Responsible Innovation in Stem Cell Research: Using Responsibility as a Strategy

References

• MacPherson A , KimmelmanJ. Ethical development of stem-cell-based interventions. Nat. Med.25(7), 1037–1044 (2019).
   PubMed Web of Science ®Google Scholar
• King NM , PerrinJ. Ethical issues in stem cell research and therapy. Stem Cell Res. Ther.5(4), 1–6 (2014).
   Google Scholar
• Assen LS , JongsmaKR , IsasiR , TryfonidouMA , BredenoordAL. Recognizing the ethical implications of stem cell research: a call for broadening the scope. Stem Cell Rep.16(7), 1656–1661 (2021).
   PubMed Web of Science ®Google Scholar
• Cyranoski D . Woo Suk Hwang convicted but not of fraud. Nature461(7268), 1181 (2009).
   PubMed Web of Science ®Google Scholar
• Cyranoski D . Stem-cell scientist found guilty of misconduct. Nature doi:10.1038/nature.2014.14974 (2014).
   Google Scholar
• Reardon S . US government halts heart stem-cell study. Nature doi:10.1038/d41586-018-07232-0 (2018).
   Google Scholar
• Day M . Disgraced tracheal transplant surgeon is handed 16month prison sentence in Italy. Br. Med. J.367, l6676 (2019).
   PubMedGoogle Scholar
• von Schomberg R . A vision of responsible research and innovation. In: Responsible Innovation: Managing the Responsible Emergence of Science and Innovation in Society.OwenR, BessantJ, HeintzM ( Eds). Wiley, London, UK, 51–74 (2013).
   Google Scholar
• Sipp D . Challenges in the regulation of autologous stem cell interventions in the United States. Perspect. Biol. Med.61(1), 25–41 (2018).
   PubMed Web of Science ®Google Scholar
• Sipp D , Sleeboom-FaulknerM. Downgrading of regulation in regenerative medicine. Science365(6454), 644–646 (2019).
   PubMed Web of Science ®Google Scholar
• International Society for Stem Cell Research (ISSCR) . Guidelines for Stem Cell Research and Clinical Translation.Society for Stem Cell Research (ISSCR), Skokie, Illinois, IL, USA (2021).
   Google Scholar
• Lee TL , LysaghtT , LipworthWet al. Regulating the stem cell industry: needs and responsibilities. Bull. World Health Organ.95(9), 663 (2017).
   PubMed Web of Science ®Google Scholar
• European Research Council . https://erc.europa.eu/managing-your-project/ethics
   Google Scholar
• Davis M . “Ain’t no one here but us social forces”: constructing the professional responsibility of engineers. Sc. Eng. Ethics18(1), 13–34 (2010).
   PubMed Web of Science ®Google Scholar
• Van de Poel I , SandM. Varieties of responsibility: two problems of responsible innovation. Synthese198(S19), 4769–4787 (2021).
   Google Scholar
• Coeckelbergh M . Regulation or responsibility? Autonomy, moral imagination, and engineering. Sci. Technol. Human Values31(3), 237–260 (2006).
   Web of Science ®Google Scholar
• Pellé S , ReberB. Responsible innovation in the light of moral responsibility. J. Chain Netw. Sci.15(2), 107–117 (2015).
   Google Scholar
• Douglas HE . The moral responsibilities of scientists (tensions between autonomy and responsibility). Am. Philos. Q.40(1), 59–68 (2003).
   Web of Science ®Google Scholar
• Daley GQ , HyunI , ApperleyJFet al. Setting global standards for stem cell research and clinical translation: the 2016 ISSCR guidelines. Stem Cell Rep.6(6), 787–797 (2016).
   PubMed Web of Science ®Google Scholar
• Gosselin RD . Insufficient transparency of statistical reporting in preclinical research: a scoping review. Sci. Rep.11(1), 1–8 (2021).
   PubMed Web of Science ®Google Scholar
• Percie du Sert N , HurstV , AhluwaliaAet al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J. Cereb. Blood Flow Metab.40(9), 1769–1777 (2020).
   PubMed Web of Science ®Google Scholar
• Orr JE , OrrK. Restoring honor and integrity through integrating restorative practices in academic integrity with student leaders. J. Acad. Ethics doi:10.1007/s10805-021-09437-x (2021).
   Web of Science ®Google Scholar
• Van de Poel I . The relation between forward-looking and backward-looking responsibility. In:Moral Responsibility.VincentN, vande Poel I, vanden Hoven J ( Eds). Springer, Dordrecht, Berlin, Germany, 37–52 (2011).
   Google Scholar
• Glerup C , HorstM. Mapping ‘social responsibility’ in science. J. Responsible Innov.1(1), 31–50 (2014).
   Google Scholar
• Grinbaum A , GrovesC. What is “responsible” about responsible innovation? Understanding the ethical issues. In: Responsible Innovation: Managing the Responsible Emergence of Science and Innovation in Society.OwenR, BessantJ, HeintzM ( Eds). Wiley, London, UK, 119–142 (2013).
   Google Scholar
• Banks C , MetzM , SmythDS. The Sustainability Challenges Facing Research and Teaching Laboratories When Going Green, Environment: Science and Policy for Sustainable Development. Environ. Sci. Policy Sustain. Dev.62(2), 4–13 (2020).
   Google Scholar
• Kaplowitz MD , ThorpL , ColemanK , YeboahFK. Energy conservation attitudes, knowledge, and behaviors in science laboratories. Energy Policy50, 581–591 (2012).
   Web of Science ®Google Scholar
• Greenlabs-nl . ( n.d.). www.greenlabs-nl.eu/
   Google Scholar
• Harvard University . ( n.d.). https://green.harvard.edu/programs/green-labs/lab-reuse-and-recycling
   Google Scholar
• Labconscious . ( n.d.). www.labconscious.com
   Google Scholar
• Giesbertz NA , van HartenWH , BredenoordAL. A duty to recontact in genetics: context matters. Nat. Rev. Genet.20(7), 371–372 (2019).
   PubMed Web of Science ®Google Scholar
• van der Burg S . Taking the “soft impacts” of technology into account: broadening the discourse in research practice. Soc. Epistemol.23(3-4), 301–316 (2009).
   Google Scholar
• Van Lente H , SwierstraT , JolyPB. Responsible innovation as a critique of technology assessment. J. Responsible Innov.4(2), 254–261 (2017).
   Web of Science ®Google Scholar
• Pennock RT , O’RourkeM. Developing a scientific virtue-based approach to science ethics training. Sci. Eng. Ethics23(1), 243–262 (2017).
   PubMed Web of Science ®Google Scholar
• Montmarquet JA . Epistemic virtue. Mind96(384), 482–497 (1987).
   Web of Science ®Google Scholar
• Goddiksen MP , GjerrisM. Teaching phronesis in a research integrity course. FACETS7(1), 139–152 (2022).
   Google Scholar
• Sand M , DuránJM , JongsmaKR. Responsibility beyond design: physicians’ requirements for ethical medical AI. Bioethics36(2), 162–169 (2022).
   PubMed Web of Science ®Google Scholar
• Reincke CM , BredenoordAL , van MilMH. From deficit to dialogue in science communication: the dialogue communication model requires additional roles from scientists. EMBO Rep.21(9). e51278 (2020).
   PubMed Web of Science ®Google Scholar
• Benjaminy S , LoC , IllesJ. Social responsibility in stem cell research – is the news all bad?. Stem Ccell Rev. Rep.12(3), 269–275 (2016).
   PubMed Web of Science ®Google Scholar
• Pennock RT . Fostering a culture of scientific integrity: legalistic vs. scientific virtue-based approaches. Prof. Ethics Rep.28(2), 1–3 (2015).
   Google Scholar
• Marchant GE . The growing gap between emerging technologies and the law. In: The Growing Gap between Emerging Technologies and Legal-Ethical Oversight.MarchantG, AllenbyB, HerkertJ ( Eds). Springer, Dordrecht, Berlin, Germany, 19–33 (2011).
   Google Scholar
• Mejlgaard N , BouterLM , GaskellGet al. Research integrity: nine ways to move from talk to walk. Nature586, 358–360 (2020).
   PubMed Web of Science ®Google Scholar
• Assen LS , JongsmaKR , IsasiR , TryfonidouMA , BredenoordAL. Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients. Regen. Med.17(7), 445–459 (2022).
   PubMed Web of Science ®Google Scholar
• Haven T , PasmanHR , WiddershovenG , BouterL , TijdinkJ. Researchers’ perceptions of a responsible research climate: a multi focus group study. Sci. Eng. Ethics26(6), 3017–3036 (2020).
   PubMed Web of Science ®Google Scholar
• Owen R , MacNaghtenP , StilgoeJ. Responsible research and innovation: from science in society to science for society, with society. Sci. Public Policy39, 751–760 (2012).
   Web of Science ®Google Scholar
• Rip A . The past and future of RRI. Life Sci. Soc. Policy10, 17 (2014).
   Google Scholar
• Nollkaemper A . The duality of shared responsibility. Contemp. Politics24(5), 524–544 (2018).
   Web of Science ®Google Scholar