1,169
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Altered hMSC Functional Characteristics in Short-Term Culture and when Placed in Low Oxygen Environments: Implications for Cell Retention at Physiologic Sites

, , , , &
Pages 153-165 | Published online: 22 Apr 2014

References

  • Madeira A , da Silva CL , dos Santos F , Camafeita E , Cabral JM , Sá-Correia I . Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomics . PLoS ONE 7 ( 8 ), e43523 ( 2012 ).
  • Lovell MJ , Mathur A . Cardiac stem cell therapy: progress from the bench to bedside . Heart 96 ( 19 ), 1531 – 1537 ( 2010 ).
  • Passier R , van Laake LW , Mummery CL . Stem-cell-based therapy and lessons from the heart . Nature 453 ( 7193 ), 322 – 329 ( 2008 ).
  • Li Y , Chopp M . Marrow stromal cell transplantation in stroke and traumatic brain injury . Neurosci. Lett. 456 ( 3 ), 120 – 123 ( 2009 ).
  • Sinden JD , Muir KW . Stem cells in stroke treatment: the promise and the challenges . Int. J. Stroke 7 ( 5 ), 426 – 434 ( 2012 ).
  • Placzek MR , Chung IM , Macedo HM et al. Stem cell bioprocessing: fundamentals and principles . J. R. Soc. Interface 6 ( 32 ), 209 – 232 ( 2009 ).
  • Carmen J , Burger SR , McCaman M , Rowley JA . Developing assays to address identity, potency, purity and safety: cell characterization in cell therapy process development . Regen. Med. 7 ( 1 ), 85 – 100 ( 2012 ).
  • Richardson JD , Nelson AJ , Zannettino AC , Gronthos S , Worthley SG , Psaltis PJ . Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells-taking the next step . Stem Cell Rev. 9 ( 3 ), 281 – 302 ( 2012 ).
  • Ghadge SK , Muhlstedt S , Ozcelik C , Bader M . SDF-1alpha as a therapeutic stem cell homing factor in myocardial infarction . Pharmacol. Ther. 129 ( 1 ), 97 – 108 ( 2011 ).
  • Abbott JD , Huang Y , Liu D , Hickey R , Krause DS , Giordano FJ . Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury . Circulation 110 ( 21 ), 3300 – 3305 ( 2004 ).
  • Askari AT , Unzek S , Popovic ZB et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy . Lancet 362 ( 9385 ), 697 – 703 ( 2003 ).
  • Cheng Z , Ou L , Zhou X et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance . Mol. Ther. 16 ( 3 ), 571 – 579 ( 2008 ).
  • Dong F , Harvey J , Finan A , Weber K , Agarwal U , Penn MS . Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction . Circulation 126 ( 3 ), 314 – 324 ( 2012 ).
  • Tang J , Wang J , Guo L et al. Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction . Mol. Cells 29 ( 1 ), 9 – 19 ( 2010 ).
  • Ryser MF , Ugarte F , Thieme S , Bornhauser M , Roesen-Wolff A , Brenner S . mRNA transfection of CXCR4–GFP fusion – simply generated by PCR-results in efficient migration of primary human mesenchymal stem cells . Tissue Eng. Part C Methods 14 ( 3 ), 179 – 184 ( 2008 ).
  • Pasha Z , Wang Y , Sheikh R , Zhang D , Zhao T , Ashraf M . Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium . Cardiovasc. Res. 77 ( 1 ), 134 – 142 ( 2008 ).
  • Zhang D , Fan GC , Zhou X et al. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium . J. Mol. Cell. Cardiol. 44 ( 2 ), 281 – 292 ( 2008 ).
  • Bertolo A , Mehr M , Janner-Jametti T et al. An in vitro expansion score for tissue-engineering applications with human bone marrow-derived mesenchymal stem cells . J. Tissue Eng. Regen. Med . doi:10.1002/term.1734 ( 2013 ) (Epub ahead of print) .
  • Mondragon-Teran P , Lye GJ , Veraitch FS . Lowering oxygen tension enhances the differentiation of mouse embryonic stem cells into neuronal cells . Biotechnol. Prog. 25 ( 5 ), 1480 – 1488 ( 2009 ).
  • Lu X , Dunn J , Dickinson AM , Gillespie JI , Baudouin SV . Smooth muscle alpha-actin expression in endothelial cells derived from CD34+ human cord blood cells . Stem Cells Dev. 13 ( 5 ), 521 – 527 ( 2004 ).
  • Knowlton AA , Connelly CM , Romo GM , Mamuya W , Apstein CS , Brecher P . Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion . J. Clin. Invest. 89 ( 4 ), 1060 – 1068 ( 1992 ).
  • Zhuang Y , Chen X , Xu M , Zhang LY , Xiang F . Chemokine stromal cell-derived factor 1/CXCL12 increases homing of mesenchymal stem cells to injured myocardium and neovascularization following myocardial infarction . Chin. Med. J. (Engl.) 122 ( 2 ), 183 – 187 ( 2009 ).
  • Suzuki K , Murtuza B , Beauchamp JR et al. Role of interleukin-1beta in acute inflammation and graft death after cell transplantation to the heart . Circulation 110 ( 11 Suppl. 1 ), II219 – II224 ( 2004 ).
  • Wall IB , Moseley R , Baird DM et al. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers . J. Invest. Dermatol. 128 ( 10 ), 2526 – 2540 ( 2008 ).
  • Ip JE , Wu Y , Huang J , Zhang L , Pratt RE , Dzau VJ . Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment . Mol. Biol. Cell 18 ( 8 ), 2873 – 2882 ( 2007 ).
  • Brenner S , Whiting-Theobald N , Kawai T et al. CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells . Stem Cells 22 ( 7 ), 1128 – 1133 ( 2004 ).
  • Wynn RF , Hart CA , Corradi-Perini C et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow . Blood 104 ( 9 ), 2643 – 2645 ( 2004 ).
  • Kaiser R , Friedrich D , Chavakis E , Bohm M , Friedrich EB . Effect of hypoxia on integrin-mediated adhesion of endothelial progenitor cells . J. Cell. Mol. Res. 16 ( 10 ), 2387 – 2393 ( 2012 ).
  • Penn MS . Importance of the SDF-1:CXCR4 axis in myocardial repair . Circ. Res. 104 ( 10 ), 1133 – 1135 ( 2009 ).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.