Management of Adult Patients with Long-Standing Complex Regional Pain Syndrome

• Veldman PH , ReynenHM, ArntzIE, GorisRJ. Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet342(8878) , 1012–1016 (1993).
   PubMed Web of Science ®Google Scholar
• Goebel A . Complex regional pain syndrome in adults. Rheumatology (Oxford)50(10) , 1739–1750 (2011).
   PubMed Web of Science ®Google Scholar
• de Mos M , HuygenFJ, van der Hoeven-Borgman M, Dieleman JP, Ch Stricker BH, Sturkenboom MC. Outcome of the complex regional pain syndrome. Clin. J. Pain25(7) , 590–597 (2009).
   PubMed Web of Science ®Google Scholar
• Kemler MA , FurneeCA. Economic evaluation of spinal cord stimulation for chronic reflex sympathetic dystrophy. Neurology59(8) , 1203–1209 (2002).
   PubMed Web of Science ®Google Scholar
• Demos M , De Bruijn AG, Huygen FJ, Dieleman JP, Stricker BH, Sturkenboom MC. The incidence of complex regional pain syndrome: a population-based study. Pain129(1–2) , 12–20 (2007).
   PubMed Web of Science ®Google Scholar
• Harden RN , BruehlS, Stanton-HicksM, WilsonPR. Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med.8(4) , 326–331 (2007).
   PubMed Web of Science ®Google Scholar
• Moon JY , ParkSY, KimYC et al. Analysis of patterns of three-phase bone scintigraphy for patients with complex regional pain syndrome diagnosed using the proposed research criteria (the ‘Budapest criteria‘). Br. J. Anaesth. 108(4) , 655–661 (2012).
   PubMed Web of Science ®Google Scholar
• Birklein F . Complex regional pain syndrome. J. Neurol.252(2) , 131–138 (2005).
   PubMed Web of Science ®Google Scholar
• Placzek JD , BoyerMI, GelbermanRH, SoppB, GoldfarbCA. Nerve decompression for complex regional pain syndrome type II following upper extremity surgery. J. Hand Surg. Am.30(1) , 69–74 (2005).
   PubMedGoogle Scholar
• Zollinger PE , TuinebreijerWE, KreisRW, BreederveldRS. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet354 , 2025–2028 (1999).
   PubMed Web of Science ®Google Scholar
• Veldman PH , GorisRJ. Surgery on extremities with reflex sympathetic dystrophy. Unfallchirurg98 , 45–48 (1995).
   PubMed Web of Science ®Google Scholar
• Van Der Laan L , VeldmanPH, GorisRJ. Severe complications of reflex sympathetic dystrophy: infection, ulcers, chronic edema, dystonia, and myoclonus. Arch. Phys. Med. Rehabil.79(4) , 424–429 (1998).
   PubMed Web of Science ®Google Scholar
• Turner-Stokes L , GoebelA. Complex regional pain syndrome: concise guidance. Clin. Med.11(6) , 596–600 (2011).
   PubMed Web of Science ®Google Scholar
• Oerlemans HM , OostendorpRA, de Boo T, Goris RJ. Pain and reduced mobility in complex regional pain syndrome I: outcome of a prospective randomised controlled clinical trial of adjuvant physical therapy versus occupational therapy. Pain83(1) , 77–83 (1999).
   PubMed Web of Science ®Google Scholar
• McCabe CS , HaighRC, BlakeDR. Mirror visual feedback for the treatment of complex regional pain syndrome (type 1). Curr. Pain Headache Rep.12(2) , 103–107 (2008).
   PubMed Web of Science ®Google Scholar
• Moseley GL . Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial. Pain108(1–2) , 192–198 (2004).
   PubMed Web of Science ®Google Scholar
• Daly AE , BialocerkowskiAE. Does evidence support physiotherapy management of adult complex regional pain syndrome type one? A systematic review. Eur. J. Pain13(4) , 339–353 (2008).
   PubMed Web of Science ®Google Scholar
• Johnson S , HallJ, BarnettS et al. Using graded motor imagery for complex regional pain syndrome in clinical practice: failure to improve pain. Eur. J. Pain 16(4) , 550–561 (2012).
   PubMed Web of Science ®Google Scholar
• Beerthuizen A , StronksDL, HuygenFJ, PasschierJ, KleinJ, SpijkerAV. The association between psychological factors and the development of complex regional pain syndrome type 1 (CRPS1) – a prospective multicenter study. Eur. J. Pain15(9) , 971–975 (2011).
   PubMed Web of Science ®Google Scholar
• de Mos M , HuygenFJ, DielemanJP, KoopmanJS, StrickerBH, SturkenboomMC. Medical history and the onset of complex regional pain syndrome (CRPS). Pain139(2) , 458–466 (2008).
   PubMed Web of Science ®Google Scholar
• Morley S , EcclestonC, WilliamsA. Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache. Pain80(1–2) , 1–13 (1999).
   PubMed Web of Science ®Google Scholar
• Kemler MA , BarendseGA, van Kleef M et al. Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. N. Engl. J. Med.343(9) , 618–624 (2000).
   PubMed Web of Science ®Google Scholar
• Dworkin RH , O‘ConnorAB, BackonjaM et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132(3) , 237–251 (2007).
   PubMed Web of Science ®Google Scholar
• Brunner F , SchmidA, KisslingR, HeldU, BachmannLM. Biphosphonates for the therapy of complex regional pain syndrome I – systematic review. Eur. J. Pain13(1) , 17–21 (2009).
   PubMed Web of Science ®Google Scholar
• Christensen K , JensenEM, NoerI. The reflex dystrophy syndrome response to treatment with systemic corticosteroids. Acta Chir. Scand.148(8) , 653–655 (1982).
   PubMedGoogle Scholar
• Perez RS , ZuurmondWW, BezemerPD et al. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 102(3) , 297–307 (2003).
   PubMed Web of Science ®Google Scholar
• Turner JA , LoeserJD, DeyoRA, SandersSB. Spinal cord stimulation for patients with failed back surgery syndrome or complex regional pain syndrome: a systematic review of effectiveness and complications. Pain108(1–2) , 137–147 (2004).
   PubMed Web of Science ®Google Scholar
• Kemler MA , de Vet HC, Barendse GA, van den Wildenberg FA, van Kleef M. Effect of spinal cord stimulation for chronic complex regional pain syndrome Type I: five-year final follow-up of patients in a randomized controlled trial. J. Neurosurg.108(2) , 292–298 (2008).
   PubMed Web of Science ®Google Scholar
• Schattschneider J , BinderA, SiebrechtD, WasnerG, BaronR. Complex regional pain syndromes: the influence of cutaneous and deep somatic sympathetic innervation on pain. Clin. J. Pain22(3) , 240–244 (2006).
   PubMed Web of Science ®Google Scholar
• Carroll I , ClarkJD, MackeyS. Sympathetic block with botulinum toxin to treat complex regional pain syndrome. Ann. Neurol.65(3) , 348–351 (2009).
   PubMed Web of Science ®Google Scholar
• Mailis A , FurlanA. Sympathectomy for neuropathic pain. Cochrane Database Syst. Rev. (2) , CD002918 (2003).
   PubMedGoogle Scholar
• Sigtermans MJ , van Hilten JJ, Bauer MC et al. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain145(3) , 304–311 (2009).
   PubMed Web of Science ®Google Scholar
• Schwartzman RJ , AlexanderGM, GrothusenJR, PaylorT, ReichenbergerE, PerreaultM. Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study. Pain147(1–3) , 107–115 (2009).
   PubMed Web of Science ®Google Scholar
• Perez RS , PragtE, GeurtsJ, ZuurmondWW, PatijnJ, van Kleef M. Treatment of patients with complex regional pain syndrome type I with mannitol: a prospective, randomized, placebo-controlled, double-blinded study. J. Pain9(8) , 678–686 (2008).
   PubMed Web of Science ®Google Scholar
• Munts AG , van der Plas AA, Ferrari MD, Teepe-Twiss IM, Marinus J, van Hilten JJ. Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome. Eur. J. Pain14(5) , 523–528 (2010).
   PubMed Web of Science ®Google Scholar
• Cossins L , OkellRW, SimpsonB, CameronH, PooleH, GoebelA. Treatment of complex regional pain syndrome in adults: a systematic review of randomised controlled trials published from June 2000 to February 2012. Eur. J. Pain17(2) , 158–173 (2013).
   PubMed Web of Science ®Google Scholar
• Rauck RL , EisenachJC, JacksonK, YoungLD, SouthernJ. Epidural clonidine treatment for refractory reflex sympathetic dystrophy. Anesthesiology79(6) , 1163–1169 (1993).
   PubMed Web of Science ®Google Scholar
• Forouzanfar T , KokeAJ, van Kleef M, Weber WE. Treatment of complex regional pain syndrome type I. Eur. J. Pain6(2) , 105–122 (2002).
   PubMed Web of Science ®Google Scholar
• Tran de QH , DuongS, BertiniP, FinlaysonRJ. Treatment of complex regional pain syndrome: a review of the evidence. Can. J. Anaesth.57(2) , 149–166 (2010).
   PubMed Web of Science ®Google Scholar
• Li WW , GuoTZ, LiXQ, KingeryWS, ClarkJD. Fracture induces keratinocyte activation, proliferation, and expression of pro-nociceptive inflammatory mediators. Pain151(3) , 843–852 (2010).
   PubMed Web of Science ®Google Scholar
• Leis S , WeberM, SchmelzM, BirkleinF. Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome. Neurosci. Lett.359(3) , 163–166 (2004).
   PubMed Web of Science ®Google Scholar
• Birklein F , SchmelzM, SchifterS, WeberM. The important role of neuropeptides in complex regional pain syndrome. Neurology57(12) , 2179–2184 (2001).
   PubMed Web of Science ®Google Scholar
• de Mos M , HuygenFJ, StrickerBH, DielemanJP, SturkenboomMC. The association between ACE inhibitors and the complex regional pain syndrome: suggestions for a neuro-inflammatory pathogenesis of CRPS. Pain142(3) , 218–224 (2009).
   PubMed Web of Science ®Google Scholar
• Huygen FJ , De Bruijn AG, De Bruin MT, Groeneweg JG, Klein J, Zijistra FJ. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators. Inflamm.11(1) , 47–51 (2002).
   PubMed Web of Science ®Google Scholar
• Huygen FJ , RamdhaniN, VanTA, KleinJ, ZijlstraFJ. Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1. Immunol. Lett.91(2–3) , 147–154 (2004).
   PubMed Web of Science ®Google Scholar
• Munnikes RJ , MuisC, BoersmaM, Heijmans-AntonissenC, ZijlstraFJ, HuygenFJ. Intermediate stage complex regional pain syndrome type 1 is unrelated to proinflammatory cytokines. Mediators. Inflamm.2005(6) , 366–372 (2005).
   PubMedGoogle Scholar
• Kohr D , SinghP, TschernatschM et al. Autoimmunity against the beta(2) adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain 152(12) , 2690–2700 (2011).
   PubMed Web of Science ®Google Scholar
• Blaes F , SchmitzK, TschernatschM et al. Autoimmune etiology of complex regional pain syndrome (M. Sudeck). Neurology 63(9) , 1734–1736 (2004).
   PubMed Web of Science ®Google Scholar
• Goebel A , VogelH, CanerisO et al. Immune responses to Campylobacter and serum autoantibodies in patients with complex regional pain syndrome. J. Neuroimmunol. 162(1–2) , 184–189 (2005).
   PubMed Web of Science ®Google Scholar
• Goebel A , StockM, DeaconR, SprotteG, VincentA. Intravenous immunoglobulin response and evidence for pathogenic antibodies in a case of complex regional pain syndrome 1. Ann. Neurol.57(3) , 463–464 (2005).
   PubMed Web of Science ®Google Scholar
• Goebel A , LeiteMI, YangL et al. The passive transfer of immunoglobulin G serum antibodies from patients with longstanding complex regional pain syndrome. Eur. J. Pain 15(5) , 504 e1–e6 (2011).
   Web of Science ®Google Scholar
• Goebel A , NetalS, SchedelR, SprotteG. Human pooled immunoglobulin in the treatment of chronic pain syndromes. Pain Med.3(2) , 119–127 (2002).
   PubMed Web of Science ®Google Scholar
• Goebel A , BaranowskiAP, MaurerK, GhiaiA, MccabeC, AmblerG. Intravenous immunoglobulin treatment of complex regional pain syndrome: a randomized trial. Ann. Intern. Med.152(3) , 152–158 (2010).
   PubMed Web of Science ®Google Scholar
• Steinman L . Inverse vaccination, the opposite of Jenner‘s concept, for therapy of autoimmunity. J. Intern. Med.267(5) , 441–451 (2010).
   PubMed Web of Science ®Google Scholar
• Goebel A , BlaesF. Complex regional pain syndrome, prototype of a novel kind of autoimmune disease. Autoimmun. Rev. doi:10.1016/j.autrev.2012.10.015 (2012) (Epub ahead of print).
   PubMedGoogle Scholar
• Goebel A , DutoitN, PerezJ, HuygenF. Anesthesiologists‘ views on using immune modulating drugs in pain medicine. Pain Pract.11(4) , 344–352 (2011).
   PubMed Web of Science ®Google Scholar

▪ Websites

• Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin. www.nice.org.uk/nicemedia/live/12082/42367/42367.pdf
   Google Scholar
• Department of Health. Shifting care closer to home demonstration sites – report of the speciality subgroups. www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_079728
   Google Scholar
• Complex regional pain syndrome in adults: UK guidelines for diagnosis, referral and management in primary and secondary care. www.rcplondon.ac.uk/sites/default/files/documents/complex-regional-pain-full-guideline.pdf
   Google Scholar