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Acta Oto-Laryngologica Volume 99, 1985 - Issue 3-4
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Original Article

Metachromasia as the Key to Aminoglycoside Ototoxicity

N. Sitaras Department of Experimental Pharmacology, University of Athens and the ENT Clinic of the Athens General Hospital, Athens, Greece
,
P. Vrouvidou Department of Experimental Pharmacology, University of Athens and the ENT Clinic of the Athens General Hospital, Athens, Greece
,
D. Varonos Department of Experimental Pharmacology, University of Athens and the ENT Clinic of the Athens General Hospital, Athens, Greece
&
A. Coyas Department of Experimental Pharmacology, University of Athens and the ENT Clinic of the Athens General Hospital, Athens, Greece
Pages 336-338 | Published online: 08 Jul 2009

References

  • Brown D R, Feldman MA. Pharmacology of hearing and ototoxicity. Ann Rev Pharm Toxicol 1978; 18: 233–52
  • Saito H, Daly JF. Quantitative analysis of acid mucopolysaccharides in the normal and kanamycin intoxicated cochlea. Acta Otolaryngol (Stockh) 1971; 71: 22–5
  • Tachibana M, Saito H, Yamamichi I, Marioka H. A possible involvement of acidic glycosamino-glycans in kanamycin ototoxicity. Acta Otolaryngol (Stockh) 1978; 86: 15–21
  • Kunin MC. Binding of antibiotics to tissue homogenates. Infect Dis 1970; 121: 55–64
  • Juhn S K, Niederweiser A. Biochemistry of connective tissue of cochlear duct. Biochemical mechanisms in hearing and deafness, MM Paparella. Ch. C. Thomas, Springfield, Ill. 1970; 249–64
  • Tachibana M, Saito H, Machino M. Sulfated acid mucopolysaccharides in the tectorial membrane. Acta Otolaryngol (Stockh) 1973; 76: 37
  • Stupp H, Rauch S, Sous H, Brun P J, Lagler F. Kanamycin dosage and levels in the ear and other organs. Arch Otolaryngol 1967; 86: 515–21
  • Tachibana M. On the mechanism of kanamycin ototoxicity. 1. Tissue levels of kanamycin and acidic glycosaminoglycans. Jap J Otol 1977; 80: 40

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