The Herbal Medicine, Sairei-to, Prevents Endotoxin-induced Otitis Media with Effusion in the Guinea Pig

References

• Stewart I A., Guy A M., Allison R S., Thomson N J. Bromhexine in the treatment of otitis media with effusion. Clin Otolaryngol 1985; 10: 145–9
   PubMedGoogle Scholar
• Ernstson S, Anari M, Cederberg A, et al. Cefaclor in otitis media with effusion. Acta Otolaryngol (Stockh) 1985; 424: 7–12, Suppl
   Google Scholar
• Lambert P R. Oral steroid therapy for chronic middle ear perfusion: a double‐blind crossover study. Otolaryngol Head Neck Surg 1986; 95: 193–9
   PubMedGoogle Scholar
• Kumazawa T, Ushiro K. Clinical evaluation of S‐CMC syrup applied in the treatment of otitis media with effusion: double‐blind comparative test with placebo. Acta Otolaryngol (Stockh) 1988; 458: 56–62, Suppl
   Google Scholar
• Healy G B., Smith H G. Current concept in the management of otitis media with effusion. Am J Otolaryngol 1981; 2: 138–44
   PubMedGoogle Scholar
• Giebink G S. Otitis media update: pathogenesis and treatment. Ann Otol Rhinol Laryngol 1992; 101: 21–3
   Web of Science ®Google Scholar
• Ohashi Y, Nakai Y. Current concept of mucociliary dysfunction in otitis media with effusion. Acta Otolaryngol (Stockh) 1991; 486: 149–61, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Furuya H, et al. Mucociliary disease of the middle ear during experimental otitis media with effusion induced by bacterial endotoxin. Ann Otol Rhinol Laryngol 1989; 98: 479–84
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Esaki Y, et al. Acute effects of irradiation on the middle ear. Ann Otol Rhinol Laryngol 1988; 97: 173–8
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Ohno Y, . The influence of allergic response on the ear. the auditory system, I Honjo, et al. KuglerAmsterdam/New York. 1994; 15–25
   Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Acute effects of sulfur dioxide exposure on the middle ear mucosa. Ann Otol Rhinol Laryngol 1989; 98: 301–7
   PubMed Web of Science ®Google Scholar
• Esaki Y, Ohashi Y, Furuya H, et al. Histamine‐induced mucociliary dysfunction and otitis media with effusion. Acta Otolaryngol (Stockh) 1991; 486: 116–34, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Ohno Y, et al. Influenza A modification of endotoxin‐induced otitis media with effusion in the guinea pig. Eur Arch Otorhinolaryngol 1993; 250: 27–32
   PubMedGoogle Scholar
• Bakaletz L O., Ohashi Y, DeMaria T F., Lim D J. Effect of formalin‐fixed Hemophilus influenzae and Streptococcus pneumoniae on dye transport by the chinchilla eustachian tube. Acta Otolaryngol (Stockh) 1989; 107: 235–43
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Functional disorder of eustachian tube in experimental otitis media with effusion following inoculation of bacterial endotoxin. Ann Otol Rhinol Laryngol 1988; 97: 422–6
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Esaki Y, Onoyama Y. An experimental study of mucociliary pathology of the eustachian tube in otitis media with effusion induced by irradiation. Arch Otorhinolaryngol 1989; 246: 428–32
   PubMedGoogle Scholar
• Wacker D F., Howe M L. Middle ear cilia activity as a determinant of tympanostomy tube placement. Otolaryngol Head Neck Surg 1986; 95: 434–7
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Nakata J, et al. Ciliary activity on adenoids of patients with otitis media with effusion. Am J Otolaryngol 1988; 9: 323–6
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y, Koshimo H, et al. Reversibility of reduced ciliary activity on adenoids of patients with otitis media with effusion following culture. Clin Otolaryngol 1988; 13: 179–84
   PubMed Web of Science ®Google Scholar
• Esaki Y, Ohashi Y, Furuya H, et al. Effect of sairei‐to on the ciliary activity in the middle ear. Pract Otol (Kyoto) 1989; 82: 1791–5
   Google Scholar
• Sugiura Y, Ohashi Y, Nakai Y. A herbal medicine “sairei‐to” enhances the mucociliary activity of the tubotympanum in the healthy guinea pig. Acta Otolaryngol (Stockh), under submission
   Google Scholar
• Ohashi Y, Nakai Y, Kihara S. Ciliary activity of the middle ear lining in guinea pigs. Ann Otol Rhinol Laryngol 1985; 94: 419–23
   PubMed Web of Science ®Google Scholar
• Moore G E., Gerner R E., Franklin H A. Culture of normal human leukocytes. JAMA 1967; 199: 519–24
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Koshimo H, et al. Ciliary activity in the in vitro tubotympanum. Arch Otorhinolaryngol 1986; 243: 317–9
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol (Stockh) 1983; 397: 3–9, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Esaki Y, et al. Influenza A virus‐induced otitis media and mucociliary dysfunction in the guinea pig. Acta Otolaryngol (Stockh) 1991; 486: 135–48, Suppl
   Google Scholar
• Takaksaka T, Ikeda K. Therapeutic effect with Chinese medicine Tsumura Sairetio on secretory otitis media. Prog Med 1988; 8: 591–9
   Google Scholar
• Hirakawa K, Harada Y, Yajin K, et al. Clinical evalutation of Tsumura Saireito in treatment of otitis media with effusion. Pract Otol (Kyoto) 1991; 84: 383–7
   Google Scholar
• Sato H, Nakamura H, Honjo I, et al. Clinical evaluation of Tsumura Saireito in children with otitis media with effusion. Pract Otol (Kyoto) 1988; 81: 1383–7
   Google Scholar
• DeMaria T F., Prior R B., Briggs B R. Endotoxin in middle‐ear effusions from patients with chronic otitis media with effusion. J Clin Microbiol 1984; 20: 14–7
   Google Scholar
• Giebink G S., Ripley M L., Wright P F. Eustachian tube histopathology during influenza A virus infection in the chinchilla. Ann Otol Rhinol Laryngol 1987; 96: 199–206
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Effects of carbocysteine on the experimental otitis media with effusion caused by long‐term exposure to SO2. J Otolaryngol Jpn 1985; 88: 1051–5
   Google Scholar
• Ohashi Y, Nakai Y, Koshimo H, et al. Mucosal pathology of experimental otitis meida with effusion due to nitrogen dioxide exposure and the effects of carbocysteine on pathological middle ear mucosa. J Otolaryngol Jpn 1988; 91: 71–87
   Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Experimental otitis media with effusion induced by lipopolysaccharide from Klebsiella pneumoniae: mucociliary pathology of the middle ear. Am J Otolaryngol 1988; 9: 83–9
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y, Esaki Y, et al. Experimental otitis meida with effusion induced by lipopolysaccharide from Klebsiella pneumoniae: mucociliary pathology of Eustachian tube. Acta Otolaryngol (Stockh) 1991; 486: 105–15, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Ikeika H, et al. Effects of bacterial endotoxin on the ciliary activity in the in vitro middle ear mucosa. Acta Otolaryngol (Stockh) 1987; 104: 495–9
   PubMed Web of Science ®Google Scholar
• Lim D J., Viall J, Birck H, Pierre R S. The morphological basis for understanding middle ear effusions. An electron microscopic, cytochemical, and autoradio‐graphic investigation. Laryngoscope 1972; 82: 1625–42
   PubMedGoogle Scholar
• Möller P, Dalén H. Ultrastructure of the middle ear mucosa in secretory otitis media. Acta Otolaryngol (Stockh) 1981; 91: 95–110
   Google Scholar