Premotor Symptoms and Early Diagnosis of Parkinson's Disease

REFERENCES

• Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron. 2010;66:646–61.
   PubMedGoogle Scholar
• Cookson MR, Bandmann O. Parkinson's disease: insights from pathways. Hum Mol Genet. 2010;19:R21-7.
   PubMedGoogle Scholar
• Langston JW. The Parkinson's complex: parkinsonism is just the tip of the iceberg. Ann Neurol. 2006;59:591–6.
   PubMedGoogle Scholar
• Haehner A, Boesveldt S, Berendse HW, Mackay-Sim A, Fleischmann J, Silburn PA, Johnston AN, Mellick GD, Herting B, Reichmann H, Hummel T. Prevalence of smell loss in Parkinson's disease—a multicenter study. Parkinsonism Relat Disord. 2009;15:490–4.
   PubMedGoogle Scholar
• Ansari KA, Johnson A. Olfactory function in patients with Parkinson's disease. J Chron Dis. 1975;28:493–7.
   PubMedGoogle Scholar
• Ward CD, Hess WA, Calne DB. Olfactory impairment in Parkinson's disease. Neurology. 1983;33:943–6.
   PubMedGoogle Scholar
• Quinn NP, Rossor MN, Marsden CD. Olfactory threshold in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1987;50:88–9.
   PubMedGoogle Scholar
• Herting B, Schulze S, Reichmann H, Haehner A, Hummel T. A longitudinal study of olfactory function in patients with idiopathic Parkinson's disease. J Neurol. 2008;255:367–70.
   PubMedGoogle Scholar
• Ashendorf L, Constantinou M, Duff K, McCaffrey RJ. Performance of community-dwelling adults ages 55 to 75 on the University of Pennsylvania smell identification test: an item analysis. Appl Neuropsychol. 2005;12:24–9.
   PubMedGoogle Scholar
• Lafreniere D, Mann N. Anosmia: loss of smell in the elderly. Otolaryngol Clin North Am. 2009;42:123–31.
   Google Scholar
• McShane RH, Nagy Z, Esiri MM, King E, Joachim C, Sullivan N, Smith AD. Anosmia in dementia is associated with Lewy bodies rather than Alzheimer's pathology. J Neurol Neurosurg Psychiatry. 2001;70:739–43.
   PubMedGoogle Scholar
• Williams SS, Williams J, Combrinck M, Christie S, Smith AD, McShane R. Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease. J Neurol Neurosurg Psychiatry. 2009;80:667–70.
   PubMedGoogle Scholar
• Garland EM, Raj SR, Peltier AC, Robertson D, Biaggioni I. A cross-sectional study contrasting olfactory function in autonomic disorders. Neurology. 2011;76:456–60.
   PubMedGoogle Scholar
• Silveira-Moriyama L, Hughes G, Church A, Ayling H, Williams DR, Petrie A, Holton J, Revesz T, Kingsbury A, Morris HR, Burn DJ, Lees AJ. Hyposmia in progressive supranuclear palsy. Mov Disord. 2010;25:570–7.
   PubMedGoogle Scholar
• Katzenschlager R, Zijlmans J, Evans A, Watt H, Lees AJ. Olfactory function distinguishes vascular parkinsonism from Parkinson's disease. J Neurol Neurosurg Psychiatry. 2004;75:1749–52.
   PubMedGoogle Scholar
• Busenbark KL, Huber SJ, Greer G, Pahwa R, Koller WC. Olfactory function in essential tremor. Neurology. 1992;42: 1631–2.
   PubMedGoogle Scholar
• Silveira-Moriyama L, Schwingenschuh P, O'Donnell A, Schneider SA, Mir P, Carrillo F, Terranova C, Petrie A, Grosset DG, Quinn NP, Bhatia KP, Lees AJ. Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs). J Neurol Neurosurg Psychiatry. 2009;80:744–8.
   PubMedGoogle Scholar
• Shah M, Muhammed N, Findley LJ, Hawkes CH. Olfactory tests in the diagnosis of essential tremor. Parkinsonism Relat Disord. 2008;14:563–8.
   PubMedGoogle Scholar
• McKinnon J, Evidente V, Driver-Dunckley E, Premkumar A, Hentz J, Shill H, Sabbagh M, Caviness J, Connor D, Adler C. Olfaction in the elderly: a cross-sectional analysis comparing Parkinson's disease with controls and other disorders. Int J Neurosci. 2010;120:36–9.
   PubMedGoogle Scholar
• Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope. 1984;94:176–8.
   PubMedGoogle Scholar
• Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G. “Sniffin’ sticks”: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses. 1997;22:39–52.
   PubMedGoogle Scholar
• Muller T, Kuhn W, Buttner T, Przuntek H. Distorted colour discrimination in Parkinson's disease is related to severity of the disease. Acta Neurol Scand. 1997;96:293–6.
   PubMedGoogle Scholar
• Price MJ, Feldman RG, Adelberg D, Kayne H. Abnormalities in color vision and contrast sensitivity in Parkinson's disease. Neurology. 1992;42:887–90.
   PubMedGoogle Scholar
• Buttner T, Kuhn W, Muller T, Patzold T, Heidbrink K, Przuntek H. Distorted color discrimination in “de novo” parkinsonian patients. Neurology. 1995;45:386–7.
   PubMedGoogle Scholar
• Hutton JT, Morris JL, Elias JW, Varma R, Poston JN. Spatial contrast sensitivity is reduced in bilateral Parkinson's disease. Neurology. 1991;41:1200–2.
   PubMedGoogle Scholar
• Muller T, Kuhn W, Buttner T, Eising E, Coenen H, Haas M, Przuntek H. Colour vision abnormalities do not correlate with dopaminergic nigrostriatal degeneration in Parkinson's disease. J Neurol. 1998;245:659–64.
   PubMedGoogle Scholar
• Muller T, Woitalla D, Peters S, Kohla K, Przuntek H. Progress of visual dysfunction in Parkinson's disease. Acta Neurol Scand. 2002;105:256–60.
   PubMedGoogle Scholar
• Diederich NJ, Raman R, Leurgans S, Goetz CG. Progressive worsening of spatial and chromatic processing deficits in Parkinson disease. Arch Neurol. 2002;59:1249–52.
   PubMedGoogle Scholar
• Muller T, Meisel M, Russ H, Przuntek H. Motor impairment influences Farnsworth-Munsell 100 Hue test error scores in Parkinson's disease patients. J Neurol Sci. 2003;213:61–5.
   PubMedGoogle Scholar
• Bulens C, Meerwaldt JD, Van der Wildt GJ, Van Deursen JB. Effect of levodopa treatment on contrast sensitivity in Parkinson's disease. Ann Neurol. 1987;22:365–9.
   PubMedGoogle Scholar
• Hutton JT, Morris JL, Elias JW. Levodopa improves spatial contrast sensitivity in Parkinson's disease. Arch Neurol. 1993;50:721–4.
   PubMedGoogle Scholar
• Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res. 2004;44:2793–7.
   PubMedGoogle Scholar
• Altintas O, Iseri P, Ozkan B, Caglar Y. Correlation between retinal morphological and functional findings and clinical severity in Parkinson's disease. Doc Ophthalmol. 2008;116: 137–46.
   PubMedGoogle Scholar
• Hajee ME, March WF, Lazzaro DR, Wolintz AH, Shrier EM, Glazman S, Bodis-Wollner IG. Inner retinal layer thinning in Parkinson disease. Arch Ophthalmol. 2009;127:737–41.
   PubMedGoogle Scholar
• Moschos MM, Tagaris G, Markopoulos I, Margetis I, Tsapakis S, Kanakis M, Koutsandrea C. Morphologic changes and functional retinal impairment in patients with Parkinson disease without visual loss. Eur J Ophthalmol. 2011;21(1):24–9.
   PubMedGoogle Scholar
• Cubo E, Tedejo RP, Rodriguez Mendez V, Lopez Pena MJ, Trejo Gabriel YGJM. Retina thickness in Parkinson's disease and essential tremor. Mov Disord. 2010;25:2461–2.
   Google Scholar
• Abbott RD, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD, Grandinetti A, Blanchette PL, Popper JS, Ross GW. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology. 2001;57:456–62.
   PubMedGoogle Scholar
• Savica R, Carlin JM, Grossardt BR, Bower JH, Ahlskog JE, Maraganore DM, Bharucha AE, Rocca WA. Medical records documentation of constipation preceding Parkinson disease: a case-control study. Neurology. 2009;73:1752–8.
   PubMedGoogle Scholar
• Kupsky WJ, Grimes MM, Sweeting J, Bertsch R, Cote LJ. Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells. Neurology. 1987;37:1253–5.
   PubMedGoogle Scholar
• Qualman SJ, Haupt HM, Yang P, Hamilton SR. Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology. 1984;87:848–56.
   PubMedGoogle Scholar
• Beach TG, Adler CH, Sue LI, Vedders L, Lue L, White Iii CL, Akiyama H, Caviness JN, Shill HA, Sabbagh MN, Walker DG; Arizona Parkinson's Disease Consortium. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119:689–702.
   PubMedGoogle Scholar
• Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging. 2003;24:197–211.
   PubMedGoogle Scholar
• Beach TG, Adler CH, Lue L, Sue LI, Bachalakuri J, Henry-Watson J, Sasse J, Boyer S, Shirohi S, Brooks R, Eschbacher J, White CL 3rd, Akiyama H, Caviness J, Shill HA, Connor DJ, Sabbagh MN, Walker DG; Arizona Parkinson's Disease Consortium. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol. 2009;117:613–34.
   PubMedGoogle Scholar
• Yoshita M, Hayashi M, Hirai S. Decreased myocardial accumulation of 123I-meta-iodobenzyl guanidine in Parkinson's disease. Nucl Med Commun. 1998;19:137–42.
   PubMedGoogle Scholar
• Takatsu H, Nishida H, Matsuo H, Watanabe S, Nagashima K, Wada H, Noda T, Nishigaki K, Fujiwara H. Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG. J Nucl Med. 2000;41:71–7.
   PubMedGoogle Scholar
• Iwasa K, Nakajima K, Yoshikawa H, Tada A, Taki J, Takamori M. Decreased myocardial 123I-MIBG uptake in Parkinson's disease. Acta Neurol Scand. 1998;97:303–6.
   PubMedGoogle Scholar
• Kashihara K, Imamura T, Shinya T. Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. Parkinsonism Relat Disord. 2010;16:252–5.
   PubMedGoogle Scholar
• Fujishiro H, Frigerio R, Burnett M, Klos KJ, Josephs KA, Delledonne A, Parisi JE, Ahlskog JE, Dickson DW. Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease. Mov Disord. 2008;23:1085–92.
   PubMedGoogle Scholar
• Bonuccelli U, Lucetti C, Del Dotto P, Ceravolo R, Gambaccini G, Bernardini S, Rossi G, Piaggesi A. Orthostatic hypotension in de novo Parkinson disease. Arch Neurol. 2003;60:1400–4.
   PubMedGoogle Scholar
• Ferini-Strambi L, Franceschi M, Pinto P, Zucconi M, Smirne S. Respiration and heart rate variability during sleep in untreated Parkinson patients. Gerontology. 1992;38:92–8.
   PubMedGoogle Scholar
• Kallio M, Suominen K, Haapaniemi T, Sotaniemi K, Myllyla VV, Astafiev S, Tolonen U. Nocturnal cardiac autonomic regulation in Parkinson's disease. Clin Auton Res. 2004;14:119–24.
   PubMedGoogle Scholar
• Mihci E, Kardelen F, Dora B, Balkan S. Orthostatic heart rate variability analysis in idiopathic Parkinson's disease. Acta Neurol Scand. 2006;113:288–93.
   PubMedGoogle Scholar
• Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, Curb JD, Petrovitch H. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. 2005;65:1442–6.
   PubMedGoogle Scholar
• Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, Incidental Lewy body disease in a patient with REM sleep behavior disorder. Neurology. 1995;45:709–12.
   PubMedGoogle Scholar
• Boeve BF, Silber MH, Parisi JE, Dickson DW, Ferman TJ, Benarroch EE, Schmeichel AM, Smith GE, Petersen RC, Ahlskog JE, Matsumoto JY, Knopman DS, Schenck CH, Mahowald MW. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology. 2003;61:40–5.
   PubMedGoogle Scholar
• Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010;75:494–9.
   PubMedGoogle Scholar
• Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology. 1998;51:526–9.
   PubMedGoogle Scholar
• Gagnon J, Bedard M, Fantini ML, Petit D, Panisset M, Rompre S, Carrier J, Montplaisir J. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology. 2002;59:585–9.
   PubMedGoogle Scholar
• Boeve BF, Silber MH, Ferman TJ. REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol. 2004;17:146–57.
   PubMedGoogle Scholar
• Stiasny-Kolster K, Doerr Y, Moller JC, Hoffken H, Behr TM, Oertel WH, Mayer G. Combination of “idiopathic” REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain. 2005;128:126–37.
   PubMedGoogle Scholar
• Postuma RB, Lang AE, Massicotte-Marquez J, Montplaisir J. Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder. Neurology. 2006;66: 845–51.
   PubMedGoogle Scholar
• Fantini ML, Postuma RB, Montplaisir J, Ferini-Strambi L. Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder. Brain Res Bull. 2006;70:386–90.
   PubMedGoogle Scholar
• Miyamoto T, Miyamoto M, Suzuki K, Nishibayashi M, Iwanami M, Hirata K. 123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. Sleep. 2008;31: 717–23.
   PubMedGoogle Scholar
• Nomura T, Inoue Y, Hogl B, Uemura Y, Kitayama M, Abe T, Miyoshi H, Nakashima K. Relationship between (123)I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease. Parkinsonism Relat Disord. 2010;16:683–5.
   PubMedGoogle Scholar
• Valappil RA, Black JE, Broderick MJ, Carrillo O, Frenette E, Sullivan SS, Goldman SM, Tanner CM, Langston JW. Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease. Mov Disord. 2010;25:2296–303.
   PubMedGoogle Scholar
• Foltynie T, Brayne CE, Robbins TW, Barker RA. The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study. Brain. 2004;127:550–60.
   PubMedGoogle Scholar
• Muslimovic D, Post B, Speelman JD, Schmand B. Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology. 2005;65:1239–45.
   PubMedGoogle Scholar
• Aarsland D, Bronnick K, Larsen JP, Tysnes OB, Alves G. Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study. Neurology. 2009;72:1121–6.
   PubMedGoogle Scholar
• Shiba M, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, Schaid DJ, Rocca WA. Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study. Mov Disord. 2000;15:669–77.
   PubMedGoogle Scholar
• Leentjens AF, Van den Akker M, Metsemakers JF, Lousberg R, Verhey FR. Higher incidence of depression preceding the onset of Parkinson's disease: a register study. Mov Disord. 2003;18:414–8.
   PubMedGoogle Scholar
• Ravina B, Camicioli R, Como PG, Marsh L, Jankovic J, Weintraub D, Elm J. The impact of depressive symptoms in early Parkinson disease. Neurology. 2007;69:342–7.
   PubMedGoogle Scholar
• Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988;51:745–52.
   PubMedGoogle Scholar
• Jellinger KA. Lewy body-related alpha-synucleinopathy in the aged human brain. J Neural Transm. 2004;111:1219–35.
   PubMedGoogle Scholar
• Saito Y, Ruberu NN, Sawabe M, Arai T, Kazama H, Hosoi T, Yamanouchi H, Murayama S. Lewy body-related alpha-synucleinopathy in aging. J Neuropathol Exp Neurol. 2004;63:742–9.
   PubMedGoogle Scholar
• Adler CH, Connor DJ, Hentz JG, Sabbagh MN, Caviness JN, Shill HA, Noble B, Beach TG. Incidental Lewy body disease: clinical comparison to a control cohort. Mov Disord. 2010;25:642–6.
   PubMedGoogle Scholar
• Beach TG, Adler CH, Sue LI, Peirce JB, Bachalakuri J, Dalsing-Hernandez JE, Lue LF, Caviness JN, Connor DJ, Sabbagh MN, Walker DG. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta Neuropathol. 2008;115:445–51.
   PubMedGoogle Scholar
• Dickson DW, Fujishiro H, DelleDonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE. Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease. Acta Neuropathol. 2008;115:437–44.
   PubMedGoogle Scholar
• DelleDonne A, Klos KJ, Fujishiro H, Ahmed Z, Parisi JE, Josephs KA, Frigerio R, Burnett M, Wszolek ZK, Uitti RJ, Ahlskog JE, Dickson DW. Incidental Lewy body disease and preclinical Parkinson disease. Arch Neurol. 2008;65:1074–80.
   PubMedGoogle Scholar