Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy

References

• Goodwin TM. Hyperemesis gravidarum. Clin Obstet Gynecol. 1998;41:597–605.
   PubMed Web of Science ®Google Scholar
• Chiossi G, Neri I, Cavazzuti M, Basso G, Facchinetti F. Hyperemesis gravidarum complicated by Wernicke encephalopathy: background, case report, and review of the literature. Obstet Gynecol Surv. 2006;61:255–68.
   PubMed Web of Science ®Google Scholar
• Philip B. Hyperemesis gravidarum: literature review. WMJ. 2003;102:46–51.
   PubMedGoogle Scholar
• Trogstad LI, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. BJOG. 2005;112:1641–5.
   PubMed Web of Science ®Google Scholar
• Dodds L, Fell DB, Joseph KS, Allen VM, Butler B. Outcomes of pregnancies complicated by hyperemesis gravidarum. Obstet Gynecol. 2006;107:285–92.
   PubMed Web of Science ®Google Scholar
• Matteson S, Roscoe J, Hickok J, Morrow GR. The role of behavioral conditioning in the development of nausea. Am J Obstet Gynecol. 2002;186:S239–43.
   PubMed Web of Science ®Google Scholar
• Buckwalter JG, Simpson SW. Psychological factors in the etiology and treatment of severe nausea and vomiting in pregnancy. Am J Obstet Gynecol. 2002;186:S210–4.
   PubMed Web of Science ®Google Scholar
• Golberg, Szilagyi, Graves. Hyperemesis gravidarum and Helicobacter pylori infection: a systematic review. Obstet Gynecol. 2007;110:695–703.
   PubMed Web of Science ®Google Scholar
• Walsh JW, Hasler WL, Nugent CE, Owyang C. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am J Physiol. 1996;270:G506–14.
   PubMed Web of Science ®Google Scholar
• Broussard CN RJ. Nausea and vomiting of pregnancy Gastroenterol Clin North Am. 1998:123–51.
   Google Scholar
• Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007;132:397–414.
   PubMed Web of Science ®Google Scholar
• Einarson A, Maltepe C, Navioz Y, Kennedy D, Tan MP, Koren G. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. BJOG. 2004;111:940–3.
   PubMed Web of Science ®Google Scholar
• Miyake A, Mochizuki S, Takemoto Y, Akuzawa S. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Mol Pharmacol. 1995;48:407–16.
   PubMed Web of Science ®Google Scholar
• Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999;397:359–63.
   PubMed Web of Science ®Google Scholar
• Reeves DC, Lummis SC. The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review). Mol Membr Biol. 2002;19:11–26.
   PubMed Web of Science ®Google Scholar
• Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem. 1999;274:30799–810.
   PubMed Web of Science ®Google Scholar
• Boyd GW, Low P, Dunlop JI, Robertson LA, Vardy A, Lambert JJ, Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. Mol Cell Neurosci. 2002;21:38–50.
   Google Scholar
• Niesler B, Frank B, Kapeller J, Rappold GA. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene. 2003;310:101–11.
   PubMed Web of Science ®Google Scholar
• Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene. 2003;319:137–48.
   PubMed Web of Science ®Google Scholar
• Niesler B, Walstab J, Combrink S, Moeller D, Kapeller J, Rietdorf J, Characterization of the novel human serotonin receptor subunits 5-HT3C, 5- HT3D and 5-HT3E. Mol Pharmacol. 2007;72:8–17.
   Google Scholar
• Tremblay PB, Kaiser R, Sezer O, Rosler N, Schelenz C, Possinger K, Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. J Clin Oncol. 2003;21:2147–55.
   PubMed Web of Science ®Google Scholar
• Fasching PA, Kollmannsberger B, Strissel PL, Niesler B, Engel J, Kreis H, Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J Cancer Res Clin Oncol. 2008; DOI: 10.1007/s00432-008-0387-1.
   Google Scholar
• Navari RM, Reinhardt RR, Gralla RJ, Kris MG, Hesketh PJ, Khojasteh A, Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group. N Engl J Med. 1999;340:190–5.
   PubMed Web of Science ®Google Scholar
• Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin--the Aprepitant Protocol 052 Study Group. J Clin Oncol. 2003;21:4112–9.
   PubMed Web of Science ®Google Scholar
• Schrauder M, Frank S, Strissel PL, Lux MP, Bani MR, Rauh C, Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer. J Cancer Res Clin Oncol 2008: DOI: 10.1007/s00432-008-0355–9.
   Google Scholar
• Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–5.
   PubMed Web of Science ®Google Scholar
• Kapeller J, Houghton LA, Monnikes H, Walstab J, Moller D, Bonisch H, First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet. 2008; epub ahead of print.
   Google Scholar