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Original Article

Tissue Levels of Kanamycin in Correlation with Oto- And Nephrotoxicity

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Pages 9-14 | Received 27 May 1977, Published online: 08 Jul 2009

Reference

  • Mootz W., Schöndorf J., Werner G. Elektronen-mikroskopische Untersuchungen am Plexus Cochlearis nach Kanamycin-Intoxikation. Acta Otolaryngol (Stockh) 1972; 73: 38
  • Saito H., Daly J. F. Quantitative analysis of acidic mucopolysaccharides in the normal and kanamycin intoxicated cochlea. Acta Otolaryngol (Stockh) 1971; 71: 2
  • Saito H., Nakamura A., Lida T. A comparison of acidic mucopolysaccharides in the normal and organs: electrophoretic microanalysis. Arch Oto-Rhino-Laryngol 1976; 214: 149
  • Stupp H. Untersuchung der Innenohrflüssigkeiten und ihre Bedeutung für die spezifische Ototoxicität der Aminoglykosidantibiotica. Acta Otolaryngol (Stockh) 1970, Suppl. 262
  • Stupp H., Rauch S., Sous H., Brun J. P., Lagler F. Kanamycin dosage and levels in ear and other organs. Arch Otolaryngol (Chic) 1967; 86: 515
  • Tachibana M. On the mechanism of kanamycin ototoxicity. (I) Tissue levels of kanamycin and acidic glycosaminoglycans. Jap Jour Otol (Tokyo) 1977; 80: 40
  • Tachibana M., Mizukoshi O., Kuriyama K. Inhibitory effects of kanamycin on glycolysis in cochlea and kidney-possible involvement in the formation of oto- and nephrotoxicities. Biochem Pharmacol 1976; 25: 2297
  • Voldrich L. The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryngol (Stockh) 1965; 60: 243
  • Vrabec D. P., Cody T., Ulrich J. A. Antibiotic concentration levels in perilymph studied. JAMA 1965; 193: 29

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