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Original Articles

Analysis of the fitness effect of compensatory mutations

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Pages 47-54 | Received 05 Jun 2008, Published online: 07 Sep 2010

References

  • Burch , CL and Chao , L . 1999 . “Evolution by small steps and rugged landscapes in the RNA virus phi6.” . Genetics , 151 : 921 – 927 .
  • Crow , JF and Kimura , M . 1970 . An Introduction to Population Genetics Theory , New York : Harper & Row .
  • Davies , EK , Peters , AD and Keightley , PD . 1999 . “High frequency of cryptic deleterious mutations in Caenorhabditis elegans.” . Science , 285 : 1748 – 1751 .
  • Estes , S , Phillips , PC , Denver , DR , Thomas , WK and Lynch , M . 2004 . “Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans.” . Genetics , 166 : 1269 – 1279 .
  • Eyre‐Walker , A , Woolfit , M and Phelps , T . 2006 . “The distribution of fitness effects of new deleterious amino acid mutations in humans.” . Genetics , 173 : 891 – 900 .
  • Fares , MA , Ruiz‐Gonzalez , MX , Moya , A , Elena , SF and Barrio , E . 2002 . “Endosymbiotic bacteria: groEL buffers against deleterious mutations.” . Nature London , 417 : 398
  • Frankham , R . 1995 . “Effective population size/adult population size ratios in wildlife: a review.” . Genet. Res. , 66 : 95 – 106 .
  • Keightley , PD . 1994 . “The distribution of mutation effects on viability in Drosophila melanogaster.” . Genetics , 138 : 1315 – 1322 .
  • Kelley , SO , Steinberg , SV and Schimmel , P . 2000 . “Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility.” . Nat. Struct. Biol. , 7 : 862 – 865 .
  • Kimura , M . 1968 . “Evolutionary rate at the molecular level.” . Nature London , 217 : 624 – 626 .
  • Lande , R . 1998 . “Risk of population extinction from fixation of deleterious and reverse mutations.” . Genetics , 102–103 : 21 – 27 .
  • Lynch , M , Burger , R , Butcher , D and Gabriel , W . 1993 . “The mutational meltdown in asexual populations.” . J. Hered , 84 : 339 – 344 .
  • Nielsen , R and Yang , Z . 2003 . “Estimating the distribution of selection coefficients from phylogenetic data with applications to mitochondrial and viral DNA.” . Mol. Biol. Evol. , 20 : 1231 – 1239 .
  • Palstra , FP and Ruzzante , DE . 2008 . “Genetic estimates of contemporary effective population size: what can they tell us about the importance of genetic stochasticity for wild population persistence?” . Mol. Ecol. , 17 : 3428 – 3447 .
  • Piganeau , G and Eyre‐Walker , A . 2003 . “Estimating the distribution of fitness effects from DNA sequence data: implications for the molecular clock.” . Proc. Natl. Acad. Sci. U.S.A. , 100 : 10335 – 10340 .
  • Poon , A and Chao , L . 2005 . “The rate of compensatory mutation in the DNA bacteriophage phiX174.” . Genetics , 170 : 989 – 999 .
  • Poon , A and Otto , SP . 2000 . “Compensating for our load of mutations: freezing the meltdown of small populations.” . Evolution Int. J. Org. Evolution. , 54 : 1467 – 1479 .
  • Poon , A and Chao , L . 2006 . “Functional origins of fitness effect‐sizes of compensatory mutations in the DNA bacteriophage phiX174.” . Evolution , 60 : 2032 – 2043 .
  • Sanjuan , R , Moya , A and Elena , SF . 2004 . “The distribution of fitness effects caused by single‐nucleotide substitutions in an RNA virus.” . Proc. Natl. Acad. Sci. U.S.A. , 101 : 8396 – 8401 .
  • Vassilieva , LL , Hook , AM and Lynch , M . 2000 . “The fitness effects of spontaneous mutations in Caenorhabditis elegans.” . Evolution Int. J. Org. Evolution. , 54 : 1234 – 1246 .
  • Whitlock , MC . 2000 . “Fixation of new alleles and the extinction of small populations: drift load, beneficial alleles, and sexual selection.” . Evolution Int. J. Org. Evolution. , 54 : 1855 – 1861 .
  • Wilke , CO , Lenski , RE and Adami , C . 2003 . “Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding.” . BMC Evol. Biol. , 3 : 3
  • Wright , S . 1931 . “Evolution in Mendelian populations.” . Genetics , 16 : 97 – 159 .
  • Yampolsky , LY , Kondrashov , FA and Kondrashov , AS . 2005 . “Distribution of the strength of selection against amino acid replacements in human proteins.” . Hum. Mol. Genet. , 14 : 3191 – 3201 .
  • Zhang , L and Watson , LT . 2007 . “Note on the computation of critical effective population sizes.” . J. Comput. Biol. , 14 : 950 – 960 .

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