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INNER EAR

Age-related changes in the ratio of Mcl-1/Bax expression in the rat cochlea

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Pages 123-132 | Received 19 Aug 2011, Accepted 30 Sep 2011, Published online: 27 Dec 2011

References

  • Park SN, Back SA, Park KH, Kim DK, Park SY, Oh JH, Comparison of cochlear morphology and apoptosis in mouse models of presbycusis. Clin Exp Otorhinolaryngol 2010;3:126–35.
  • Hu BH, Yang WP, Bielefeld EC, Li M, Chen GD, Henderson D. Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats. Hear Res 2008;245:48–57.
  • Tadros SF, D'Souza M, Zhu X, Frisina RD. Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 2008;13:1303–21.
  • Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A 2009;106:19432–7.
  • Ghibelli L, Diederich M. Multistep and multitask Bax activation. Mitochondrion 2010;10:604–13.
  • Ganju N, Eastman A. Bcl-X(L) and calyculin A prevent translocation of Bax to mitochondria during apoptosis. Biochem Biophys Res Commun 2002;291:1258–64.
  • Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 2001;276:18361–74.
  • Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609–19.
  • Hu BH, Cai Q. Acoustic overstimulation modifies Mcl-1 expression in cochlear sensory epithelial cells. J Neurosci Res 2010; 88:1812–21.
  • Thomas LW, Lam C, Edwards SW. Mcl-1; the molecular regulation of protein function. FEBS Lett 2010;584:2981–9.
  • Yang WP, Henderson D, Hu BH, Nicotera TM. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise. Hear Res 2004;196:69–76.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402–8.
  • Alam SA, Oshima T, Suzuki M, Kawase T, Takasaka T, Ikeda K. The expression of apoptosis-related proteins in the aged cochlea of Mongolian gerbils. Laryngoscope 2001;111:528–34.
  • Chao JR, Wang JM, Lee SF, Peng HW, Lin YH, Chou CH, Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol Cell Biol 1998;18:4883–98.
  • Cuconati A, Mukherjee C, Perez D, White E. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 2003;17:2922–32.
  • Iglesias-Serret D, Piqué M, Gil J, Pons G, López JM. Transcriptional and translational control of Mcl-1 during apoptosis. Arch Biochem Biophys 2003;417:141–52.
  • Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 2003;17:1475–86.
  • Michels J, O'Neill JW, Dallman CL, Mouzakiti A, Habens F, Brimmell M, Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. Oncogene 2004;23:4818–27.
  • Germain M, Milburn J, Duronio V. MCL-1 inhibits BAX in the absence of MCL-1/BAX Interaction. J Biol Chem 2008;283:6384–92.
  • Aiba-Masago S, Liu Xb XB, Masago R, Vela-Roch N, Jimenez F, Lau CM, Bax gene expression alters Ca(2+) signal transduction without affecting apoptosis in an epithelial cell line. Oncogene 2002;21:2762–7.

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