Advanced search
Publication Cover
International Journal of Neuroscience Volume 121, 2011 - Issue 9
Submit an article Journal homepage
285
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Study of Methylation Levels of Parkin Gene Promoter in Parkinson's Disease Patients

Miao CaiDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education)
,
Jun TianDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education)
,
Guo-hua ZhaoDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education)
,
Wei LuoDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education)
&
Bao-rong ZhangDepartment of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education)Correspondence[email protected]
Pages 497-502 | Received 19 Dec 2010, Published online: 10 Jun 2011

REFERENCES

  • Agirre, X., Roman-Gomez, J., Vazquez, I., Jimenez-Velasco, A., Garate, L., Montiel-Duarte, C., (2006). Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. International Journal of Cancer, 118(8), 1945–1953.
  • Asakawa, S., Tsunematsu, K., Takayanagi, A., Sasaki, T., Shimizu, A., Shintani, A., et al. (2001). The genomic structure and promoter region of the human parkin gene. Biochemical and Biophysical Research Communications, 286(5), 863–868.
  • Cesari, R., Martin, E. S., Calin, G. A., Pentimalli, F., Bichi, R., McAdams, H., (2003). Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proceedings of the National Academy of Science of the United States of America, 100(10), 5956–5961.
  • Clark, L. N., Afridi, S., Karlins, E., Wang, Y., Mejia-Santana, H., Harris, J., (2006). Case-control study of the parkin gene in early-onset Parkinson disease. Archives of Neurology, 63(4), 548–552.
  • de Rijk, M. C., Tzourio, C., Breteler, M. M., Dartigues, J. F., Amaducci, L., Lopez-Pousa, S., et al., (1997). Prevalence of parkinsonism and Parkinson's disease in Europe: The EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 62(1), 10–15.
  • Denison, S. R., Callahan, G., Becker, N. A., Phillips, L. A., & Smith, D. I. (2003). Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Genes Chromosomes Cancer, 38(1), 40–52.
  • Denison, S. R., Wang, F., Becker, N. A., Schule, B., Kock, N., Phillips, L. A., (2003). Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene, 22(51), 8370–8378.
  • Douglas, M. R., Lewthwaite, A. J., & Nicholl, D. J. (2007). Genetics of Parkinson's disease and parkinsonism. Expert Review of Neurotherapeutics, 7(6), 657–666.
  • Esteller, M. (2002). CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future. Oncogene, 21(35), 5427–5440.
  • Gardiner-Garden, M., & Frommer, M. (1987). CpG islands in vertebrate genomes. Journal of Molecular Biology, 196(2), 261–282.
  • Hedrich, K., Eskelson, C., Wilmot, B., Marder, K., Harris, J., Garrels, J., et al.(2004). Distribution, type, and origin of Parkin mutations: Review and case studies. Movement Disorders, 19(10), 1146–1157.
  • Henn, I. H., Gostner, J. M., Lackner, P., Tatzelt, J., & Winklhofer, K. F. (2005). Pathogenic mutations inactivate parkin by distinct mechanisms. Journal of Neurochemistry, 92(1), 114–122.
  • Jones, A. C., Yamamura, Y., Almasy, L., Bohlega, S., Elibol, B., Hubble, J., et al.(1998). Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: Detailed genetic mapping of the linked region. American Journal of Human Genetics, 63(1), 80–87.
  • Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., et al.(1998). Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 392(6676), 605–608.
  • Klein, C., & Schlossmacher, M. G. (2007). Parkinson disease, 10 years after its genetic revolution: Multiple clues to a complex disorder. Neurology, 69(22), 2093–2104.
  • Picchio, M. C., Martin, E. S., Cesari, R., Calin, G. A., Yendamuri, S., Kuroki, T., et al.(2004). Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer. Clinical Cancer Research, 10(8), 2720–2724.
  • Staropoli, J. F. (2008). Tumorigenesis and neurodegeneration: Two sides of the same coin? Bioessays, 30(8), 719–727.
  • Wang, F., Denison, S., Lai, J. P., Philips, L. A., Montoya, D., Kock, N., et al.(2004). Parkin gene alterations in hepatocellular carcinoma. Genes Chromosomes Cancer, 40(2), 85–96.
  • West, A., Farrer, M., Petrucelli, L., Cookson, M., Lockhart, P., & Hardy, J. (2001). Identification and characterization of the human parkin gene promoter. Journal of Neurochemistry, 78(5), 1146–1152.
  • West, A. B., Lockhart, P. J., O'Farell, C., & Farrer, M. J. (2003). Identification of a novel gene linked to parkin via a bi-directional promoter. Journal of Molecular Biology, 326(1), 11–19.
  • West, A., Periquet, M., Lincoln, S., Lucking, C. B, Nicholl, D., Bonifati, V., et al.(2002). Complex relationship between Parkin mutations and Parkinson disease. American Journal of Medical Genetics, 114(5), 584–591.
  • Zhang, B. R., Hu, Z. X., Yin, X. Z., Cai, M., Zhao, G. H., Liu, Z. R., et al.(2010). Mutation analysis of parkin and PINK1 genes in early-onset Parkinson's disease in China. Neuroscience Letters, 477(1), 19–22.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.