Spinal Cord Injury-Induced Pain: Mechanisms and Treatments

References

• Bryce TN , Biering-SorensenF , FinnerupNBet al. International spinal cord injury pain classification: Part I. Background and description . Spinal Cord50 ( 6 ), 413 – 417 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Siddall PJ , McclellandJM , RutkowskiSB , CousinsMJ . A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury . Pain103 , 249 – 257 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Michailidou C , MarstonL , De SouzaLH , SutherlandI . A systematic review of the prevalence of musculoskeletal pain, back and low back pain in people with spinal cord injury . Disabil. Rehabil.36 ( 9 ), 705 – 715 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Wasner G , LeeBB , EngelS , MclachlanE . Residual spinothalamic tract pathways predict development of central pain after spinal cord injury . Brain131 ( 9 ), 2387 – 2400 ( 2008 ).
   PubMedGoogle Scholar
• Loeser JD , WardAA , WhiteLE . Chronic deafferentation of human spinal cord neurons . J. Neurosurg.29 , 48 – 50 ( 1968 ).
   PubMed Web of Science ®Google Scholar
• Vierck CJ , SiddallPJ , YezierskiRP . Pain following spinal cord injury: animal models and mechanistic studies . Pain89 , 1 – 5 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Hao JX , XuXJ , YuYX , SeigerA , Wiesenfeld-HallinZ . Transient spinal cord ischaemia induces temporary hypersensitivity of dorsal horn wide dynamic range neurons to myelinated, but not unmyelinated, fiber input . J. Neurophysiol.68 , 384 – 391 ( 1992 ).
   PubMed Web of Science ®Google Scholar
• Yezierski RP , ParkSH . The mechanosensitivity of spinal sensory neurons following intraspinal injections of quisqualic acid in the rat . Neurosci. Lett.157 , 115 – 119 ( 1993 ).
   PubMed Web of Science ®Google Scholar
• Christensen MD , EverhartAW , PickelmanJT , HulseboschCE . Mechanical and thermal allodynia in chronic central pain following spinal cord injury . Pain68 , 97 – 107 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Yezierski RP . Pathophysiology and animal models of spinal cord injury pain . In : Spinal Cord Injury Pain: Assessment, Mechanisms, Management. Progress in Pain Research and Management (Volume 23) . YezierskiRP , BurchielKJ ( Eds ). IASP Press , Seattle, WA, USA , 117 – 136 ( 2002 ).
   Google Scholar
• Finnerup NB , JensenTS . Spinal cord injury pain mechanisms and treatment . Eur. J. Neurol.11 , 73 – 82 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Hulsebosch CE , HainsBC , CrownED , CarltonSM . Mechanisms of chronic central neuropathic pain after spinal cord injury . Brain Res. Rev.60 ( 1 ), 202 – 213 ( 2009 ).
   PubMedGoogle Scholar
• Albu S , Gómez-SorianoJ , Avila-MartinG , TaylorJ . Deficient conditioned pain modulation after spinal cord injury correlates with clinical spontaneous pain measures . Pain156 ( 2 ), 260 – 272 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Telles SC , AlvesRC , ChadiG . Periodic limb movements during sleep and restless legs syndrome in patients with ASIA A spinal cord injury . J. Neurol. Sci.303 ( 1–2 ), 119 – 123 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gerke MB , DugganAW , XuL , SiddallPJ . Thalamic neuronal activity in rats with mechanical allodynia following contusive spinal cord injury . Neuroscience117 , 715 – 722 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Radhakrishnan V , TsoukatosJ , DavisKD , TaskerRR , LozanoAM , DostrovskyJO . A comparison of the burst activity of lateral thalamic neurons in chronic pain and non-pain patients . Pain80 , 567 – 575 ( 1999 ).
   PubMed Web of Science ®Google Scholar
• Hains BC , SaabCY , WaxmanSG . Changes in electrophysiological properties and sodium channel Na(v)1.3 expression in thalamic neurons after spinal cord injury . Brain128 , 2359 – 2371 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Knerlich-Lukoschus F , NoackM , Von Der Ropp-BrennerB , LuciusR , MehdornHM , Held-FeindtJ . Spinal cord injuries induce changes in CB1 cannabinoid receptor and C-C chemokine expression in brain areas underlying circuitry of chronic pain conditions . J. Neurotrauma28 ( 4 ), 619 – 634 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Pattany PM , YezierskiRP , Widerström-NogaEGet al. Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury . Am. J. Neuroradiol.23 , 901 – 905 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Gustin SM , WrigleyPJ , YoussefAMet al. Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury . Pain155 ( 5 ), 1027 – 1036 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Gustin SM , WrigleyPJ , SiddallPJ , HendersonLA . Brain anatomy changes associated with persistent neuropathic pain following spinal cord injury . Cereb. Cortex20 ( 6 ), 1409 – 1419 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Wrigley PJ , PressSR , GustinSMet al. Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury . Pain141 ( 1–2 ), 52 – 59 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Carlton SM , DuJ , TanHYet al. Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury . Pain147 ( 1–3 ), 265 – 276 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Finnerup NB , JohannesenIL , Fuglsang-FrederiksenA , BachFW , JensenTS . Sensory function in spinal cord injury patients with and without central pain . Brain126 , 57 – 70 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Finnerup NB , GyldenstedC , NielsenE , KristensenAD , BachFW , JensenTS . MRI in chronic spinal cord injury patients with and without central pain . Neurology61 , 1569 – 1575 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Cardenas DD , JensenMP . Treatments for chronic pain in persons with spinal cord injury: a survey study . J. Spinal Cord Med.29 ( 2 ), 109 – 117 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Murphy D , ReidDB . Pain treatment satisfaction in spinal cord injury . Spinal Cord39 , 44 – 46 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Norrbrink Budh C , LundebergT . Non-pharmacological pain-relieving therapies in individuals with spinal cord injury: a patient perspective . Complement. Ther. Med.12 , 189 – 197 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Siddall PJ , MiddletonJW . A proposed algorithm for the management of pain following spinal cord injury . Spinal Cord44 , 67 – 77 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Siddall PJ , MiddletonJW . Pain following spinal cord injury . In : ISCoS Textbook on Comprehensive Management of Spinal Cord Injuries . ChhabraHS ( Ed. ). Wolters Kluwer , New Delhi, India , 825 – 848 ( 2015 ).
   Google Scholar
• Kahan M , Mailis-GagnonA , WilsonL , SrivastavaA . Canadian guideline for safe and effective use of opioids for chronic noncancer pain . Can. Fam. Physician57 ( 11 ), 1257 – 1266 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Hsieh JTC , WolfeDL , TownsonAFet al. Spasticity following spinal cord injury . In : Spinal Cord Injury Rehabilitation Evidence (Version 3.0) . EngJJ , TeasellRW , MillerWCet al. Eds ). The SCIRE Project , Vancouver, BC, Canada ( 2010 ).
   Google Scholar
• Latimer AE , GinisKA , HicksAL , MccartneyN . An examination of the mechanisms of exercise-induced change in psychological well-being among people with spinal cord injury . J. Rehabil. Res. Dev.41 ( 5 ), 643 – 652 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Nawoczenski DA , Ritter-SoronenJM , WilsonCM , HoweBA , LudewigPM . Clinical trial of exercise for shoulder pain in chronic spinal injury . Phys. Ther.86 ( 12 ), 1604 – 1618 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Taricco M , PagliacciMC , TelaroE , AdoneR . Pharmacological interventions for spasticity following spinal cord injury: results of a cochrane systematic review . Eura Medicophys.42 ( 1 ), 5 – 15 ( 2006 ).
   PubMedGoogle Scholar
• Finnerup NB , YezierskiRP , SangCN , BurchielKJ , JensenTS . Treatment of spinal cord injury pain . Pain Clin. Updates9 , 1 – 6 ( 2001 ).
   Google Scholar
• Snedecor SJ , SudharshanL , CappelleriJCet al. Systematic review and comparison of pharmacologic therapies for neuropathic pain associated with spinal cord injury . J. Pain Res.6 , 539 – 547 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Guy S , MehtaS , LeffL , TeasellR , LohE . Anticonvulsant medication use for the management of pain following spinal cord injury: systematic review and effectiveness analysis . Spinal Cord52 ( 2 ), 89 – 96 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Dworkin RH , O’ConnorAB , BackonjaMet al. Pharmacologic management of neuropathic pain: evidence-based recommendations . Pain132 ( 3 ), 237 – 251 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Moulin DE , ClarkAJ , GilronIet al. Pharmacological management of chronic neuropathic pain – consensus statement and guidelines from the Canadian pain society . Pain Res. Manag.12 ( 1 ), 13 – 21 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Attal N , MazaltarineG , Perrouin-VerbeB , AlbertT . Chronic neuropathic pain management in spinal cord injury patients. What is the efficacy of pharmacological treatments with a general mode of administration? (oral, transdermal, intravenous) . Ann. Phys. Rehabil. Med52 ( 2 ), 124 – 141 ( 2009 ).
   PubMedGoogle Scholar
• Levendoglu F , OgunCO , OzerbilO , OgunTC , UgurluH . Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury . Spine29 , 743 – 751 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Tai Q , KirshblumS , ChenB , MillisS , JohnstonM , DelisaJA . Gabapentin in the treatment of neuropathic pain after spinal cord injury: a prospective, randomized, double-blind, crossover trial . J. Spinal Cord Med.25 , 100 – 105 ( 2002 ).
   PubMedGoogle Scholar
• Putzke JD , RichardsJS , KezarL , HickenBL , NessTJ . Long-term use of gabapentin for treatment of pain after traumatic spinal cord injury . Clin. J. Pain18 , 116 – 121 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Cardenas DD , NieshoffEC , SudaKet al. A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury . Neurology80 ( 6 ), 533 – 539 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Siddall PJ , CousinsMJ , OtteA , GriesingT , ChambersR , MurphyTK . Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial . Neurology67 ( 10 ), 1792 – 1800 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Vranken JH , DijkgraafMGW , KruisMR , Van Der VegtMH , HollmannMW , HeesenM . Pregabalin in patients with central neuropathic pain: a randomized, double-blind, placebo-controlled trial of a flexible-dose regimen . Pain136 ( 1,2 ), 150 – 157 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Drewes AM , AndreasenA , PoulsenLH . Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study . Paraplegia32 , 565 – 569 ( 1994 ).
   PubMedGoogle Scholar
• Erzurumlu A , DursunH , GunduzS . The management of chronic pain in spinal cord injured patients. The comparison of effectiveness of amitriptyline and carbamazepine combination and electroacupuncture application . J. Rheumatol. Med. Rehabil.7 , 176 – 180 ( 1996 ).
   Google Scholar
• Finnerup NB , SindrupSH , FlemmingWB , JohannesenIL , JensenTS . Lamotrigine in spinal cord injury pain: a randomized controlled trial . Pain96 , 375 – 383 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Finnerup NB , GrydehojJ , BingJet al. Levetiracetam in spinal cord injury pain: a randomized controlled trial . Spinal Cord47 ( 12 ), 861 – 867 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Harden RN , BrenmanE , SaltzS , HouleTT . Topiramate in the management of spinal cord injury pain: a double-blind, randomized, placebo-controlled pilot study . In : Spinal Cord Injury Pain: Assessment, Mechanisms, Management. Progress in Pain Research and Management (Volume 23) . YezierskiRP , BurchielKJ ( Eds ). IASP Press , Seattle, WA, USA , 393 – 407 ( 2002 ).
   Google Scholar
• Cardenas DD , WarmsCA , TurnerJA , MarshallH , BrookeMM , LoeserJD . Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial . Pain96 , 365 – 373 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Rintala DH , HolmesSA , CourtadeD , FiessRN , TastardLV , LoubserPG . Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury . Arch. Phys. Med. Rehabil.88 ( 12 ), 1547 – 1560 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Vranken JH , HollmannMW , Van Der VegtMHet al. Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial . Pain152 ( 2 ), 267 – 273 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Gilron I , BaileyJM , TuD , HoldenRR , JacksonAC , HouldenRL . Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial . Lancet374 ( 9697 ), 1252 – 1261 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Attal N , GuirimandF , BrasseurL , GaudeV , ChauvinM , BouhassiraD . Effects of iv morphine in central pain – a randomized placebo-controlled study . Neurology58 , 554 – 563 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Eide PK , StubhaugA , StenehjemAE . Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation . Neurosurgery37 , 1080 – 1087 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Norrbrink C , LundebergT . Tramadol in neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled trial . Clin. J. Pain25 ( 3 ), 177 – 184 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Attal N , Gaud‚V , BrasseurLet al. Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study . Neurology54 , 564 – 574 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Finnerup NB , Biering-SorensenF , JohannesenILet al. Intravenous lidocaine relieves spinal cord injury pain: a randomized controlled trial . Anesthesiology102 , 1023 – 1030 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Kvarnstrom A , KarlstenR , QuidingH , GordhT . The analgesic effect of intravenous ketamine and lidocaine on pain after spinal cord injury . Acta Anaesthesiol. Scand.48 , 498 – 506 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Chiou Tan FY , TuelSM , JohnsonJC , PriebeMM , HirshDD , StrayerJR . Effect of mexiletine on spinal cord injury dysesthetic pain . Am. J. Phys. Med. Rehabil.75 , 84 – 87 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Canavero S , BonicalziV . Intravenous subhypnotic propofol in central pain: a double-blind, placebo-controlled, crossover study . Clin. Neuropharmacol.27 , 182 – 186 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Hama A , SagenJ . Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain . Brain Res.1412 , 44 – 54 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Rintala DHP , FiessRN , TanGP , HolmesSaMD , BruelBMMD . Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study . Am. J. Phys. Med. Rehabil.89 ( 10 ), 840 – 848 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Middleton JW , SiddallPJ , WalkerS , MolloyAR , RutkowskiSB . Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study . Arch. Phys. Med. Rehabil.77 , 824 – 826 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Siddall PJ , MolloyAR , WalkerS , MatherLe , RutkowskiSB , CousinsMJ . The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury . Anesth. Analg.91 ( 6 ), 1493 – 1498 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Loubser PG , AkmanNM . Effects of intrathecal baclofen on chronic spinal cord injury pain . J. Pain Symptom Manage.12 ( 4 ), 241 – 247 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Saulino M , BurtonAW , DanyoDA , FrostS , GlanzerJ , SolankiDR . Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports . Eur. J. Phys. Rehabil. Med.45 ( 1 ), 61 – 67 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Saulino M . Successful reduction of neuropathic pain associated with spinal cord injury via of a combination of intrathecal hydromorphone and ziconotide: a case report . Spinal Cord45 ( 11 ), 749 – 752 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Norrbrink C . Transcutaneous electrical nerve stimulation for treatment of spinal cord injury neuropathic pain . J. Rehabil. Res. Dev.46 ( 1 ), 85 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Nayak S , ShiflettSC , SchoenbergerNEet al. Is acupuncture effective in treating chronic pain after spinal cord injury? Arch. Phys. Med. Rehabil. 82 , 1578 – 1586 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Rapson LM , WellsN , PepperJ , MajidN , BoonH . Acupuncture as a promising treatment for below-level central neuropathic pain: a retrospective study . J. Spinal Cord Med.26 , 21 – 26 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Lagauche D , FacioneJ , AlbertT , FattalC . The chronic neuropathic pain of spinal cord injury: which efficiency of neuropathic stimulation?Ann. Phys. Rehabil. Med52 ( 2 ), 180 – 187 ( 2009 ).
   PubMedGoogle Scholar
• Defrin R , GrunhausL , ZamirD , ZeiligG . The effect of a series of repetitive transcranial magnetic stimulations of the motor cortex on central pain after spinal cord injury . Arch. Phys. Med. Rehabil.88 ( 12 ), 1574 – 1580 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Fregni F , BoggioPS , LimaMCet al. A sham-controlled, Phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury . Pain122 ( 1–2 ), 197 – 209 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Wrigley PJ , GustinSM , McindoeLN , ChakiathRJ , HendersonLA , SiddallPJ . Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: a randomized controlled trial . Pain154 ( 10 ), 2178 – 2184 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Soler MD , KumruH , PelayoRet al. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury . Brain133 ( 9 ), 2565 – 2567 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Kumru H , SolerD , VidalJet al. The effects of transcranial direct current stimulation with visual illusion in neuropathic pain due to spinal cord injury: an evoked potentials and quantitative thermal testing study . Eur. J. Pain17 ( 1 ), 55 – 66 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Boldt I , Eriks-HooglandI , BrinkhofMW , De BieR , JoggiD , Von ElmE . Non-pharmacological interventions for chronic pain in people with spinal cord injury . Cochrane Database Syst. Rev.11 , CD009177 ( 2014 ).
   Google Scholar
• Sindou M , MertensP , WaelM . Microsurgical drezotomy for pain due to spinal cord and/or cauda equina injuries: long-term results in a series of 44 patients . Pain92 , 159 – 171 ( 2001 ).
   PubMed Web of Science ®Google Scholar
• Falci S , BestL , BaylesR , LammertseD , StarnesC . Dorsal root entry zone microcoagulation for spinal cord injury-related central pain: operative intramedullary electrophysiological guidance and clinical outcome . J. Neurosurg.97 , 193 – 200 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Cairns MD , AdkinsRH , ScottMD . Pain and depression in acute traumatic spinal cord injury – origins of chronic problematic pain . Arch. Phys. Med. Rehabil.77 ( 4 ), 329 – 335 ( 1996 ).
   PubMed Web of Science ®Google Scholar
• Wollaars MM , PostMWM , Van AsbeckFWA , BrandN . Spinal cord injury pain: the influence of psychologic factors and impact on quality of life . Clin. J. Pain23 ( 5 ), 383 – 391 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Craig A , TranY , SiddallPet al. Developing a model of associations between chronic pain, depressive mood, chronic fatigue, and self-efficacy in people with spinal cord injury . J. Pain ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Turner JA , JensenMP , WarmsCA , CardenasDD . Catastrophizing is associated with pain intensity, psychological distress, and pain-related disability among individuals with chronic pain after spinal cord injury . Pain98 , 127 – 134 ( 2002 ).
   PubMed Web of Science ®Google Scholar
• Middleton J , TranY , CraigA . Relationship between quality of life and self-efficacy in persons with spinal cord injuries . Arch. Phys. Med. Rehabil.88 ( 12 ), 1643 – 1648 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Widerstrom-Noga EG , FelixER , Cruz-AlmeidaY , TurkDC . Psychosocial subgroups in persons with spinal cord injuries and chronic pain . Arch. Phys. Med. Rehabil.88 ( 12 ), 1628 – 1635 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Norrbrink Budh C , KowalskiJ , LundebergT . A comprehensive pain management programme comprising educational, cognitive and behavioural interventions for neuropathic pain following spinal cord injury . J. Rehabil. Med.38 , 172 – 180 ( 2006 ).
   PubMed Web of Science ®Google Scholar
• Ehde DM , JensenMP , EngelJM , TurnerJA , HoffmanAJ , CardenasDD . Chronic pain secondary to disability: a review . Clin. J. Pain19 , 3 – 17 ( 2003 ).
   PubMed Web of Science ®Google Scholar
• Heutink M , PostMWM , Bongers-JanssenHMHet al. The CONECSI trial: results of a randomized controlled trial of a multidisciplinary cognitive behavioral program for coping with chronic neuropathic pain after spinal cord injury . Pain153 ( 1 ), 120 – 128 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Nicholson Perry K , NicholasMK , MiddletonJW . Comparison of a pain management program with usual care in a pain management center for people with spinal cord injury-related chronic pain . Clin. J. Pain26 ( 3 ), 206 – 216 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Heutink M , PostMW , LuthartPet al. Long-term outcomes of a multidisciplinary cognitive behavioural programme for coping with chronic neuropathic spinal cord injury pain . J. Rehabil. Med.46 ( 6 ), 540 – 545 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Jensen MP , BarberJ , RomanoJMet al. Effects of self-hypnosis training and EMG biofeedback relaxation training on chronic pain in persons with spinal-cord injury . Int. J. Clin. Exp. Hypnosis57 ( 3 ), 239 – 268 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Moseley GL . Using visual illusion to reduce at-level neuropathic pain in paraplegia . Pain130 ( 3 ), 294 – 298 ( 2007 ).
   PubMed Web of Science ®Google Scholar
• Gustin SM , WrigleyPJ , GandeviaSC , MiddletonJW , HendersonLA , SiddallPJ . Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury . Pain137 ( 2 ), 237 – 244 ( 2008 ).
   PubMed Web of Science ®Google Scholar
• Detloff MR , SmithEJ , Quiros MolinaD , GanzerPD , HouleJD . Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) C-fibers after spinal cord injury . Exp. Neurol.255 , 38 – 48 ( 2014 ).
   PubMed Web of Science ®Google Scholar
• Dugan EA , SagenJ . An intensive locomotor training paradigm improves neuropathic pain following spinal cord compression injury in rats . J. Neurotrauma32 ( 9 ), 622 – 632 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Lindberg T , ArndtA , NorrbrinkC , WahmanK , BjerkeforsA . Effects of seated double-poling ergometer training on aerobic and mechanical power in individuals with spinal cord injury . J. Rehabil. Med.44 ( 10 ), 893 – 898 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Hama A , SagenJ . Antinociceptive effects of the marine snail peptides conantoking and conotoxin MVIIA alone and in combination in rat models of pain . Neuropharmacology56 ( 2 ), 556 – 563 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Winquist RJ , PanJQ , GribkoffVK . Use-dependent blockade of Cav2.2 voltage-gated calcium channels for neuropathic pain . Biochem. Pharmacol.70 ( 4 ), 489 – 499 ( 2005 ).
   PubMed Web of Science ®Google Scholar
• Kerr CE , WassermanRH , MooreCI . Cortical dynamics as a therapeutic mechanism for touch healing . J. Altern. Complement. Med.13 ( 1 ), 59 – 66 ( 2007 ).
   PubMed Web of Science ®Google Scholar