Clinician Perspectives on Communication and Implementation Challenges in Precision Oncology

References

• Collins FS , VarmusH. A new initiative on precision medicine. N. Engl. J. Med.372(9), 793–795 (2015).
   PubMed Web of Science ®Google Scholar
• U.S. National Library of Medicine . What is the difference between precision medicine and personalized medicine? What about pharmacogenomics? (2020). https://medlineplus.gov/genetics/understanding/precisionmedicine/precisionvspersonalized/
   Google Scholar
• Giusti A , NkhomaK , PetrusRet al. The empirical evidence underpinning the concept and practice of person-centered care for serious illness: a systematic review. BMJ Glob. Health5(12), e003330 (2020).
   PubMed Web of Science ®Google Scholar
• Dueck AC , MendozaTR , MitchellSAet al. Validity and reliability of the US National Cancer Institute’s Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). JAMA Oncol.1(8), 1051–1059 (2015).
   PubMed Web of Science ®Google Scholar
• Murciano-Goroff YR , DrilonA , StadlerZK. The NCI-MATCH: a national, collaborative precision oncology trial for diverse tumor histologies. Cancer Cell39(1), 22–24 (2021).
   PubMed Web of Science ®Google Scholar
• Shaw KRM , MaitraA. The status and impact of clinical tumor genome sequencing. Annu. Rev. Genomics Hum. Genet.20, 413–432 (2019).
   PubMed Web of Science ®Google Scholar
• Cornetta K , BrownCG. Balancing personalized medicine and personalized care. Acad. Med.88(3), 309–313 (2013).
   PubMed Web of Science ®Google Scholar
• Kamps R , BrandaoRD , BoschBJet al. Next-generation sequencing in oncology: genetic diagnosis, risk prediction and cancer classification. Int. J. Mol. Sci.18(2), 308 (2017).
   PubMed Web of Science ®Google Scholar
• Hamilton JG , Watsula-MorleyA , LathamA. Psychosocial issues related to liquid biopsy for ctDNA in individuals at normal and elevated risk. In: Psycho-Oncology. (4th Edition). BreitbartWS, ButowPN, JacobsenPB, LamWT, LazenbyM, LoscalzoMJ ( Eds). NY, USA, 116–118 (2021).
   Google Scholar
• Mcgowan ML , SetterstenRAJr , JuengstET , FishmanJR. Integrating genomics into clinical oncology: ethical and social challenges from proponents of personalized medicine. Urol. Oncol.32(2), 187–192 (2014).
   PubMed Web of Science ®Google Scholar
• De Moor JS , GraySW , MitchellSA , KlabundeCN , FreedmanAN. Oncologist confidence in genomic testing and implications for using multimarker tumor panel tests in practice. JCO Precis. Oncol.4, PO.19.00338 (2020).
   PubMed Web of Science ®Google Scholar
• Mcgill BC , WakefieldCE , HetheringtonKet al. “Balancing expectations with actual realities”: conversations with clinicians and scientists in the first year of a high-risk childhood cancer precision medicine trial. J. Pers. Med.10(1), 9 (2020).
   PubMed Web of Science ®Google Scholar
• Vetsch J , WakefieldCE , TechakesariPet al. Healthcare professionals’ attitudes toward cancer precision medicine: a systematic review. Semin. Oncol.46(3), 291–303 (2019).
   PubMed Web of Science ®Google Scholar
• Adams SA , PetersenC. Precision medicine: opportunities, possibilities, and challenges for patients and providers. J. Am. Med. Inform. Assoc.23(4), 787–790 (2016).
   PubMed Web of Science ®Google Scholar
• Kurnit KC , DumbravaEEI , LitzenburgerBet al. Precision oncology decision support: current approaches and strategies for the future. Clin. Cancer Res.24(12), 2719–2731 (2018).
   PubMed Web of Science ®Google Scholar
• Brothers KB , RothsteinMA. Ethical, legal and social implications of incorporating personalized medicine into healthcare. Per. Med.12(1), 43–51 (2015).
   PubMed Web of Science ®Google Scholar
• Salari P , LarijaniB. Ethical issues surrounding personalized medicine: a literature review. Acta Med. Iran.55(3), 209–217 (2017).
   PubMedGoogle Scholar
• Stadler ZK , MaioA , ChakravartyDet al. Therapeutic implications of germline testing in patients with advanced cancers. J. Clin. Oncol.39(24), 2698–2709 (2021).
   PubMed Web of Science ®Google Scholar
• Flaherty KT , GrayRJ , ChenAPet al. Molecular landscape and actionable alterations in a genomically guided cancer clinical trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH). J. Clin. Oncol.38(33), 3883–3894 (2020).
   PubMed Web of Science ®Google Scholar
• Wheler JJ , JankuF , NaingAet al. Cancer therapy directed by comprehensive genomic profiling: a single center study. Cancer Res.76(13), 3690–3701 (2016).
   PubMed Web of Science ®Google Scholar
• Marcon AR , BieberM , CaulfieldT. Representing a “revolution”: how the popular press has portrayed personalized medicine. Genet. Med.20(9), 950–956 (2018).
   PubMed Web of Science ®Google Scholar
• Szabo L . Are we being misled about precision medicine?The New York Times (2018). https://www.nytimes.com/2018/09/11/opinion/cancer-genetic-testing-precision-medicine.html
   Google Scholar
• Cavallo J . Has the promise of precision medicine been oversold? A roundtable discussion with Edward S. Kim, MD; Vinay Prasad, MD, MPH; and Richard L. Schilsky, MD, FACP, FSCT, FASCO. The ASCO Post. American Society of Clinical Oncology (2018). https://ascopost.com/issues/october-25-2018/has-the-promise-of-precision-medicine-been-oversold/
   Google Scholar
• Mcfarland DC , BlacklerE , BanerjeeS , HollandJ. Communicating about precision oncology. JCO Precis. Oncol.1, PO.17.00066 (2017).
   PubMed Web of Science ®Google Scholar
• Schrag D , BaschE. Oncology in transition: changes, challenges, and opportunities. JAMA320(21), 2203–2204 (2018).
   PubMed Web of Science ®Google Scholar
• Pichler T , RohrmoserA , LetschAet al. Information, communication, and cancer patients’ trust in the physician: what challenges do we have to face in an era of precision cancer medicine? Support. Care Cancer 29(4), 2171–2178 (2021).
   PubMed Web of Science ®Google Scholar
• Kitzinger J . The methodology of focus groups: the importance of interaction between research participants. Sociol. Health Illn.16(1), 103–121 (1994).
   Web of Science ®Google Scholar
• Krueger RA . Quality control in focus group research. In: Successful focus groups: Advancing the state of the art.MorganDL ( Ed.). Sage, London, UK, 65–85 (1993).
   Google Scholar
• Bernard HR . Research Methods in Anthropology: Qualitative and Quantitative Approaches.AltaMira Press, MD, USA (2006).
   Google Scholar
• Boyatzis RE . Transforming Qualitative Information: Thematic Analysis and Code Development.Sage Publications, CA, USA (1998).
   Google Scholar
• Green J , ThorogoodN. In: Qualitative Methods for Health Research.Sage Publications, London, UK (2004).
   Google Scholar
• Patton MQ . Enhancing the quality and credibility of qualitative analysis. Health Serv. Res.34(5 Pt 2), 1189–1208 (1999).
   PubMed Web of Science ®Google Scholar
• Creswell J . In: Qualitative Inquiry and Research Design: Choosing Among Five Traditions.Sage Publications, CA, USA (1998).
   Google Scholar
• Morse JM , BarrettM , MayanM , OlsenK , SpiersJ. Verification strategies for establishing reliability and validity in qualitative research. Int. J. Qual. Methods1, 1–19 (2002).
   Google Scholar
• Won HH , ScottSN , BrannonAR , ShahRH , BergerMF. Detecting somatic genetic alterations in tumor specimens by exon capture and massively parallel sequencing. J. Vis. Exp. (80), e50710(2013). https://www.jove.com/t/50710/detecting-somatic-genetic-alterations-tumor-specimens-exon-capture
   PubMed Web of Science ®Google Scholar
• Cheng DT , MitchellTN , ZehirAet al. Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology. J. Mol. Diagn.17(3), 251–264 (2015).
   PubMed Web of Science ®Google Scholar
• National Cancer Institute . Biomarker testing for cancer treatment (2021). https://www.cancer.gov/about-cancer/treatment/types/biomarker-testing-cancer-treatment
   Google Scholar
• Juengst ET , McgowanML. Why does the shift from “personalized medicine” to “precision health” and “wellness genomics” matter?AMA J. Ethics20(9), E881–E890 (2018).
   PubMedGoogle Scholar
• Khoury MJ . The shift from personalized medicine to precision medicine and precision public health: words matter!Office of Public Health Genomics, Centers for Disease Control and Prevention, GA, USA (2016). https://blogs.cdc.gov/genomics/2016/04/21/shift/
   Google Scholar
• Shin SH , BodeAM , DongZ. Precision medicine: the foundation of future cancer therapeutics. NPJ Precis. Oncol.1(1), 12 (2017).
   PubMedGoogle Scholar
• How advances in precision oncology are shaping a new diagnostic and treatment frontier. Am. J. Manag. Care (January), 3–8 (2020). https://www.ajmc.com/view/how-advances-in-precision-oncology-new-diagnostic-and-treatment-frontier
   Google Scholar
• Murciano-Goroff YR , TaylorBS , HymanDM , SchramAM. Toward a more precise future for oncology. Cancer Cell37(4), 431–442 (2020).
   PubMed Web of Science ®Google Scholar
• Ersek JL , BlackLJ , ThompsonMA , KimES. Implementing precision medicine programs and clinical trials in the community-based oncology practice: barriers and best practices. Am. Soc. Clin. Oncol. Educ. Book38, 188–196 (2018).
   PubMedGoogle Scholar
• Nadauld LD , FordJM , PritchardD , BrownT. Strategies for clinical implementation: precision oncology at three distinct institutions. Health Aff. (Millwood)37(5), 751–756 (2018).
   PubMed Web of Science ®Google Scholar
• Lau-Min KS , GuerraCE , NathansonKL , BekelmanJE. From race-based to precision oncology: leveraging behavioral economics and the electronic health record to advance health equity in cancer care. JCO Precis. Oncol.5, 403–407 (2021).
   Web of Science ®Google Scholar
• Chanfreau-Coffinier C , PeredoJ , RussellMMet al. A logic model for precision medicine implementation informed by stakeholder views and implementation science. Genet. Med.21(5), 1139–1154 (2019).
   PubMed Web of Science ®Google Scholar
• Wright S , Daker-WhiteG , NewmanW , PayneK. Understanding barriers to the introduction of precision medicines in non-small cell lung cancer: a qualitative interview protocol. Wellcome Open Res.3, 24 (2018).
   PubMedGoogle Scholar
• Wolyniec K , SharpJ , LazarakisS , MileshkinL , SchofieldP. Understanding and information needs of cancer patients regarding treatment-focused genomic testing: a systematic review. Psychooncology29(4), 632–638 (2020).
   PubMed Web of Science ®Google Scholar
• Elwyn G , FroschD , ThomsonRet al. Shared decision making: a model for clinical practice. J. Gen. Intern. Med.27(10), 1361–1367 (2012).
   PubMed Web of Science ®Google Scholar
• Brown R , BylundC , KissaneD. Shared decision making about treatment options. Communication Training Program in Oncology.MSK Comskil Laboratory,NY, USA (2006).
   Google Scholar
• Sisk BA , KodishE. Therapeutic misperceptions in early-phase cancer trials: from categorical to continuous. IRB40(4), 13–20 (2018).
   PubMedGoogle Scholar
• Appelbaum PS . Clinical practice. Assessment of patients’ competence to consent to treatment. N. Engl. J. Med.357(18), 1834–1840 (2007).
   PubMed Web of Science ®Google Scholar
• Horng S , GradyC. Misunderstanding in clinical research: distinguishing therapeutic misconception, therapeutic misestimation, and therapeutic optimism. IRB25(1), 11–16 (2003).
   PubMedGoogle Scholar
• Crites J , KodishE. Unrealistic optimism and the ethics of Phase I cancer research. J. Med. Ethics39(6), 403–406 (2013).
   PubMed Web of Science ®Google Scholar
• Kissane DW , BylundCL , BanerjeeSCet al. Communication skills training for oncology professionals. J. Clin. Oncol.30(11), 1242–1247 (2012).
   PubMed Web of Science ®Google Scholar
• Simpkin AL , ArmstrongKA. Communicating uncertainty: a narrative review and framework for future research. J. Gen. Intern. Med.34(11), 2586–2591 (2019).
   PubMed Web of Science ®Google Scholar
• Damschroder LJ , AronDC , KeithRE , KirshSR , AlexanderJA , LoweryJC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement. Sci.4, 50 (2009).
   PubMed Web of Science ®Google Scholar
• Gilligan T , CoyleN , FrankelRMet al. Patient-clinician communication: American Society of Clinical Oncology consensus guideline. J. Clin. Oncol.35(31), 3618–3632 (2017).
   PubMed Web of Science ®Google Scholar
• Epstein RM , StreetRLJr. Patient-Centered Communication in Cancer Care: Promoting Healing and Reducing Suffering.National Cancer Institute, MD, USA (2007).
   Google Scholar
• Street RL Jr , MakoulG , AroraNK , EpsteinRM. How does communication heal? Pathways linking clinician-patient communication to health outcomes. Patient Educ. Couns.74(3), 295–301 (2009).
   PubMed Web of Science ®Google Scholar