing paradigm of cancer therapy: precision medicine by next-generation sequencing. Cancer Biol. Med.13(1), 12–18 (2016).
  • Tsai HJ , ChangJS. Environmental risk factors of pancreatic cancer. J. Clin. Med.8(9), 1427 (2019).
  • Zanini S , RenziS , LimongiAR , BellaviteP , GiovinazzoF , BermanoG. A review of lifestyle and environment risk factors for pancreatic cancer. Eur. J. Cancer145, 53–70 (2021).
  • Ben QW , LiuJ , SunYW , WangLF , ZouDW , YuanYZ. Cigarette smoking and mortality in patients with pancreatic cancer: a systematic review and meta-analysis. Pancreas48(8), 985–995 (2019).
  • Candido S , AbramsSL , SteelmanLet al. Metformin influences drug sensitivity in pancreatic cancer cells. Adv. Biol. Regul.68, 13–30 (2018).
  • Menini S , IacobiniC , DeLatouliere Let al. The advanced glycation end-product N(ϵ)-carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention. J. Pathol.245(2), 197–208 (2018).
  • Vallianou N , KounatidisD. Mycobiome and cancer: what is the evidence?Cancers (Basel)13(13), 3149 (2021).
  • Archibugi L , SignorettiM , CapursoG. The microbiome and pancreatic cancer: an evidence-based association?J. Clin. Gastroenterol.52(Suppl. 1), S82–S85 (2018). Proceedings of: The 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting. Rome, Italy 10–, 12 September 2017.
  • Wei MY , ShiS , LiangCet al. The microbiota and microbiome in pancreatic cancer: more influential than expected. Mol. Cancer18(1), 97 (2019).
  • Geller LT , Barzily-RokniM. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science357(6356), 1156–1160 (2017).
  • Perez-Chanona E , TrinchieriG. The role of microbiota in cancer therapy. Curr. Opin. Immunol.39, 75–81 (2016).
  • Iida N , DzutsevA , StewartCAet al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science342(6161), 967–970 (2013).
  • Ogino S , NowakJA , HamadaT , MilnerDAJr , NishiharaR. Insights into pathogenic interactions among environment, host, and tumor at the crossroads of molecular pathology and epidemiology. Annu. Rev. Pathol.14, 83–103 (2019).
  • Hasan S , JacobR , ManneU , PaluriR. Advances in pancreatic cancer biomarkers. Oncol. Rev.13(1), 410 (2019).
  • Golan T , KanjiZS , EpelbaumRet al. Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. Br. J. Cancer111(6), 1132–1138 (2014).
  • Wei X , MeiC , LiX , XieY. The unique microbiome and immunity in pancreatic cancer. Pancreas50(2), 119–129 (2021).
  • Karamitopoulou E . Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features. Br. J. Cancer121(1), 5–14 (2019).
  • Jansen RJ , TanXL , PetersenGM. Gene-by-environment interactions in pancreatic cancer: implications for prevention. Yale J. Biol. Med.88(2), 115–126 (2015).
  • Van Kampen JG , Marijnissen-VanZanten MA , SimmerF , VanDer Graaf WT , LigtenbergMJ , NagtegaalID. Epigenetic targeting in pancreatic cancer. Cancer Treat. Rev.40(5), 656–664 (2014).
  • Gonzalez RS . WHO classification. PathologyOutlines.com (2019). www.pathologyoutlines.com/topic/pancreaswho.html
  • Schlitter AM , SeglerA , SteigerKet al. Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): identification of prognostic subtypes. Sci. Rep.7(1), 41064 (2017).
  • Torres C , GrippoPJ. Pancreatic cancer subtypes: a roadmap for precision medicine. Ann. Med.50(4), 277–287 (2018).
  • Jones S , ZhangX , ParsonsDWet al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science321(5897), 1801–1806 (2008).
  • Collisson EA , SadanandamA , OlsonPet al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med.17(4), 500–503 (2011).
  • Bailey P , ChangDK , NonesKet al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature531(7592), 47–52 (2016).
  • Moffitt RA , MarayatiR , FlateELet al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat. Genet.47(10), 1168–1178 (2015).
  • Waddell N , PajicM , PatchA-Met al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature518(7540), 495–501 (2015).
  • Cancer Genome Atlas Research Network . Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell32(2), 185–203.e113 (2017).
  • Zhao L , ZhaoH , YanH. Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypes. BMC Cancer18(1), 603 (2018).
  • Janky R , BindaMM , AllemeerschJet al. Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma. BMC Cancer16, 632 (2016).
  • Kim S , KangM , LeeSet al. Identifying molecular subtypes related to clinicopathologic factors in pancreatic cancer. Biomed. Eng. Online13(Suppl. 2), S5 (2014).
  • Bertucci F , BirnbaumDJ , FinettiPet al. Prognostic value of molecular subtypes in pancreatic cancer. Pancreas46(4), e29–e31 (2017).
  • Birnbaum DJ , FinettiP , BirnbaumD , MamessierE , BertucciF. Validation and comparison of the molecular classifications of pancreatic carcinomas. Mol. Cancer16(1), 168 (2017).
  • Dreyer SB , JamiesonNB , Upstill-GoddardRet al. Defining the molecular pathology of pancreatic body and tail adenocarcinoma. Br. J. Surg.105(2), e183–e191 (2018).
  • Birnbaum DJ , BertucciF , FinettiP , BirnbaumD , MamessierE. Head and body/tail pancreatic carcinomas are not the same tumors. Cancers11(4), 497 (2019).
  • Sahni S , MoonEA , HowellVMet al. Tissue biomarker panel as a surrogate marker for squamous subtype of pancreatic cancer. Eur. J. Surg. Oncol.46(8), 1539–1542 (2020).
  • Dreyer S , PineseM , JamiesonNet al. 10. Precision oncology in surgery: patient selection biomarkers for operable pancreatic cancer. Eur. J. Surg. Oncol.44(11), 1838 (2018).
  • Mueller S , EngleitnerT , MareschRet al. Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes. Nature554(7690), 62–68 (2018).
  • Bibikova M , LeJ , BarnesBet al. Genome-wide DNA methylation profiling using Infinium® assay. Epigenomics1(1), 177–200 (2009).
  • Shapiro J , Van LanschotJJB , HulshofMet al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol.16(9), 1090–1098 (2015).
  • Al-Batran SE , HomannN , PauligkCet al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, Phase 2/3 trial. Lancet393(10184), 1948–1957 (2019).
  • Shivnani AT , SmallW , StrykerSJet al. Preoperative chemoradiation for rectal cancer: results of multimodality management and analysis of prognostic factors. Am. J. Surg.193(3), 389–394 (2007).
  • Ferrone CR , MarchegianiG , HongTSet al. Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer. Ann. Surg.261(1), 12–17 (2015).
  • Wagner M , AntunesC , PietraszDet al. CT evaluation after neoadjuvant FOLFIRINOX chemotherapy for borderline and locally advanced pancreatic adenocarcinoma. Eur. Radiol.27(7), 3104–3116 (2016).
  • Oba A , HoF , BaoQR , Al-MusawiMH , SchulickRD , DelChiaro M. Neoadjuvant treatment in pancreatic cancer. Front. Oncol.10, 245 (2020).
  • Conroy T , DesseigneF , YchouMet al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N. Eng. J. Med.364(19), 1817–1825 (2011).
  • Von Hoff DD , RamanathanRK , BoradMJet al. Gemcitabine plusnab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a Phase I/II trial. J. Clin. Oncol.29(34), 4548–4554 (2011).
  • Rangelova E , WeferA , PerssonSet al. Surgery improves survival after neoadjuvant therapy for borderline and locally advanced pancreatic cancer. Ann. Surg.273(3), 579–586 (2019).
  • Tee MC , KrajewskiAC , GroeschlRTet al. Indications and perioperative outcomes for pancreatectomy with arterial resection. J. Am. Coll. Surg.227(2), 255–269 (2018).
  • Peddi PF , LubnerS , McwilliamsRet al. Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma. JOP13(5), 497–501 (2012).
  • Macedo FI , RyonE , MaithelSKet al. Survival outcomes associated with clinical and pathological response following neoadjuvant FOLFIRINOX or Gemcitabine/Nab-paclitaxel chemotherapy in resected pancreatic cancer. Ann. Surg.270(3), 400–413 (2019).
  • Hackert T , SachsenmaierM , HinzUet al. Locally advanced pancreatic cancer. Ann. Surg.264(3), 457–463 (2016).
  • Byun Y , HanY , KangJSet al. Role of surgical resection in the era of FOLFIRINOX for advanced pancreatic cancer. J. Hepatobiliary Pancreat. Sci.26(9), 416–425 (2019).
  • Reni M , BalzanoG , ZanonSet al. Phase 1B trial of Nab-paclitaxel plus gemcitabine, capecitabine, and cisplatin (PAXG regimen) in patients with unresectable or borderline resectable pancreatic adenocarcinoma. Br. J. Cancer115(3), 290–296 (2016).
  • Reni M , ZanonS , BalzanoGet al. A randomised Phase 2 trial of nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in locally advanced or borderline resectable pancreatic adenocarcinoma. Eur. J. Cancer102, 95–102 (2018).
  • Philip PA , LacyJ , PortalesFet al. Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer (LAPACT): a multicentre, open-label Phase 2 study. Lancet Gastroenterol. Hepatol.5(3), 285–294 (2020).
  • Ghaneh P , PalmerDH , CicconiSet al. ESPAC-5F: four-arm, prospective, multicenter, international randomized Phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer. J. Clin. Oncol.38(Suppl. 15), 4505–4505 (2020).
  • Versteijne E , SukerM , GroothuisKet al. Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the dutch randomized Phase III PREOPANC trial. J. Clin. Oncol.38(16), 1763–1773 (2020).
  • Rose JB , RochaFG , AlseidiAet al. Extended neoadjuvant chemotherapy for borderline resectable pancreatic cancer demonstrates promising postoperative outcomes and survival. Ann. Surg. Oncol.21(5), 1530–1537 (2014).
  • Janssen QP , BuettnerS , SukerMet al. Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis. J. Natl Cancer Inst.111(8), 782–794 (2019).
  • Suker M , BeumerBR , SadotEet al. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis. Lancet Oncol.17(6), 801–810 (2016).
  • Merkow RP , BilimoriaKY , TomlinsonJSet al. Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer. Ann. Surg.260(2), 372–377 (2014).
  • Motoi F , KosugeT , UenoHet al. Randomized Phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05). Jpn J. Clin. Oncol.49(2), 190–194 (2019).
  • Golcher H , BrunnerTB , WitzigmannHet al. Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer. Strahlenther. Onkol.191(1), 7–16 (2014).
  • O’reilly EM , PerelshteynA , JarnaginWRet al. A single-arm, nonrandomized Phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma. Ann. Surg.260(1), 142–148 (2014).
  • Tzeng C-WD , FlemingJB , LeeJEet al. Defined clinical classifications are associated with outcome of patients with anatomically resectable pancreatic adenocarcinoma treated with neoadjuvant therapy. Ann. Surg. Oncol.19(6), 2045–2053 (2012).
  • Gillen S , SchusterT , BüschenfeldeZum Meyer C , FriessH , KleeffJ. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med.7(4), e1000267 (2010).
  • Satoi S , YamamotoT , YamakiS , SakaguchiT , SekimotoM. Surgical indication for and desirable outcomes of conversion surgery in patients with initially unresectable pancreatic ductal adenocarcinoma. Ann. Gastroenterol. Surg.4(1), 6–13 (2019).
  • Herbst B , ZhengL. Precision medicine in pancreatic cancer: treating every patient as an exception. Lancet Gastroenterol. Hepatol.4(10), 805–810 (2019).
  • Wang CF . Significance of precision medicine in pancreatic cancer prevention and treatment. Zhonghua Zhong Liu Za Zhi38(3), 161–164 (2016).
  • Tsai S , ChristiansKK , GeorgeBet al. A Phase II clinical trial of molecular profiled neoadjuvant therapy for localized pancreatic ductal adenocarcinoma. Ann. Surg.268(4), 610–619 (2018).
  • Chantrill LA , NagrialAM , WatsonCet al. Precision medicine for advanced pancreas cancer: the individualized molecular pancreatic cancer therapy (IMPaCT) trial. Clin. Cancer Res.21(9), 2029–2037 (2015).
  • Dreyer SB , JamiesonNB , MortonJP , SansomOJ , BiankinAV , ChangDK. Pancreatic cancer: from genome discovery to PRECISION-Panc. Clin. Oncol.32(1), 5–8 (2020).

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