Clinical Evaluation of the Oral Gonadotropin-Releasing Hormone-Antagonist Elagolix for the Management of Endometriosis-Associated Pain

References

• Giudice LC . Clinical practice. Endometriosis. N. Engl. J. Med.362(25), 2389–2398 (2010).
   PubMed Web of Science ®Google Scholar
• Bulun SE . Endometriosis. N. Engl. J. Med.360(3), 268–279 (2009).
   PubMed Web of Science ®Google Scholar
• Vercellini P , MeanaM , HummelshojL , SomiglianaE , ViganoP , FedeleL. Priorities for endometriosis research: a proposed focus on deep dyspareunia. Reprod. Sci.18(2), 114–118 (2011).
   PubMed Web of Science ®Google Scholar
• Gao X , OutleyJ , BottemanM , SpaldingJ , SimonJA , PashosCL. Economic burden of endometriosis. Fertil. Steril.86(6), 1561–1572 (2006).
   PubMed Web of Science ®Google Scholar
• Nnoaham KE , HummelshojL , WebsterPet.al Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil. Steril.96(2), 366–373 (2011).
   PubMed Web of Science ®Google Scholar
• Simoens S , DunselmanG , DirksenCet.al The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum. Reprod.27(5), 1292–1299 (2012).
   PubMed Web of Science ®Google Scholar
• Soliman AM , TaylorHS , BonafedeM , NelsonJK , Castelli-HaleyJ. Incremental direct and indirect cost burden attributed to endometriosis surgeries in the United States. Fertil. Steril.107(5), 1181.e2–1190.e2 (2017).
   Web of Science ®Google Scholar
• Simoens S , HummelshojL , DunselmanGet.al Endometriosis cost assessment (the EndoCost study): a cost-of-illness study protocol. Gynecol. Obstet. Invest.71(3), 170–176 (2011).
   PubMed Web of Science ®Google Scholar
• Culley L , LawC , HudsonNet.al The social and psychological impact of endometriosis on women’s lives: a critical narrative review. Hum. Reprod. Update19(6), 625–639 (2013).
   PubMed Web of Science ®Google Scholar
• Du H , TaylorHS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells25(8), 2082–2086 (2007).
   PubMed Web of Science ®Google Scholar
• Johnson NP , HummelshojL. World Endometriosis Society Montpellier C. Consensus on current management of endometriosis. Hum. Reprod.28(6), 1552–1568 (2013).
   PubMed Web of Science ®Google Scholar
• Vercellini P , CrosignaniPG , AbbiatiA , SomiglianaE , ViganoP , FedeleL. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum. Reprod. Update15(2), 177–188 (2009).
   PubMed Web of Science ®Google Scholar
• Seracchioli R , MabroukM , ManuzziLet.al Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis. Hum. Reprod.24(11), 2729–2735 (2009).
   PubMed Web of Science ®Google Scholar
• Guo SW . Recurrence of endometriosis and its control. Hum. Reprod. Update15(4), 441–461 (2009).
   PubMed Web of Science ®Google Scholar
• Practice bulletin no. 114: management of endometriosis. Obstet. Gynecol.116(1), 223–236 (2010).
   PubMed Web of Science ®Google Scholar
• Dunselman GA , VermeulenN , BeckerCet.al ESHRE guideline: management of women with endometriosis. Hum. Reprod.29(3), 400–412 (2014).
   PubMed Web of Science ®Google Scholar
• Jensen JT , SchlaffW , GordonK. Use of combined hormonal contraceptives for the treatment of endometriosis-related pain: a systematic review of the evidence. Fertil. Steril.110(1), 137.e1–152.e1 (2018).
   Web of Science ®Google Scholar
• Flores VA , VanhieA , DangT , TaylorHS. Progesterone receptor status predicts response to progestin therapy in endometriosis. J. Clin. Endocrinol. Metab.103(12), 4561–4568 (2018).
   PubMed Web of Science ®Google Scholar
• Hornstein MD , SurreyES , WeisbergGW , CasinoLA. Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group. Obstet. Gynecol.91(1), 16–24 (1998).
   PubMed Web of Science ®Google Scholar
• Barbieri RL . Hormone treatment of endometriosis: the estrogen threshold hypothesis. Am. J. Obstet. Gynecol.166(2), 740–745 (1992).
   PubMed Web of Science ®Google Scholar
• Abbvie Inc . Prescribing information for Orilissa™ (elagolix) tablets, for oral use (2018). https://www.orilissa.com/
   Google Scholar
• Millar RP , NewtonCL. Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat. Rev. Endocrinol.9(8), 451–466 (2013).
   PubMed Web of Science ®Google Scholar
• Maggi R , CariboniAM , MarelliMMet.al GnRH and GnRH receptors in the pathophysiology of the human female reproductive system. Hum. Reprod. Update22(3), 358–381 (2016).
   PubMed Web of Science ®Google Scholar
• Sampson JA . Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet. Gynecol.14(4), 422–469 (1927).
   Google Scholar
• Nunley WC Jr , KitchinJD3rd. Congenital atresia of the uterine cervix with pelvic endometriosis. Arch. Surg.115(6), 757–758 (1980).
   PubMedGoogle Scholar
• Olive DL , HendersonDY. Endometriosis and mullerian anomalies. Obstet. Gynecol.69(3 Pt 1), 412–415 (1987).
   PubMed Web of Science ®Google Scholar
• Sanfilippo JS , WakimNG , SchiklerKN , YussmanMA. Endometriosis in association with uterine anomaly. Am. J. Obstet. Gynecol.154(1), 39–43 (1986).
   PubMed Web of Science ®Google Scholar
• Sampson JA . Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am. J. Pathol.3(2), 93.43–110.43 (1927).
   Google Scholar
• Sampson JA . Heterotopic or misplaced endometrial tissue. Am. J. Obstet. Gynecol.10, 664 (1925).
   Google Scholar
• Leyendecker G , HerbertzM , KunzG , MallG. Endometriosis results from the dislocation of basal endometrium. Hum. Reprod.17(10), 2725–2736 (2002).
   PubMed Web of Science ®Google Scholar
• Sasson IE , TaylorHS. Stem cells and the pathogenesis of endometriosis. Ann. NY Acad. Sci.1127, 106–115 (2008).
   PubMed Web of Science ®Google Scholar
• Taylor HS . Endometrial cells derived from donor stem cells in bone marrow transplant recipients. JAMA292(1), 81–85 (2004).
   PubMed Web of Science ®Google Scholar
• Fung JN , RogersPA , MontgomeryGW. Identifying the biological basis of GWAS hits for endometriosis. Biol. Reprod.92(4), 87 (2015).
   PubMed Web of Science ®Google Scholar
• Dun EC , TaylorRN , WieserF. Advances in the genetics of endometriosis. Genome Med.2(10), 75 (2010).
   PubMedGoogle Scholar
• Sapkota Y , SteinthorsdottirV , MorrisAPet.al Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. Nat. Commun.8, 15539 (2017).
   PubMed Web of Science ®Google Scholar
• Chettier R , WardK , AlbertsenHM. Endometriosis is associated with rare copy number variants. PLoS ONE9(8), e103968 (2014).
   PubMed Web of Science ®Google Scholar
• Anglesio MS , PapadopoulosN , AyhanAet.al Cancer-associated mutations in endometriosis without cancer. N. Engl. J. Med.376(19), 1835–1848 (2017).
   PubMed Web of Science ®Google Scholar
• Bulun SE , MonsavaisD , PavoneMEet.al Role of estrogen receptor-beta in endometriosis. Semin. Reprod. Med.30(1), 39–45 (2012).
   PubMed Web of Science ®Google Scholar
• Han SJ , JungSY , WuSPet.al Estrogen receptor beta modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis. Cell163(4), 960–974 (2015).
   PubMed Web of Science ®Google Scholar
• Han SJ , O’MalleyBW. The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis. Hum. Reprod. Update20(4), 467–484 (2014).
   PubMed Web of Science ®Google Scholar
• Amaral JD , SolaS , SteerCJ , RodriguesCM. Role of nuclear steroid receptors in apoptosis. Curr. Med. Chem.16(29), 3886–3902 (2009).
   PubMed Web of Science ®Google Scholar
• Shi Z , AraiKY , JinWet.al Expression of nerve growth factor and its receptors NTRK1 and TNFRSF1B is regulated by estrogen and progesterone in the uteri of golden hamsters. Biol. Reprod.74(5), 850–856 (2006).
   PubMed Web of Science ®Google Scholar
• Anaf V , SimonP , ElNakadi Iet.al Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis. Hum. Reprod.17(7), 1895–1900 (2002).
   PubMed Web of Science ®Google Scholar
• Bulun SE , LinZ , ImirGet.al Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol. Rev.57(3), 359–383 (2005).
   PubMed Web of Science ®Google Scholar
• Sun HS , HsiaoKY , HsuCC , WuMH , TsaiSJ. Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. Endocrinology144(9), 3934–3942 (2003).
   PubMed Web of Science ®Google Scholar
• Yoo JY , KimTH , FazleabasATet.al KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance. Sci. Rep.7(1), 6765 (2017).
   PubMedGoogle Scholar
• Zeitoun K , TakayamaK , SasanoHet.al Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J. Clin. Endocrinol. Metab.83(12), 4474–4480 (1998).
   PubMed Web of Science ®Google Scholar
• Huhtinen K , DesaiR , StahleMet.al Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. J. Clin. Endocrinol. Metab.97(11), 4228–4235 (2012).
   PubMed Web of Science ®Google Scholar
• Riccio L , SantulliP , MarcellinL , AbraoMS , BatteuxF , ChapronC. Immunology of endometriosis. Best Pract. Res. Clin. Obstet. Gynaecol.50, 39–49 (2018).
   PubMed Web of Science ®Google Scholar
• Reis FM , PetragliaF , TaylorRN. Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum. Reprod. Update19(4), 406–418 (2013).
   PubMed Web of Science ®Google Scholar
• Coxon L , HorneAW , VincentK. Pathophysiology of endometriosis-associated pain: a review of pelvic and central nervous system mechanisms. Best Pract. Res. Clin. Obstet. Gynaecol.51, 53–67 (2018).
   PubMed Web of Science ®Google Scholar
• Chen DB , YangZM , HilsenrathR , LeSP , HarperMJ. Stimulation of prostaglandin (PG) F2 alpha and PGE2 release by tumour necrosis factor-alpha and interleukin-1 alpha in cultured human luteal phase endometrial cells. Hum. Reprod.10(10), 2773–2780 (1995).
   PubMed Web of Science ®Google Scholar
• Jabbour HN , SalesKJ , SmithOP , BattersbyS , BoddySC. Prostaglandin receptors are mediators of vascular function in endometrial pathologies. Mol. Cell. Endocrinol.252(1–2), 191–200 (2006).
   PubMed Web of Science ®Google Scholar
• Tokushige N , MarkhamR , RussellP , FraserIS. Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis. Fertil. Steril.88(4), 795–803 (2007).
   PubMed Web of Science ®Google Scholar
• Wang G , TokushigeN , MarkhamR , FraserIS. Rich innervation of deep infiltrating endometriosis. Hum. Reprod.24(4), 827–834 (2009).
   PubMed Web of Science ®Google Scholar
• Zhang X , LuB , HuangX , XuH , ZhouC , LinJ. Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids. Fertil. Steril.92(5), 1799–1801 (2009).
   PubMed Web of Science ®Google Scholar
• Zhang X , LuB , HuangX , XuH , ZhouC , LinJ. Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids. Fertil. Steril.94(2), 730–737 (2010).
   PubMed Web of Science ®Google Scholar
• Morotti M , VincentK , BrawnJ , ZondervanKT , BeckerCM. Peripheral changes in endometriosis-associated pain. Hum. Reprod. Update20(5), 717–736 (2014).
   PubMed Web of Science ®Google Scholar
• Berkley KJ , RapkinAJ , PapkaRE. The pains of endometriosis. Science308(5728), 1587–1589 (2005).
   PubMed Web of Science ®Google Scholar
• Stratton P , BerkleyKJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum. Reprod. Update17(3), 327–346 (2011).
   PubMed Web of Science ®Google Scholar
• Ding S , ZhuL , TianY , ZhuT , HuangX , ZhangX. P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS ONE12(9), e0184647 (2017).
   PubMed Web of Science ®Google Scholar
• Bours MJ , DagneliePC , GiulianiAL , WesseliusA , DiVirgilio F. P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. Front. Biosci. (Schol. Ed.)3, 1443–1456 (2011).
   PubMedGoogle Scholar
• Whitaker LH , ReidJ , ChoaAet.al An exploratory study into objective and reported characteristics of neuropathic pain in women with chronic pelvic pain. PLoS ONE11(4), e0151950 (2016).
   PubMed Web of Science ®Google Scholar
• Fauconnier A , ChapronC. Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications. Hum. Reprod. Update11(6), 595–606 (2005).
   PubMed Web of Science ®Google Scholar
• Vercellini P , TrespidiL , DeGiorgi O , CortesiI , ParazziniF , CrosignaniPG. Endometriosis and pelvic pain: relation to disease stage and localization. Fertil. Steril.65(2), 299–304 (1996).
   PubMed Web of Science ®Google Scholar
• Howard FM . Endometriosis and mechanisms of pelvic pain. J. Minim. Invasive Gynecol.16(5), 540–550 (2009).
   PubMed Web of Science ®Google Scholar
• Brawn J , MorottiM , ZondervanKT , BeckerCM , VincentK. Central changes associated with chronic pelvic pain and endometriosis. Hum. Reprod. Update20(5), 737–747 (2014).
   PubMed Web of Science ®Google Scholar
• Mcallister SL , DmitrievaN , BerkleyKJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS ONE7(2), e31758 (2012).
   PubMed Web of Science ®Google Scholar
• Schmidt-Wilcke T , LeinischE , StraubeAet.al Gray matter decrease in patients with chronic tension type headache. Neurology65(9), 1483–1486 (2005).
   PubMed Web of Science ®Google Scholar
• Schmidt-Wilcke T , GanssbauerS , NeunerT , BogdahnU , MayA. Subtle grey matter changes between migraine patients and healthy controls. Cephalalgia28(1), 1–4 (2008).
   PubMed Web of Science ®Google Scholar
• As-Sanie S , HarrisRE , NapadowVet.al Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study. Pain153(5), 1006–1014 (2012).
   PubMed Web of Science ®Google Scholar
• As-Sanie S , KimJ , Schmidt-WilckeTet.al Functional connectivity is associated with altered brain chemistry in women with endometriosis-associated chronic pelvic pain. J. Pain17(1), 1–13 (2016).
   PubMed Web of Science ®Google Scholar
• Millar RP , ZhuYF , ChenC , StruthersRS. Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications. Br. Med. Bull.56(3), 761–772 (2000).
   PubMed Web of Science ®Google Scholar
• Tucci FC , ZhuYF , StruthersRSet.al 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J. Med. Chem.48(4), 1169–1178 (2005).
   PubMed Web of Science ®Google Scholar
• Betz SF , ZhuYF , ChenC , StruthersRS. Non-peptide gonadotropin-releasing hormone receptor antagonists. J. Med. Chem.51(12), 3331–3348 (2008).
   PubMed Web of Science ®Google Scholar
• Chen C , WuD , GuoZet.al Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4 -methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J. Med. Chem.51(23), 7478–7485 (2008).
   PubMed Web of Science ®Google Scholar
• Miwa K , HitakaT , ImadaTet.al Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor. J. Med. Chem.54(14), 4998–5012 (2011).
   PubMed Web of Science ®Google Scholar
• Markham A . Relugolix: first global approval. Drugs79(6), 675–679 (2019).
   PubMed Web of Science ®Google Scholar
• Osuga Y , EnyaK , KudouK , TanimotoM , HoshiaiH. Oral gonadotropin-releasing hormone antagonist relugolix compared with leuprorelin injections for uterine leiomyomas: a randomized controlled trial. Obstet. Gynecol.133(3), 423–433 (2019).
   PubMed Web of Science ®Google Scholar
• Pohl O , MarchandL , FawkesN , GottelandJP , LoumayeE. Gonadotropin-releasing hormone receptor antagonist mono- and combination therapy with estradiol/norethindrone acetate add-back: pharmacodynamics and safety of OBE2109. J. Clin. Endocrinol. Metab.103(2), 497–504 (2018).
   PubMed Web of Science ®Google Scholar
• ObsEva . ObsEva SA announces initiation of Phase 3 EDELWEISS 2 and 3 trials of linzagolix for endometriosis associated pain in U.S., Canada and Europe (2019). http://www.obseva.com/news/obseva-sa-announces-initiation-of-phase-3-edelweiss-2-and-3-trials-of-linzagolix-for-endometriosis-associated-pain-in-u-s-canada-and-europe
   Google Scholar
• Zhang N , ShonJ , KimMJet.al Role of CYP3A in oral contraceptives clearance. Clin. Transl. Sci.11(3), 251–260 (2018).
   PubMed Web of Science ®Google Scholar
• Struthers RS , NichollsAJ , GrundyJet.al Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix. J. Clin. Endocrinol. Metab.94(2), 545–551 (2009).
   PubMed Web of Science ®Google Scholar
• Ng J , ChwaliszK , CarterDC , KleinCE. Dose-dependent suppression of gonadotropins and ovarian hormones by elagolix in healthy premenopausal women. J. Clin. Endocrinol. Metab.102(5), 1683–1691 (2017).
   PubMed Web of Science ®Google Scholar
• Winzenborg I , NaderA , PolepallyARet.al Population pharmacokinetics of elagolix in healthy women and women with endometriosis. Clin. Pharmacokinet.57(10), 1295–1306 (2018).
   PubMed Web of Science ®Google Scholar
• Carr B , DmowskiWP , O’BrienCet.al Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density. Reprod. Sci.21(11), 1341–1351 (2014).
   PubMed Web of Science ®Google Scholar
• Crosignani PG , LucianoA , RayA , BergqvistA. Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain. Hum. Reprod.21(1), 248–256 (2006).
   PubMed Web of Science ®Google Scholar
• Schlaff WD , CarsonSA , LucianoA , RossD , BergqvistA. Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain. Fertil. Steril.85(2), 314–325 (2006).
   PubMed Web of Science ®Google Scholar
• Diamond MP , CarrB , DmowskiWPet.al Elagolix treatment for endometriosis-associated pain: results from a Phase II, randomized, double-blind, placebo-controlled study. Reprod. Sci.21(3), 363–371 (2014).
   PubMed Web of Science ®Google Scholar
• Ács N , O’BrienC , JiangPet.al Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist: results from a Phase II, randomized controlled study. J. Endometr. Pelvic Pain Disord.7(2), 56–62 (2015).
   Web of Science ®Google Scholar
• Carr B , GiudiceL , DmowskiWPet.al Elagolix, an oral GnRH antagonist for endometriosis-associated pain: a randomized controlled study. J. Endometr. Pelvic Pain Disord.5(3), 105–115 (2013).
   PubMedGoogle Scholar
• Wyrwich KW , O’BrienCF , SolimanAM , ChwaliszK. Development and validation of the endometriosis daily pain impact diary items to assess dysmenorrhea and nonmenstrual pelvic pain. Reprod. Sci. (25(11), 1567–1576 (2018).
   PubMed Web of Science ®Google Scholar
• USA FDA . FDA Guidance for industry: patient reported outcome measures. Use in medical product development to support labeling claims (2009). https://www.fda.gov/regulatory-information/search-fda-guidance-documents/patient-reported-outcome-measures-use-medical-product-development-support-labeling-claims
   Google Scholar
• Taylor HS , GiudiceLC , LesseyBAet.al Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist. N. Engl. J. Med.377, 28–40 (2017).
   PubMed Web of Science ®Google Scholar
• Surrey E , TaylorHS , GiudiceLet.al Long-term outcomes of elagolix in women with endometriosis: results from two extension studies. Obstet. Gynecol.132(1), 147–160 (2018).
   PubMed Web of Science ®Google Scholar
• Farrar JT , YoungJPJr , LamoreauxL , WerthJL , PooleRM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain94(2), 149–158 (2001).
   PubMed Web of Science ®Google Scholar
• Cosar E , MamillapalliR , ErsoyGS , ChoS , SeiferB , TaylorHS. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil. Steril.106(2), 402–409 (2016).
   PubMed Web of Science ®Google Scholar
• Tamaresis JS , IrwinJC , GoldfienGAet.al Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology155(12), 4986–4999 (2014).
   PubMed Web of Science ®Google Scholar
• Zondervan KT , BeckerCM , KogaK , MissmerSA , TaylorRN , ViganoP. Endometriosis. Nat. Rev. Dis. Primers4(1), 9 (2018).
   PubMed Web of Science ®Google Scholar
• Carr BR , StewartEA , ArcherDFet.al Elagolix alone or with add-back therapy in women with heavy menstrual bleeding and uterine leiomyomas: a randomized controlled trial. Obstet. Gynecol. (132(5), 1252–1264 (2018).
   PubMed Web of Science ®Google Scholar
• Archer DF , StewartEA , JainRIet.al Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a Phase IIa proof-of-concept study. Fertil. Steril.108(1), 152–160.e4 (2017).
   PubMed Web of Science ®Google Scholar