Analgesic Properties of Dexketoprofen Trometamol

• Hayball PJ , NationRL, BochnerF. Enantioselective pharmacodynamics of the nonsteroidal antiinflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity. Chirality4(8) , 484–487 (1992).
   PubMed Web of Science ®Google Scholar
• Hardikar MS . Chiral non-steroidal anti-inflammatory drugs – a review. J. Indian Med. Assoc.106(9) , 615–618, 622, 624 (2008).
   PubMedGoogle Scholar
• Cabre F , FernandezMF, CalvoL,Ferrer X, Garcia ML, Mauleon D.Analgesic, antiinflammatory, and antipyretic effects of S(+)-ketoprofen in vivo. J. Clin. Pharmacol.38(Suppl. 12) , 3S–10S(1998).
   Web of Science ®Google Scholar
• Mauleon D , ArtigasR, GarciaML, CarganicoG. Preclinical and clinical development of dexketoprofen. Drugs52(Suppl. 5) , 24–45 (1996).
   PubMed Web of Science ®Google Scholar
• Wechter WJ . Dexketoprofen trometamol. J. Clin. Pharmacol.38(Suppl. 12) , 1S–2S (1998).
   Web of Science ®Google Scholar
• Barbanoj MJ , GichI, ArtigasR et al. Pharmacokinetics of dexketoprofen trometamol in healthy volunteers after single and repeated oral doses. J. Clin. Pharmacol. 38(Suppl. 12) , 33S–40S (1998).
   Web of Science ®Google Scholar
• Sweetman BJ . Development and use of the quick acting chiral NSAID dexketoprofen trometamol (Keral). Acute Pain4(3) , 109–115 (2003).
   Google Scholar
• Valles J , ArtigasR, CreaA et al. Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods Find. Exp. Clin. Pharmacol. 28(Suppl. A) , 7–12 (2006).
   PubMedGoogle Scholar
• Zippel H , WagenitzA. Comparison of the efficacy and safety of intravenously administered dexketoprofen trometamol and ketoprofen in the management of pain after orthopaedic surgery: a multicentre, double-blind, randomised, parallel-group clinical trial. Clin. Drug Investig.26(9) , 517–528 (2006).
   PubMed Web of Science ®Google Scholar
• Rodriguez MJ , ArbosRM, AmaroSR. Dexketoprofen trometamol: clinical evidence supporting its role as a painkiller. Expert Rev. Neurother.8(11) , 1625–1640 (2008).
   PubMedGoogle Scholar
• Valles J , ArtigasR, BertolottiM et al. Single and repeated dose pharmacokinetics of dexketoprofen trometamol in young and elderly subjects. Methods Find. Exp. Clin. Pharmacol. 28(Suppl. A) , 13–19 (2006).
   PubMedGoogle Scholar
• McEwen J , De Luca M, Casini A et al. The effect of food and an antacid on the bioavailability of dexketoprofen trometamol. J. Clin. Pharmacol.38(Suppl. 12) , 41S–45S (1998).
   Web of Science ®Google Scholar
• Barbanoj MJ , AntonijoanRM, GichI. Clinical pharmacokinetics of dexketoprofen. Clin. Pharmacokinet.40(4) , 245–262 (2001).
   PubMed Web of Science ®Google Scholar
• Jamali F , BrocksDR. Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin. Pharmacokinet.19(3) , 197–217 (1990).
   PubMed Web of Science ®Google Scholar
• Martinez C , BlancoG, LaderoJM et al. Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use. Br. J. Pharmacol. 141(2) , 205–208 (2004).
   PubMed Web of Science ®Google Scholar
• Sweetman BJ . Development and use of the quick acting chiral NSAID dexketoprofen trometamol (Keral). Acute Pain4 , 109–115 (2003).
   Google Scholar
• Moore RA , BardenJ. Systematic review of dexketoprofen in acute and chronic pain. BMC Clin. Pharmacol.8 , 11 (2008).
   PubMedGoogle Scholar
• McGurk M , RobinsonP, RajayogeswaranV et al. Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain. J. Clin. Pharmacol. 38(Suppl. 12) , 46S–54S (1998).
   PubMed Web of Science ®Google Scholar
• Jackson ID , HeidemannBH, WilsonJ, PowerI, BrownRD. Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry. Br. J. Anaesth.92(5) , 675–680 (2004).
   PubMed Web of Science ®Google Scholar
• Jimenez-Martinez E , Gasco-GarciaC, Arrieta-BlancoJJ, Gomez del Torno J, Bartolome Villar B. Study of the analgesic efficacy of dexketoprofen trometamol25mg. vs. ibuprofen 600 mg. after their administration in patients subjected tooral surgery. Med. Oral9(2) , 138–143 (2004).
   Google Scholar
• Barden J , DerryS, McQuayHJ,Moore RA. Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. Cochrane Database Syst. Rev.4 , CD007355 (2009).
   Google Scholar
• Hanna MH , ElliottKM,Stuart-Taylor ME, Roberts DR, Buggy D, Arthurs GJ. Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery. Br J. Clin. Pharmacol.55(2) , 126–133 (2003).
   PubMed Web of Science ®Google Scholar
• Yazar MA , InanN, CeyhanA, SutE, DikmenB. Postoperative analgesic efficacy of intravenous dexketoprofen in lumbar disc surgery. J. Neurosurg. Anesthesiol.23(3) , 193–197 (2011).
   PubMed Web of Science ®Google Scholar
• Jamdade PT , PorwalA, ShindeJV et al. Efficacy and tolerability of intramuscular dexketoprofen in postoperative pain management following hernia repairsurgery. Anesthesiol. Res. Pract. 2011 , 579038 (2011).
   PubMedGoogle Scholar
• Zippel H , WagenitzA. A multicentre, randomised, double-blind study comparing the efficacy and tolerability of intramuscular dexketoprofen versus diclofenac in the symptomatic treatment of acute low back pain. Clin. Drug Investig.27(8) , 533–543 (2007).
   PubMed Web of Science ®Google Scholar
• Sanchez-Carpena J , Dominguez-HervellaF, GarciaI et al. Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. Eur J. Clin. Pharmacol. 63(8) , 751–760 (2007).
   PubMed Web of Science ®Google Scholar
• Sanchez-Carpena J , Sesma-SanchezJ, Sanchez-JuanC et al. Comparison of dexketoprofen trometamol and dipyrone in the treatment of renal colic. Clin. Drug Investig. 139–152 (2003).
   PubMed Web of Science ®Google Scholar
• Tokgoz H , YurtluS, HanciV et al. Comparison of the analgesic effects of dexketoprofen and diclofenac during shockwave lithotripsy: a randomized, double-blind clinical trial. J. Endourol. 24(6) , 1031–1035 (2010).
   PubMed Web of Science ®Google Scholar
• Ezcurdia M , CortejosoFJ, LanzónR et al. Comparison of the efficacy and tolerability of dexketoprofen and ketoprofen in the treatment of primary dysmenorrhea. J. Clin. Pharmacol. 38(Suppl. 12) , 65S–73S (1998).
   Web of Science ®Google Scholar
• Balani M , GawadeP, MaheshgauriS, GholeS, ShindeV, SatheV. Results of two multicentric, comparative, randomized, parallel group clinical trials to evaluate the efficacy and safety of dexketoprofen trometamol in the treatment of dental pain and dysmenorrhoea in Indian patients. J. Clin. Diagn. Res.2(5) , 1086–1091 (2008).
   Google Scholar
• Api O , ErgenB, ApiM, UgurelV, EmeksizMB, UnalO. Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial. Am. J. Obstet. Gynecol.203(1) , e21–e27 (2010).
   Google Scholar
• Mercorio F , De Simone R, Landi P, Sarchianaki A, Tessitore G, Nappi C. Oral dexketoprofen for pain treatment during diagnostic hysteroscopy in postmenopausal women. Maturitas43(4) , 277–281 (2002).
   PubMed Web of Science ®Google Scholar
• Beltran J , Martin-MolaE, FigueroaM et al. Comparison of dexketoprofen trometamol and ketoprofen in the treatment of osteoarthritis of the knee. J. Clin. Pharmacol. 38(Suppl. 12) , 74S–80S (1998).
   PubMed Web of Science ®Google Scholar
• Marenco JL , PerezM, NavarroFJ et al. A multicentre, randomised, double-blind study to compare the efficacy and tolerability of dexketoprofen trometamol versus diclofenac in the symptomatic treatment of knee osteoarthritis. Clin. Drug Investig. 19 , 247–256 (2000).
   Web of Science ®Google Scholar
• Rodriguez MJ , ContrerasD, GalvezR et al. Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. Pain 104(1–2) , 103–110 (2003).
   PubMed Web of Science ®Google Scholar
• Laporte JR , IbanezL, VidalX, VendrellL, LeoneR. Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents. Drug Saf.27(6) , 411–420 (2004).
   PubMed Web of Science ®Google Scholar
• Trelle S , ReichenbachS, WandelS et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 342 , c7086 (2011).
   PubMed Web of Science ®Google Scholar
• Ritter JM , HardingI, WarrenJB. Precaution, cyclooxygenase inhibition, and cardiovascular risk. Trends Pharmacol. Sci.30(10) , 503–508 (2009).
   PubMed Web of Science ®Google Scholar
• Carne X , RiosJ, TorresF. Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. Methods Find. Exp. Clin. Pharmacol.31(8) , 533–540 (2009).
   PubMedGoogle Scholar
• Asensio T , SanchisME, SanchezP, VegaJM, GarciaJC. Photocontact dermatitis because of oral dexketoprofen. Contact Dermatitis58(1) , 59–60 (2008).
   PubMed Web of Science ®Google Scholar
• Goday-Bujan JJ , Rodriguez-LozanoJ, Martinez-GonzalezMC, FonsecaE. Photoallergic contact dermatitis from dexketoprofen: study of 6 cases. Contact Dermatitis55(1) , 59–61 (2006).
   PubMed Web of Science ®Google Scholar
• Zabala S , CalpeMJ, PerezG, LerinFJ, MouronvalL. Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in a previously healthy 35-year-old woman. J. Clin. Pharm. Ther.33(1) , 79–81 (2008).
   PubMed Web of Science ®Google Scholar
• Jacqz-Aigrain E , SerreauR, BoissinotC et al. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther. Drug Monit. 29(6) , 815–818 (2007).
   PubMed Web of Science ®Google Scholar
• Valles J , ArtigasR, BertolottiM et al. Single and repeated dose pharmacokinetics of dexketoprofen trometamol in patients with impaired liver function. Methods Find. Exp. Clin. Pharmacol. 28(Suppl. A) , 29–36 (2006).
   PubMedGoogle Scholar
• Valles J , ArtigasR, MasM et al. Pharmacokinetics of dexketoprofen trometamol in subjects with mild and moderate chronic renal insufficiency. Methods Find. Exp. Clin. Pharmacol. 28(Suppl. A) , 21–28 (2006).
   PubMedGoogle Scholar

▪ Websites

• The electronic Medicines Compendium – Keral (2011) www.medicines.org.uk/EMC/medicine/17099/SPC/Keral/#POSOLOGY
   Google Scholar
• Oxford league table of analgesics in acute pain www.medicine.ox.ac.uk/bandolier/booth/painpag/Acutrev/Analgesics/Leagtab.html
   Google Scholar