1,114
Views
89
CrossRef citations to date
0
Altmetric
Original Article

Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis

, , , , , , & show all
Pages 42-47 | Received 21 Feb 2013, Accepted 02 Apr 2013, Published online: 22 Jul 2013

References

  • Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int Biochem Cell Biol 2007;39:44–84.
  • Canakci CF, Ciek Y, Canakci V. Reactive oxygen species and human inflammatory periodontal diseases. Biochemistry (Mosc) 2005;70:619–28.
  • Ridgeway EE. Periodontal disease: diagnosis and management. J Am Acad Nurse Pract 2000;12:79–84.
  • Esen C, Alkan BA, Kırnap M, Akgül O, Işıkoğlu S, Erel O. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. Periodontol 2012;83:773–9.
  • D'Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res 2010;89:1241–6.
  • Bullon P, Morillo JM, Ramirez-Tortosa MC, Quiles JL, Newman HN, Battino M. Metabolic syndrome and periodontitis: is oxidative stress a common link? J Dent Res 2009;88:503–18.
  • Bullon P, Cordero MD, Quiles JL, Morillo JM, del Carmen Ramirez-Tortosa M, Battino M. Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis. Free Radic Biol Med 2011;50:1336–43.
  • Greabu M, Battino M, Mohora M, Totan A, Spinu T, Totan C, et al. Could constitute saliva the first line of defence against oxidative stress? Rom J Int Med 2007;45:209–13.
  • Konopka T, Krol K, Kopec W, Gerber H. Total antioxidant status and 8-hydroxy-2'deoxiguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz) 2007;55:417–22.
  • Scully DV, Langlez-Evans SC. Salivary antioxidants and periodontal disease status. Proc Nutr Soc 2002;61:137–43.
  • Wong DT. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J Am Dent Assoc 2006;137:313–21.
  • Lee JM, Wong DT. Salivary diagnostics. Orthod Craniofac Res 2009;12:206–11.
  • Lamster IB, Kaufman E, Grbic JT, Winston LJ, Singer RE. β-glucuronidase activity in saliva: relationship to clinical periodontal parameters. J Periodontol 2003;74:353–9.
  • Miller CS, King CP, Langub MC, M, Kryscio RJ, Thomas MV. Salivary biomarkers of existing periodontal disease: a cross-sectional study. J Am Dent Assoc 2006;137:322–9.
  • Pederson ED, Stanke SR, Whitener SJ, Sebastiani PT, Lamberts BL, Turner DW. Salivary levels of α2- macroglobulin, α1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. Arch Oral Biol 1995;40:1151–5.
  • Ng YP, Donley M, Hausmann E, Hutson AD, Rossomando EF, Scannapieco FA. Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vivo studies. FEMS Immunol Med Microbiol 2007;49:252–60.
  • Aurer A, Jorgic-Srdjak K, Plancak D, Stavljenic-Rukavina A, Aurer-Kozelj A. Proinflammatory factors in saliva as possible markers for periodontal disease. Coll Antropol 2005;29:435–9.
  • Totan A, Greabu M, Totan C, Spinu T. Salivary aspartate aminotransferase, alanine aminotransferase and alkaline phoshatase: possible markers in periodontal diseases? Clin Chem Lab Med 2006;44:612–15.
  • Gursay UK, Kononen E, Huumonen S, Tervahartiala T, Pussinen PJ, Suominen AL, et al. Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J Clin Periodontol 2012;40:18–25.
  • Miller CS, Foley JD, Bailey AL, Campell CL, Humphries RL, Christodoulides N, et al. Curent developments in salivary diagnostics. Biomarkers Med 2010;4:171–89.
  • Philstrom BL, Michalowicz BS, Johnson NW. Periodontal disease. Lancet 2005;366:1809–20.
  • Floriano PN, Christodoulides N, Miller CS, Ebersole JL, Spertus J, Rose BG, et al. Use of saliva -based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study. Clin Chem 2009;55:1530–8.
  • Galli C, Passeri G, Macaluso GM. FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena? J Periodontal Res 2011;46:397–406.
  • Ohnish T, Bandow K, Kakimoto K, Machigashira M, Matsuyama T, Matsuquchi T. Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes. J Periodontal Res 2009;44:43–51.
  • Balwant R, Simmi K, Rajnish J, Suresh CA. Biomarkers of periodontitis in oral fluids. J Oral Sci 2008;50:53–6.
  • Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000 1997;14:9–11.
  • Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA. Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases. J Periodontol 1999;70:1292–302.
  • Kinney J, Ramseier C, Giannobile WV. Oral fluid- based biomarkers of alveolar bone loss in periodontitis. Ann N Y Acad Sci 2007;1098:230–51.
  • Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, et al. Collagenases in different categories of peri-implant vertical bone loss. J Dent Res 2000;79:1870–3.
  • Bataille R, Delmas P, Sany J. Serum bone gla-protein in multiple myeloma. Cancer 1987;59:329–34.
  • Lee AJ, Walsh TF, Hodges SJ, Rawlinson A. Gingival crevicular fluid osteocalcin in adult periodontitis. J Clin Periodontol 1994;26:252–6.
  • Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003;18:859–67.
  • Wu Y, Shu R, Luo LJ, Ge LH, Xie YF. Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. J Periodontal Res 2009;44:636–44.
  • Zhang X, Meng H, Sun X, Xu L, Zhang L, Shi D, et al. Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis. J Periodontal Res 2013;48:74–9.
  • Su H, Gornitsky M, Velly AM, Yu H, Benarroch M, Schipper HM. Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic Biol Med 2009;46:914–21.
  • Takane M, Sugano N, Ezawa T, Uchiyama T, Ito K. A marker of oxidative stress in saliva: association with periodontally- involved teeth of a hopeless prognosis. J Oral Sci 2005;47:53–7.
  • Niki E. Antioxidant capacity: which capacity and how to assess it? J Berry Res 2011;1:169–76.
  • Niki E. Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products? FEBS Lett 2012;586:3767–70.
  • Bullon P, Cordero MD, Quiles JL, Ramirez-Tortosa M del C, Gonzalez-Alonso A, Alfonsi S, et al. Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Med 2012;10:122.
  • Thomas MV, Puleo DA. Infection, inflammation, and bone regeneration: a paradoxical relationship. J Dent Res 2011;90:1052–61.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.