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Acta Oto-Laryngologica Volume 91, 1981 - Issue 1-6
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Original Article

An Experimental Study on the Progressiveness of Cochlear Damage by Aminoglycoside Drug

Y. Nakai Department of Otolaryngology, Osaka City University Medical School, Osaka, Japan
,
K. Zushi Department of Otolaryngology, Osaka City University Medical School, Osaka, Japan
,
K. C. Chang Department of Otolaryngology, Osaka City University Medical School, Osaka, Japan
,
H Yagi Department of Otolaryngology, Osaka City University Medical School, Osaka, Japan
&
T. Tokimoto Department of Physiology, Osaka City University Medical School, Osaka, Japan
Pages 199-206 | Received 09 Apr 1980, Published online: 08 Jul 2009

References

  • Akiyoshi M. Evaluation of ototoxicity and safety of aminoglycoside antibiotics in the guinea pig. Adv Clin Pharmacol 1977; 13: 374
  • Beck C., Krahl P. Experimentelle und feinge-webliche Untersuchung uber die Ototoxicitat von Kanamycin. Arch Ohr Nas Kehlk Heilk 1962; 179: 594
  • Dallos P., Wang C. Y. Bioelectric correlates of Kanamycin intoxication. Audiology 1974; 13: 277
  • Engstrom H., Kohonen A. Cochlear damage from ototoxic antibiotics. Acta Otolaryngol (Stockh) 1965; 59: 171
  • Farkachidy T., Black R. G., Briant J. D. R. The effect of kanamycin on the internal ear. An electrophysiological and electron microscopic study. Laryngoscope 1964; 73: 713
  • Galambos R. Studies of the auditory system with implanted electrodes. Neural mechanisms of the auditory and vestubular systems, Rasmussen, Windle. Charles C. Thomas, Springfield, Ill 1965; 137
  • Goto T. An experimental study of cochlear microphonics in vestibule conditions. Jap Otol Tokyo 1973; 76: 220
  • Hawkins J. E., Jr. The ototoxicity of kanamycin. Ann Otol 1959; 169: 698
  • Hawkins J. E., Jr., Engstrom H. Effect of kanamycin on cochlear cytoarchitecture. Acta Otolaryngol (Stockh) 1964; 100, Suppl. 188
  • Reddy J. B., Igarashi M. Change produced by Kanamycin. Arch Otolaryngol (Chic.) 1962; 76: 146
  • Simmons F. B., Galambos R., Albrite J. P. Serial studies of the onset and progression of drug induced cochlear damage in cat. Arch Otolaryngol 1960; 72: 233
  • Toyoda Y. Quantitative evaluation of kanamycin ototoxicity on guinea pig inner ear. Pract Otol Kyoto 1976; 69: 179
  • Ward P. H., Fernandez C. The ototoxicity of kanamycin in guinea pigs. Ann Otol 1961; 70: 132

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