Recent Advances in Pain Treatment for Children With Serious Illness

References

• Connor SR , DowningJ , MarstonJ. Estimating the global need for palliative care for children: a cross-sectional analysis. J. Pain Symptom Manage.53(2), 171–177 (2017).
   PubMed Web of Science ®Google Scholar
• Wolfe J , OrellanaL , UllrichCet.al Symptoms and distress in children with advanced cancer: prospective patient-reported outcomes from the PediQUEST study. J. Clin. Oncol.33(17), 1928–1935 (2015).
   PubMed Web of Science ®Google Scholar
• Friedrichsdorf SJ , PostierAC , AndrewsGS , HamreKE , SteeleR , SidenH. Pain reporting and analgesia management in 270 children with a progressive neurologic, metabolic or chromosomally based condition with impairment of the central nervous system: cross- sectional, baseline results from an observational, longitudinal study. J. Pain Res.10, 1841–1852 (2017).
   PubMed Web of Science ®Google Scholar
• Hechler T , MartinA , BlankenburgMet.al Specialized multimodal outpatient treatment for children with chronic pain: treatment pathways and long-term outcome. Eur. J. Pain15(9), 976–984 (2011).
   PubMed Web of Science ®Google Scholar
• Michelson JD , AddanteRA , CharlsonMD. Multimodal analgesia therapy reduces length of hospitalization in patients undergoing fusions of the ankle and hindfoot. Foot Ankle Int.34(11), 1526–1534 (2013).
   PubMed Web of Science ®Google Scholar
• Friedrichsdorf SJ . Prevention and treatment of pain in hospitalized infants, children, and teenagers: from myths and morphine to multimodal analgesia. In: Pain 2016: Refresher Courses. 16th World Congress on Pain.International Association for the Study of Pain, IASP Press, DC, USA, 309–319 (2016).
   Google Scholar
• Friedrichsdorf SJ , RemkeS , HauserJet.al Development of a pediatric palliative care curriculum and dissemination model: education in palliative and end-of-life care (EPEC) pediatrics. J. Pain Symptom Manage.58(4), 707–720 (2019).
   PubMed Web of Science ®Google Scholar
• Israel FJ , ParkerG , CharlesM , ReymondL. Lack of benefit from paracetamol (acetaminophen) for palliative cancer patients requiring high-dose strong opioids: a randomized, double-blind, placebo-controlled, crossover trial. J. Pain Symptom Manage.39(3), 548–554 (2010).
   PubMed Web of Science ®Google Scholar
• Moore RA , DerryS , StraubeS , Ireson-PaineJ , WiffenPJ. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain155(1), 14–21 (2014).
   PubMed Web of Science ®Google Scholar
• de Leeuw TG , DirckxM , GonzalezCandel A , ScoonesGP , HuygenF , de WildtSN. The use of dipyrone (metamizol) as an analgesic in children: what is the evidence? A review. Paediatr. Anaesth.27(12), 1193–1201 (2017).
   PubMed Web of Science ®Google Scholar
• Teerawattananon C , TantayakomP , SuwanawiboonB , KatchamartW. Risk of perioperative bleeding related to highly selective cyclooxygenase-2 inhibitors: a systematic review and meta-analysis. Semin. Arthritis Rheum.46(4), 520–528 (2017).
   PubMed Web of Science ®Google Scholar
• Nissen SE , YeomansND , SolomonDHet.al Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N. Engl. J. Med.375(26), 2519–2529 (2016).
   PubMed Web of Science ®Google Scholar
• World Health Organization . WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses.WHO Press, Geneva, Switzerland (2012).
   Google Scholar
• Drake R , LongworthJ , CollinsJJ. Opioid rotation in children with cancer. J. Palliat. Med.7(3), 419–422 (2004).
   PubMedGoogle Scholar
• Friedrichsdorf SJ . From tramadol to methadone: opioids in the treatment of pain and dyspnea in pediatric palliative care. Clin. J. Pain35(6), 501–508 (2019).
   PubMed Web of Science ®Google Scholar
• Mercadante S , BrueraE. Methadone as a first-line opioid in cancer pain management: a systematic review. J. Pain Symptom Manage.55(3), 998–1003 (2018).
   PubMed Web of Science ®Google Scholar
• Madden K , BrueraE. Very-low-dose methadone to treat refractory neuropathic pain in children with cancer. J. Palliat. Med.20(11), 1280–1283 (2017).
   PubMed Web of Science ®Google Scholar
• Fife A , PostierA , FloodA , FriedrichsdorfSJ. Methadone conversion in infants and children: retrospective cohort study of 199 pediatric inpatients. J. Opioid Manag.12(2), 123–130 (2016).
   PubMedGoogle Scholar
• Friedrichsdorf S , FinneyD , BerginM , StevensM , CollinsJ. Breakthrough pain in children with cancer. J. Pain Symptom Manage.34(2), 209–216 (2007).
   PubMed Web of Science ®Google Scholar
• Friedrichsdorf SJ , PostierA. Management of breakthrough pain in children with cancer. J. Pain Res.7, 117–123 (2014).
   PubMed Web of Science ®Google Scholar
• Hauer JM , SolodiukJC. Gabapentin for management of recurrent pain in 22 nonverbal children with severe neurological impairment: a retrospective analysis. J. Palliat. Med.18(5), 453–456 (2015).
   PubMed Web of Science ®Google Scholar
• Edwards L , DeMeoS , HornikCDet.al Gabapentin use in the neonatal intensive care unit. J. Pediatr.169, 310–312 (2016).
   PubMed Web of Science ®Google Scholar
• Horvath R , HalbrooksEF , OvermanDM , FriedrichsdorfSJ. Efficacy and safety of postoperative dexmedetomidine administration in infants and children undergoing cardiac surgery: a retrospective cohort study. J. Pediatr. Intensive Care (3), 138–145 (2015).
   PubMedGoogle Scholar
• Burns J , JacksonK , SheehyKA , FinkelJC , QuezadoZM. The use of dexmedetomidine in pediatric palliative care: a preliminary study. J. Palliat. Med.20(7), 779–783 (2017).
   PubMed Web of Science ®Google Scholar
• Chrysostomou C , SchulmanSR , HerreraCastellanos Met.al A Phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates. J. Pediatr.164(2), 276.e1–282.e3 (2014).
   Web of Science ®Google Scholar
• Kajiume T , SeraY , NakanunoRet.al Continuous intravenous infusion of ketamine and lidocaine as adjuvant analgesics in a 5-year-old patient with neuropathic cancer pain. J. Palliat. Med.15(6), 719–722 (2012).
   PubMed Web of Science ®Google Scholar
• Finkel J , PestieauS , QuezadoZ. Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. J. Pain8(6), 515–521 (2007).
   PubMed Web of Science ®Google Scholar
• Peixoto RD , HawleyP. Intravenous lidocaine for cancer pain without electrocardiographic monitoring: a retrospective review. J. Palliat. Med.18(4), 373–377 (2015).
   PubMed Web of Science ®Google Scholar
• Seah DSE , HerschtalA , TranH , ThakerarA , FullertonS. Subcutaneous lidocaine infusion for pain in patients with cancer. J. Palliat. Med.20(6), 667–671 (2017).
   PubMed Web of Science ®Google Scholar
• Wallace MS , LeeJ , SorkinL , DunnJS , YakshT , YuA. Intravenous lidocaine: effects on controlling pain after anti-GD2 antibody therapy in children with neuroblastoma – a report of a series. Anesth. Analg.85(4), 794–796 (1997).
   PubMed Web of Science ®Google Scholar
• Massey GV , PedigoS , DunnNL , GrossmanNJ , RussellEC. Continuous lidocaine infusion for the relief of refractory malignant pain in a terminally ill pediatric cancer patient. J. Pediatr. Hematol. Oncol.24(7), 566–568 (2002).
   PubMed Web of Science ®Google Scholar
• Ferrini R , PaiceJA. How to initiate and monitor infusional lidocaine for severe and/or neuropathic pain. J. Support. Oncol.2(1), 90–94 (2004).
   PubMedGoogle Scholar
• Hill KP . Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA313(24), 2474–2483 (2015).
   PubMed Web of Science ®Google Scholar
• Deshpande A , Mailis-GagnonA , ZoheiryN , LakhaSF. Efficacy and adverse effects of medical marijuana for chronic noncancer pain: systematic review of randomized controlled trials. Can. Fam. Physician61(8), e372–e381 (2015).
   PubMed Web of Science ®Google Scholar
• Pediatrics AAo . Updated AAP policy opposes marijuana use, citing potential harms, lack of research. (2015). http://aapnews.aappublications.org/content/early/2015/01/26/aapnews.20150126-1
   Google Scholar
• Casadio P , FernandesC , MurrayRM , DiForti M. Cannabis use in young people: the risk for schizophrenia. Neurosci. Biobehav. Rev.35(8), 1779–1787 (2011).
   PubMed Web of Science ®Google Scholar
• Daling JR , DoodyDR , SunXet.al Association of marijuana use and the incidence of testicular germ cell tumors. Cancer115(6), 1215–1223 (2009).
   PubMed Web of Science ®Google Scholar
• Trabert B , SigurdsonAJ , SweeneyAM , StromSS , McGlynnKA. Marijuana use and testicular germ cell tumors. Cancer117(4), 848–853 (2011).
   PubMed Web of Science ®Google Scholar
• Lacson JC , CarrollJD , TuazonE , CastelaoEJ , BernsteinL , CortessisVK. Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk. Cancer118(21), 5374–5383 (2012).
   PubMed Web of Science ®Google Scholar
• Meier MH , CaspiA , AmblerAet.al Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc. Natl Acad. Sci. USA109(40), E2657–E2664 (2012).
   PubMed Web of Science ®Google Scholar
• Moffitt TE , MeierMH , CaspiA , PoultonR. Reply to Rogeberg and Daly: no evidence that socioeconomic status or personality differences confound the association between cannabis use and IQ decline. Proc. Natl Acad. Sci. USA110(11), E980–E982 (2013).
   PubMed Web of Science ®Google Scholar
• Meier MH , HallW , CaspiAet.al Which adolescents develop persistent substance dependence in adulthood? Using population-representative longitudinal data to inform universal risk assessment. Psychol. Med.46(4), 877–889 (2016).
   PubMed Web of Science ®Google Scholar
• Bussing A , OstermannT , LudtkeR , MichalsenA. Effects of yoga interventions on pain and pain-associated disability: a meta-analysis. J. Pain13(1), 1–9 (2012).
   PubMed Web of Science ®Google Scholar
• Evans S , MoieniM , TaubRet.al Iyengar yoga for young adults with rheumatoid arthritis: results from a mixed-methods pilot study. J. Pain Symptom Manage.39(5), 904–913 (2010).
   PubMed Web of Science ®Google Scholar
• Vas J , Santos-ReyK , Navarro-PabloRet.al Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupunct. Med.34(4), 257–266 (2016).
   PubMed Web of Science ®Google Scholar
• Verkamp EK , FlowersSR , Lynch-JordanAM , TaylorJ , TingTV , Kashikar-ZuckS. A survey of conventional and complementary therapies used by youth with juvenile-onset fibromyalgia. Pain Manag. Nurs.14(4), e244–e250 (2013).
   PubMed Web of Science ®Google Scholar
• Friedrichsdorf S , KuttnerL , WestendorpK , McCartyR. Integrative pediatric palliative care. In: Integrative Pediatrics. CulbertTP, OlnessK ( Eds). Oxford University Press, Oxford, UK, 569–593 (2010).
   Google Scholar
• Kuttner L , FriedrichsdorfSJ. Hypnosis and palliative care for children and their families. In: Therapeutic Hypnosis with Children and Adolescents.SugarmanLiWesterWC ( Eds). Crown House Publishing Limited, Bethel, UK, 491–509 (2013).
   Google Scholar
• Hunt K , ErnstE. The evidence-base for complementary medicine in children: a critical overview of systematic reviews. Arch. Dis. Child.96(8), 769–776 (2011).
   PubMed Web of Science ®Google Scholar
• Evans S , TsaoJC , ZeltzerLK. Complementary and alternative medicine for acute procedural pain in children. Altern. Ther. Health Med.14(5), 52–56 (2008).
   PubMed Web of Science ®Google Scholar
• Richardson J , SmithJE , McCallG , PilkingtonK. Hypnosis for procedure-related pain and distress in pediatric cancer patients: a systematic review of effectiveness and methodology related to hypnosis interventions. J. Pain Symptom Manage.31(1), 70–84 (2006).
   PubMed Web of Science ®Google Scholar
• Friedrichsdorf SJ , KohenDP. Integration of hypnosis into pediatric palliative care. Ann. Palliat. Med.7(1), 136–150 (2018).
   PubMed Web of Science ®Google Scholar
• Evans S , TsaoJC , ZeltzerLK. Paediatric pain management: using complementary and alternative medicine. Rev. Pain2(1), 14–20 (2008).
   PubMedGoogle Scholar
• Kohen DP , OlnessKN. Hypnosis and Hypnotherapy with Children.Routledge Publications, Taylor & Francis, NY, USA (2011).
   Google Scholar
• Institute TNPHT . www.nphti.org
   Google Scholar
• Stubberud A , VarkeyE , McCroryDC , PedersenSA , LindeM. Biofeedback as prophylaxis for pediatric migraine: a meta-analysis. Pediatrics138(2), (2016).
   PubMed Web of Science ®Google Scholar
• Kovacic K , HainsworthK , SoodMet.al Neurostimulation for abdominal pain-related functional gastrointestinal disorders in adolescents: a randomised, double-blind, sham-controlled trial. Lancet Gastroenterol. Hepatol.2(10), 727–737 (2017).
   PubMed Web of Science ®Google Scholar
• Baeumler PI , FleckensteinJ , BenediktF , BaderJ , IrnichD. Acupuncture-induced changes of pressure pain threshold are mediated by segmental inhibition – a randomized controlled trial. Pain156(11), 2245–2255 (2015).
   PubMed Web of Science ®Google Scholar
• Xiang A , ChengK , ShenX , XuP , LiuS. The immediate analgesic effect of acupuncture for pain: a systematic review and meta-analysis. J. Evid. Based Complementary Altern. Med.2017, 3837194 (2017).
   Google Scholar
• Tegethoff M , BelardiA , StalujanisE , MeinlschmidtG. Comorbidity of mental disorders and chronic pain: chronology of onset in adolescents of a national representative cohort. J. Pain16(10), 1054–1064 (2015).
   PubMed Web of Science ®Google Scholar
• Cohen LL , VowlesKE , EcclestonC. The impact of adolescent chronic pain on functioning: disentangling the complex role of anxiety. J. Pain11(11), 1039–1046 (2010).
   PubMed Web of Science ®Google Scholar
• Palermo TM , EcclestonC , LewandowskiAS , WilliamsAC , MorleyS. Randomized controlled trials of psychological therapies for management of chronic pain in children and adolescents: an updated meta-analytic review. Pain148(3), 387–397 (2010).
   PubMed Web of Science ®Google Scholar
• Eccleston C , PalermoTM , WilliamsACet.al Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst. Rev. (5), CD003968 (2014).
   PubMed Web of Science ®Google Scholar
• Kashikar-Zuck S , SilS , Lynch-JordanAMet.al Changes in pain coping, catastrophizing, and coping efficacy after cognitive-behavioral therapy in children and adolescents with juvenile fibromyalgia. J. Pain14(5), 492–501 (2013).
   PubMed Web of Science ®Google Scholar
• Seminowicz DA , ShpanerM , KeaserMLet.al Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain. J. Pain14(12), 1573–1584 (2013).
   PubMed Web of Science ®Google Scholar
• Muriel AC , WolfeJ , BlockSD. Pediatric palliative care and child psychiatry: a model for enhancing practice and collaboration. J. Palliat. Med.19(10), 1032–1038 (2016).
   PubMed Web of Science ®Google Scholar
• Horowitz LM , BridgeJA , TeachSJet.al Ask suicide-screening questions (ASQ): a brief instrument for the pediatric emergency department. Arch. Pediatr. Adolesc. Med.166(12), 1170–1176 (2012).
   PubMedGoogle Scholar
• American Academy of Pediatrics . Mental health screening and assessment tools for primary care. (2012). www.aap.org/en-us/advocacy-and-policy/aap-health-initiatives/Mental-Health/Documents/MH_ScreeningChart.pdf
   Google Scholar
• Logan DE , CarpinoEA , ChiangGet.al A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin. J. Pain28(9), 766–774 (2012).
   PubMed Web of Science ®Google Scholar
• Eccleston C , MallesonPN , ClinchJ , ConnellH , SourbutC. Chronic pain in adolescents: evaluation of a programme of interdisciplinary cognitive behaviour therapy. Arch. Dis. Child.88(10), 881–885 (2003).
   PubMed Web of Science ®Google Scholar
• Maynard CS , AmariA , WieczorekB , ChristensenJR , SliferKJ. Interdisciplinary behavioral rehabilitation of pediatric pain-associated disability: retrospective review of an inpatient treatment protocol. J. Pediatr. Psychol.35(2), 128–137 (2010).
   PubMed Web of Science ®Google Scholar
• Palermo TM , ScherMS. Treatment of functional impairment in severe somatoform pain disorder: a case example. J. Pediatr. Psychol.26(7), 429–434 (2001).
   PubMed Web of Science ®Google Scholar
• Lynch-Jordan AM , SilS , PeughJ , CunninghamN , Kashikar-ZuckS , GoldschneiderKR. Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain. Pain155(10), 1955–1961 (2014).
   PubMed Web of Science ®Google Scholar
• Sherry DD , WallaceCA , KelleyC , KidderM , SappL. Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin. J. Pain15(3), 218–223 (1999).
   PubMed Web of Science ®Google Scholar
• Odell S , LoganDE. Pediatric pain management: the multidisciplinary approach. J. Pain Res.6, 785–790 (2013).
   PubMed Web of Science ®Google Scholar
• Lee BH , ScharffL , SethnaNFet.al Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J. Pediatr.141(1), 135–140 (2002).
   PubMed Web of Science ®Google Scholar
• Wilson AC , PalermoTM. Physical activity and function in adolescents with chronic pain: a controlled study using actigraphy. J. Pain13(2), 121–130 (2012).
   PubMed Web of Science ®Google Scholar
• Jerstad SJ , BoutelleKN , NessKK , SticeE. Prospective reciprocal relations between physical activity and depression in female adolescents. J. Consult. Clin. Psychol.78(2), 268–272 (2010).
   PubMed Web of Science ®Google Scholar
• Ramsey LH , KarlsonCW , CollierAB. Mirror therapy for phantom limb pain in a 7-year-old male with osteosarcoma. J. Pain Symptom Manage.53(6), e5–e7 (2017).
   PubMed Web of Science ®Google Scholar
• Hexem KR , MollenCJ , CarrollK , LanctotDA , FeudtnerC. How parents of children receiving pediatric palliative care use religion, spirituality, or life philosophy in tough times. J. Palliat. Med.14(1), 39–44 (2011).
   PubMed Web of Science ®Google Scholar
• Grossoehme DH , SzczesniakR , McPhailGL , SeidM. Is adolescents’ religious coping with cystic fibrosis associated with the rate of decline in pulmonary function? A preliminary study. J. Health Care Chaplain.19(1), 33–42 (2013).
   PubMedGoogle Scholar
• Reynolds N , MrugS , GuionK. Spiritual coping and psychosocial adjustment of adolescents with chronic illness: the role of cognitive attributions, age, and disease group. J. Adolesc. Health52(5), 559–565 (2013).
   PubMed Web of Science ®Google Scholar
• Sen IM , SenRK. Regional anesthesia for lower limb burn wound debridements. Arch. Trauma Res.1(3), 135–136 (2012).
   PubMedGoogle Scholar
• Cuignet O , MbuyambaJ , PirsonJ. The long-term analgesic efficacy of a single-shot fascia iliaca compartment block in burn patients undergoing skin-grafting procedures. J. Burn Care Rehabil.26(5), 409–415 (2005).
   PubMedGoogle Scholar
• Bussolin L , BusoniP , GiorgiL , CrescioliM , MesseriA. Tumescent local anesthesia for the surgical treatment of burns and postburn sequelae in pediatric patients. Anesthesiology99(6), 1371–1375 (2003).
   PubMed Web of Science ®Google Scholar
• Hernandez JL , SavetamalA , CrombieREet.al Use of continuous local anesthetic infusion in the management of postoperative split-thickness skin graft donor site pain. J. Burn Care Res.34(4), e257–e262 (2013).
   PubMed Web of Science ®Google Scholar
• Shank ES , MartynJA , DonelanMB , PerroneA , FirthPG , DriscollDN. Ultrasound-guided regional anesthesia for pediatric burn reconstructive surgery: a prospective study. J. Burn Care Res.37(3), e213–e217 (2016).
   PubMed Web of Science ®Google Scholar
• Cuignet O , PirsonJ , BoughrouphJ , DuvilleD. The efficacy of continuous fascia iliaca compartment block for pain management in burn patients undergoing skin grafting procedures. Anesth. Analg.98(4), 1077–1081 (2004).
   PubMed Web of Science ®Google Scholar
• Rork JF , BerdeCB , GoldsteinRD. Regional anesthesia approaches to pain management in pediatric palliative care: a review of current knowledge. J. Pain Symptom Manage.46(6), 859–873 (2013).
   PubMed Web of Science ®Google Scholar
• Burns DA . Using regional anesthesia to manage pediatric acute pain. Presented at: 10th Pediatric Pain Master’s Class.MN, USA, 11–17 June 2017.
   Google Scholar
• Friedrichsdorf SJ , EullD , WeidnerC , PostierA. A hospital-wide initiative to eliminate or reduce needle pain in children using lean methodology. Pain Rep.3(Suppl. 1), e671 (2018).
   PubMedGoogle Scholar
• Goubert L , FriedrichsdorfSJ. Factsheet pain in children: management. 2019 Global year against pain in the vulnerable (2019). http://s3.amazonaws.com/rdcms-iasp/files/production/public/2019GlobalYear/Fact_Sheets/7_Pain_children_management.pdf
   Google Scholar
• Postier AC , EullD , SchulzCet.al Pain experience in a US children’s hospital: a point prevalence survey undertaken after the implementation of a system-wide protocol to eliminate or decrease pain caused by needles. Hospital Pediatr.8(9), 515–523 (2018).
   PubMedGoogle Scholar
• Lunoe MM , DrendelAL , LevasMNet.al A randomized clinical trial of jet-injected lidocaine to reduce venipuncture pain for young children. Ann. Emerg. Med.66(5), 466–474 (2015).
   PubMed Web of Science ®Google Scholar
• Lunoe MM , DrendelAL , BrousseauDC. The use of the needle-free jet injection system with buffered lidocaine device does not change intravenous placement success in children in the emergency department. Acad. Emerg. Med.22(4), 447–451 (2015).
   PubMed Web of Science ®Google Scholar
• Stevens B , YamadaJ , OhlssonA , HaliburtonS , ShorkeyA. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst. Rev.2016(7), CD001069 (2016).
   Google Scholar
• Gao H , GaoH , XuGet.al Efficacy and safety of repeated oral sucrose for repeated procedural pain in neonates: a systematic review. Int. J. Nurs. Stud.62, 118–125 (2016).
   PubMed Web of Science ®Google Scholar
• Shah PS , HerbozoC , AliwalasLL , ShahVS. Breastfeeding or breast milk for procedural pain in neonates. Cochrane Database Syst. Rev.12, CD004950 (2012).
   PubMedGoogle Scholar
• CHEO’s Be Sweet to Babies research team and the University of Ottawa’s School of Nursing . Be Sweet to Babies. (2014). www.cheo.on.ca/en/BeSweet2Babies
   Google Scholar
• Karlson K , DarcyL , EnskärK. The use of restraint is never supportive (Poster). Presented at: Nordic Society of Pediatric Hematology/Oncology (NOPHO) 34th Annual Meeting 2016 and 11th Biannual Meeting of Nordic Society of Pediatric Oncology Nurses (NOBOS). Reykjavik, Iceland, 27–31 May, 2016.
   Google Scholar
• Uman LS , BirnieKA , NoelMet.al Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst. Rev.10, CD005179 (2013).
   Google Scholar