Curcumin inhibits inflammatory response and bone loss during experimental periodontitis in rats

References

• Visser MB, Ellen RP. New insights into the emerging role of oral spirochaetes in periodontal disease. Clin Microbiol Infect 2011;17:502–12.
   PubMed Web of Science ®Google Scholar
• Deo V, Bhongade ML. Pathogenesis of periodontitis: role of cytokines in host response. Dent Today 2010;29:60–2; 4–6; quiz 8–9.
   PubMedGoogle Scholar
• Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res 2010;89:1349–63.
   PubMed Web of Science ®Google Scholar
• Liu YC, Lerner UH, Teng YT. Cytokine responses against periodontal infection: protective and destructive roles. Periodontology 2000 201052:163–206.
   Google Scholar
• Chambrone LA, Chambrone L. Tooth loss in well-maintained patients with chronic periodontitis during long-term supportive therapy in Brazil. J Clin Periodontol 2006;33:759–64.
   PubMed Web of Science ®Google Scholar
• Verdrengh M, Bokarewa M, Ohlsson C, Stolina M, Tarkowski A. RANKL-targeted therapy inhibits bone resorption in experimental Staphylococcus aureus-induced arthritis. Bone 2010;46:752–8.
   Google Scholar
• Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345–57.
   PubMed Web of Science ®Google Scholar
• Kirkwood KL, Cirelli JA, Rogers JE, Giannobile WV. Novel host response therapeutic approaches to treat periodontal diseases. Periodontology 2000 200743:294–315.
   Google Scholar
• Crotti T, Smith MD, Hirsch R, Soukoulis S, Weedon H, Capone M, Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. J Periodontal Res 2003;38:380–7.
   PubMed Web of Science ®Google Scholar
• Paquette DW, Williams RC. Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases. Periodontology 2000 2000;24:239–52.
   Google Scholar
• Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009;30:85–94.
   PubMed Web of Science ®Google Scholar
• Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011;16:4567–98.
   PubMed Web of Science ®Google Scholar
• Kundu P, De R, Pal I, Mukhopadhyay AK, Saha DR, Swarnakar S. Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS One 2011;6:e16306.
   Google Scholar
• Kurup VP, Barrios CS, Raju R, Johnson BD, Levy MB, Fink JN. Immune response modulation by curcumin in a latex allergy model. Clin Mol Allergy 2007;5:1.
   Google Scholar
• Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 2010;15:337–44.
   PubMed Web of Science ®Google Scholar
• Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem 1995;270:24995–5000.
   PubMed Web of Science ®Google Scholar
• Chan MM. Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol 1995;49:1551–6.
   PubMed Web of Science ®Google Scholar
• Suda T, Nagasawa T, Wara-Aswapati N, Kobayashi H, Iwasaki K, Yashiro R, Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells. Oral Microbiol Immunol 2009;24:384–9.
   PubMedGoogle Scholar
• Bereswill S, Munoz M, Fischer A, Plickert R, Haag LM, Otto B, Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One 2010;5:e15099.
   PubMed Web of Science ®Google Scholar
• Cho JW, Lee KS, Kim CW. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int J Mol Med 2007;19:469–74.
   PubMed Web of Science ®Google Scholar
• Hie M, Yamazaki M, Tsukamoto I. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur J Pharmacol 2009;621:1–9.
   PubMed Web of Science ®Google Scholar
• Bharti AC, Takada Y, Aggarwal BB. Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 2004;172:5940–7.
   PubMed Web of Science ®Google Scholar
• Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 2004;304:600–2.
   PubMed Web of Science ®Google Scholar
• Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46:269–79.
   PubMed Web of Science ®Google Scholar
• Guimarães MR, de Aquino SG, Coimbra LS, Spolidorio LC, Kirkwood KL, Rossa C Jr. Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats. Innate Immun 2012;18:155–63.
   Google Scholar
• Chen D, Nie M, Fan MW, Bian Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology 2008;82:264–9.
   PubMed Web of Science ®Google Scholar
• Liu S, Cheng Y, Fan M, Chen D, Bian Z. FSH aggravates periodontitis-related bone loss in ovariectomized rats. J Dent Res 2010;89:366–71.
   PubMed Web of Science ®Google Scholar
• Gulcubuk A, Altunatmaz K, Sonmez K, Haktanir-Yatkin D, Uzun H, Gurel A, Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet Med A Physiol Pathol Clin Med 2006;53:49–54.
   Google Scholar
• Napimoga MH, Benatti BB, Lima FO, Alves PM, Campos AC, Pena-Dos-Santos DR, Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. Int Immunopharmacol 2009;9:216–22.
   PubMed Web of Science ®Google Scholar
• Crawford JM, Taubman MA, Smith DJ. The natural history of periodontal bone loss in germfree and gnotobiotic rats infected with periodontopathic microorganisms. J Periodontal Res 1978;13:316–25.
   PubMed Web of Science ®Google Scholar
• Duarte PM, Goncalves PF, Sallum AW, Sallum EA, Casati MZ, Humberto Nociti F Jr. Effect of an estrogen-deficient state and its therapy on bone loss resulting from an experimental periodontitis in rats. J Periodontal Res 2004;39:107–10.
   Google Scholar
• Bartold PM, Cantley MD, Haynes DR. Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 2000 201053:55–69.
   Google Scholar
• Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta 2007;1770:989–96.
   PubMed Web of Science ®Google Scholar
• Leibbrandt A, Penninger JM. RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci 2008;1143:123–50.
   PubMed Web of Science ®Google Scholar
• Oh S, Kyung TW, Choi HS. Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol Cells 2008;26:486–9.
   Google Scholar
• Yuan H, Gupte R, Zelkha S, Amar S. Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J Clin Periodontol 2011;38:1029–36.
   Google Scholar
• Tham CL, Liew CY, Lam KW, Mohamad AS, Kim MK, Cheah YK, A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis. Eur J Pharmacol 2010;628:247–54.
   PubMed Web of Science ®Google Scholar
• Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, TNF-alpha and pathologic bone resorption. Keio J Med 2005;54:127–31.
   PubMedGoogle Scholar
• Palmqvist P, Persson E, Conaway HH, Lerner UH. IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J Immunol 2002;169:3353–62.
   PubMed Web of Science ®Google Scholar
• Dai J, Lin D, Zhang J, Habib P, Smith P, Murtha J, Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J Clin Invest 2000;106:887–95.
   Google Scholar