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Personalized Medicine Volume 12, 2015 - Issue 2
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Case Report

Detecting Resistance in Egfr-Mutated Non-Small-Cell Lung Cancer After Clonal Selection Through Targeted Therapy

Justine L Kuiper1 Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The NetherlandsCorrespondence[email protected]
,
Idris Bahce1 Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
,
Charlotte Voorhoeve2 Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
,
Maqsood Yaqub2 Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
,
Daniëlle AM Heideman3 Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
,
Erik Thunnissen3 Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
,
Marinus A Paul4 Department of Cardiothoracic Surgery, VU University Medical Center, Amsterdam, The Netherlands
,
Pieter E Postmus1 Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
,
N Harry Hendrikse2 Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands;5 Department of Clinical Pharmacology & Pharmacy, VU University Medical Center, Amsterdam, The Netherlands
&
Egbert F Smit1 Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
 show all
Pages 63-66 | Published online: 23 Mar 2015

References

  • Schepers AG , SnippertHJ , StangeDEet al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas . Science337 ( 6095 ), 730 – 735 ( 2012 ).
  • Burrell RA , McGranahanN , BartekJ , SwantonC . The causes and consequences of genetic heterogeneity in cancer evolution . Nature501 ( 7467 ), 338 – 345 ( 2013 ).
  • Meacham CE , MorrisonSJ . Tumour heterogeneity and cancer cell plasticity . Nature501 ( 7467 ), 328 – 337 ( 2013 ).
  • Fisher R , PusztaiL , SwantonC . Cancer heterogeneity: implications for targeted therapeutics . Br. J. Cancer108 ( 3 ), 479 – 485 ( 2013 ).
  • Yu HA , ArcilaME , RekhtmanNet al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers . Clin. Cancer Res.19 ( 8 ), 2240 – 2247 ( 2013 ).
  • Slobbe P , PootAJ , WindhorstAD , van DongenGA . PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET . Drug Discov. Today17 ( 21–22 ), 1175 – 1187 ( 2012 ).
  • Carey KD , GartonAJ , RomeroMSet al. Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib . Cancer Res.66 ( 16 ), 8163 – 8171 ( 2006 ).
  • Bahce I , SmitEF , LubberinkMet al. Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status . Clin. Cancer Res.19 ( 1 ), 183 – 193 ( 2013 ).
  • Heideman DA , ThunnissenFB , DoelemanMet al. A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes . Cell. Oncol.31 ( 5 ), 329 – 333 ( 2009 ).
  • Janne PA , RamalingamSS , Chih-Hsin YangJet al. Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small-cell lung cancer (NSCLC) . Presented at : ASCO 2014 . Chicago, IL, USA , 30 May–3 June 2014 .
  • Sequist LV , SoriaJC , GadgeelSMet al. First in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations of EGFR (activating and T790M) . Presented at : ASCO 2014 . Chicago, IL, USA , 30 May–3 June 2014 .

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