207
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Tolerability of the COX-1/COX-2 Inhibitor Lornoxicam in the Treatment of Acute and Rheumatic Pain

, &
Pages 445-454 | Received 25 Jun 2015, Accepted 16 Feb 2016, Published online: 18 Apr 2016

References

  • Rostom A , MuirK , DubéCet al. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review . Clin. Gastroenterol. Hepatol.5 ( 7 ), 818 – 828 ( 2007 ).
  • Scott PA , KingsleyGH , SmithCM , ChoyEH , ScottDL . Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomized controlled trials . Ann. Rheum. Dis.66 ( 10 ), 1296 – 1304 ( 2007 ).
  • McGettigan P , HenryD . Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2 . JAMA296 ( 13 ), 1633 – 1644 ( 2006 ).
  • Bhala N , EmbersonJ , MerhiAet al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials . Lancet382 ( 9894 ), 769 – 779 ( 2013 ).
  • Massó González EL , PatrignaniP , TacconelliS , García RodríguezLA . Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding . Arthritis Rheum.62 ( 6 ), 1592 – 15601 ( 2010 ).
  • Castellsague J , Riera-GuardiaN , CalingaertBet al. Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project) . Drug Saf.35 ( 12 ), 1127 – 1146 ( 2012 ).
  • Bernstein RM , FrenzelW . A comparative study of 2 dosage regimens of lornoxicam and a standard dosage of naproxen in patients with rheumatoid arthritis . Eur. J. Clin. Res.7 , 259 – 273 ( 1995 ).
  • Kidd B , FrenzelW . A multicenter, randomized, double blind study comparing lornoxicam with diclofenac in osteoarthritis . J. Rheumatol.23 ( 9 ), 1605 – 1611 ( 1996 ).
  • Yakhno N , GuekhtA , SkorometsAet al. Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium: randomised, double-blind trial in acute low back pain . Clin. Drug Invest.26 ( 5 ), 267 – 277 ( 2006 ).
  • Hernández-Díaz S , RodríguezLA . Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s . Arch. Intern. Med.160 ( 14 ), 2093 – 2099 ( 2000 ).
  • Yuhara H , CorleyDA , NakaharaFet al. Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis . J. Gastroenterol.49 ( 6 ), 992 – 1000 ( 2014 ).
  • Rostom A , MuirK , DubeC , LanasA , JolicoeurE , TugwellP . Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors . Drug Healthc. Patient Saf.1 , 47 – 71 ( 2009 ).
  • Moore RA , DerryS , PhillipsCJ , McQuayH . Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice . BMC Musculoskelet. Disord.7 , 79 ( 2006 ).
  • Van der Linden MW , GaugrisS , KuipersEJ , Van den BemtBJ , van Herk-SukelMP , HeringsRM . Gastroprotection among new chronic users of non-steroidal anti-inflammatory drugs: a study of utilization and adherence in The Netherlands . Curr. Med. Res. Opin.25 ( 1 ), 195 – 204 ( 2009 ).
  • van Soest EM , ValkhoffVE , MazzagliaGet al. Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases . Gut60 ( 12 ), 1650 – 1659 ( 2011 ).
  • EMA . Assessment report for non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular risk . EMA , London , 2012 . www.ema.europa.eu/docs/en_GB/document_library/Report/2012/11/WC500134717.pdf .
  • Kearney PM , BaigentC , GodwinJ , HallsH , EmbersonJR , PatronoC . Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials . BMJ332 ( 7553 ), 1302 – 1308 ( 2006 ).
  • Sostres C , GargalloCJ , LanasA . Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage . Arthritis Res. Ther.15 ( Suppl. 3 ), S3 ( 2013 ).
  • García Rodríguez LA , Barreales TolosaL . Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population . Gastroenterology132 ( 2 ), 498 – 506 ( 2007 ).
  • Adams SS . Non-steroidal anti-inflammatory drugs, plasma half-lives, and adverse reactions . Lancet2 ( 8569 ), 1204 – 1205 ( 1987 ).
  • Aabakken L , OsnesM , FrenzelW . Gastrointestinal tolerability of lornoxicam compared to that of naproxen in healthy male volunteers . Aliment. Pharmacol. Ther.10 ( 2 ), 151 – 156 ( 1996 ).
  • Berg J , FellierH , ChristophT , GrarupJ , StimmederD . The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro . Inflamm. Res.48 ( 7 ), 369 – 379 ( 1999 ).
  • Warrington SJ , DebbasNM , FarthingMet al. Lornoxicam, indomethacin and placebo: comparison of effects on faecal blood loss and upper gastrointestinal endoscopic appearances in healthy men . Postgrad. Med. J.66 ( 778 ), 622 – 626 ( 1990 ).
  • Mallen SR , EssexMN , ZhangR . Gastrointestinal tolerability of NSAIDs in elderly patients: a pooled analysis of 21 randomized clinical trials with celecoxib and nonselective NSAIDs . Curr. Med. Res. Opin.27 ( 7 ), 1359 – 1366 ( 2011 ).
  • de Groot NL , HagenaarsMP , SmeetsHM , SteyerbergEW , SiersemaPD , van OijenMG . Primary non-variceal upper gastrointestinal bleeding in NSAID and low-dose aspirin users: development and validation of risk scores for either medication in two large Dutch cohorts . J. Gastroenterol.49 ( 2 ), 245 – 253 ( 2014 ).
  • Henry D , DobsonA , TurnerC . Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs . Gastroenterology105 ( 4 ), 1078 – 1088 ( 1993 ).
  • Neutel CI , MaxwellCJ , AppelWC . Differences between males and females in risk of NSAID-related severe gastrointestinal events . Pharmacoepidemiol. Drug Saf.8 ( 7 ), 501 – 507 ( 1999 ).
  • Song F , ParekhS , HooperLet al. Dissemination and publication of research findings: an updated review of related biases . Health Technol. Assess.14 ( 8 ), 1 – 93 ( 2010 ).
  • Rawal N , Kr⊘nerK , Simin-GeertsenM , HejlC , LikarR . Safety of lornoxicam in the treatment of postoperative pain: a post-marketing study of analgesic regimens containing lornoxicam compared with standard analgesic treatment in 3752 day-case surgery patients . Clin. Drug Invest.30 ( 10 ), 687 – 697 ( 2010 ).
  • Lustenberger FD , GrätzKW , MutzbauerTS . Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study . Oral Maxillofac. Surg.15 ( 1 ), 57 – 62 ( 2011 ).
  • Pektas ZO , SenerM , BayramBet al. A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study . Int. J. Oral Maxillofac. Surg.36 ( 2 ), 123 – 127 ( 2007 ).
  • Tuzuner Oncul AM , YaziciogluD , AlanogluZ , DemiralpS , OzturkA , UcokC . Postoperative analgesia in impacted third molar surgery: the role of preoperative diclofenac sodium, paracetamol and lornoxicam . Med. Princ. Pract.20 ( 5 ), 470 – 476 ( 2011 ).
  • Jacobson E , AssarehH , CannerfeltR , RenströmP , JakobssonJ . Pain after elective arthroscopy of the knee: a prospective, randomised, study comparing conventional NSAID to coxib . Knee Surg. Sports Traumatol. Arthrosc.14 ( 11 ), 1166 – 1170 ( 2006 ).
  • Sener M , YilmazerC , YilmazIet al. Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone . J. Clin. Anesth.20 ( 2 ), 103 – 108 ( 2008 ).
  • Kouroukli I , ZompolasV , TsekouraVet al. Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy: a prospective randomized, placebo-controlled trial . J. Anaesthesiol. Clin. Pharmacol.29 ( 4 ), 485 – 490 ( 2013 ).
  • Cevik E , CinarO , SalmanNet al. Comparing the efficacy of intravenous tenoxicam, lornoxicam, and dexketoprofen trometamol for the treatment of renal colic . Am. J. Emerg. Med.30 ( 8 ), 1486 – 1490 ( 2012 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.