Relax? Don't do it!—Linking presynaptic vesicle clustering with mechanical tension

References

• Ackley , BD and Jin , Y . 2004 . “Genetic analysis of synaptic target recognition and assembly.” . Trends Neurosci. , 27 : 540 – 547 .
   PubMedGoogle Scholar
• Chen , BM and Grinnell , AD . 1995 . “Integrins and modulation of transmitter release from motor nerve terminals by stretch.” . Science , 269 : 1578 – 1580 .
   PubMedGoogle Scholar
• Cheng , G , Tse , J , Jain , RK and Munn , LL . 2009 . “Micro‐environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.” . PLoS ONE , 4 : e4632
   PubMed Web of Science ®Google Scholar
• Chien , S . 2007 . “Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.” . Am. J. Physiol. Heart Circ. Physiol. , 292 : 1209 – 1224 .
   PubMed Web of Science ®Google Scholar
• Cingolani , LA and Goda , Y . 2008 . “Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.” . Nat. Rev. Neurosci. , 9 : 344 – 356 .
   PubMed Web of Science ®Google Scholar
• Colicos , MA , Collins , BE , Sailor , MJ and Goda , Y . 2001 . “Remodeling of synaptic actin induced by photoconductive stimulation.” . Cell , 107 : 605 – 616 .
   PubMedGoogle Scholar
• Collins , CA and DiAntonio , A . 2007 . “Synaptic development: insights from Drosophila.” . Curr. Opin. Neurobiol. , 17 : 35 – 42 .
   PubMed Web of Science ®Google Scholar
• Delgado , R , Maureira , C , Oliva , C , Kidokoro , Y and Labarca , P . 2000 . “Size of vesicle pools, rates of mobilization, and recycling at neuromuscular synapses of a Drosophila mutant, shibire.” . Neuron , 28 : 941 – 953 .
   PubMed Web of Science ®Google Scholar
• Dillon , C and Goda , Y . 2005 . “The actin cytoskeleton: integrating form and function at the synapse.” . Annu. Rev. Neurosci. , 28 : 25 – 55 .
   PubMed Web of Science ®Google Scholar
• Drenckhahn , D and Kaiser , HW . 1983 . “Evidence for the concentration of F‐actin and myosin in synapses and in the plasmalemmal zone of axons.” . Eur. J. Cell Biol. , 31 : 235 – 240 .
   PubMedGoogle Scholar
• Fatt , P and Katz , B . 1952 . “Spontaneous subthreshold activity at motor nerve endings.” . J. Physiol. (London) , 117 : 109 – 128 .
   Google Scholar
• Featherstone , DE and Broadie , K . 2000 . “Surprises from Drosophila: genetic mechanisms of synaptic development and plasticity.” . Brain Res. Bull. , 53 : 501 – 511 .
   PubMedGoogle Scholar
• Forscher , P . 1989 . “Calcium and polyphosphoinositide control of cytoskeletal dynamics.” . Trends Neurosci. , 12 : 468 – 474 .
   PubMed Web of Science ®Google Scholar
• Fouquet , W , Owald , D , Wichmann , C , Mertel , S , Depner , H , Dyba , M , Hallermann , S , Kittel , RJ , Eimer , S and Sigrist , SJ . 2009 . “Maturation of active zone assembly by Drosophila bruchpilot.” . J. Cell Biol. , 186 : 129 – 145 .
   PubMed Web of Science ®Google Scholar
• Geiger , B and Bershadsky , A . 2002 . “Exploring the neighborhood: adhesion‐coupled cell mechanosensors.” . Cell , 110 : 139 – 142 .
   PubMed Web of Science ®Google Scholar
• Glogauer , M , Arora , P , Yao , G , Sokholov , I , Ferrier , J and McCulloch , CA . 1997 . “Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretching.” . J. Cell Sci. , 110 (1) : 11 – 21 . 0021 – 9533 .
   PubMedGoogle Scholar
• Grinnell , AD , Chen , BM , Kashani , A , Lin , J , Suzuki , K and Kidokoro , Y . 2003 . “The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity.” . J. Neurocytol. , 32 : 489 – 503 .
   PubMedGoogle Scholar
• Hawkins , RD , Kandel , ER and Siegelbaum , SA . 1993 . “Learning to modulate transmitter release: themes and variations in synaptic plasticity.” . Annu. Rev. Neurosci. , 16 : 625 – 665 .
   PubMed Web of Science ®Google Scholar
• Keshishian , H , Broadie , K , Chiba , A and Bate , M . 1996 . “The Drosophila neuromuscular junction: a model system for studying synaptic development and function.” . Annu. Rev. Neurosci. , 19 : 545 – 575 .
   PubMed Web of Science ®Google Scholar
• Kuromi , H and Kidokoro , Y . 1998 . “Two distinct pools of synaptic vesicles in single presynaptic boutons in a temperature‐sensitive Drosophila mutant, shibire.” . Neuron , 20 : 917 – 925 .
   PubMedGoogle Scholar
• Littleton , JT , Bellen , HJ and Perin , MS . 1993 . “Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse.” . Development , 118 : 1077 – 1088 .
   PubMedGoogle Scholar
• Nelson , CM , Jean , RP , Tan , JL , Liu , WF , Sniadecki , NJ , Spector , AA and Chen , CS . 2005 . “Emergent patterns of growth controlled by multicellular form and mechanics.” . Proc. Natl. Acad. Sci. U.S.A. , 102 : 11594 – 11599 .
   PubMed Web of Science ®Google Scholar
• Oertner , TG and Matus , A . 2005 . “Calcium regulation of actin dynamics in dendritic spines.” . Cell Calcium , 37 : 477 – 482 .
   PubMedGoogle Scholar
• Owald , D and Sigrist , SJ . 2009 . “Assembling the presynaptic active zone.” . Curr. Opin. Neurobiol. , 19 : 311 – 318 .
   PubMedGoogle Scholar
• Papusheva , E , Mello de Queiroz , F , Dalous , J , Han , Y , Esposito , A , Jares‐Erijmanxa , EA , Jovin , TM and Bunt , G . 2009 . “Dynamic conformational changes in the FERM domain of FAK are involved in focal‐adhesion behavior during cell spreading and motility.” . J. Cell Sci. , 122 : 656 – 666 .
   PubMedGoogle Scholar
• Phillips , GR , Huang , JK , Wang , Y , Tanaka , H , Shapiro , L , Zhang , W , Shan , WS , Arndt , K , Frank , M , Gordon , RE , Gawinowicz , MA , Zhao , Y and Colman , DR . 2001 . “The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution.” . Neuron , 32 : 63 – 77 .
   PubMedGoogle Scholar
• Pollard , TD , Blanchoin , L and Mullins , RD . 2000 . “Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.” . Annu. Rev. Biophys. Biomol. Struct. , 29 : 545 – 576 .
   PubMedGoogle Scholar
• Pollard , TD and Borisy , GG . 2003 . “Cellular motility driven by assembly and disassembly of actin filaments.” . Cell , 112 : 453 – 465 .
   PubMed Web of Science ®Google Scholar
• Rasse , TM , Fouquet , W , Schmid , A , Kittel , RJ , Mertel , S , Sigrist , CB , Schmidt , M , Guzman , A , Merino , C , Qin , G , Quentin , C , Madeo , FF , Heckmann , M and Sigrist , SJ . 2005 . “Glutamate receptor dynamics organizing synapse formation in vivo.” . Nat. Neurosci. , 8 : 898 – 905 .
   PubMed Web of Science ®Google Scholar
• Rohrbough , J , Grotewiel , MS , Davis , RL and Broadie , K . 2000 . “Integrin‐mediated regulation of synaptic morphology, transmission, and plasticity.” . J. Neurosci. , 20 : 6868 – 6878 .
   PubMedGoogle Scholar
• Siechen , S , Yang , S , Chiba , A and Saif , T . 2009 . “Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminals.” . Proc. Natl. Acad. Sci. U.S.A. , 106 : 12611 – 12616 .
   PubMed Web of Science ®Google Scholar
• Squire , L , Berg , D , Bloom , E , du Lac , S , Ghosh , A and Spitzer , N . 2008 . Fundamental Neuroscience , San Diego : Academic .
   Google Scholar
• Staubli , U , Vanderklish , P and Lynch , G . 1990 . “An inhibitor of integrin receptors blocks long‐term potentiation.” . Behav. Neural Biol. , 53 : 1 – 5 .
   PubMedGoogle Scholar
• Vale , RD . 2003 . “The molecular motor toolbox for intracellular transport.” . Cell , 112 : 467 – 480 .
   PubMed Web of Science ®Google Scholar
• Vogel , V and Sheetz , M . 2006 . “Local force and geometry sensing regulate cell functions.” . Nat Rev. Mol. Cell Biol. , 7 : 265 – 275 .
   PubMed Web of Science ®Google Scholar
• Yang , S and Saif , T . 2005 . “Reversible and repeatable linear local cell force response under large stretches.” . Exp. Cell Res. , 305 : 42 – 50 .
   PubMedGoogle Scholar
• Yildiz , A , Forkey , JN , McKinney , SA , Ha , T , Goldman , YE and Selvin , PR . 2003 . “Myosin V walks hand‐over‐hand: single fluorophore imaging with 1.5‐nm localization.” . Science , 300 : 2061 – 2065 .
   PubMed Web of Science ®Google Scholar
• Zhang , W and Benson , DL . 2001 . “Stages of synapse development defined by dependence on F‐actin.” . J. Neurosci. , 21 : 5169 – 5181 .
   PubMedGoogle Scholar