10,361
Views
0
CrossRef citations to date
0
Altmetric
Commentary

Therapies and Mechanisms of Opioid Withdrawal

, &
Pages 455-459 | Received 04 May 2017, Accepted 09 Jun 2017, Published online: 10 Nov 2017

References

  • Paulozzi LJ , MackKA , HockenberryJM , Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC . Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines: United States, 2012 . MMWR Morb. Mortal. Wkly Rep.63 ( 26 ), 563 – 568 ( 2014 ).
  • Clinical Guidelines for Withdrawal Management and Treatment of Drug Dependence in Closed Settings . WHO , Geneva, Switzerland ( 2009 ). www.ncbi.nlm.nih.gov/books/NBK310652/ .
  • Weiss RD , PotterJS , GriffinMLet al. Reasons for opioid use among patients with dependence on prescription opioids: the role of chronic pain . J. Subst. Abuse Treat.47 ( 2 ), 140 – 145 ( 2014 ).
  • Alberta College of Pharmacists, College of Pharmacists of British Columbia , NakatsuN , SloanM . Principles for the Provision of Opioid Dependence Treatment by Manitoba Pharmacists . College of Pharmacists of ManitobaGeneva, Switzerland1 – 49 ( 2016 ).
  • Dugosh K , AbrahamA , SeymourB , McLoydK , ChalkM , FestingerD . A systematic review on the use of psychosocial interventions in conjunction with medications for the treatment of opioid addiction . J. Addict. Med.10 ( 2 ), 91 – 101 ( 2016 ).
  • Bagley EE , ChiengBCH , ChristieMJ , ConnorM . Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine . Br. J. Pharmacol.146 ( 1 ), 68 – 76 ( 2005 ).
  • Bie B , PengY , ZhangY , PanZZ . cAMP-mediated mechanisms for pain sensitization during opioid withdrawal . J. Neurosci.25 ( 15 ), 3824 – 3832 ( 2005 ).
  • Drdla R , GassnerM , GinglE , SandkühlerJ . Induction of synaptic long-term potentiation after opioid withdrawal . Science325 ( 5937 ), 207 – 210 ( 2009 ).
  • Noda Y , NabeshimaT . Opiate physical dependence and N-methyl-d-aspartate receptors . Eur. J. Pharmacol.500 ( 1–3 ), 121 – 128 ( 2004 ).
  • Streel E , DanB , AntonialiVet al. Effects of anaesthetic agents in interference of naloxone-induced opiate-withdrawal are dose-dependent in opiate-dependent rats . Life Sci.77 ( 6 ), 650 – 655 ( 2005 ).
  • Jovaisa T , LaurinenasG , VosyliusS , SipylaiteJ , BadarasR , IvaskeviciusJ . Effects of ketamine on precipitated opiate withdrawal . Medicina42 ( 8 ), 625 – 634 ( 2006 ).
  • Chizh BA , HeadleyPM . NMDA antagonists and neuropathic pain: multiple drug targets and multiple uses . Curr. Pharm. Des.11 ( 23 ), 2977 – 2994 ( 2005 ).
  • Evans CJ , CahillCM . Neurobiology of opioid dependence in creating addiction vulnerability . F1000Res.5 , doi:10.12688/f1000research.8369.1 ( 2016 ).
  • Vargas-Perez H , BahiA , BufalinoMRet al. BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions . J. Neurosci.34 ( 23 ), 7899 – 7909 ( 2014 ).
  • Taylor AMW , CastonguayA , GhoghaAet al. Neuroimmune regulation of GABAergic neurons within the ventral tegmental area during withdrawal from chronic morphine . Neuropsychopharmacol.41 ( 4 ), 949 – 959 ( 2016 ).
  • Sharf R , SarhanM , DileoneRJ . Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell . Biol. Psychiatry64 ( 3 ), 175 – 183 ( 2008 ).
  • Anderson EM , ReevesT , KapernarosK , NeubertJK , CaudleRM . Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal . J. Pharmacol. Exp. Ther.355 ( 3 ), 496 – 505 ( 2015 ).
  • Raehal KM , WalkerJKL , BohnLM . Morphine side-effects in beta-arrestin 2 knockout mice . J. Pharmacol. Exp. Ther.314 ( 3 ), 1195 – 1201 ( 2005 ).
  • Manglik A , LinH , AryalDKet al. Structure-based discovery of opioid analgesics with reduced side effects . Nature537 ( 7619 ), 185 – 190 ( 2016 ).
  • Spahn V , Del VecchioG , LabuzDet al. A nontoxic pain killer designed by modeling of pathological receptor conformations . Science355 ( 6328 ), 966 – 969 ( 2017 ).
  • Ledeboer A , HutchinsonMR , WatkinsLR , JohnsonKW . Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes . Expert Opin. Investig. Drugs16 ( 7 ), 935 – 950 ( 2007 ).
  • Hutchinson MR , LewisSS , CoatsBDet al. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast) . Brain Behav. Immun.23 ( 2 ), 240 – 250 ( 2009 ).
  • Zhang Y , LiH , LiYet al. Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice . Neurosci. Lett.489 ( 1 ), 43 – 47 ( 2011 ).
  • Burma NE , BoninRP , Leduc-PessahHet al. Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents . Nat. Med.23 ( 3 ), 355 – 360 ( 2017 ).
  • Kronschläger MT , Drdla-SchuttingR , GassnerM , HonsekSD , TeuchmannHL , SandkühlerJ . Gliogenic LTP spreads widely in nociceptive pathways . Science354 ( 6316 ), 1144 – 1148 ( 2016 ).
  • Watkins LR , HutchinsonMR , MilliganED , MaierSF . ‘Listening’ and ‘talking’ to neurons: implications of immune activation for pain control and increasing the efficacy of opioids . Brain Res. Rev.56 ( 1 ), 148 – 169 ( 2007 ).
  • Corder G , TawfikVL , WangDet al. Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia . Nat. Med.23 ( 2 ), 164 – 173 ( 2017 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.