Young girls with malignant ovarian germ cell tumors can undergo normal menarche and menstruation after fertility-preserving surgery and adjuvant chemotherapy

References

• Mitchell PL, Al-Nasiri N, A'Hern R, Fisher C, Horwich A, Pinkerton CR, Treatment of nondysgerminomatous ovarian germ cell tumors: an analysis of 69 cases. Cancer. 1999;85:2232–44.
   PubMed Web of Science ®Google Scholar
• Gershenson DM. Management of ovarian germ cell tumors. J Clin Oncol. 2007;25:2938–43.
   PubMed Web of Science ®Google Scholar
• Abu-Rustum NR, Aghajanian C. Management of malignant germ cell tumors of the ovary. Semin Oncol. 1998;25:235–42.
   PubMed Web of Science ®Google Scholar
• Peccatori F, Bonazzi C, Chiari S, Landoni F, Colombo N, Mangioni C. Surgical management of malignant ovarian germ-cell tumors: 10 years' experience of 129 patients. Obstet Gynecol. 1995;86:367–72.
   PubMed Web of Science ®Google Scholar
• Tewari K, Cappuccini F, Disaia PJ, Berman ML, Manetta A, Kohler MF. Malignant germ cell tumors of the ovary. Obstet Gynecol. 2000;95:128–33.
   PubMed Web of Science ®Google Scholar
• Ayhan A, Celik H, Taskiran C, Bozdag G, Aksu T. Oncologic and reproductive outcome after fertility-saving surgery in ovarian cancer. Eur J Gynaecol Oncol. 2003;24:223–32.
   PubMed Web of Science ®Google Scholar
• Lu KH, Gershenson DM. Update on the management of ovarian germ cell tumors. J Reprod Med. 2005;50:417–25.
   PubMedGoogle Scholar
• Terenziani M, Massimino M, Casanova M, Cefalo G, Ferrari A, Luksch R, Childhood malignant ovarian germ cell tumors: A monoinstitutional experience. Gynecol Oncol. 2001;81:436–40.
   Google Scholar
• Brewer M, Gershenson DM, Herzog CE, Mitchell MF, Silva EG, Wharton JT. Outcome and reproductive function after chemotherapy for ovarian dysgerminoma. J Clin Oncol. 1999;17:2670–75.
   PubMed Web of Science ®Google Scholar
• Zanetta G, Bonazzi C, Cantu M, Binidagger S, Locatelli A, Bratina G, Survival and reproductive function after treatment of malignant germ cell ovarian tumors. J Clin Oncol. 2001;19:1015–20.
   PubMed Web of Science ®Google Scholar
• Sagae S, Sasaki H, Nishioka Y, Terasawa K, Kudo R. Reproductive function after treatment of malignant germ cell ovarian tumors. Mol Cell Endocrinol. 2003;202:117–21.
   Google Scholar
• Billmire D, Vinocur C, Rescorla F, Cushing B, London W, Schlatter M, Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: An intergroup study. J Pediatr Surg. 2004;39:424–9.
   PubMed Web of Science ®Google Scholar
• Beiner ME, Gotlieb WH, Korach Y, Shrim A, Stockheim D, Segal Y, Cystectomy for immature teratoma of the ovary. Gynecol Oncol. 2004;93:381–4.
   PubMed Web of Science ®Google Scholar
• Low JJ, Perrin LC, Crandon AJ, Hacker NF. Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. A review of 74 cases. Cancer. 2000;89:391–8.
   Google Scholar
• Tangir J, Zelterman D, Ma W, Schwartz PE. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101:251–7.
   PubMed Web of Science ®Google Scholar
• Nishio S, Ushijima K, Fukui A, Fujiyoshi N, Kawano K, Komai K, Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary. J Obstet Gynaecol Res. 2006;32:416–21.
   PubMedGoogle Scholar
• Gershenson DM, Miller AM, Champion VL, Monahan PO, Zhao Q, Cella D, Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. J Clin Oncol. 2007;25:2792–7.
   PubMed Web of Science ®Google Scholar
• FIGO cancer committee. Staging announcement. Gynecol Oncol. 1986;25:383–5.
   Google Scholar
• Serov SF, Scully RE, Sobin LH, World Health Organization. Histological typing of ovarian tumours. Geneva, World Health Organization, 1973.
   Google Scholar
• de La Motte Rouge T, Pautier P, Duvillard P, Rey A, Morice P, Haie-Meder C, Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. Ann Oncol. 2008;19:1435–41.
   PubMedGoogle Scholar
• Chan JK, Tewari KS, Waller S, Cheung MK, Shin JY, Osann K, The influence of conservative surgical practices for malignant ovarian germ cell tumors. J Surg Oncol. 2008;98:111–6.
   Google Scholar
• De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW. Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer. 2006;46:459–64.
   PubMed Web of Science ®Google Scholar
• Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C, Premature menopause in survivors of childhood cancer: A report from the childhood cancer survivor study. J Natl Cancer Inst. 2006;98:890–6.
   PubMed Web of Science ®Google Scholar
• Meirow D, Nugent D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update. 2001;7:535–43.
   PubMed Web of Science ®Google Scholar
• Chemaitilly W, Mertens AC, Mitby P, Whitton J, Stovall M, Yasui Y, Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab. 2006;91:1723–8.
   PubMed Web of Science ®Google Scholar
• Blumenfeld Z, Eckman A. Preservation of fertility and ovarian function and minimization of chemotherapy-induced gonadotoxicity in young women by gnrh-a. J Natl Cancer Inst Monogr. 2005;40–3.
   Google Scholar
• Blumenfeld Z. How to preserve fertility in young women exposed to chemotherapy? The role of gnrh agonist cotreatment in addition to cryopreservation of embrya, oocytes, or ovaries. Oncologist. 2007;12:1044–54.
   PubMed Web of Science ®Google Scholar
• Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316:1435–40.
   PubMed Web of Science ®Google Scholar
• Gershenson DM, Morris M, Cangir A, Kavanagh JJ, Stringer CA, Edwards CL, Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin. J Clin Oncol. 1990;8:715–20.
   PubMed Web of Science ®Google Scholar
• Williams S, Blessing JA, Liao SY, Ball H, Hanjani P. Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: A trial of the gynecologic oncology group. J Clin Oncol. 1994;12:701–6.
   PubMedGoogle Scholar