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International Journal of Neuroscience Volume 103, 2000 - Issue 1-4
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Original Article

Modulation by Extracellular Ph of GabaA Receptors Expressed in Xenopus Oocytes Injected with Rat Brain Mrna

M. Robello Unià INFM, Dipartimenlo di Fisica, Università di Genova, C.N.R., Genoa, ItalyCorrespondence[email protected]
&
R. Balduzzi Unià INFM, Dipartimenlo di Fisica, Università di Genova, C.N.R., Genoa, Italy; Centra di Neurofisiologia Cerehrale, CNR, Genoa, Italy
Pages 41-51 | Received 03 Sep 1999, Published online: 07 Jul 2009

References

  • Angeloui I. P., Vlacdonald R. I. Assembly of GABAA receptor subuniis: ol 31 and al 31–2s subuniis produce unique ion channels with dissimilar single-channel properties. Journal of NeuroScience 1993; 13: 1424–1440
  • Barnard E. A., Darlinson A., Seeburg P. Molecular biology of the GABAN receptor: the receptor channel superfamtly. Trends in NeuroScience 1997; 10: 502–509
  • Buhr A., Baur R., Sigel H. Subtle changes in residue 77 of the-subunit o/ nl V2-.2 (jABA./ receptors drastically alter the attinity lor ligands of the benzodiazepine binding site. Journal of Rioloieal Chemistry. 1997; 272: I1799–11X04
  • Chapman A. G., Meldrtirn B. S., Siesjo B. K. Cerebral metabolic changes during prolonged epileptic seizures in rats. Journal of Neuroelienusiry. 1977; 28: 1025–1035
  • Clarke D. D., Sokolol V. I. Circulation and energy metabolism of the brain. Basil Xeitrodieniisiry, G. J. Siegel, et al. Raven Press, New York 1994; 645–680
  • Dean P., Gale K. Anticonvulsant action of GABA receptor blockade in the nigroleclal target region. Brain Research. 1989; 477: 391–395
  • Gale K. GABA in epilepsv: the pharmacological basis. Epilepsia. 1989; 30: SI, suppl
  • Houamed K. M., Bilbe G., Smart T. G., Coiistanti A., Brown D. A., Barnard I. A., Richards B. M. Expression of functional GABA. glycine and glutamale receptors in Xenopus oocytes injected with rat brain mRNA. Suture. 1984; 310: MX 321
  • Kaila K., Paalasmaa P., Taira T., Voipio J. pH transients due to monosynaptic activation ot' GABAA receptors in rat hippocampal slices. Neururepori. 1992; 3: 105–408
  • Kaila K., Voipio J. Postsynaptic fall in intracellular pll induced by GABA-activated bicarbonate conductance. Nature 1987; 330: 163–165
  • Koesis J. D., Malison R. H. GABA levels in the brain: a target for new anliepileptic drugs. I'hc Seuroseientist. 1996; 6: 326–334
  • Krishek B. J., Amato A., Connolly C. N., Moss S. J., Smart T. G. Proton sensitivity of the GABAA receptor is associated with the receptor subunit composition. Journal of Physiology. 1996; 492: 431–436
  • McLdrum B. S. Update on the mechanism of action of antiepileptic drugs. Epilepsia. 1996; 37: S4–S11, (suppl.)
  • Mody I., Dc Koninck Y., Otis L. S., Sokesz I. Bridging the cleft at GABA synapses in the brain. Trends in Neuroscienee. 1994; 17: 517–525
  • Robello M., Baldelli P., Cupcllo A. Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells. Neuroscienee. 1994; 61: 833–837
  • Saxena N. C., Macdonald R. L. Assembly of GABAA receptor subunits: role of the o subunit. Journal of Neuroscienee. 1994; 14: 7077–7086
  • Saxena N. C., Macdonald R. L. Properties of putative cerebellar-aminobutyric acid A receptor isoforms. Molecular Pharmacology. 1996; 49: 567–579
  • Schofield P. R., Darlison M. G., Fujita N., Burt D. R., Stephenson F. A., Rodriguez H., Rhee L. M., Ramachandran J., Reale V., Glencorse T. A., Seeburg P. K., Barnard E. A. Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor superfamily. Nature 1987; 328: 221–227
  • Sigel F., Baur R., Trube G., Mohler H., Malherbe P. The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron. 1990; 5: 703–711
  • Smart T. G., Houamed K. M., Van Reiiterghem C., Constanti A. mRNA directed synthesis and insertion of functional aminoacid receptors in Xenopus laevis oocytes. Biochemical Society Transactions 1987; 15: 117–122
  • Tang C. M., Dichter M., Morad M. Modulation of the N-methyl-D-aspartate channel by extracellular H. Proceedings of the National Aeailemv of Sciences. USA. 1990; 87: 6445–6449
  • Tretter V., Ehya N., Fuchs K., Sieghart W. Stoichiometry and assembly of a recombinant GABAA receptor subtype. Journal of Neuroscienee. 1997; 17: 2728–2737
  • Van Reiiterghem C., Bilbe G., Moss S., Smart T. G., Constanti A., Brown D. A., Barnard E. A. GABA receptors induced in Xenopus oocytes by chick brain mRNA: evaluation of TBPS as a use-dependent channel-blocker. Molecular Brain Research. 1987; 2: 21–31
  • Verdoon T. A., Draguhn A., Ymer S., Seeburg P. H., Sackmann B. Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron. 1990; 4: 919–928
  • Zhai J., Peoples R. W., Li C. Proton inhibition of GABA activated current in rat primary sensory neurons. Pfhigers Archives. 1998; 435: 539–545

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