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Review

Safety and Efficacy of Intrathecal Drug Delivery for Pain

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Pages 55-61 | Published online: 21 Dec 2011

References

  • Wang JK , NaussLA, ThomasJE. Pain relief by intrathecally applied morphine in man. Anesthesiology50(2) , 149–151 (1979).
  • Deer T , KramesES, HassenbuschSJ et al. Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation 10(4) , 300–328 (2007).
  • Coffey RJ , OwensML, BrosteSK et al. Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain. Anesthesiology 111(4) , 881–891 (2009).
  • Coffey RJ , OwensML, BrosteSK et al. Medical practice perspective: identification and mitigation of risk factors for mortality associated with intrathecal opioids for non-cancer pain. Pain Med. 11(7) , 1001–1009 (2010).
  • Hassenbusch S . Current practices in intraspinal therapy – a survey of clinical trends and decision making. J. Pain Symptom Manage.20 , S4–S11 (2000).
  • Brill S , GurmanGM, FisherA. A history of neuraxial administration of local analgesics and opioids. Eur. J. Anaesthesiol.20 , 682–689 (2003).
  • Winkelmüller M , WinkelmüllerW. Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. J. Neurosurg.85(3) , 458–467 (1996).
  • Yaksh T , HassenbuschS, BurchielK. Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med.3 , 300–312 (2002).
  • Deer TR , KramesE, LevyRM, HassenbuschSJ, PragerJP. Practice choices and challenges in the current intrathecal therapy environment: an online survey. Pain Med.10(2) , 304–309 (2009).
  • Atli A , TheodoreB, TurkD. Intrathecal opioid therapy for chronic nonmalignant pain: a retrospective cohort study with 3-year follow-up. Pain Med.11(7) , 1010–1016 (2010).
  • Coffey RJ , BurchielK. Inflammatory mass lesions associated with intrathecal drug infusion catheters: report and observations on 41 patients. Neurosurgery50(1) , 78–86; discussion 86–87 (2002).
  • Duarte RV , RaphaelJH, SouthallJL, BakerC, Hanu-CernatD. Intrathecal inflammatory masses: is the yearly opioid dose increase an early indicator? Neuromodulation13 , 109–113 (2009).
  • Yaksh TL , HoraisKA, TozierNA et al. Chronically infused intrathecal morphine in dogs. Anesthesiology 99(1) , 174–187 (2003).
  • Toombs JD , FollettKA, RosenquistRW, BentonLM. Intrathecal catheter tip inflammatory mass: a failure of clonidine to protect. Anesthesiology102(3) , 687–690 (2005).
  • Murakami M , NakagawasaiO, SuzukiT et al. Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 1024(1–2) , 122–129 (2004).
  • Wallace MS . Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain. Exp. Rev. Neurother.6(10) , 1423–1428 (2006).
  • Rauck RL , WallaceMS, LeongMS et al. A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J. Pain Symptom Manage. 31(5) , 393–406 (2006).
  • Wermeling DP . Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain. Pharmacotherapy25(8) , 1084–1094 (2005).
  • Coffey RJ , CahillD, SteersW et al. Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. J. Neurosurg. 78 , 226–232 (1993).
  • Coffey RJ , EdgarTS, FranciscoGE et al. Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome. Arch. Phys. Med. Rehabil. 83 , 735–741 (2002).
  • Lind G , SchechtmannG, WinterJ, MeyersonBA, LinderothB. Baclofen-enhanced spinal cord stimulation and intrathecal baclofen alone for neuropathic pain: long-term outcome of a pilot study. Eur. J. Pain12 , 132–136 (2008).
  • Wallace MS , KosekPS, StaatsP, FisherR, SchultzDM, LeongM. Phase 2, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain. Pain Med.9(3) , 271–281 (2008).
  • Webster LR , FakataKL, CharapataS, FisherR, MineHartM. Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain. Pain Med.9(3) , 282–290 (2008).
  • Prialt®, package insert. Azur Pharma, PA, USA.
  • Follett KA , NaumannCP. A prospective study of catheter-related complications of intrathecal drug delivery systems. J. Pain Symptom Manage.19(3) , 209–215 (2000).
  • Lew SM , PsatyEL, AbbottR. An unusual cause of overdose after baclofen pump implantation: case report. Neurosurgery56(3) , E624; discussion E624 (2005).
  • Dvorak EM , McGuireJR, NelsonME. Incidence and identification of intrathecal baclofen catheter malfunction. PM R2(8) , 751–756 (2010).
  • Albrecht E , DurrerA, ChédelD, MaederP, BuchserE. Intraparenchymal migration of an intrathecal catheter three years after implantation. Pain118(1–2) , 274–278 (2005).
  • Ko WM , FerranteFM. New onset lumbar radicular pain after implantation of an intrathecal drug delivery system: imaging catheter migration. Reg. Anesth. Pain Med.31(4) , 363–367 (2006).
  • Vaidyanathan S , SoniBM, OoT et al. Bladder stones – red herring for resurgence of spasticity in a spinal cord injury patient with implantation of medtronic SynchroMed pump for intrathecal delivery. BMC Urol. 3(1) , 3 (2003).
  • Wörner J , KothbauerK, GerberH. Intrathecal morphine pump malfunction due to leakage at the catheter connection site: a rare problem and its prevention. Anesth. Analg.108(6) , 1994–1995; discussion 1995 (2009).
  • Maugans TA . Intracranial migration of a fractured intrathecal catheter from a baclofen pump system: case report and analysis of possible causes. Neurosurgery66(2) , 319–322 (2010).
  • Fukuhara T , TanakaT, NambaY, KuyamaH. Tangled catheter as a rare cause of baclofen pump malfunction. Surg. Neurol.72(1) , 80–82 (2009).
  • Johnson ML , VisserEJ, GouckeCR. Massive clonidine overdose during refill of an implanted drug delivery device for intrathecal analgesia: a review of inadvertent soft-tissue injection during implantable drug delivery device refills and its management. Pain Med.12(7) , 1032–1040 (2011).
  • Frye CB , VanceMA. Hypertensive crisis and myocardial infarction following massive clonidine overdose. Ann. Pharmacother.34(5) , 611–615 (2000).
  • Gofeld M , McQueenCK. Ultrasound-guided intrathecal pump access and prevention of the pocket fill. Pain Med.12(4) , 607–611 (2011).
  • Larson EF , WallaceMS. Current developments in intraspinal agents for cancer and noncancer pain. Curr. Pain Headache Rep.14 , 8–16 (2010).
  • Sgouros S , CharalambidesC, MatsotaP, TsangarisI, KostopanagiotouG. Malfunction of SynchroMed 2 baclofen pump delivers a near-lethal baclofen overdose. Pediatr. Neurosurg.46(1) , 62–65 (2010).
  • Rigoli G , TerriniG, CordioliZ. Intrathecal baclofen withdrawal syndrome caused by low residual volume in the pump reservoir: a report of 2 cases. Arch. Phys. Med. Rehabil.85(12) , 2064–2066 (2004).
  • Smith TJ , StaatsPS, DeerT et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J. Clin. Oncol. 20(19) , 4040–4049 (2002).
  • Smith TJ , CoynePJ. Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patients. J. Palliat. Med.8(4) , 736–742 (2005).
  • Smith TJ , CoynePJ, StaatsPS et al. An implantable drug delivery system (IDDS) for refractory cancer pain provides sustained pain control, less drug-related toxicity, and possibly better survival compared with comprehensive medical management (CMM). Ann. Oncol. 16(5) , 825–833 (2005).
  • Patel VB , ManchikantiL, SinghV, SchultzDM, HayekSM, SmithHS. Systematic review of intrathecal infusion systems for long-term management of chronic non-cancer pain. Pain Physician12(2) , 345–360 (2009).
  • Auld AW , Maki-JokelaA, MurdochDM. Intraspinal narcotic analgesia in the treatment of chronic pain. Spine10(8) , 777–781 (1985).
  • Paice JA , PennRD, ShottS. Intraspinal morphine for chronic pain: a retrospective, multicenter study. J. Pain Symptom Manage.11(2) , 71–80 (1996).
  • Kumar K , KellyM, PirlotT. Continuous intrathecal morphine treatment for chronic pain of nonmalignant etiology: long-term benefits and efficacy. Surg. Neurol.55(2) , 79–86; discussion 86–88 (2001).
  • Staats PS , YearwoodT, CharapataSG et al. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291(1) , 63–70 (2004).

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