340
Views
51
CrossRef citations to date
0
Altmetric
Research Article

Luteolin Inhibits Microglial Inflammation and Improves Neuron Survival Against Inflammation

, , , &
Pages 329-336 | Received 28 Dec 2010, Published online: 01 Jun 2011

REFERENCES

  • Bureau, G., Longpre, F., & Martinoli, M. G. (2008). Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. Journal of Neuroscience Research, 86(2), 403–410. [PubMed: 17929310]
  • Chen, C. Y., Peng, W. H., Tsai, K. D., & Hsu, S. L. (2007). Luteolin suppresses inflammation-associated gene expression by blocking NF- kappa B and AP-1 activation pathway in mouse alveolar macrophages. Life Sciences, 81(23/24), 1602–1614. [PubMed: 17977562]
  • Chen, H. Q., Jin, Z. Y., Wang, X. J., Xu, X. M., Deng, L., & Zhao, J. W. (2008). Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neuroscience Letters, 448(2), 175–179.
  • Comalada, M., Ballester, I., Bailon, E., Sierra, S., Xaus, J., Galvez, J., (2006). Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure–activity relationship. Biochemical Pharmacology, 72(8), 1010–1021. [PubMed: 16934226]
  • Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., (2010). Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. Journal of Neuroinflammation, 14(7), 3–18. [PubMed: 20074346]
  • Gloria, G. V., Perla, K. C., Santa, R. A., & Slivia, M. F. (2006). Luteolin inhibits lipopolysaccharide actions on human gingival fibroblasts. European Journal of Pharmacology, 541(1–2), 95–105. [PubMed: 16762341]
  • Harris, G. K., Qian, Y., Leonard, S. S., Sbarra, D. C., & Shi, X. (2006). Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells. Journal of Nutrition, 136(6), 1517–1521. [PubMed: 16702314]
  • Hunter, R. L., Dragicevic, N., Seifert, K., Choi, D. Y., Liu, M., Kim, H. C., (2007). Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. Journal of Neurochemistry, 100(5), 1375–1386. [PubMed: 17254027]
  • Jang, S., Dilger, R. N., & Johnson, R. W. (2010). Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. Journal of Nutrition, 140(10), 1892–1898. [PubMed: 20685893]
  • Jang, S., Kelley, K. W., & Johnson, R. W. (2008). Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proceedings of the National Academy of Sciences of the United States of America, 105(21), 7534–7539. [PubMed: 18490655]
  • Jung, W. K., Heo, S. J., Jeon, Y. J., Lee, C. M., Park, Y. M., Byun, H. G., (2009). Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells. Journal of Agricultural and Food Chemistry, 57(10), 4439–4446. [PubMed: 19408937]
  • Kang, S. S., Lee, Y. K., Choi, Y. K., Kim, G. S., & Han, B. H. (2004). Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cell. Bioorg Med Chem Lett, 14(9), 2261–2264.
  • Kim, J. H., Na, H. J., Kim, C. K., Kim, J. Y., Ha, K. S., Lee, H., (2008). The nonprovitamin A carotenoid, luteolin, inhibits NF-kappa B-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: Role of H(2)O(2) in NF-kappaB activation. Free Radical Biology and Medicine, 45(6), 885–896. [PubMed: 18620044]
  • Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., (2002). Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. American Journal of Respiratory and Critical Care Medicine, 165(6), 818–823. [PubMed: 11897650]
  • Kumazawa, Y., Kawaguchi, K., & Takimoto, H. (2006). Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Current Pharmaceutical Design, 12(32), 4271–4279. [PubMed: 17100629]
  • Lee, Y. B., Nagai, A., & Kim, S. U. (2002). Cytokines, chemokines, and cytokine receptors in human microglia. Journal of Neuroscience Research, 69(1), 94–103. [PubMed: 12111820]
  • Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., (1999). Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nature Medicine, 5(12), 1403–1409. [PubMed: 10581083]
  • Linnartz, B., Wang, Y., & Neumann, H. (2010). Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation. International Journal of Alzheimer Disease, 1000, pii:587463. [PubMed: 20721346]
  • Liu, B., Gao, H. M., Wang, J. Y., Jeohn, G. H., Cooper, C. L., & Hong, J. S. (2002). Role of nitric oxide in inflammation-mediated neurodegenration. Annals of the New York Academy of Sciences, 962(1), 318–331. [PubMed: 12076984]
  • Liu, B., & Hong, J. S. (2003). Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention. Journal of Pharmacology and Experimental Therapeutics, 304(1), 1–7. [PubMed: 12490568]
  • Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402–408. [PubMed: 11846609]
  • McGeer, E. G., & McGeer, P. L. (2010). Neuroinflammation in Alzheimer's disease and mild cognitive impairment: A field in its infancy. Journal of Alzheimer's Disease, 19(1), 355–361. [PubMed: 20061650]
  • Mrak, R. E., & Griffin, W. S. (2005). Glia and their cytokines in progression of neurodegeneration. Neurobiology of Aging, 26(3), 349–354. [PubMed: 15639313]
  • Park, E., Kum, S., Wang, C., Park, S. Y., Kim, B. S., & Schuller-Levis, G. (2005). Anti-inflammatory activity of herbal medicines: Inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line. American Journal of Chinese Medicine, 33(3), 415–424. [PubMed: 16047559]
  • Singer, C. A., Figueroa-Masot, X. A., Batchelor, R. H., & Dorsa, D. M. (1999). The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. Journal of Neuroscience, 19(7), 2455–2463. [PubMed: 10087060]
  • Streit, W. J. (2005). Microglia and neuroprotection: Implications for Alzheimer's disease. Brain Research Reviews, 48(2), 234–239. [PubMed: 15850662]
  • Tarkowski, E., Liljeroth, A. M., Minthon, L., Tarkowski, A., Wallin, A., & Blennow, K. (2003). Cerebral pattern of pro- and anti-inflammatory cytokines in dementias. Brain Research Bulletin, 61(3), 255–260. [PubMed: 12909295]
  • Van Aker, S. A., Tromp, M. N., Griffioen, D. H., van Bennekom, W. P., van der Vijgh, W. J., & Bast, A. (1996). Structural aspects of antioxidant activity of flavonoids. Free Radical Biology and Medicine, 20(3), 331–342. [PubMed: 8720903]
  • Wang, S. X., Hu, L. M., Gao, X. M., Guo, H., & Fan, G. W. (2010). Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect. Neurochemical Research, 35(7), 1029–1037. [PubMed: 8720903]
  • Zhao, G., Chen, Y. Y., Qine, G. W., & Guo, L. H. (2010). Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons. Neurobiology of Aging. 2010 Apr. 9. [Epub ahead of print]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.