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Personalized Medicine Volume 12, 2015 - Issue 2
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Editorial

Cyp450 Pharmacogenomics: A Cardiology Perspective

Jeremiah P Deptaa Brigham & Women’s Hospital, Heart & Vascular Center & Harvard Medical School, Boston, MA, USAView further author information
&
Sharon Crescib Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8086, St. Louis, MO 63110, USA;c Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USACorrespondence[email protected]
View further author information
Pages 59-62 | Published online: 23 Mar 2015

References

  • Lazarou J , PomeranzBH , CoreyPN . Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies . JAMA279 ( 15 ), 1200 – 1205 ( 1998 ).
  • Guengerich FP . Cytochrome p450 and chemical toxicology . Chem. Res. Toxicol.21 ( 1 ), 70 – 83 ( 2008 ).
  • Preissner SC , HoffmannMF , PreissnerR , DunkelM , GewiessA , PreissnerS . Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy . PLoS One8 ( 12 ), e82562 ( 2013 ).
  • Depta JP , BhattDL . Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance . Am. J. Cardiovasc. Drugs.8 ( 2 ), 91 – 112 ( 2008 ).
  • Depta JP , BhattDL . Antiplatelet therapy and proton pump inhibition: cause for concern?Curr. Opin. Cardiol.27 ( 6 ), 642 – 650 ( 2012 ).
  • Tantry US , BonelloL , AradiDet al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding . J. Am. Coll. Cardiol.62 ( 24 ), 2261 – 2273 ( 2013 ).
  • Mega JL , CloseSL , WiviottSDet al. Cytochrome p-450 polymorphisms and response to clopidogrel . N. Engl. J. Med.360 ( 4 ), 354 – 362 ( 2009 ).
  • Cresci S , DeptaJP , LenziniPAet al. Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction . Circ. Cardiovasc. Genet.7 ( 3 ), 277 – 286 ( 2014 ).
  • O’Donoghue ML , BhattDL , WiviottSDet al. Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial . Circulation123 ( 17 ), 1843 – 1853 ( 2011 ).
  • Bhatt DL , CryerBL , ContantCFet al. Clopidogrel with or without omeprazole in coronary artery disease . N. Engl. J. Med.363 ( 20 ), 1909 – 1917 ( 2010 ).
  • Depta JP , LenziniPA , LanfearDEet al. Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction . Pharmacogenomics J.15 ( 1 ), 20 – 25 ( 2015 ).
  • Schalekamp T , de BoerA . Pharmacogenetics of oral anticoagulant therapy . Curr. Pharm. Des.16 ( 2 ), 187 – 203 ( 2010 ).
  • Weeke P , RodenDM . Pharmacogenomics and cardiovascular disease . Curr. Cardiol. Rep.15 ( 7 ), 376 ( 2013 ).
  • Gage BF , EbyC , JohnsonJAet al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin . Clin. Pharmacol. Ther.84 ( 3 ), 326 – 331 ( 2008 ).
  • Sanderson S , EmeryJ , HigginsJ . CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis . Genet. Med.7 ( 2 ), 97 – 104 ( 2005 ).
  • Lindh JD , HolmL , AnderssonML , RaneA . Influence of CYP2C9 genotype on warfarin dose requirements: a systematic review and meta-analysis . Eur. J. Clin. Pharmacol.65 ( 4 ), 365 – 375 ( 2009 ).
  • McDonald MG , RiederMJ , NakanoM , HsiaCK , RettieAE . CYP4F2 is a vitamin K1 oxidase: an explanation for altered warfarin dose in carriers of the V433M variant . Mol. Pharmacol.75 ( 6 ), 1337 – 1346 ( 2009 ).
  • Rieder MJ , ReinerAP , GageBFet al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose . N. Engl. J. Med.352 ( 22 ), 2285 – 2293 ( 2005 ).
  • Scott SA , EdelmannL , KornreichR , DesnickRJ . Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations . Am. J. Hum. Genet.82 ( 2 ), 495 – 500 ( 2008 ).
  • Kimmel SE , FrenchB , KasnerSEet al. A pharmacogenetic versus a clinical algorithm for warfarin dosing . N. Engl. J. Med.369 ( 24 ), 2283 – 2293 ( 2013 ).
  • Furie B . Do pharmacogenetics have a role in the dosing of vitamin K antagonists?N. Engl. J. Med.369 ( 24 ), 2345 – 2346 ( 2013 ).
  • United States Food and Drug Administration . Coumadin (warfarin sodium) tablet and injection. Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – January 2010 . www.accessdata.fda.gov/drugsatfda_docs/label/2010/009218s108lbl.pdf
  • Johnson JA , GongL , Whirl-CarrilloMet al. Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing . Clin. Pharmacol. Ther.90 ( 4 ), 625 – 629 ( 2011 ).
  • Warfarin Dosing . www.warfarindosing.org .

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