453
Views
0
CrossRef citations to date
0
Altmetric
Review

An Updated Understanding of the Mechanisms Involved in cHemotherapy-Induced Neuropathy

, , &
Pages 363-375 | Received 30 Apr 2018, Accepted 14 Jun 2018, Published online: 13 Sep 2018

References

  • Boyette-Davis JA , CataJP , ZhangHet al. Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients . J. Pain12 ( 9 ), 1017 – 1024 ( 2011 ).
  • Boyette-Davis JA , CataJP , DriverLCet al. Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine . Cancer Chemother. Pharmacol.71 ( 3 ), 619 – 626 ( 2013 ).
  • Beijers A , MolsF , DercksenW , DriessenC , VreugdenhilG . Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy . J. Community Support Oncol.12 ( 11 ), 401 – 406 ( 2014 ).
  • Briani C , ArgyriouAA , IzquierdoCet al. Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study . J. Peripher. Nerv. Syst.19 ( 4 ), 299 – 306 ( 2014 ).
  • Mols F , BeijersT , LemmensV , HurkCJVD , VreugdenhilG , Poll-FranseLVVD . Chemotherapy-induced neuropathy and its association with quality of life among 2- to 11-year colorectal cancer survivors: results from the population-based PROFILES registry . J. Clin. Oncol.31 ( 21 ), 2699 – 2707 ( 2013 ).
  • Mols F , BeijersT , VreugdenhilG , Van De Poll-FranseL . Chemotherapy-induced peripheral neuropathy and its association with quality of life: a systematic review . Support. Care Cancer22 ( 8 ), 2261 – 2269 ( 2014 ).
  • Bao T , LiSQ , MaoJJ . Prevalence, risk factors, and sequelae of long-term chemotherapy-induced peripheral neuropathy (CIPN) among breast cancer survivors . J. Clin. Oncol.34 ( 15 Suppl ), e21661 – e21661 ( 2016 ).
  • Candelario N , WongrakpanichS , MorginstinMS . Predictors of chemotherapy-induced peripheral neuropathy among breast cancer patients treated with taxanes . J. Clin. Oncol.33 ( 28 Suppl ), 90 – 90 ( 2015 ).
  • Cavaletti G , BogliunG , MarzoratiLet al. Peripheral neurotoxicity of taxol in patients previously treated with cisplatin . Cancer75 ( 5 ), 1141 – 1150 ( 1995 ).
  • De Carvalho Barbosa M , KosturakisAK , EngCet al. A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy . Cancer Res.74 ( 21 ), 5955 – 5962 ( 2014 ).
  • Kroigard T , SchroderHD , QvortrupCet al. Characterization and diagnostic evaluation of chronic polyneuropathies induced by oxaliplatin and docetaxel comparing skin biopsy to quantitative sensory testing and nerve conduction studies . Eur. J. Neurol.21 ( 4 ), 623 – 629 ( 2014 ).
  • Dougherty PM , CataJP , BurtonAW , VuK , WengHR . Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain . J. Pain Symptom Manage.33 ( 2 ), 166 – 179 ( 2007 ).
  • Postma TJ , BenardBA , HuijgensPC , OssenkoppeleGJ , HeimansJJ . Long-term effects of vincristine on the peripheral nervous system . J. Neurooncol.15 ( 1 ), 23 – 27 ( 1993 ).
  • Dougherty PM , CataJP , CordellaJV , BurtonA , WengHR . Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients . Pain109 ( 1-2 ), 132 – 142 ( 2004 ).
  • Pachman DR , QinR , SeislerDet al. Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505) . Support. Care Cancer24 ( 12 ), 5059 – 5068 ( 2016 ).
  • Li Y , NorthRY , RhinesLDet al. DRG voltage-gated sodium channel 1.7 is upregulated in paclitaxel-induced neuropathy in rats and in humans with neuropathic pain . J. Neurosci.38 ( 5 ), 1124 – 1136 ( 2018 ).
  • Ghelardini C , DesaphyJF , MuragliaMet al. Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models . Neuroscience169 ( 2 ), 863 – 873 ( 2010 ).
  • Lolignier S , BonnetC , GaudiosoCet al. The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia . Cell Rep.11 ( 7 ), 1067 – 1078 ( 2015 ).
  • Grothey A . Clinical management of oxaliplatin-associated neurotoxicity . Clin. Colorectal Cancer5 ( Suppl. 1 ), S38 – S46 ( 2005 ).
  • Lehky TJ , LeonardGD , WilsonRH , GremJL , FloeterMK . Oxaliplatin-induced neurotoxicity: acute hyperexcitability and chronic neuropathy . Muscle Nerve29 ( 3 ), 387 – 392 ( 2004 ).
  • Rao RD , FlynnPJ , SloanJAet al. Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a Phase III randomized, double-blind, placebo-controlled trial, N01C3 . Cancer112 ( 12 ), 2802 – 2808 ( 2008 ).
  • Busserolles J , TsantoulasC , EschalierA , GarcíaJAL . Potassium channels in neuropathic pain: advances, challenges, and emerging ideas . Pain157 , S7 – S14 ( 2016 ).
  • Descoeur J , PereiraV , PizzoccaroAet al. Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors . EMBO Mol. Med.3 ( 5 ), 266 – 278 ( 2011 ).
  • Thibault K , CalvinoB , DubacqSet al. Cortical effect of oxaliplatin associated with sustained neuropathic pain: exacerbation of cortical activity and down-regulation of potassium channel expression in somatosensory cortex . Pain153 ( 8 ), 1636 – 1647 ( 2012 ).
  • Zhang H , DoughertyPM . Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathy . Anesthesiology120 ( 6 ), 1463 – 1475 ( 2014 ).
  • Nodera H , SpiekerA , SungM , RutkoveS . Neuroprotective effects of Kv7 channel agonist, retigabine, for cisplatin-induced peripheral neuropathy . Neurosci. Lett.505 ( 3 ), 223 – 227 ( 2011 ).
  • Di Cesare Mannelli L , LucariniE , MicheliLet al. Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: role of Kv7 potassium channels . Neuropharmacology121 , 49 – 59 ( 2017 ).
  • Li Y , TatsuiCE , RhinesLDet al. Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy . Pain158 ( 3 ), 417 – 429 ( 2017 ).
  • Okubo K , TakahashiT , SekiguchiFet al. Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats . Neuroscience188 , 148 – 156 ( 2011 ).
  • Flatters SJ , BennettGJ . Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy . Pain109 ( 1-2 ), 150 – 161 ( 2004 ).
  • Rigo FK , DalmolinGD , TrevisanGet al. Effect of omega-conotoxin MVIIA and Phalpha1β on paclitaxel-induced acute and chronic pain . Pharmacol. Biochem. Behav.114 – 115 , 16 – 22 ( 2013 ).
  • Gauchan P , AndohT , IkedaKet al. Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel α(2)δ-1 subunit . Biol. Pharm. Bull.32 ( 4 ), 732 – 734 ( 2009 ).
  • Chen Y-F , ChenL-H , YehY-Met al. Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy . Sci. Rep.7 , 45366 ( 2017 ).
  • Rao RD , MichalakJC , SloanJAet al. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a Phase III randomized, double-blind, placebo-controlled, crossover trial (N00C3) . Cancer110 ( 9 ), 2110 – 2118 ( 2007 ).
  • Tsavaris N , KopteridesP , KosmasCet al. Gabapentin monotherapy for the treatment of chemotherapy-induced neuropathic pain: a pilot study . Pain Med.9 ( 8 ), 1209 – 1216 ( 2008 ).
  • Yilmaz E , GoldMS . Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy . Neuroscience300 , 210 – 218 ( 2015 ).
  • Yilmaz E , GoldMS . Paclitaxel-induced increase in NCX activity in subpopulations of nociceptive afferents: a protective mechanism against chemotherapy-induced peripheral neuropathy?Cell Calcium60 ( 1 ), 25 – 31 ( 2016 ).
  • Yilmaz E , WatkinsSC , GoldMS . Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca(2+) in putative nociceptive glabrous skin neurons from the rat . Cell Calcium62 , 16 – 28 ( 2017 ).
  • Ghelardini C , MenicacciC , CerretaniD , BianchiE . Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat . Neuropharmacology86 , 294 – 300 ( 2014 ).
  • Carozzi VA , CantaA , ChiorazziA . Chemotherapy-induced peripheral neuropathy: what do we know about mechanisms?Neurosci. Lett.596 , 90 – 107 ( 2015 ).
  • Ferrier J , Bayet-RobertM , PereiraBet al. A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats . PLoS One8 ( 10 ), e77828 ( 2013 ).
  • Mihara Y , EgashiraN , SadaHet al. Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats . Mol. Pain7 ( 1 ), 8 ( 2011 ).
  • Cata JP , WengHR , ChenJH , DoughertyPM . Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia . Neuroscience138 ( 1 ), 329 – 338 ( 2006 ).
  • Robinson CR , DoughertyPM . Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy . Neuroscience285 , 1 – 10 ( 2015 ).
  • Li DP , AtnipLM , ChenSR , PanHL . Regulation of synaptic inputs to paraventricular-spinal output neurons by α2 adrenergic receptors . J. Neurophysiol.93 ( 1 ), 393 – 402 ( 2005 ).
  • Kuraishi Y , HirotaN , SatoY , KanekoS , SatohM , TakagiH . Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn . Brain Res.359 ( 1-2 ), 177 – 182 ( 1985 ).
  • Pan YZ , LiDP , PanHL . Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic α(2)-adrenergic receptors . J. Neurophysiol.87 ( 4 ), 1938 – 1947 ( 2002 ).
  • Yeo JH , YoonSY , KimSJet al. Clonidine, an α-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension . Int. J. Cancer138 ( 10 ), 2466 – 2476 ( 2016 ).
  • Thibault K , Van SteenwinckelJ , BrisorgueilMJet al. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat . Pain140 ( 2 ), 305 – 322 ( 2008 ).
  • Hansen N , UceylerN , PalmFet al. Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy . Neurosci. Lett.495 ( 2 ), 93 – 97 ( 2011 ).
  • Hershman DL , LacchettiC , DworkinRHet al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline . J. Clin. Oncol.32 ( 18 ), 1941 – 1967 ( 2014 ).
  • Guindon J , LaiY , TakacsSM , BradshawHB , HohmannAG . Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment . Pharmacol. Res.67 ( 1 ), 94 – 109 ( 2013 ).
  • Uhelski ML , KhasabovaIA , SimoneDA . Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy . J. Neurophysiol.113 ( 5 ), 1501 – 1510 ( 2015 ).
  • Ward SJ , McallisterSD , KawamuraR , MuraseR , NeelakantanH , WalkerEA . Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy . Br. J. Pharmacol.171 ( 3 ), 636 – 645 ( 2014 ).
  • King KM , MyersA , Soroka-MonzoAJet al. Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain . Br. J. Pharmacol.174 ( 17 ), 2832 – 2841 ( 2017 ).
  • Lynch ME , Cesar-RittenbergP , HohmannAG . A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain . J. Pain Symptom Manage.47 ( 1 ), 166 – 173 ( 2014 ).
  • Yang Y , ZhangYG , LinGAet al. Spinal changes of a newly isolated neuropeptide endomorphin-2 concomitant with vincristine-induced allodynia . PLoS ONE9 ( 2 ), e89583 ( 2014 ).
  • Toyama S , ShimoyamaN , ShimoyamaM . The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain . Neuropeptides61 , 95 – 100 ( 2017 ).
  • Nagahara T , SaitohT , KutsumuraNet al. Design and synthesis of non-peptide, selective orexin receptor 2 agonists . J. Med. Chem.58 ( 20 ), 7931 – 7937 ( 2015 ).
  • Hara T , ChibaT , AbeKet al. Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion . Pain154 ( 6 ), 882 – 889 ( 2013 ).
  • Quartu M , CarozziVA , DorseySGet al. Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve . Biomed. Res. Int. 2014 , 180428 ( 2014 ).
  • Ta LE , BieberAJ , CarltonSM , LoprinziCL , LowPA , WindebankAJ . Transient receptor potential vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in mice . Mol. Pain.6 , 15 ( 2010 ).
  • Chen K , ZhangZF , LiaoMF , YaoWL , WangJ , WangXR . Blocking PAR2 attenuates oxaliplatin-induced neuropathic pain via TRPV1 and releases of substance P and CGRP in superficial dorsal horn of spinal cord . J. Neurol. Sci.352 ( 1-2 ), 62 – 67 ( 2015 ).
  • Nassini R , GeesM , HarrisonSet al. Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation . Pain152 ( 7 ), 1621 – 1631 ( 2011 ).
  • Zhao M , IsamiK , NakamuraS , ShirakawaH , NakagawaT , KanekoS . Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice . Mol. Pain8 , 55 ( 2012 ).
  • Yamamoto K , ChibaN , ChibaTet al. Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration . Mol. Pain11 , s12990-12015-10072-12998 ( 2015 ).
  • Duggett NA , GriffithsLA , MckennaOEet al. Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy . Neuroscience333 , 13 – 26 ( 2016 ).
  • Materazzi S , FusiC , BenemeiSet al. TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism . Pflugers Arch.463 ( 4 ), 561 – 569 ( 2012 ).
  • Wang Q , WangJ , GaoD , LiJ . Inhibition of PAR2 and TRPA1 signals alleviates neuropathic pain evoked by chemotherapeutic bortezomib . J. Biol. Regul. Homeost. Agents31 ( 4 ), 977 – 983 ( 2017 ).
  • Kawashiri T , EgashiraN , KurobeKet al. L Type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats . Mol. Pain8 , 1744-8069-1748-1747 ( 2012 ).
  • Fallon MT , StoreyDJ , KrishanAet al. Cancer treatment-related neuropathic pain: proof of concept study with menthol – a TRPM8 agonist . Support. Care Cancer23 ( 9 ), 2769 – 2777 ( 2015 ).
  • Storey DJ , ColvinLA , MackeanMJ , MitchellR , Fleetwood-WalkerSM , FallonMT . Reversal of dose-limiting carboplatin-induced peripheral neuropathy with TRPM8 activator, menthol, enables further effective chemotherapy delivery . J. Pain Symptom Manage.39 ( 6 ), e2 – e4 ( 2010 ).
  • Nazıroğlu M , BraidyN . Thermo-sensitive TRP channels: novel targets for treating chemotherapy-induced peripheral pain . Front. Physiol.8 ( 1040 ), 1 – 12 ( 2017 ).
  • Scuteri A , GalimbertiA , RavasiMet al. NGF protects dorsal root ganglion neurons from oxaliplatin by modulating JNK/Sapk and ERK1/2 . Neurosci. Lett.486 ( 3 ), 141 – 145 ( 2010 ).
  • Park SJ , WuCH , GordonJD , ZhongX , EmamiA , SafaAR . Taxol induces caspase-10-dependent apoptosis . J. Biol. Chem.279 ( 49 ), 51057 – 51067 ( 2004 ).
  • Lapointe NE , MorfiniG , BradyST , FeinsteinSC , WilsonL , JordanMA . Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy . Neurotoxicology37 , 231 – 239 ( 2013 ).
  • Zheng H , XiaoWH , BennettGJ . Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy . Exp. Neurol.238 ( 2 ), 225 – 234 ( 2012 ).
  • Xiao WH , BennettGJ . Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin . Pain153 ( 3 ), 704 – 709 ( 2012 ).
  • Zheng H , XiaoWH , BennettGJ . Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy . Exp. Neurol.232 ( 2 ), 154 – 161 ( 2011 ).
  • Flatters SJ , BennettGJ . Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction . Pain122 ( 3 ), 245 – 257 ( 2006 ).
  • Xiao WH , ZhengH , ZhengFY , NuydensR , MeertTF , BennettGJ . Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat . Neuroscience199 , 461 – 469 ( 2011 ).
  • Hui KF , LamBH , HoDN , TsaoSW , ChiangAK . Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein–Barr virus . Mol. Cancer Ther.12 ( 5 ), 747 – 758 ( 2013 ).
  • Maj MA , MaJ , KrukowskiKN , KavelaarsA , HeijnenCJ . Inhibition of mitochondrial p53 accumulation by PFT-mu prevents cisplatin-induced peripheral neuropathy . Front. Mol. Neurosci.10 , 108 ( 2017 ).
  • Georgiadis MM , ChenQ , MengJet al. Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons . DNA Repair (Amst).41 , 32 – 41 ( 2016 ).
  • Kelley MR , JiangY , GuoC , ReedA , MengH , VaskoMR . Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy . PLoS ONE9 ( 9 ), e106485 ( 2014 ).
  • Kelley MR , WikelJH , GuoCet al. Identification and characterization of new chemical entities targeting apurinic/apyrimidinic endonuclease 1 for the prevention of chemotherapy-induced peripheral neuropathy . J. Pharmacol. Exp. Ther.359 ( 2 ), 300 – 309 ( 2016 ).
  • Sanli T , SteinbergGR , SinghG , TsakiridisT . AMP-activated protein kinase (AMPK) beyond metabolism . Cancer Biol. Ther.15 ( 2 ), 156 – 169 ( 2014 ).
  • Tsubaki M , TakedaT , TaniTet al. PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects . Int. J. Cancer137 ( 1 ), 243 – 250 ( 2015 ).
  • Li Y , ZhangH , KosturakisAKet al. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy . Brain. Behav. Immun.49 , 255 – 266 ( 2015 ).
  • Scuteri A , GalimbertiA , MaggioniDet al. Role of MAPKs in platinum-induced neuronal apoptosis . Neurotoxicology30 ( 2 ), 312 – 319 ( 2009 ).
  • Joseph EK , LevineJD . Comparison of oxaliplatin- and cisplatin-induced painful peripheral neuropathy in the rat . J. Pain10 ( 5 ), 534 – 541 ( 2009 ).
  • Ta LE , EspesetL , PodratzJ , WindebankAJ . Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding . Neurotoxicology27 ( 6 ), 992 – 1002 ( 2006 ).
  • Joseph EK , LevineJD . Caspase signalling in neuropathic and inflammatory pain in the rat . Eur. J. Neurosci.20 ( 11 ), 2896 – 2902 ( 2004 ).
  • Wahlman C , DoyleTM , LittleJWet al. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms . Pain159 ( 6 ), 1025 – 1034 ( 2018 ).
  • Zylka MJ . Pain-relieving prospects for adenosine receptors and ectonucleotidases . Trends Mol. Med.17 ( 4 ), 188 – 196 ( 2011 ).
  • Ferrari G , NalassamyN , DownsH , DanaR , OaklanderAL . Corneal innervation as a window to peripheral neuropathies . Exp. Eye Res.113 , 148 – 150 ( 2013 ).
  • Boyette-Davis J , XinW , ZhangH , DoughertyPM . Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline . Pain152 ( 2 ), 308 – 313 ( 2011 ).
  • Boyette-Davis J , DoughertyPM . Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline . Exp. Neurol.229 ( 2 ), 353 – 357 ( 2011 ).
  • Zhang H , Boyette-DavisJA , KosturakisAKet al. Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy . J. Pain14 ( 10 ), 1031 – 1044 ( 2013 ).
  • Singhmar P , HuoX , LiYet al. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy . Pain159 ( 5 ), 884 – 893 ( 2018 ).
  • Pachman DR , DockterT , ZekanPJet al. A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I . Support. Care Cancer25 ( 11 ), 3407 – 3416 ( 2017 ).
  • Christensen SB , HoneAJ , RouxIet al. RgIA4 potently blocks mouse α9α10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia . Front. Cell Neurosci.11 , 219 ( 2017 ).
  • Romero HK , ChristensenSB , Di Cesare MannelliLet al. Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain . Proc. Natl Acad. Sci. USA114 ( 10 ), E1825 – E1832 ( 2017 ).
  • Kyte SL , TomaW , BagdasDet al. Nicotine prevents and reverses paclitaxel-induced mechanical allodynia in a mouse model of CIPN . J. Pharmacol. Exp. Ther.364 ( 1 ), 110 – 119 ( 2018 ).
  • Kosturakis AK , HeZ , LiYet al. Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density . J. Clin. Oncol.32 ( 28 ), 3156 – 3162 ( 2014 ).
  • Zhang H , YoonSY , ZhangH , DoughertyPM . Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of paclitaxel-induced painful neuropathy . J. Pain13 ( 3 ), 293 – 303 ( 2012 ).
  • Robinson CR , ZhangH , DoughertyPM . Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat . Neuroscience274 , 308 – 317 ( 2014 ).
  • Yoon SY , RobinsonCR , ZhangH , DoughertyPM . Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity . J. Pain14 ( 2 ), 205 – 214 ( 2013 ).
  • Makker PGS , DuffySS , LeesJGet al. Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy . PLoS ONE12 ( 1 ), 1 – 24 ( 2017 ).
  • Takeda M , TanimotoT , KadoiJet al. Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammation . Pain129 ( 1-2 ), 155 – 166 ( 2007 ).
  • Warwick RA , HananiM . The contribution of satellite glial cells to chemotherapy-induced neuropathic pain . Eur. J. Pain.17 ( 4 ), 571 – 580 ( 2013 ).
  • Cavaletti G , CavallettiE , OggioniNet al. Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration . Neurotoxicology21 ( 3 ), 389 – 393 ( 2000 ).
  • Imai S , KoyanagiM , AzimiZet al. Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms . Sci. Rep.7 ( 1 ), 5947 ( 2017 ).
  • Sorkin LS , XiaoWH , WagnerR , MyersRR . Tumour necrosis factor-α induces ectopic activity in nociceptive primary afferent fibres . Neuroscience81 ( 1 ), 255 – 262 ( 1997 ).
  • Ozaktay AC , CavanaughJM , AsikI , DeleoJA , WeinsteinJN . Dorsal root sensitivity to interleukin-1 β, interleukin-6 and tumor necrosis factor in rats . Eur. Spine J.11 ( 5 ), 467 – 475 ( 2002 ).
  • Onda A , HambaM , YabukiS , KikuchiS . Exogenous tumor necrosis factor-α induces abnormal discharges in rat dorsal horn neurons . Spine (Phila Pa 1976)27 ( 15 ), 1618 – 1624 ; discussion 1624 ( 2002 ).
  • Basu S , SodhiA . Increased release of interleukin-1 and tumour necrosis factor by interleukin-2-induced lymphokine-activated killer cells in the presence of cisplatin and FK-565 . Immunol. Cell Biol.70 ( Pt 1 ), 15 – 24 ( 1992 ).
  • Zaks-Zilberman M , ZaksTZ , VogelSN . Induction of proinflammatory and chemokine genes by lipopolysaccharide and paclitaxel (Taxol) in murine and human breast cancer cell lines . Cytokine15 ( 3 ), 156 – 165 ( 2001 ).
  • Weintraub M , AddeMA , VenzonDJet al. Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine . J. Clin. Oncol.14 ( 3 ), 935 – 940 ( 1996 ).
  • Zhang H , NeiH , DoughertyPM . A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-α . J. Neurosci.30 ( 38 ), 12844 – 12855 ( 2010 ).
  • Vetere A , ChoudharyA , BurnsSM , WagnerBK . Targeting the pancreatic β-cell to treat diabetes . Nat. Rev. Drug Discov.13 ( 4 ), 278 – 289 ( 2014 ).
  • Byrd-Leifer CA , BlockEF , TakedaK , AkiraS , DingA . The role of MyD88 and TLR4 in the LPS-mimetic activity of taxol . Eur. J. Immunol.31 ( 8 ), 2448 – 2457 ( 2001 ).
  • Li Y , ZhangH , ZhangH , KosturakisAK , JawadAB , DoughertyPM . Toll-like receptor 4 signaling contributes to paclitaxel-induced peripheral neuropathy . J. Pain15 ( 7 ), 712 – 725 ( 2014 ).
  • Park HJ , StokesJA , CorrM , YakshTL . Toll-like receptor signaling regulates cisplatin-induced mechanical allodynia in mice . Cancer Chemother. Pharmacol.73 ( 1 ), 25 – 34 ( 2014 ).
  • Krukowski K , EijkelkampN , LaumetGet al. CD8+ T cells and endogenous IL-10 are required for resolution of chemotherapy-induced neuropathic pain . J. Neurosci.36 ( 43 ), 11074 – 11083 ( 2016 ).
  • Brandolini L , BenedettiE , RuffiniPAet al. CXCR1/2 pathways in paclitaxel-induced neuropathic pain . Oncotarget8 ( 14 ), 23188 – 23201 ( 2017 ).
  • Gao YJ , ZhangL , SamadOAet al. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain . J. Neurosci.29 ( 13 ), 4096 – 4108 ( 2009 ).
  • Zhang H , LiY , De Carvalho-BarbosaMet al. Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy . J. Pain17 ( 7 ), 775 – 786 ( 2016 ).
  • Wang YS , LiYY , CuiWet al. Melatonin attenuates pain hypersensitivity and decreases astrocyte-mediated spinal neuroinflammation in a rat model of oxaliplatin-induced pain . Inflammation40 ( 6 ), 2052 – 2061 ( 2017 ).
  • Areti A , KomirishettyP , AkuthotaM , MalikRA , KumarA . Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy . J. Pineal. Res.62 ( 3 ), e12393 ( 2017 ).
  • Liu C , LuanS , OuyangHet al. Upregulation of CCL2 via ATF3/c-Jun interaction mediated the bortezomib-induced peripheral neuropathy . Brain Behav. Immun.53 , 96 – 104 ( 2016 ).
  • Cliff J , JorgensenAL , LordRet al. The molecular genetics of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis . Crit. Rev. Oncol. Hematol.120 , 127 – 140 ( 2017 ).
  • Gewandter JS , FreemanR , KittRAet al. Chemotherapy-induced peripheral neuropathy clinical trials: review and recommendations . Neurology89 ( 8 ), 859 – 869 ( 2017 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.