289
Views
0
CrossRef citations to date
0
Altmetric
Special Report

Will Optogenetics Be Used To Treat Chronic Pain Patients?

, , &
Pages 269-278 | Received 25 Nov 2016, Accepted 21 Feb 2017, Published online: 20 Jul 2017

References

  • Holmes D . The pain drain . Nature535 ( 7611 ), S2 – S3 ( 2016 ).
  • Finnerup NB , SindrupSH , JensenTS . The evidence for pharmacological treatment of neuropathic pain . Pain150 ( 3 ), 573 – 581 ( 2010 ).
  • Devulder J , RicharzU , NatarajaSH . Impact of long-term use of opioids on quality of life in patients with chronic, non-malignant pain . Curr. Med. Res. Opin.21 ( 10 ), 1555 – 1568 ( 2005 ).
  • Fischer B , RussellC , MurphyY , KurdyakP . Prescription opioids, abuse and public health in Canada: is fentanyl the new centre of the opioid crisis?Pharmacoepidemiol. Drug Saf.24 ( 12 ), 1334 – 1336 ( 2015 ).
  • Wolkerstorfer A , HandlerN , BuschmannH . New approaches to treating pain . Bioorg. Med. Chem. Lett.26 ( 4 ), 1103 – 1119 ( 2016 ).
  • Von Hehn CA , BaronR , WoolfCJ . Deconstructing the neuropathic pain phenotype to reveal neural mechanisms . Neuron73 ( 4 ), 638 – 652 ( 2012 ).
  • Nagel G , SzellasT , HuhnWet al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel . Proc. Natl Acad. Sci. USA100 ( 24 ), 13940 – 13945 ( 2003 ).
  • Boyden ES , ZhangF , BambergE , NagelG , DeisserothK . Millisecond-timescale, genetically targeted optical control of neural activity . Nat. Neurosci.8 ( 9 ), 1263 – 1268 ( 2005 ).
  • Yizhar O , FennoLE , DavidsonTJ , MogriM , DeisserothK . Optogenetics in neural systems . Neuron71 ( 1 ), 9 – 34 ( 2011 ).
  • Mattis J , TyeKM , FerencziEAet al. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins . Nat. Meth.9 ( 2 ), 159 – 172 ( 2012 ).
  • Rein ML , DeussingJM . The optogenetic (r)evolution . Mol. Genet. Genomics287 ( 2 ), 95 – 109 ( 2012 ).
  • Copits BA , PullenMY , GereauRWT . Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits . Pain157 ( 11 ), 2424 – 2433 ( 2016 ).
  • Lin JY , KnutsenPM , MullerA , KleinfeldD , TsienRY . ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation . Nat. Neurosci.16 ( 10 ), 1499 – 1508 ( 2013 ).
  • Chow BY , HanX , DobryASet al. High-performance genetically targetable optical neural silencing by light-driven proton pumps . Nature463 ( 7277 ), 98 – 102 ( 2010 ).
  • Gradinaru V , ZhangF , RamakrishnanCet al. Molecular and cellular approaches for diversifying and extending optogenetics . Cell141 ( 1 ), 154 – 165 ( 2010 ).
  • Zhang F , WangLP , BraunerMet al. Multimodal fast optical interrogation of neural circuitry . Nature446 ( 7136 ), 633 – 639 ( 2007 ).
  • Chuong AS , MiriML , BusskampVet al. Noninvasive optical inhibition with a red-shifted microbial rhodopsin . Nat. Neurosci.17 ( 8 ), 1123 – 1129 ( 2014 ).
  • Berndt A , LeeSY , RamakrishnanC , DeisserothK . Structure-guided transformation of channelrhodopsin into a light-activated chloride channel . Science344 ( 6182 ), 420 – 424 ( 2014 ).
  • Wietek J , WiegertJS , AdeishviliNet al. Conversion of channelrhodopsin into a light-gated chloride channel . Science344 ( 6182 ), 409 – 412 ( 2014 ).
  • Cosentino C , AlberioL , GazzarriniSet al. Optogenetics. Engineering of a light-gated potassium channel . Science348 ( 6235 ), 707 – 710 ( 2015 ).
  • Govorunova EG , SineshchekovOA , JanzR , LiuX , SpudichJL . NEUROSCIENCENatural light-gated anion channels: a family of microbial rhodopsins for advanced optogenetics . Science349 ( 6248 ), 647 – 650 ( 2015 ).
  • Airan RD , ThompsonKR , FennoLE , BernsteinH , DeisserothK . Temporally precise in vivo control of intracellular signalling . Nature458 ( 7241 ), 1025 – 1029 ( 2009 ).
  • Siuda ER , CopitsBA , SchmidtMJet al. Spatiotemporal control of opioid signaling and behavior . Neuron86 ( 4 ), 923 – 935 ( 2015 ).
  • Nagi K , PineyroG . Practical guide for calculating and representing biased signaling by GPCR ligands: a stepwise approach . Methods92 , 78 – 86 ( 2016 ).
  • Gu L , UhelskiML , AnandSet al. Pain inhibition by optogenetic activation of specific anterior cingulate cortical neurons . PLoS ONE10 ( 2 ), e0117746 ( 2015 ).
  • Kang SJ , KwakC , LeeJet al. Bidirectional modulation of hyperalgesia via the specific control of excitatory and inhibitory neuronal activity in the ACC . Mol. Brain8 ( 1 ), 81 ( 2015 ).
  • Crock LW , KolberBJ , MorganCDet al. Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain . J. Neurosci.32 ( 41 ), 14217 – 14226 ( 2012 ).
  • Dugue GP , LorinczML , LottemEet al. Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice . PLoS ONE9 ( 8 ), e105941 ( 2014 ).
  • Hickey L , LiY , FysonSJet al. Optoactivation of locus ceruleus neurons evokes bidirectional changes in thermal nociception in rats . J. Neurosci.34 ( 12 ), 4148 – 4160 ( 2014 ).
  • Cai YQ , WangW , HouYY , PanZZ . Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization . Mol. Pain10 , 70 ( 2014 ).
  • Eliava M , MelchiorM , Knobloch-BollmannHSet al. A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing . Neuron89 ( 6 ), 1291 – 1304 ( 2016 ).
  • Zhang Z , GadottiVM , ChenL , SouzaIA , StemkowskiPL , ZamponiGW . Role of prelimbic GABAergic circuits in sensory and emotional aspects of neuropathic pain . Cell Rep.12 ( 5 ), 752 – 759 ( 2015 ).
  • Lee M , MandersTR , EberleSEet al. Activation of corticostriatal circuitry relieves chronic neuropathic pain . J. Neurosci.35 ( 13 ), 5247 – 5259 ( 2015 ).
  • Wang F , BelangerE , PaquetME , CoteDC , De KoninckY . Probing pain pathways with light . Neuroscience338 , 248 – 271 ( 2016 ).
  • Daou I , TuttleA , LongoGet al. Remote optogenetic activation and sensitization of pain pathways in freely moving mice . J. Neurosci.33 ( 47 ), 18631 – 18640 ( 2013 ).
  • Bonin RP , WangF , Desrochers-CoutureMet al. Epidural optogenetics for controlled analgesia . Mol. Pain12 , 1 – 11 ( 2016 ).
  • Daou I , BeaudryH , AseARet al. Optogenetic silencing of Nav1.8-positive afferents alleviates inflammatory and neuropathic pain . eNeuro3 ( 1 ), 1 – 12 ( 2016 ).
  • Draxler P , HonsekSD , ForsthuberL , HadschieffV , SandkuhlerJ . VGluT3(+) primary afferents play distinct roles in mechanical and cold hypersensitivity depending on pain etiology . J. Neurosci.34 ( 36 ), 12015 – 12028 ( 2014 ).
  • Mason MR , EhlertEM , EggersRet al. Comparison of AAV serotypes for gene delivery to dorsal root ganglion neurons . Mol. Therapy18 ( 4 ), 715 – 724 ( 2010 ).
  • Boada MD , MartinTJ , PetersCMet al. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats . Pain155 ( 12 ), 2646 – 2655 ( 2014 ).
  • Li B , YangXY , QianFP , TangM , MaC , ChiangLY . A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter . Brain Res.1609 , 12 – 20 ( 2015 ).
  • Maksimovic S , NakataniM , BabaYet al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors . Nature509 ( 7502 ), 617 – 621 ( 2014 ).
  • Baumbauer KM , DeberryJJ , AdelmanPCet al. Keratinocytes can modulate and directly initiate nociceptive responses . eLife4 , e09674 ( 2015 ).
  • Fink DJ , WechuckJ , MataMet al. Gene therapy for pain: results of a Phase I clinical trial . Ann. Neurol.70 ( 2 ), 207 – 212 ( 2011 ).
  • Busskamp V , DuebelJ , BalyaDet al. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa . Science329 ( 5990 ), 413 – 417 ( 2010 ).
  • Usoskin D , FurlanA , IslamSet al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing . Nat. Neurosci.18 ( 1 ), 145 – 153 ( 2015 ).
  • Sapio MR , GoswamiSC , GrossJR , MannesAJ , IadarolaMJ . Transcriptomic analyses of genes and tissues in inherited sensory neuropathies . Exp. Neurol.283 ( Pt A ), 375 – 395 ( 2016 ).
  • Towne C , MontgomeryK , IyerS , DeisserothK , DelpS . Optogenetic control of targeted peripheral axons in freely moving animals . PLoS ONE8 ( 8 ), e72691 ( 2013 ).
  • Li B , YangX-YY , QianF-PP , TangM , MaC , ChiangL-YY . A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter . Brain Res.1609 , 12 – 20 ( 2015 ).
  • Stauffer WR , LakA , YangAet al. Dopamine neuron-specific optogenetic stimulation in rhesus macaques . Cell166 ( 6 ), 1564 – 157 ; 1 e1566 ( 2016 ).
  • De Leeuw CN , KoreckiAJ , BerryGEet al. rAAV-compatible MiniPromoters for restricted expression in the brain and eye . Mol. Brain9 ( 1 ), 52 ( 2016 ).
  • Mingozzi F , HighKA . Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges . Nat. Rev. Genet.12 ( 5 ), 341 – 355 ( 2011 ).
  • Brimble MA , ReissUM , NathwaniAC , DavidoffAM . New and improved AAVenues: current status of hemophilia B gene therapy . Expert Opin. Biol. Ther.16 ( 1 ), 79 – 92 ( 2016 ).
  • Park SI , BrennerDS , ShinGet al. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics . Nat. Biotech.33 ( 12 ), 1280 – 1286 ( 2015 ).
  • Montgomery KL , YehAJ , HoJSet al. Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice . Nat. Meth.12 ( 10 ), 969 – 974 ( 2015 ).
  • Jeong J-WW , MccallJG , ShinGet al. Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics . Cell162 ( 3 ), 662 – 674 ( 2015 ).
  • Folcher M , OesterleS , ZwickyKet al. Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant . Nat. Commun.5 , 5392 ( 2014 ).
  • Bainbridge JW , MehatMS , SundaramVet al. Long-term effect of gene therapy on Leber’s congenital amaurosis . N. Engl. J. Med.372 ( 20 ), 1887 – 1897 ( 2015 ).
  • Bryant LM , ChristopherDM , GilesARet al. Lessons learned from the clinical development and market authorization of Glybera . Hum. Gene Ther. Clin. Dev.24 ( 2 ), 55 – 64 ( 2013 ).
  • May T , OzdenI , BrushBet al. Detection of optogenetic stimulation in somatosensory cortex by non-human primates-towards artificial tactile sensation . PLoS ONE9 ( 12 ), e114529 ( 2014 ).
  • Ozden I , WangJ , LuYet al. A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates . J. Neurosci. Meth.219 ( 1 ), 142 – 154 ( 2013 ).
  • Han X , ChowBY , ZhouHet al. A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex . Front. Syst. Neurosci.5 , 18 ( 2011 ).
  • Dimidschstein J , ChenQ , TremblayRet al. A viral strategy for targeting and manipulating interneurons across vertebrate species . Nat. Neurosci.19 ( 12 ), 1743 – 1749 ( 2016 ).
  • Caspary T , AndersonKV . Patterning cell types in the dorsal spinal cord: what the mouse mutants say . Nat. Rev. Neurosci.4 ( 4 ), 289 – 297 ( 2003 ).
  • Zhang J , CavanaughDJ , NemenovMI , BasbaumAI . The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons . J. Physiol.591 ( 4 ), 1097 – 1110 ( 2013 ).
  • Cavanaugh DJ , LeeH , LoLet al. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli . Proc. Natl Acad. Sci. USA106 ( 22 ), 9075 – 9080 ( 2009 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.