Roxythromycin Prevents Endotoxin-induced Otitis Media with Effusion in the Guinea Pig

References

• Stewart I A., Guy A M., Allison R S., Thomson N J. Bromhexine in the treatment of otitis media with effusion. Clin Otolaryngol 1985; 10: 145–9
   PubMedGoogle Scholar
• Ernston S, Anari M, Cederberg A, et al. Cefaclor in otitis media with effusion. Acta Otolaryngol (Stockh) 1985; 424: 7–12, Suppl
   Google Scholar
• Lambert P R. Oral steroid therapy for chronic middle ear perfusion: a double‐blind crossover study. Otolaryngol Head Neck Surf 1986; 95: 193–9
   PubMedGoogle Scholar
• Kumazawa T, Ushiro K. Clinical evaluation of S‐CMC syrup applied in the treatment of otitis media with effusion: double‐blind comparative test with placebo. Acta Otolaryngol (Stockh) 1988; 458: 56–62, Suppl
   Google Scholar
• Ohashi Y, Nakai Y. Current concept of mucociliary dysfunction in otitis media with effusion. Acta Otolaryngql (Stockh) 1991; 486: 149–61, Suppl
   PubMedGoogle Scholar
• Lim D J., Klein J, Bluestone C, et al. Recent advantages in otitis media with effusion: report of research conference. Ann Otol Rhinol Laryngol 1985; 166: 1–32, Suppl
   Google Scholar
• Brook I, Yocum P, Shah K, et al. Aerobic and anaerobic bacteriologic features of serous otitis media in children. Am J Otolaryngol 1983; 6: 389–92
   Google Scholar
• DeMaria T F., Prior R B., Briggs B R. Endotoxin in middle‐ear effusions from patients with chronic otitis media with effusion. J Clin Microbiol 1984; 20: 14–7
   Google Scholar
• Bernstein J, Praino M D., Neter E. Detection of endotoxin in ear specimens from patients with chronic otitis media by means of limulus amebocyte test. Can J Microbiol 1980; 26: 645–8
   Web of Science ®Google Scholar
• Jung T T K. Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media. Laryngoscope 1988; 98: 980–93
   PubMed Web of Science ®Google Scholar
• Fukuyama M, Kubo N, Yamashita T. Biochemical evidence of platelet‐activating factor (PAF) in human middle ear effusions. Laryngoscope 1995; 105: 188–91
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y, Kihara S, Ikeoka H. Effects of Straphylococcus aureus on the ciliary activity of the middle ear lining. Ann Otol Rhinol Laryngol 1987; 96: 225–8
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Effects of bacterial endotoxin on the ciliary activity in the in vitro middle ear mucosa. Acta Otolaryngol (Stockh) 1987; 104: 495–9
   PubMed Web of Science ®Google Scholar
• Esaki Y, Ohashi Y, Furuya H, et al. Histamine‐induced mucociliary dysfunction and otitis media with effusion. Acta Otolaryngol (Stockh) 1991; 486: 116–34, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Ohno Y, et al. Effects of human middle ear effusions on the mucociliary system of the tubotympanum in the guinea pig. Eur Arch Otorhinolaryngol 1995; 252: 35–41
   PubMedGoogle Scholar
• Stanfanger G S., Bisgaard H, Pedersen M, et al. Effect of N‐acetylcystein on the human nasal ciliary activity in vitro. Eur J Respir Dis 1987; 70: 157–62
   PubMedGoogle Scholar
• Coles P, Griffin W. Effect of topical nasal medications on human nasal ciliary function. Eur J Respir Dis 1983; 64(Suppl 126)121–3
   PubMedGoogle Scholar
• Kimura Y, Saito H, Mori S. The effect of aspirin and prednisolone on nasal ciliary activity. ORL (Tokyo) 1996; 39: 128–31
   Google Scholar
• Tamaoki J, Takeyama K. Effect of roxythromycin on ciliary motility of rabbit tracheal epithelium in culture. Respir Circul (Tokyo) 1991; 39: 481–5
   Google Scholar
• Sugiura Y, Ohashi Y, Nakai Y. Roxythromycin stimulates mucociliary activity of the Eustachian tube and modulates neutrophil activity in the healthy guinea pig. Acta Otolaryngol (Stockh) 1997; 531: 34–38, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Kihara S. Ciliary activity of the middle ear lining in guinea pigs. Ann Otol Rhinol Laryngol 1985; 94: 419–23
   PubMed Web of Science ®Google Scholar
• Moore G E., Gerner R E., Franklin H A. Culture of normal humanleukocytes. JAMA 1967; 199: 519–24
   PubMed Web of Science ®Google Scholar
• Ohashi Y, Nakai Y, Koshimo H, et al. Ciliary activity in the in vitro tubotympanum. Arch Otorhinolaryngol 1986; 243: 317–9
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol (Stockh) 1983; 397: 3–9, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Esaki Y, et al. Influenza A virus‐induced otitis media and mucociliary dysfunction in the guinea pig. Acta Otolaryngol (Stockh) 1991; 486: 135–48, Suppl
   Google Scholar
• Carlone N A., Cuffini A M., Tullio V, Sassella D. Comparative effects of roxythromycin and erythromycin on cellular immune functions in vitro. 2 Chemotaxis and phagocytosis of 3H‐Staphylococcus aureus by human macrophages. Microbiology 1989; 58: 17–25
   Google Scholar
• Torre D, Broggini M, Botta V, et al. In vitro and ex vivo effects of recent and new macrolide antibiotics on chemotaxis on human polymorphonuclear leukocytes. J Chemothr 1991; 3: 236–9
   PubMed Web of Science ®Google Scholar
• Goswami S K., Kivity S, Marom Z. Erythromycin inhibits respiratory glycoconjugates secretion from human airways in vitro. Am Rev Respir Dis 1990; 141: 72–8
   PubMed Web of Science ®Google Scholar
• Lim D J., DeMaria T F., Bakaletz L O. Current concept of pathogenesis of otitis media: a review. Acta Otolaryngol (Stockh) 1988; 458: 174–80, Suppl
   Google Scholar
• Ohashi Y, Nakai Y, Ikeoka H, et al. Experimental otitis media with effusion induced by lipopolysaccharide from Klebsiella pneumoniae: mucociliary pathology of the middle ear. Am J Otolaryngol 1988; 9: 83–9
   PubMedGoogle Scholar
• Ohashi Y, Nakai Y, Esaki Y, et al. Experimental otitis media with effusion induced by lipopolysaccharide from Klebsiella pneumoniae: mucociliary pathology of Eustachian tube. Acta Otolaryngol (Stockh) 1991; 486: 105–15, Suppl
   Google Scholar
• Lim D J., Birck H. Ultrastructural pathology of the middle ear mucosa in serous otitis media. Ann Otol Rhinol Laryngol 1971; 80: 838–53
   PubMed Web of Science ®Google Scholar
• Möller P, Dalén H. Ultrastructure of the middle ear mucosa in secretory otitis media. Acta Otolaryngol 1981; 91: 95–110
   Google Scholar
• Lim D J., Viall J, Birck H, Pierre R S. The morphological basis for understanding middle ear effusions: an electron microscopic, cytochemical, and autoradiographic investigation. Laryngoscope 1972; 82: 1625–42
   PubMedGoogle Scholar