38
Views
24
CrossRef citations to date
0
Altmetric
Original Article

Innervation in Human Taste Buds and Its Decrease in Alzheimer's Disease Patients

, &
Pages 678-684 | Received 21 Oct 1994, Accepted 14 Feb 1995, Published online: 08 Jul 2009

References

  • Kinnamon J C. Organization and innervation of taste buds. Neurobiology of taste and smell, T E Finger, W L Silver. John Wiley & Sons, New York, Chichester 1987; 227–97
  • Yoshie S, Teraki Y, Iwanaga T, Fujita T. Immunohis-tochemistry of neuron-specific proteins and neuropep-tides in taste buds and associated nerves. Arch Histol Cytol 1989; 52 (Suppl): 389–96
  • Silverman J D, Kruger L. Calcitonin gene-related pep-tide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures. J Comp Neurol 1989; 280: 303–30
  • Lundberg J M, Höckfelt T, änggård A, Pernow B, Emson P. lmmunohistochemical evidence for substance P immunoreactive nerve fibers in the taste buds of the cat. Acta Physiol Scand 1979; 107: 389–91
  • Luts A, Montavon P, Lindstrand K, Sundler F. Pep-tide-contianing nerve fibers in the circumvallate papillae. Regul Pept 1990; 27: 209–26
  • Takami S, Getchell T V, McLaughlin S K, Margolskee R, Getchell M L. Human taste cells express the G protein α-gustducin and neuron-specific cnolase. Mol Brain Res 1994; 22: 193–203
  • Karanth S S, Springall D R, Kuhn D M, Levene M M, Polak J M. An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals. Am J Anat 1991; 191: 369–83
  • Takami S, Getchell M L, Chen Y, et al. Vomero-nasal epithelial cells of the adult human express neuron-specific molecules. NeuroReport 1993; 4: 375–8
  • Yamagishi M, Hasegawa S, Takahashi S, Iwanaga T. Immunohistochemical methods for the diagnosis of olfactory disturbance. Acta Otolaryngol (Stockh) 1987; 103: 145–50
  • Chen Y, Getchell T V, Sparks D L, Getchell M L. Patterns of adrenergic and peptidergic innervation in human olfactory mucosa: age-related trends. J Comp Neurol 1993; 334: 104–16
  • Montavon P, Lindstrand K. Immunohistochemical localization of neuron-specific enolasc and calcitonin gene-related peptide in rat taste papillae. Regul Pept 1991; 219–33
  • Fujita T, Iwanaga T, Nakajima T. Immunohistochemical detection of neurons system-specific proteinsin normal and neoplastic paraneurons in the gut and peptides. Gut pcptides and ulcer, A Miyoshi. Biochemical Research Foundation., Toyko 1983; 81–8
  • Wilkinson K D, Lee K, Deshpande S, Ducrksen-Hughes P, Boss J M, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydro-lase. Science 1989; 246: 670–3
  • Marangos P L. Neuron-specific enolase: a ncuronai and neuroendocrine protein. Neuronal and glial proteins—Structure, function and clinical application, P J Marangos, I C Campbell, R M Cohen. Academic Press, New York, Tokyo, London 1988; 119–36
  • Thompson R J, Day I NM. Protein gene product 9.5: a new neuronal and neuroendocrine marker. Neuronal and glial proteins—Structure, function and clinical application, P J Marangos, I C Campbell, R M Cohen. Academic Press., New York, Tokyo, London 1988; 209–28
  • Thompson R J, Doran J F, Jackson P, Dhillon A P, Rode J. PGP 9.5—a new marker for vertebrate neurons and neuroendocrine cells. Brain Res 1983; 278: 224–8
  • Doty R L. Olhctory dysfunction in neurodegenerativc disorders. Smell and taste in health and disease, T V Getchell, R L Doty, L M Bartoshuk, J B Snow, Jr. Raven Press, New York 1991; 735–51
  • Tabaton M, Cammarata S, Mancardi G L, Cordone G, Perry G, Lobe C. Abnormal tau-reactive filaments in olfactory mucosa in biopsy specimens of patients with probable Alzheimer's disease. Neurology 1991; 41: 391–4
  • Yamagishi M, Ishizuka Y, Seki K. Pathology of olfactory mucosa in patients with Alzheimer's disease. Ann Otol Rhinol Laryngol 1994; 103: 421–7
  • Talamo B R, Rudel R A, Kosik K S, Lee V MY, Neff S, Adelman L, Kauser J S. Pathological changes in olfactory neurons in patients with Alzheimer's disease. Nature 1989; 337: 736–9
  • Yamagishi M, Takami S, Getchell T V. Ontogenic expression of spot 35 protein (calbindin-D28k) in human olfactory receptor neurons and its decrease in Alzheimer's disease patients. Ann Otol Rhinol Laryngol 1995, in press.
  • Guth L. Degeneration and regeneration of taste buds. Taste. Handbook of sensory physiology VII, L M Beidler. Springer, Berlin, Heidelberg, New York 1971; 63–74
  • Fujimoto S, Murray R G. Fine structure of degeneration and regeneration in denervated rabbit vallate taste buds. Anat Rec 1970; 168: 393–414
  • Zalawaski A A. Regeneration of taste buds in the lingual epithelium after excision of the vallate papilla. Exp Neurol 1970; 26: 621–9
  • Schiffman S S, Clark C M, Warwick Z S. Gustatory and olfactory dysfunction in dementia: not specific to Alzheimer's disease. Neurobiology of Aging 1990; 11: 597–600

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.